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CAS 411235-57-9
cyclopropylboronic acid(Cyclopropyl)boronic acid
Codes: ELISME-007, LOU-064-014, (VI)1114845-1-a
Application context (from source-drug indications)
MigraineElismetrep糖尿病周围神经病变ElismetrepHot flushesElismetrepVasomotor symptomsElismetrepChronic urticariaRemibrutinibUrticariaRemibrutinib花生过敏Remibrutinib鸡蛋过敏Remibrutinib乳类过敏反应Remibrutinib食物过敏RemibrutinibNon-small cell lung cancerGarsorasibColorectal cancerGarsorasibSolid tumourGarsorasibRenal cell carcinomaGarsorasibPancreatic cancerGarsorasib
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Elismetrep | Tier C — Watch / trade | - |
| Remibrutinib | Tier C — Watch / trade | - |
| Garsorasib | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
isoquinolin-3-amine→ethyl 4-(chlorosulfonyl)benzoate→ethyl 4-(N-(isoquinolin-3-yl)sulfamoyl)benzoate→ethyl 4-(N-(4-iodoisoquinolin-3-yl)sulfamoyl)benzoate→1-(bromomethyl)-4-(trifluoromethoxy)benzene→ethyl 4-(N-(4-iodoisoquinolin-3-yl)-N-(4-(trifluoromethoxy)benzyl)sulfamoyl)benzoate→cyclopropylboronic acid→ethyl 4-(N-(4-cyclopropylisoquinolin-3-yl)-N-(4-(trifluoromethoxy)benzyl)sulfamoyl)benzoate→Elismetrep
4,6-dichloro-5-methoxypyrimidine→6-chloro-5-methoxypyrimidin-4-amine→4-amino-6-chloropyrimidin-5-ol→tert-butyl (2-hydroxyethyl)(methyl)carbamate→tert-butyl (2-((4-amino-6-chloropyrimidin-5-yl)oxy)ethyl)(methyl)carbamate→4-cyclopropyl-2-fluoro-N-(5-fluoro-2-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)benzamide→tert-butyl (2-((4-amino-6-(3-(4-cyclopropyl-2-fluorobenzamido)-5-fluoro-2-methylphenyl)pyrimidin-5-yl)oxy)ethyl)(methyl)carbamate→N-(3-(6-amino-5-(2-(methylamino)ethoxy)pyrimidin-4-yl)-5-fluoro-2-methylphenyl)-4-cyclopropyl-2-fluorobenzamide 2,2,2-trifluoroacetate→1-bromo-5-fluoro-2-methyl-3-nitrobenzene→2-(5-fluoro-2-methyl-3-nitrophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane→5-fluoro-2-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline→methyl 4-cyclopropyl-2-fluorobenzoate→methyl 4-bromo-2-fluorobenzoate→cyclopropylboronic acid
2,6-Bis(chloranyl)-5-fluoranylpyridine-3-carboxylic acid→2,6-Dichloro-5-fluoronicotinamide→2-Chloro-2-oxoacetyl chloride→4,6-Dicyclopropylpyrimidin-5-amine→4,6-Dichloropyrimidin-5-amine→(Cyclopropyl)boronic acid→2,6-Dichloro-N-[(4,6-dicyclopropylpyrimidin-5-yl)carbamoyl]-5-fluoropyridine-3-carboxamide→7-Chloro-1-(4,6-dicyclopropylpyrimidin-5-yl)-6-fluoropyrido[2,3-d]pyrimidine-2,4(1H,3H)-dione→Trifluoroacetic acid 1-[(2R,5S)-2,5-dimethylpiperazin-1-yl]prop-2-en-1-one→7-Chloro-1-(4,6-dicyclopropylpyrimidin-5-yl)-4-[(2S,5R)-2,5-dimethyl-4-(prop-2-enoyl)piperazin-1-yl]-6-fluoropyrido[2,3-d]pyrimidin-2(1H)-one→2-Fluoro-6-aminophenylboronic acid pinacol ester→tert-Butyl (2S,5R)-2,5-dimethylpiperazine-1-carboxylate→2-Propenoyl chloride→tert-Butyl (2S,5R)-2,5-dimethyl-4-(prop-2-enoyl)piperazine-1-carboxylate
Intermediates available on this site
Side-by-side comparison of all listed offers on this CAS; price bands are list-price ranges, final price subject to RFQ confirmation.
| Supplier | Product | Price band | MOQ | Lead time | Qualifications | Action |
|---|---|---|---|---|---|---|
| Unibest Nantong cGMP Site | 5-Fluoro-2-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline Pharmaceutical Intermediates | On request | On request | On request | — | |
| Unibest Taizhou GMP-like Site | tert-butyl 2-(4-amino-6-chloropyrimidin-5-yloxy)ethylmethylcarbamate Pharmaceutical Intermediates | On request | On request | On request | — | |
| Qualified Partner — East China API Works | 4-cyclopropyl-2-fluoro-N-(5-fluoro-2-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)benzamide Pharmaceutical Intermediates | On request | On request | On request | — |
This is a CAS-level registry record: registrations across routes are merged. Supplier offers and buyer demands will be matched on this CAS as the primary key.