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CAS 624-28-2
2,5-dibromopyridine
Codes: PERAM-010, TEDI-009, BEBT-908-012, PRAD-008
Application context (from source-drug indications)
Tonic-clonic seizurePerampanel HydratePartial-onset seizurePerampanel HydrateEpilepsyPerampanel HydrateSeizurePerampanel HydrateSkin and skin structure infectionTedizolid PhosphateStaphylococcal infectionTedizolid PhosphateBacterial skin diseaseTedizolid PhosphateDiffuse large B-cell lymphomaIfupinostat Hydrochloride大B细胞淋巴瘤Ifupinostat HydrochloridePeripheral T-cell lymphomaIfupinostat HydrochlorideNon-small cell lung cancerIfupinostat HydrochlorideBreast cancerIfupinostat HydrochlorideMetastatic breast cancerIfupinostat HydrochlorideConstipationPradigastatI型高脂蛋白血症PradigastatHypertriglyceridaemiaPradigastatCoronary artery lesionPradigastatHepatitis CPradigastatNon-alcoholic steatohepatitisPradigastat
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Perampanel Hydrate | Tier C — Watch / trade | 2028 |
| Tedizolid Phosphate | Tier C — Watch / trade | 2029 |
| Ifupinostat Hydrochloride | Tier C — Watch / trade | - |
| Pradigastat | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
phenylboronic acid→2-(1,3,2-dioxaborinan-2-yl)benzonitrile→2,5-dibromopyridine→5-bromo-2-methoxypyridine→2-(tributylstannyl)pyridine→6'-methoxy-2,3'-bipyridine→[2,3'-bipyridin]-6'(1'H)-one→5'-bromo-[2,3'-bipyridin]-6'(1'H)-one→5'-bromo-6'-methoxy-2,3'-bipyridine→2-(6'-methoxy-[2,3'-bipyridin]-5'-yl)benzonitrile→2-(6'-oxo-1',6'-dihydro-[2,3'-bipyridin]-5'-yl)benzonitrile
3-fluoroaniline→benzyl (3-fluorophenyl)carbamate→(R)-oxiran-2-ylmethyl butyrate→(R)-3-(3-fluorophenyl)-5-(hydroxymethyl)oxazolidin-2-one→(R)-3-(3-fluoro-4-iodophenyl)-5-(hydroxymethyl)oxazolidin-2-one→(R)-3-(3-fluoro-4-(tributylstannyl)phenyl)-5-(hydroxymethyl)oxazolidin-2-one→5-bromo-2-(2-methyl-2H-tetrazol-5-yl)pyridine→(R)-3-(3-fluoro-4-(6-(2-methyl-2H-tetrazol-5-yl)pyridin-3-yl)phenyl)-5-(hydroxymethyl)oxazolidin-2-one→2,5-dibromopyridine→(5-(methylsulfonyl)pyridin-2-yl)methanamine hydrochloride→5-bromo-2-(2H-tetrazol-5-yl)pyridine
N-hydroxy-2-(methyl((2-(6-(methylamino)pyridin-3-yl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)amino)pyrimidine-5-carboxamide trihydrochloride→methyl 3-aminothiophene-2-carboxylate→thieno[3,2-d]pyrimidine-2,4(1H,3H)-dione→2,4-dichlorothieno[3,2-d]pyrimidine→4-(2-chlorothieno[3,2-d]pyrimidin-4-yl)morpholine→2-chloro-4-morpholinothieno[3,2-d]pyrimidine-6-carbaldehyde→1-(2-chloro-4-morpholinothieno[3,2-d]pyrimidin-6-yl)-N-methylmethanamine→ethyl 2-chloropyrimidine-5-carboxylate→ethyl 2-(((2-chloro-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)(methyl)amino)pyrimidine-5-carboxylate→(6-(methylamino)pyridin-3-yl)boronic acid hydrochloride→ethyl 2-(methyl((2-(6-(methylamino)pyridin-3-yl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)amino)pyrimidine-5-carboxylate→N-hydroxy-2-(methyl((2-(6-(methylamino)pyridin-3-yl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)amino)pyrimidine-5-carboxamide→2,5-dibromopyridine→5-bromo-N-methylpyridin-2-amine→tert-butyl (5-bromopyridin-2-yl)(methyl)carbamate
4-(4-hydroxyphenyl)cyclohexan-1-one→methyl 2-(dimethoxyphosphoryl)acetate→methyl 2-(4-(4-hydroxyphenyl)cyclohexylidene)acetate→methyl 2-((1r,4r)-4-(4-hydroxyphenyl)cyclohexyl)acetate→methyl 2-((1r,4r)-4-(4-(((trifluoromethyl)sulfonyl)oxy)phenyl)cyclohexyl)acetate→4,4,4',4',5,5,5',5'-octamethyl-2,2'-bi(1,3,2-dioxaborolane)→methyl 2-((1r,4r)-4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)cyclohexyl)acetate→2,5-dibromopyridine→methyl 2-((1r,4r)-4-(4-(5-bromopyridin-2-yl)phenyl)cyclohexyl)acetate→6-(trifluoromethyl)pyridin-3-amine→methyl 2-((1r,4r)-4-(4-(5-((6-(trifluoromethyl)pyridin-3-yl)amino)pyridin-2-yl)phenyl)cyclohexyl)acetate
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