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CAS 97483-77-7
(5-(methylsulfonyl)pyridin-2-yl)methanamine hydrochloride
Codes: TEDI-010, ALVEL-010
Application context (from source-drug indications)
Skin and skin structure infectionTedizolid PhosphateStaphylococcal infectionTedizolid PhosphateBacterial skin diseaseTedizolid PhosphateCOVID-19Alvelestatα1抗胰蛋白酶缺乏症AlvelestatEmphysemaAlvelestatChronic obstructive pulmonary diseaseAlvelestat闭塞性细支气管炎AlvelestatGraft-versus-host diseaseAlvelestat
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Tedizolid Phosphate | Tier C — Watch / trade | 2029 |
| Alvelestat | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
3-fluoroaniline→benzyl (3-fluorophenyl)carbamate→(R)-oxiran-2-ylmethyl butyrate→(R)-3-(3-fluorophenyl)-5-(hydroxymethyl)oxazolidin-2-one→(R)-3-(3-fluoro-4-iodophenyl)-5-(hydroxymethyl)oxazolidin-2-one→(R)-3-(3-fluoro-4-(tributylstannyl)phenyl)-5-(hydroxymethyl)oxazolidin-2-one→5-bromo-2-(2-methyl-2H-tetrazol-5-yl)pyridine→(R)-3-(3-fluoro-4-(6-(2-methyl-2H-tetrazol-5-yl)pyridin-3-yl)phenyl)-5-(hydroxymethyl)oxazolidin-2-one→2,5-dibromopyridine→(5-(methylsulfonyl)pyridin-2-yl)methanamine hydrochloride→5-bromo-2-(2H-tetrazol-5-yl)pyridine
(R)-3-(3-fluoro-4-iodophenyl)-5-(hydroxymethyl)oxazolidin-2-one→(R)-3-(3-fluoro-4-(6-(2-methyl-2H-tetrazol-5-yl)pyridin-3-yl)phenyl)-5-(hydroxymethyl)oxazolidin-2-one→(5-(methylsulfonyl)pyridin-2-yl)methanamine hydrochloride→5-bromo-2-(2H-tetrazol-5-yl)pyridine→4-bromo-3-fluoroaniline→benzyl (4-bromo-3-fluorophenyl)carbamate→(4-(((benzyloxy)carbonyl)amino)-2-fluorophenyl)boronic acid→benzyl (3-fluoro-4-(6-(2-methyl-2H-tetrazol-5-yl)pyridin-3-yl)phenyl)carbamate→ammonium 5-(5-bromopyridin-2-yl)tetrazol-2-ide
3-(trifluoromethyl)aniline→ethyl 3-chloro-3-oxopropanoate→ethyl 3-oxo-3-[3-(trifluoromethyl)anilino]propanoate →ethyl 3-oxo-3-((3-(trifluoromethyl)phenyl)amino)propanoate→(E)-4-methoxybut-3-en-2-one→6-methyl-2-oxo-1-(3-(trifluoromethyl)phenyl)-1,2-dihydropyridine-3-carboxylic acid→1-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole→6-methyl-5-(1-methyl-1H-pyrazol-5-yl)-2-oxo-1-(3-(trifluoromethyl)phenyl)-1,2-dihydropyridine-3-carboxylic acid→6-methyl-5-(1-methyl-1H-pyrazol-5-yl)-2-oxo-1-(3-(trifluoromethyl)phenyl)-1,2-dihydropyridine-3-carboxylic acid→(5-(methylsulfonyl)pyridin-2-yl)methanamine hydrochloride→5-bromopicolinonitrile→5-(methylsulfonyl)picolinonitrile
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