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CAS 7252-83-7
2-bromo-1,1-dimethoxyethane
Codes: TREP-065, VEDR-019, INDI-001
Application context (from source-drug indications)
Interstitial lung diseaseTreprostinilPulmonary hypertensionTreprostinilPulmonary arterial hypertensionTreprostinilIdiopathic pulmonary fibrosisTreprostinilPulmonary fibrosisTreprostinilIdiopathic pulmonary arterial hypertensionTreprostinil慢性炎症性脱髓鞘性多发性神经病VedroprevirChronic hepatitis CVedroprevirHepatitis CVedroprevirNauseaIndisetron Dihydrochloride呕吐Indisetron DihydrochlorideChemotherapy-induced nausea and vomitingIndisetron Dihydrochloride
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Treprostinil | Tier B — Position early | - |
| Vedroprevir | Tier C — Watch / trade | - |
| Indisetron Dihydrochloride | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
(1R,2R,3aS,9aS)-1-((S)-3-hydroxyoctyl)-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[b]naphthalene-2,5-diol→2-bromo-1,1-dimethoxyethane→(1R,2R,3aS,9aS)-5-(2,2-dimethoxyethoxy)-1-((S)-3-hydroxyoctyl)-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[b]naphthalen-2-ol→2-(((1R,2R,3aS,9aS)-2-hydroxy-1-((S)-3-hydroxyoctyl)-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[b]naphthalen-5-yl)oxy)ethane-1,1-diol
(2S,4R)-methyl 4-hydroxypyrrolidine-2-carboxylate→4-bromobenzene-1-sulfonyl chloride→(2S,4S)-methyl 4-(((4-bromophenyl)sulfonyl)oxy)pyrrolidine-2-carboxylate hydrochloride→(S)-2-((tert-butoxycarbonyl)amino)-3,3-dimethylbutanoic acid→(2S,4S)-methyl 4-(((4-bromophenyl)sulfonyl)oxy)-1-((S)-2-((tert-butoxycarbonyl)amino)-3,3-dimethylbutanoyl)pyrrolidine-2-carboxylate→(2S,4S)-4-(((4-bromophenyl)sulfonyl)oxy)-1-((S)-2-((tert-butoxycarbonyl)amino)-3,3-dimethylbutanoyl)pyrrolidine-2-carboxylic acid→(1R,2R)-methyl 1-amino-2-ethylcyclopropanecarboxylate→(1R,2R)-methyl 1-((2S,4S)-4-(((4-bromophenyl)sulfonyl)oxy)-1-((S)-2-((tert-butoxycarbonyl)amino)-3,3-dimethylbutanoyl)pyrrolidine-2-carboxamido)-2-ethylcyclopropanecarboxylate→(1R,3r,5S)-bicyclo[3.1.0]hexan-3-yl (2,5-dioxopyrrolidin-1-yl) carbonate→(1R,2R)-methyl 1-((2S,4S)-1-((S)-2-((((1R,3r,5S)-bicyclo[3.1.0]hexan-3-yloxy)carbonyl)amino)-3,3-dimethylbutanoyl)-4-(((4-bromophenyl)sulfonyl)oxy)pyrrolidine-2-carboxamido)-2-ethylcyclopropanecarboxylate→8-chloro-7-(2,2-dimethoxyethoxy)-2-(2-(isopropylamino)thiazol-4-yl)quinolin-4-ol→(1R,2R)-methyl 1-((2S,4R)-1-((S)-2-((((1R,3r,5S)-bicyclo[3.1.0]hexan-3-yloxy)carbonyl)amino)-3,3-dimethylbutanoyl)-4-((8-chloro-7-(2,2-dimethoxyethoxy)-2-(2-(isopropylamino)thiazol-4-yl)quinolin-4-yl)oxy)pyrrolidine-2-carboxamido)-2-ethylcyclopropanecarboxylate→(1R,2R)-methyl 1-((2S,4R)-1-((S)-2-((((1R,3r,5S)-bicyclo[3.1.0]hexan-3-yloxy)carbonyl)amino)-3,3-dimethylbutanoyl)-4-((8-chloro-2-(2-(isopropylamino)thiazol-4-yl)-7-(2-morpholinoethoxy)quinolin-4-yl)oxy)pyrrolidine-2-carboxamido)-2-ethylcyclopropanecarboxylate→cyclopent-3-en-1-ol→(1R,3r,5S)-bicyclo[3.1.0]hexan-3-ol→bis(2,5-dioxopyrrolidin-1-yl) carbonate→1-(2-amino-3-chloro-4-methoxyphenyl)ethanone→1-(2-amino-3-chloro-4-hydroxyphenyl)ethanone→2-bromo-1,1-dimethoxyethane→1-(2-amino-3-chloro-4-(2,2-dimethoxyethoxy)phenyl)ethanone→2-(isopropylamino)thiazole-4-carboxylic acid→N-(6-acetyl-2-chloro-3-(2,2-dimethoxyethoxy)phenyl)-2-(isopropylamino)thiazole-4-carboxamide
2-bromo-1,1-dimethoxyethane→bis(2,2-dimethoxyethyl)amine→3-oxopentanedioic acid→(1R,5S)-3,9-dimethyl-3,9-diazabicyclo[3.3.1]nonan-7-one→(1R,5S,7s)-3,9-dimethyl-3,9-diazabicyclo[3.3.1]nonan-7-amine→1H-indazole-3-carbonyl chloride
Intermediates available on this site
Side-by-side comparison of all listed offers on this CAS; price bands are list-price ranges, final price subject to RFQ confirmation.
| Supplier | Product | Price band | MOQ | Lead time | Qualifications | Action |
|---|---|---|---|---|---|---|
| Qualified Partner — East China API Works | (1R,2R,3aS,9aS)-2,3,3a,4,9,9a-Hexahydro-1-[(3S)-3-hydroxyoctyl]-1H-benz[f]indene-2,5-diol Pharmaceutical Intermediates | On request | On request | On request | — | |
| Unibest Nantong cGMP Site | 1-broMo-5-fluoro-2-Methyl-3-nitrobenzene Pharmaceutical Intermediates | On request | On request | On request | — | |
| Unibest Taizhou GMP-like Site | methyl 4-cyclopropyl-2-fluorobenzoate Pharmaceutical Intermediates | On request | On request | On request | — | |
| Qualified Partner — East China API Works | tert-butyl 2-(4-amino-6-chloropyrimidin-5-yloxy)ethylmethylcarbamate Pharmaceutical Intermediates | On request | On request | On request | — | |
| Unibest Nantong cGMP Site | 2H-Benz[f]inden-2-one, 9-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3,3a,4,9-tetrahydro-5-methoxy-1-[(3S)-3-[(tetrahydro-2H-pyran-2-yl)oxy]octyl]-, (3aS,9R)- Pharmaceutical Intermediates | On request | On request | On request | — | |
| Unibest Taizhou GMP-like Site | 2-allyl-3-methoxybenzaldehyde Pharmaceutical Intermediates | On request | On request | On request | — | |
| Qualified Partner — East China API Works | (5S)-1-Decyn-5-ol Pharmaceutical Intermediates | On request | On request | On request | — |
This is a CAS-level registry record: registrations across routes are merged. Supplier offers and buyer demands will be matched on this CAS as the primary key.