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CAS 608141-42-0
(S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethanamine(1S)-1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethanamine
Codes: APER-016, (VII)989842-1-a,(VII)989842-1-b, (III)989842-2-a,(III)989842-2-b
Application context (from source-drug indications)
Plaque psoriasisApremilastBehçet's syndromeApremilastOral ulcerApremilastPsoriasisApremilastPsoriatic arthritisApremilastPlaque psoriasisMufemilastUlcerative colitisMufemilastBehçet's syndromeMufemilastPsoriasisMufemilastChronic obstructive pulmonary diseaseMufemilastAtopic dermatitisMufemilast
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Apremilast | Tier B — Position early | 2028 |
| Mufemilast | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
3-ethoxy-4-methoxybenzaldehyde→N-(1,3-dioxo-1,3-dihydroisobenzofuran-4-yl)acetamide→(R)-1-(amino(phenyl)methyl)naphthalen-2-ol→(1R,3S)-3-(3-ethoxy-4-methoxyphenyl)-1-phenyl-2,3-dihydro-1H-naphtho[1,2-e][1,3]oxazine→lithium (methylsulfonyl)methanide→1-((R)-(((S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)amino)(phenyl)methyl)naphthalen-2-ol→(S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethanamine
N-(1,3-dioxo-1,3-dihydroisobenzofuran-4-yl)acetamide→3-ethoxy-4-methoxybenzonitrile→(S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethanamine→(E)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethenamine
3-ethoxy-4-methoxybenzaldehyde→3-ethoxy-4-methoxybenzonitrile→(S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethanamine→(E)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethenamine→1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethanone→(S)-1-phenylethan-1-amine→1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)-N-((S)-1-phenylethyl)ethanamine hydrochloride→(R)-2-methylpropane-2-sulfinamide→(E)-N-(3-ethoxy-4-methoxybenzylidene)-2-methylpropane-2-sulfinamide→N-((S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-2-methylpropane-2-sulfinamide
3,4-Bis(bromanyl)thiophene→3,4-Dicyanothiophene→Thiophene-3,4-dicarboxylic acid→1H,3H-Thieno[3,4-c]furan-1,3-dione→2-Nitrothiophene-3,4-dicarboxylic acid→4-Nitro-1H,3H-thieno[3,4-c]furan-1,3-dione→(1S)-1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethanamine→3-Nitro-5-[1(S)-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]thieno[3,4-c]pyrrole-4,6-dione→1-Amino-5-[(1S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methanesulfonyl)ethyl]-4H-thieno[3,4-c]pyrrole-4,6(5H)-dione→Acetic acid acetic anhydride→Acetic acid chloride
(1S)-1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethanamine→3-Hydroxy-4-methoxybenzaldehyde→1-Iodoethane→(3-Ethoxy-4-methoxy-phenyl)-methanone→1,1,1-Trimethyl-N-(trimethylsilyl)silanamine lithium salt→1-(Methylsulfonyl)methane→1-(3-Ethoxy-4-methoxyphenyl)-2-methylsulfonyl-N-trimethylsilylethanamine→1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethanamine
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