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CAS 286961-14-6
tert-Butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,6-dihydropyridine-1(2H)-carboxylateN-Boc-1,2,5,6-tetrahydropyridine-4-boronic acid pinacol ester(1-tert-Butoxycarbonyl-1,2,3,6-tetrahydropyridin-4-yl)boronic acid pinacol ester
Codes: Dalpiciclib Isethionate-019, (VII)965082-1-a, (XXII)805433-1-b, (IX)919110-1-a,(IX)919110-1-b
Application context (from source-drug indications)
Breast cancerDalpiciclib IsethionateMetastatic breast cancerDalpiciclib IsethionateProstate cancerDalpiciclib Isethionate三阴性乳腺癌Dalpiciclib IsethionateMeningiomaDalpiciclib IsethionateHepatic function declineDalpiciclib IsethionateMarginal zone B-cell lymphomaOrelabrutinibMantle cell lymphomaOrelabrutinibChronic lymphocytic leukaemiaOrelabrutinibImmune thrombocytopenic purpuraOrelabrutinibSystemic lupus erythematosusOrelabrutinibMultiple sclerosisOrelabrutinibIdiopathic pulmonary fibrosisNerandomilastInterstitial lung diseaseNerandomilastPulmonary fibrosisNerandomilast肌炎NerandomilastSystemic sclerosisNerandomilast肌病NerandomilastNon-small cell lung cancerDirozalkib
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Dalpiciclib Isethionate | Tier C — Watch / trade | - |
| Orelabrutinib | Tier C — Watch / trade | - |
| Nerandomilast | Tier C — Watch / trade | - |
| Dirozalkib | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
6-Bromo-2-chloro-8-cyclopentyl-5-methylpyrido[2,3-d]pyrimidin-7-one→tert-Butyl 4-[6-[(6-bromo-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino]pyridin-3-yl]piperidine-1-carboxylate→1-(Vinyloxy)butane→tert-Butyl 4-(6-[[6-(1-butoxyethenyl)-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl]amino]pyridin-3-yl)piperidine-1-carboxylate→tert-Butyl 4-[6-[(6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino]pyridin-3-yl]piperidine-1-carboxylate→2-Hydroxyethane-1-sulfonic acid 6-acetyl-8-cyclopentyl-5-methyl-2-[[5-(piperidin-4-yl)pyridin-2-yl]amino]pyrido[2,3-d]pyrimidin-7(8H)-one→2-Amino-6-bromo-8-cyclopentyl-5-methylpyrido[2,3-d]pyrimidin-7(8H)-one→2-Amino-6-(1-butoxyethenyl)-8-cyclopentyl-5-methylpyrido[2,3-d]pyrimidin-7(8H)-one→tert-Butyl 6-chloro-3',6'-dihydro[3,4'-bipyridine]-1'(2'H)-carboxylate→5-Bromo-2-chloropyridine→tert-Butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,6-dihydropyridine-1(2H)-carboxylate→tert-Butyl 6-[[6-(1-butoxyethenyl)-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl]amino]-3',6'-dihydro[3,4'-bipyridine]-1'(2'H)-carboxylate
2,6-Dichloronicotinonitrile→2,6-Dichloronicotinamide→2,6-Dichloropyridine-3-carboxylic acid→(3-Phenoxyphenyl)boronic acid→4,4,5,5-Tetramethyl-2-(3-phenoxyphenyl)-1,3,2-dioxaborolane→6-Chloro-2-(4-phenoxyphenyl)pyridine-3-carboxamide→N-Boc-1,2,5,6-tetrahydropyridine-4-boronic acid pinacol ester→tert-Butyl 5-carbamoyl-6-(4-phenoxyphenyl)-3',6'-dihydro[2,4'-bipyridine]-1'(2'H)-carboxylate→tert-Butyl 4-[5-carbamoyl-6-(4-phenoxyphenyl)pyridin-2-yl]piperidine-1-carboxylate→2-(4-Phenoxyphenyl)-6-(piperidin-4-yl)pyridine-3-carboxamide→2-(4-Phenoxyphenyl)-6-(piperidin-4-yl)pyridine-3-carboxamide hydrogen chloride→Acryloyl chloride
5-Chloro-2-(piperidin-4-yl)pyrimidine hydrogen chloride→4-Methylbenzene-1-sulfonic acid 5-chloro-2-(piperidin-4-yl)pyrimidine→5-Chloro-2-(piperidin-4-yl)pyrimidine sulfate→4-(5-Chloropyrimidin-2-yl)piperidin-1-ium hexafluoridophosphate(1-)→2,4,5-Trichloropyrimidine→4-Piperidinecarbonitrile→Methyl piperidine-4-carboximidate hydrogen chloride→Piperidine-4-carboximidamide→Piperidine-4-carboximidamide hydrogen chloride→2-Chloro-1,3-bis(dimentylamino)trimethinium hexafluorophosphate→2,5-Dichloropyrimidine→5-Chloro-2-iodopyrimidine→(1-tert-Butoxycarbonyl-1,2,3,6-tetrahydropyridin-4-yl)boronic acid pinacol ester→Boc-4-(5-chloropyrimidin-2-yl)-3,6-dihydropyridine→Boc-4-(5-chloropyrimidin-2-yl)piperidine
2-Hydroxy-5-methylanisole→2-Methoxy-4-methyl-6-nitrophenol→5-Methyl-3-nitrobenzene-1,2-diol→1,2-Dibromoethane→7-Methyl-5-nitro-2,3-dihydro-1,4-benzodioxine→6-Bromo-7-methyl-5-nitro-2,3-dihydro-1,4-benzodioxine→6-Bromo-7-methyl-2,3-dihydro-1,4-benzodioxin-5-amine→6-Bromo-8-iodo-7-methyl-2,3-dihydro-1,4-benzodioxin-5-amine→(1-tert-Butoxycarbonyl-1,2,3,6-tetrahydropyridin-4-yl)boronic acid pinacol ester→tert-Butyl 4-(8-amino-7-bromo-6-methyl-2,3-dihydro-1,4-benzodioxin-5-yl)-3,6-dihydropyridine-1(2H)-carboxylate→tert-Butyl 4-(8-amino-6-methyl-2,3-dihydro-1,4-benzodioxin-5-yl)piperidine-1-carboxylate→2,5-Dichloro-N-(2-((1-methylethyl)sulfonyl)phenyl)-4-pyrimidinamine→1-Amino-2-(isopropylsulphonyl)benzene→2,4,5-Trichloropyrimidine→tert-Butyl 4-(8-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-6-methyl-2,3-dihydrobenzo[b][1,4]dioxin-5-yl)piperidine-1-carboxylate
7-Methyl-5-nitro-2,3-dihydro-1,4-benzodioxine→(1-tert-Butoxycarbonyl-1,2,3,6-tetrahydropyridin-4-yl)boronic acid pinacol ester→tert-Butyl 4-(8-amino-6-methyl-2,3-dihydro-1,4-benzodioxin-5-yl)piperidine-1-carboxylate→7-Methyl-2,3-dihydro-1,4-benzodioxin-5-amine→8-Bromo-7-methyl-2,3-dihydro-1,4-benzodioxin-5-amine→tert-Butyl 4-(8-amino-6-methyl-2,3-dihydro-1,4-benzodioxin-5-yl)-3,6-dihydropyridine-1(2H)-carboxylate
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