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CAS 411235-57-9
cyclopropylboronic acid(Cyclopropyl)boronic acid
登记编号：ELISME-007、LOU-064-014、(VI)1114845-1-a
应用背景（按来源药适应症）
偏头痛Elismetrep糖尿病周围神经病变Elismetrep热潮红Elismetrep血管舒缩症Elismetrep慢性荨麻疹瑞米布替尼荨麻疹瑞米布替尼花生过敏瑞米布替尼鸡蛋过敏瑞米布替尼乳类过敏反应瑞米布替尼食物过敏瑞米布替尼非小细胞肺癌格索雷塞结直肠癌格索雷塞实体瘤格索雷塞肾细胞癌格索雷塞胰腺癌格索雷塞
来源药（使用该中间体的合成路线）
| 品种 | 梯队 | 到期年 |
|---|---|---|
| Elismetrep | Tier C · 观察 / 贸易 | - |
| 瑞米布替尼Remibrutinib | Tier C · 观察 / 贸易 | - |
| 格索雷塞Garsorasib | Tier C · 观察 / 贸易 | - |
合成路线中的位置（上下游链）
按路线登记顺序排列，左→右为合成方向；高亮为当前 CAS，其余可点击跳转对应档案。
isoquinolin-3-amine→ethyl 4-(chlorosulfonyl)benzoate→ethyl 4-(N-(isoquinolin-3-yl)sulfamoyl)benzoate→ethyl 4-(N-(4-iodoisoquinolin-3-yl)sulfamoyl)benzoate→1-(bromomethyl)-4-(trifluoromethoxy)benzene→ethyl 4-(N-(4-iodoisoquinolin-3-yl)-N-(4-(trifluoromethoxy)benzyl)sulfamoyl)benzoate→cyclopropylboronic acid→ethyl 4-(N-(4-cyclopropylisoquinolin-3-yl)-N-(4-(trifluoromethoxy)benzyl)sulfamoyl)benzoate→Elismetrep
4,6-dichloro-5-methoxypyrimidine→6-chloro-5-methoxypyrimidin-4-amine→4-amino-6-chloropyrimidin-5-ol→tert-butyl (2-hydroxyethyl)(methyl)carbamate→tert-butyl (2-((4-amino-6-chloropyrimidin-5-yl)oxy)ethyl)(methyl)carbamate→4-cyclopropyl-2-fluoro-N-(5-fluoro-2-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)benzamide→tert-butyl (2-((4-amino-6-(3-(4-cyclopropyl-2-fluorobenzamido)-5-fluoro-2-methylphenyl)pyrimidin-5-yl)oxy)ethyl)(methyl)carbamate→N-(3-(6-amino-5-(2-(methylamino)ethoxy)pyrimidin-4-yl)-5-fluoro-2-methylphenyl)-4-cyclopropyl-2-fluorobenzamide 2,2,2-trifluoroacetate→1-bromo-5-fluoro-2-methyl-3-nitrobenzene→2-(5-fluoro-2-methyl-3-nitrophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane→5-fluoro-2-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline→methyl 4-cyclopropyl-2-fluorobenzoate→methyl 4-bromo-2-fluorobenzoate→cyclopropylboronic acid
2,6-Bis(chloranyl)-5-fluoranylpyridine-3-carboxylic acid→2,6-Dichloro-5-fluoronicotinamide→2-Chloro-2-oxoacetyl chloride→4,6-Dicyclopropylpyrimidin-5-amine→4,6-Dichloropyrimidin-5-amine→(Cyclopropyl)boronic acid→2,6-Dichloro-N-[(4,6-dicyclopropylpyrimidin-5-yl)carbamoyl]-5-fluoropyridine-3-carboxamide→7-Chloro-1-(4,6-dicyclopropylpyrimidin-5-yl)-6-fluoropyrido[2,3-d]pyrimidine-2,4(1H,3H)-dione→Trifluoroacetic acid 1-[(2R,5S)-2,5-dimethylpiperazin-1-yl]prop-2-en-1-one→7-Chloro-1-(4,6-dicyclopropylpyrimidin-5-yl)-4-[(2S,5R)-2,5-dimethyl-4-(prop-2-enoyl)piperazin-1-yl]-6-fluoropyrido[2,3-d]pyrimidin-2(1H)-one→2-Fluoro-6-aminophenylboronic acid pinacol ester→tert-Butyl (2S,5R)-2,5-dimethylpiperazine-1-carboxylate→2-Propenoyl chloride→tert-Butyl (2S,5R)-2,5-dimethyl-4-(prop-2-enoyl)piperazine-1-carboxylate
本站可供应的对应中间体
同 CAS 多家在售供应横向对比；价格区间为供应方挂牌口径，实价以询价确认为准。
| 供应商 | 产品 | 价格区间 | 最小起订 | 货期 | 资质 | 操作 |
|---|---|---|---|---|---|---|
| Unibest Nantong cGMP Site | 5-Fluoro-2-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Unibest Taizhou GMP-like Site | tert-butyl 2-(4-amino-6-chloropyrimidin-5-yloxy)ethylmethylcarbamate Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Qualified Partner — East China API Works | 4-cyclopropyl-2-fluoro-N-(5-fluoro-2-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)benzamide Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
本页为中间体 CAS 注册档案：同 CAS 的多条路线登记已合并；后续供应商报价与买方需求以该 CAS 为主键撮合。