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CAS 114772-54-2

4'-(bromomethyl)-[1,1'-biphenyl]-2-carbonitrile

Codes: TELM-029, OLME-011, IRBE-004, ALIS-008, VALS-001, AZILS-017, AZIL-004, CAND-004

Application context (from source-drug indications)

HypertensionTelmisartan/Amlodipine Besylate/HydrochlorothiazideHypertensionRosuvastatin Calcium/TelmisartanHyperlipidaemiaRosuvastatin Calcium/TelmisartanHypertensionOlmesartan Medoxomil/Amlodipine MaleateHypertensionOlmesartan Medoxomil/Amlodipine orotateHypertensionAtorvastatin Calcium Hydrate/IrbesartanHyperlipidaemiaAtorvastatin Calcium Hydrate/IrbesartanHypertensionAllisartan IsoproxilHypertensionLevamlodipine Besylate/ValsartanEssential hypertensionLevamlodipine Besylate/ValsartanEssential hypertensionValsartan/Amlodipine OrotateEssential hypertensionValsartan/Lercanidipine HydrochlorideHypertensionIrbesartan/TrichlormethiazideHypertensionAzilsartanEssential hypertensionAzilsartanType 2 diabetesAzilsartanObesityAzilsartanDiabetesAzilsartanHypertensionAzilsartan Medoxomil Potassium/ChlorthalidoneEssential hypertensionAzilsartan Medoxomil Potassium/ChlorthalidoneHypertensionAmlodipine Besylate/Candesartan CilexetilHypertensionOlmesartan Medoxomil/AzelnidipineHypertensionAmlodipine Besylate/TelmisartanEssential hypertensionAmlodipine Besylate/Olmesartan MedoxomilHypertensionAmlodipine Besylate/Olmesartan MedoxomilHypertensionOlmesartan MedoxomilIschaemic strokeOlmesartan MedoxomilHeart failureOlmesartan MedoxomilMetabolic syndromeOlmesartan MedoxomilGlomerulonephritisOlmesartan MedoxomilType 2 diabetesOlmesartan MedoxomilHypertensionTelmisartanBreast cancerTelmisartanCardiomyopathyTelmisartanAlzheimer's diseaseTelmisartanRisk-reduction measureTelmisartanMyocardial infarctionTelmisartanLeft ventricular dysfunctionValsartanHypertensionValsartanEssential hypertensionValsartanPulmonary arterial hypertensionValsartanRight ventricular dysfunctionValsartanPost-myocardial infarction syndromeValsartanOesophageal diseaseIrbesartanHypertensionIrbesartanDiabetic nephropathyIrbesartanHypercholesterolaemiaIrbesartanAlbuminuriaIrbesartanType 2 diabetesIrbesartanEssential hypertensionAzilsartan Medoxomil PotassiumHypertensionAzilsartan Medoxomil PotassiumHypertensionCandesartan CilexetilHeart failureCandesartan CilexetilEssential hypertensionCandesartan CilexetilMigraineCandesartan CilexetilCOVID-19Candesartan CilexetilManiaCandesartan Cilexetil

Source drugs (routes using this intermediate)

DrugTierExpiry
Telmisartan/Amlodipine Besylate/HydrochlorothiazideTier C — Watch / trade-
Rosuvastatin Calcium/TelmisartanTier C — Watch / trade-
Olmesartan Medoxomil/Amlodipine MaleateTier C — Watch / trade-
Olmesartan Medoxomil/Amlodipine orotateTier C — Watch / trade-
Atorvastatin Calcium Hydrate/IrbesartanTier C — Watch / trade-
Allisartan IsoproxilTier C — Watch / trade-
Levamlodipine Besylate/ValsartanTier C — Watch / trade-
Valsartan/Amlodipine OrotateTier C — Watch / trade-
Valsartan/Lercanidipine HydrochlorideTier C — Watch / trade-
Irbesartan/TrichlormethiazideTier C — Watch / trade-
AzilsartanTier C — Watch / trade-
Azilsartan Medoxomil Potassium/ChlorthalidoneTier C — Watch / trade-
Amlodipine Besylate/Candesartan CilexetilTier C — Watch / trade-
Olmesartan Medoxomil/AzelnidipineTier C — Watch / trade-
Amlodipine Besylate/TelmisartanTier C — Watch / trade-
Amlodipine Besylate/Olmesartan MedoxomilTier C — Watch / trade-
Olmesartan MedoxomilTier B — Position early-
TelmisartanTier B — Position early-
ValsartanTier B — Position early-
IrbesartanTier B — Position early-
Azilsartan Medoxomil PotassiumTier C — Watch / trade-
Candesartan CilexetilTier B — Position early-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

Telmisartan/Amlodipine Besylate/HydrochlorothiazideOptimised routesteps: 4total yield: 0.20 g
1,7'-dimethyl-2'-propyl-1H,3'H-2,5'-bibenzo[d]imidazole→4'-methyl-[1,1'-biphenyl]-2-carbonitrile→4'-(bromomethyl)-[1,1'-biphenyl]-2-carbonitrile→4'-(bromomethyl)-[1,1'-biphenyl]-2-carbaldehyde→4'-((1,7'-dimethyl-2'-propyl-1H,3'H-[2,5'-bibenzo[d]imidazol]-3'-yl)methyl)-[1,1'-biphenyl]-2-carbaldehyde
Rosuvastatin Calcium/TelmisartanOptimised routesteps: 4total yield: 0.20 g
1,7'-dimethyl-2'-propyl-1H,3'H-2,5'-bibenzo[d]imidazole→4'-methyl-[1,1'-biphenyl]-2-carbonitrile→4'-(bromomethyl)-[1,1'-biphenyl]-2-carbonitrile→4'-(bromomethyl)-[1,1'-biphenyl]-2-carbaldehyde→4'-((1,7'-dimethyl-2'-propyl-1H,3'H-[2,5'-bibenzo[d]imidazol]-3'-yl)methyl)-[1,1'-biphenyl]-2-carbaldehyde
Olmesartan Medoxomil/Amlodipine MaleateOptimised routesteps: 5total yield: /
diethyl 2-propyl-1H-imidazole-4,5-dicarboxylate→ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate→4-(chloromethyl)-5-methyl-1,3-dioxol-2-one→(5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 4-(2-hydroxypropan-2-yl)-2-propyl-1-((2'-(1-trityl-1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-imidazole-5-carboxylate→4'-(bromomethyl)-[1,1'-biphenyl]-2-carbonitrile→ethyl 1-((2'-cyano-[1,1'-biphenyl]-4-yl)methyl)-4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate→1-((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylic acid
Olmesartan Medoxomil/Amlodipine MaleateOptimised routesteps: 5total yield: /
4-(chloromethyl)-5-methyl-1,3-dioxol-2-one→4'-(bromomethyl)-[1,1'-biphenyl]-2-carbonitrile→4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carbonitrile→4,4-dimethyl-2-propyl-4,6-dihydro-1H-furo[3,4-d]imidazol-6-ol→4'-((6-hydroxy-4,4-dimethyl-2-propyl-4,6-dihydro-1H-furo[3,4-d]imidazol-1-yl)methyl)-[1,1'-biphenyl]-2-carbonitrile→1-((2'-cyano-[1,1'-biphenyl]-4-yl)methyl)-4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylic acid→(5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 1-((2'-cyano-[1,1'-biphenyl]-4-yl)methyl)-4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate
Olmesartan Medoxomil/Amlodipine orotateOptimised routesteps: 5total yield: /
diethyl 2-propyl-1H-imidazole-4,5-dicarboxylate→ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate→4-(chloromethyl)-5-methyl-1,3-dioxol-2-one→(5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 4-(2-hydroxypropan-2-yl)-2-propyl-1-((2'-(1-trityl-1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-imidazole-5-carboxylate→4'-(bromomethyl)-[1,1'-biphenyl]-2-carbonitrile→ethyl 1-((2'-cyano-[1,1'-biphenyl]-4-yl)methyl)-4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate→1-((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylic acid

Intermediates available on this site

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This is a CAS-level registry record: registrations across routes are merged. Supplier offers and buyer demands will be matched on this CAS as the primary key.