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CAS 253168-94-4
1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethan-1-amine1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethanamine
Codes: APER-002, (XVII)989842-1-b
Application context (from source-drug indications)
Plaque psoriasisApremilastBehçet's syndromeApremilastOral ulcerApremilastPsoriasisApremilastPsoriatic arthritisApremilastPlaque psoriasisMufemilastUlcerative colitisMufemilastBehçet's syndromeMufemilastPsoriasisMufemilastChronic obstructive pulmonary diseaseMufemilastAtopic dermatitisMufemilast
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Apremilast | Tier B — Position early | 2028 |
| Mufemilast | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
3-ethoxy-4-methoxybenzaldehyde→1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethan-1-amine→(2S)-2-acetamido-4-methylpentanoic acid→(S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethanamine (S)-2-acetamido-4-methylpentanoate→N-(1,3-dioxo-1,3-dihydroisobenzofuran-4-yl)acetamide→3-nitrophthalic acid→3-aminophthalic acid
3-ethoxy-4-methoxybenzaldehyde→1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethan-1-amine→3-nitrophthalic acid→3-ethoxy-4-methoxybenzonitrile→4-nitroisobenzofuran-1,3-dione→2-(1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-4-nitroisoindoline-1,3-dione→4-amino-2-(1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)isoindoline-1,3-dione
(1S)-1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethanamine→3-Hydroxy-4-methoxybenzaldehyde→1-Iodoethane→(3-Ethoxy-4-methoxy-phenyl)-methanone→1,1,1-Trimethyl-N-(trimethylsilyl)silanamine lithium salt→1-(Methylsulfonyl)methane→1-(3-Ethoxy-4-methoxyphenyl)-2-methylsulfonyl-N-trimethylsilylethanamine→1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethanamine
Intermediates available on this site
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