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CAS 7252-83-7
2-bromo-1,1-dimethoxyethane
登记编号：TREP-065、VEDR-019、INDI-001
应用背景（按来源药适应症）
间质性肺疾病曲前列尼尔肺性高血压曲前列尼尔肺动脉高压曲前列尼尔特发性肺纤维化曲前列尼尔肺纤维化曲前列尼尔特发性肺动脉高压曲前列尼尔慢性炎症性脱髓鞘性多发性神经病Vedroprevir慢性丙型肝炎Vedroprevir丙型肝炎Vedroprevir恶心盐酸吲地司琼呕吐盐酸吲地司琼化疗导致的恶心和呕吐盐酸吲地司琼
来源药（使用该中间体的合成路线）
| 品种 | 梯队 | 到期年 |
|---|---|---|
| 曲前列尼尔Treprostinil | Tier B · 提前布局 | - |
| Vedroprevir | Tier C · 观察 / 贸易 | - |
| 盐酸吲地司琼Indisetron Dihydrochloride | Tier C · 观察 / 贸易 | - |
合成路线中的位置（上下游链）
按路线登记顺序排列，左→右为合成方向；高亮为当前 CAS，其余可点击跳转对应档案。
(1R,2R,3aS,9aS)-1-((S)-3-hydroxyoctyl)-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[b]naphthalene-2,5-diol→2-bromo-1,1-dimethoxyethane→(1R,2R,3aS,9aS)-5-(2,2-dimethoxyethoxy)-1-((S)-3-hydroxyoctyl)-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[b]naphthalen-2-ol→2-(((1R,2R,3aS,9aS)-2-hydroxy-1-((S)-3-hydroxyoctyl)-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[b]naphthalen-5-yl)oxy)ethane-1,1-diol
(2S,4R)-methyl 4-hydroxypyrrolidine-2-carboxylate→4-bromobenzene-1-sulfonyl chloride→(2S,4S)-methyl 4-(((4-bromophenyl)sulfonyl)oxy)pyrrolidine-2-carboxylate hydrochloride→(S)-2-((tert-butoxycarbonyl)amino)-3,3-dimethylbutanoic acid→(2S,4S)-methyl 4-(((4-bromophenyl)sulfonyl)oxy)-1-((S)-2-((tert-butoxycarbonyl)amino)-3,3-dimethylbutanoyl)pyrrolidine-2-carboxylate→(2S,4S)-4-(((4-bromophenyl)sulfonyl)oxy)-1-((S)-2-((tert-butoxycarbonyl)amino)-3,3-dimethylbutanoyl)pyrrolidine-2-carboxylic acid→(1R,2R)-methyl 1-amino-2-ethylcyclopropanecarboxylate→(1R,2R)-methyl 1-((2S,4S)-4-(((4-bromophenyl)sulfonyl)oxy)-1-((S)-2-((tert-butoxycarbonyl)amino)-3,3-dimethylbutanoyl)pyrrolidine-2-carboxamido)-2-ethylcyclopropanecarboxylate→(1R,3r,5S)-bicyclo[3.1.0]hexan-3-yl (2,5-dioxopyrrolidin-1-yl) carbonate→(1R,2R)-methyl 1-((2S,4S)-1-((S)-2-((((1R,3r,5S)-bicyclo[3.1.0]hexan-3-yloxy)carbonyl)amino)-3,3-dimethylbutanoyl)-4-(((4-bromophenyl)sulfonyl)oxy)pyrrolidine-2-carboxamido)-2-ethylcyclopropanecarboxylate→8-chloro-7-(2,2-dimethoxyethoxy)-2-(2-(isopropylamino)thiazol-4-yl)quinolin-4-ol→(1R,2R)-methyl 1-((2S,4R)-1-((S)-2-((((1R,3r,5S)-bicyclo[3.1.0]hexan-3-yloxy)carbonyl)amino)-3,3-dimethylbutanoyl)-4-((8-chloro-7-(2,2-dimethoxyethoxy)-2-(2-(isopropylamino)thiazol-4-yl)quinolin-4-yl)oxy)pyrrolidine-2-carboxamido)-2-ethylcyclopropanecarboxylate→(1R,2R)-methyl 1-((2S,4R)-1-((S)-2-((((1R,3r,5S)-bicyclo[3.1.0]hexan-3-yloxy)carbonyl)amino)-3,3-dimethylbutanoyl)-4-((8-chloro-2-(2-(isopropylamino)thiazol-4-yl)-7-(2-morpholinoethoxy)quinolin-4-yl)oxy)pyrrolidine-2-carboxamido)-2-ethylcyclopropanecarboxylate→cyclopent-3-en-1-ol→(1R,3r,5S)-bicyclo[3.1.0]hexan-3-ol→bis(2,5-dioxopyrrolidin-1-yl) carbonate→1-(2-amino-3-chloro-4-methoxyphenyl)ethanone→1-(2-amino-3-chloro-4-hydroxyphenyl)ethanone→2-bromo-1,1-dimethoxyethane→1-(2-amino-3-chloro-4-(2,2-dimethoxyethoxy)phenyl)ethanone→2-(isopropylamino)thiazole-4-carboxylic acid→N-(6-acetyl-2-chloro-3-(2,2-dimethoxyethoxy)phenyl)-2-(isopropylamino)thiazole-4-carboxamide
2-bromo-1,1-dimethoxyethane→bis(2,2-dimethoxyethyl)amine→3-oxopentanedioic acid→(1R,5S)-3,9-dimethyl-3,9-diazabicyclo[3.3.1]nonan-7-one→(1R,5S,7s)-3,9-dimethyl-3,9-diazabicyclo[3.3.1]nonan-7-amine→1H-indazole-3-carbonyl chloride
本站可供应的对应中间体
同 CAS 多家在售供应横向对比；价格区间为供应方挂牌口径，实价以询价确认为准。
| 供应商 | 产品 | 价格区间 | 最小起订 | 货期 | 资质 | 操作 |
|---|---|---|---|---|---|---|
| Qualified Partner — East China API Works | (1R,2R,3aS,9aS)-2,3,3a,4,9,9a-Hexahydro-1-[(3S)-3-hydroxyoctyl]-1H-benz[f]indene-2,5-diol Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Unibest Nantong cGMP Site | 1-broMo-5-fluoro-2-Methyl-3-nitrobenzene Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Unibest Taizhou GMP-like Site | methyl 4-cyclopropyl-2-fluorobenzoate Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Qualified Partner — East China API Works | tert-butyl 2-(4-amino-6-chloropyrimidin-5-yloxy)ethylmethylcarbamate Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Unibest Nantong cGMP Site | 2H-Benz[f]inden-2-one, 9-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3,3a,4,9-tetrahydro-5-methoxy-1-[(3S)-3-[(tetrahydro-2H-pyran-2-yl)oxy]octyl]-, (3aS,9R)- Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Unibest Taizhou GMP-like Site | 2-allyl-3-methoxybenzaldehyde Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Qualified Partner — East China API Works | (5S)-1-Decyn-5-ol Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
本页为中间体 CAS 注册档案：同 CAS 的多条路线登记已合并；后续供应商报价与买方需求以该 CAS 为主键撮合。