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CAS 5713-61-1
2-Thienylmagnesium bromidethiophen-2-ylmagnesium bromide
Codes: Ticlopidine-020, GACYC-001
Application context (from source-drug indications)
Arterial occlusive diseaseTiclopidine Hydrochloride/Ginkgo Biloba Leaf Dried ExtractCerebrovascular diseaseTiclopidine Hydrochloride/Ginkgo Biloba Leaf Dried ExtractEmbolism and thrombosisTiclopidine Hydrochloride/Ginkgo Biloba Leaf Dried ExtractCarotid artery stenosisTiclopidine Hydrochloride/Ginkgo Biloba Leaf Dried ExtractThromboembolismTiclopidine HydrochlorideArterial occlusive diseaseTiclopidine HydrochlorideTransient ischaemic attackTiclopidine HydrochlorideIntracranial vasospasmTiclopidine HydrochlorideCerebrovascular diseaseTiclopidine HydrochlorideSubarachnoid haemorrhageTiclopidine Hydrochloride耳鸣Gacyclidine
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Ticlopidine Hydrochloride/Ginkgo Biloba Leaf Dried Extract | Tier C — Watch / trade | - |
| Ticlopidine Hydrochloride | Tier C — Watch / trade | - |
| Gacyclidine | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
2-Bromothiophene→2-Iodothiophene→2-Chlorothiophene→2-Thienylmagnesium bromide→Iodido(thiophen-2-yl)magnesium→Chlorido(thiophen-2-yl)magnesium→1-(Triethylsilyl)aziridine→1-(Trimethylsilyl)aziridine→1-(4-Methylbenzene-1-sulfonyl)aziridine→1,1,1-Triethyl-N-[2-(thiophen-2-yl)ethyl]silanamine→1,1,1-Trimethyl-N-[2-(thiophen-2-yl)ethyl]silanamine→4-Methyl-N-[2-(thiophen-2-yl)ethyl]benzene-1-sulfonamide→2-(2-Thienyl)ethylamine<-fgf->2-(Thiophen-2-yl)ethanamine<-fgf->2-Thien-2-ylethanamine
2-Bromothiophene→2-Iodothiophene→2-Chlorothiophene→2-Thienylmagnesium bromide→Iodido(thiophen-2-yl)magnesium→Chlorido(thiophen-2-yl)magnesium→1-(Triethylsilyl)aziridine→1-(Trimethylsilyl)aziridine→1-(4-Methylbenzene-1-sulfonyl)aziridine→1,1,1-Triethyl-N-[2-(thiophen-2-yl)ethyl]silanamine→1,1,1-Trimethyl-N-[2-(thiophen-2-yl)ethyl]silanamine→4-Methyl-N-[2-(thiophen-2-yl)ethyl]benzene-1-sulfonamide→2-(2-Thienyl)ethylamine<-fgf->2-(Thiophen-2-yl)ethanamine<-fgf->2-Thien-2-ylethanamine
thiophen-2-ylmagnesium bromide→2-methylcyclohexan-1-one→(2S)-2-methyl-1-(thiophen-2-yl)cyclohexan-1-ol→2-((2S)-1-azido-2-methylcyclohexyl)thiophene→(2S)-2-methyl-1-(thiophen-2-yl)cyclohexan-1-amine→1,5-dibromopentane→1-((2S)-2-methyl-1-(thiophen-2-yl)cyclohexyl)piperidine→1-((1R,2S)-2-methyl-1-(thiophen-2-yl)cyclohexyl)piperidine hydrochloride
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