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盐酸去氧肾上腺素
Tier C · 观察 / 贸易Phenylephrine Hydrochloride
-
原研
1955
首批上市
-
到期年（公开口径）
$0.03B ▲
峰值销售
化学药
类型
靶点：ADRA1
商品名：Mydfrin、Alcon Efrin、Incostop、Nostril、Efrin、Biomydrin、Vazculep、Neo-Synephrine hydrochloride
适应症（已批准）：瞳孔散大、低血压、睫状肌麻痹、室上性心动过速、休克
各地区研发/上市状态
美国
批准上市
2012-12-20
欧盟
终止
2007-02-01
中国
批准上市
1995-01-01
日本
批准上市
1955-01-01
合成路线与中间体7 routes
原研路线 × 0优化路线（非专利）× 6工艺路线 × 1
路线按「原研路线 → 优化路线 / 工艺路线（非专利）」排序。每条路线附本站自绘的路线流程图（中间体 → 原料药）与中间体表（编号 / CAS / 英文名），可直接用于供应商开发与询价。流程图由本站依据已授权的结构化数据自行渲染，未使用任何第三方路线图。
优化Route 1步骤 6 · 总收率 /
Phenylephrine Hydrochloride-001—Phenylephrine Hydrochloride-002139461-72-6Phenylephrine Hydrochloride-0031774-47-6Phenylephrine Hydrochloride-004215439-42-2Phenylephrine Hydrochloride-005215439-44-4Phenylephrine Hydrochloride-006215439-43-3Phenylephrine Hydrochloride-007215439-45-5API · 盐酸去氧肾上腺素
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Phenylephrine Hydrochloride-001 | - | (3-Hydroxyphenyl)formaldehyde |
| Phenylephrine Hydrochloride-002 | 139461-72-6 | 3-[(2-methoxyethoxy)methoxy]benzaldehyde |
| Phenylephrine Hydrochloride-003 | 1774-47-6 | Trimethyl sulfoxide iodide |
| Phenylephrine Hydrochloride-004 | 215439-42-2 | 2-{3-[(2-methoxyethoxy)methoxy]phenyl}oxirane |
| Phenylephrine Hydrochloride-005 | 215439-44-4 | (1S)-1-{3-[(2-methoxyethoxy)methoxy]phenyl}ethane-1,2-diol |
| Phenylephrine Hydrochloride-006 | 215439-43-3 | (2R)-2-{3-[(2-methoxyethoxy)methoxy]phenyl}oxirane |
| Phenylephrine Hydrochloride-007 | 215439-45-5 | (1R)-1-{3-[(2-methoxyethoxy)methoxy]phenyl}-2-(methylamino)ethanol |
优化Route 2步骤 9 · 总收率 /
Phenylephrine Hydrochloride-001—Phenylephrine Hydrochloride-01096013-95-5Phenylephrine Hydrochloride-0113487-44-3Phenylephrine Hydrochloride-012—Phenylephrine Hydrochloride-013—Phenylephrine Hydrochloride-014603983-65-9Phenylephrine Hydrochloride-015603983-66-0Phenylephrine Hydrochloride-016603983-67-1Phenylephrine Hydrochloride-017603983-68-2Phenylephrine Hydrochloride-018—Phenylephrine Hydrochloride-019—API · 盐酸去氧肾上腺素
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Phenylephrine Hydrochloride-001 | - | (3-Hydroxyphenyl)formaldehyde |
| Phenylephrine Hydrochloride-010 | 96013-95-5 | 3-(tert-Butyldimethylsilyloxy)benzaldehyde |
| Phenylephrine Hydrochloride-011 | 3487-44-3 | Methylene(triphenyl)phosphorane |
| Phenylephrine Hydrochloride-012 | - | Methyl(triphenyl)phosphonium iodide |
| Phenylephrine Hydrochloride-013 | - | tert-Butyl(dimethyl)(3-vinylphenoxy)silane |
| Phenylephrine Hydrochloride-014 | 603983-65-9 | (1R)-1-(3-[[tert-Butyl(dimethyl)silyl]oxy]phenyl)ethane-1,2-diol |
| Phenylephrine Hydrochloride-015 | 603983-66-0 | (2R)-2-(3-[[tert-Butyl(dimethyl)silyl]oxy]phenyl)-2-hydroxyethyl 4-methylbenzenesulfonate |
| Phenylephrine Hydrochloride-016 | 603983-67-1 | (2R)-2-Hydroxy-2-(3-hydroxyphenyl)ethyl 4-methylbenzenesulfonate |
| Phenylephrine Hydrochloride-017 | 603983-68-2 | 3-[(1R)-1-Hydroxy-2-iodoethyl]phenol |
| Phenylephrine Hydrochloride-018 | - | Aminomethane |
| Phenylephrine Hydrochloride-019 | - | 3-[(1R)-1-Hydroxy-2-(methylamino)ethyl]phenol |
优化Route 3步骤 9 · 总收率 146.9g(Phenylephrine Hydrochloride (API))
Phenylephrine Hydrochloride-020614-03-9Phenylephrine Hydrochloride-0211515872-98-6Phenylephrine Hydrochloride-022—Phenylephrine Hydrochloride-0231515873-00-3Phenylephrine Hydrochloride-024—Phenylephrine Hydrochloride-025—Phenylephrine Hydrochloride-019—Phenylephrine Hydrochloride-026—API · 盐酸去氧肾上腺素
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Phenylephrine Hydrochloride-020 | 614-03-9 | 3-[(1S)-1-Hydroxy-2-(methylamino)ethyl]phenol |
| Phenylephrine Hydrochloride-021 | 1515872-98-6 | 3-[(1S)-1-Hydroxy-2-(methylamino)ethyl]phenyl benzoate |
| Phenylephrine Hydrochloride-022 | - | 3-[(1S)-2-[Acetyl(methyl)amino]-1-hydroxyethyl]phenyl benzoate |
| Phenylephrine Hydrochloride-023 | 1515873-00-3 | 3-(N-Acetyl-N-methylglycyl)phenyl benzoate |
| Phenylephrine Hydrochloride-024 | - | 1-(3-Hydroxyphenyl)-2-(methylamino)ethanone sulfate |
| Phenylephrine Hydrochloride-025 | - | 3-[1-Hydroxy-2-(methylamino)ethyl]phenol |
| Phenylephrine Hydrochloride-019 | - | 3-[(1R)-1-Hydroxy-2-(methylamino)ethyl]phenol |
| Phenylephrine Hydrochloride-026 | - | (1R)-1-(3-Hydroxyphenyl)-2-(methylamino)ethyl acetate sulfate |
优化Route 4步骤 3 · 总收率 5.3g(Phenylephrine Hydrochloride-031)
Phenylephrine Hydrochloride-027—Phenylephrine Hydrochloride-02838396-89-3Phenylephrine Hydrochloride-029—Phenylephrine Hydrochloride-030—Phenylephrine Hydrochloride-031—API · 盐酸去氧肾上腺素
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Phenylephrine Hydrochloride-027 | - | 3-Acetoxy acetophenone |
| Phenylephrine Hydrochloride-028 | 38396-89-3 | 3-(Bromoacetyl)phenyl acetate |
| Phenylephrine Hydrochloride-029 | - | Benzylmethylamine |
| Phenylephrine Hydrochloride-030 | - | 3-(N-Benzyl-N-methylglycyl)phenyl acetate |
| Phenylephrine Hydrochloride-031 | - | 1-(3-Hydroxyphenyl)-2-[methyl(phenylmethyl)amino]ethanone hydrochloride |
优化Route 6步骤 6 · 总收率 108g(Phenylephrine Hydrochloride (API))
Phenylephrine Hydrochloride-034—Phenylephrine Hydrochloride-03562932-90-5Phenylephrine Hydrochloride-029—Phenylephrine Hydrochloride-031—Phenylephrine Hydrochloride-025—Phenylephrine Hydrochloride-03613998-27-1Phenylephrine Hydrochloride-019—API · 盐酸去氧肾上腺素
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Phenylephrine Hydrochloride-034 | - | 1-(3-Hydroxyphenyl)ethanone |
| Phenylephrine Hydrochloride-035 | 62932-90-5 | 2-Chloro-1-(3-hydroxyphenyl)ethan-1-one |
| Phenylephrine Hydrochloride-029 | - | Benzylmethylamine |
| Phenylephrine Hydrochloride-031 | - | 1-(3-Hydroxyphenyl)-2-[methyl(phenylmethyl)amino]ethanone hydrochloride |
| Phenylephrine Hydrochloride-025 | - | 3-[1-Hydroxy-2-(methylamino)ethyl]phenol |
| Phenylephrine Hydrochloride-036 | 13998-27-1 | (2R,3R)-2,3-Dihydroxybutanedioic acid 3-[(1S)-1-hydroxy-2-(methylamino)ethyl]phenol |
| Phenylephrine Hydrochloride-019 | - | 3-[(1R)-1-Hydroxy-2-(methylamino)ethyl]phenol |
优化Route 7步骤 5 · 总收率 /
Phenylephrine Hydrochloride-034121-71-1Phenylephrine Hydrochloride-03562932-90-5Phenylephrine Hydrochloride-037925430-39-3Phenylephrine Hydrochloride-03874-89-5Phenylephrine Hydrochloride-03959-42-7API · 盐酸去氧肾上腺素
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Phenylephrine Hydrochloride-034 | 121-71-1 | 3-Hydroxyacetophenone |
| Phenylephrine Hydrochloride-035 | 62932-90-5 | 2-Chloro-1-(3-hydroxyphenyl)ethanone |
| Phenylephrine Hydrochloride-037 | 925430-39-3 | 3-[(1R)-2-Chloro-1-hydroxyethyl]phenol |
| Phenylephrine Hydrochloride-038 | 74-89-5 | Methylamine |
| Phenylephrine Hydrochloride-039 | 59-42-7 | Phenylephrine |
工艺Route 5步骤 2 · 总收率 85.2kg(Phenylephrine Hydrochloride-034)
Phenylephrine Hydrochloride-032—Phenylephrine Hydrochloride-033—Phenylephrine Hydrochloride-034—API · 盐酸去氧肾上腺素
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Phenylephrine Hydrochloride-032 | - | 1-(3-Nitrophenyl)ethanone |
| Phenylephrine Hydrochloride-033 | - | 1-(3-Aminophenyl)ethan-1-one |
| Phenylephrine Hydrochloride-034 | - | 1-(3-Hydroxyphenyl)ethanone |
常见问题（FAQ）
盐酸去氧肾上腺素的适应症有哪些？
已批准的适应症包括：瞳孔散大、低血压、睫状肌麻痹、室上性心动过速、休克。
盐酸去氧肾上腺素的专利什么时候到期？
盐酸去氧肾上腺素的专利到期年暂无公开口径，本页会在数据管道核实后更新。
盐酸去氧肾上腺素有几条合成路线？
本站收录 7 条合成路线，最短路线 2 步、总收率 85.2kg(Phenylephrine Hydrochloride-034)。每条路线的中间体均带登记编号与 CAS 号。
盐酸去氧肾上腺素的关键中间体在哪里可以采购？
盐酸去氧肾上腺素路线中的中间体均已建立 CAS 档案，可直接按 CAS 发起询价，需求会进入供应网络撮合池。
如何获取盐酸去氧肾上腺素中间体的报价？
在本页选择目标中间体的 CAS 进入档案页，或在询价页直接提交需求；CAS 会自动带入供需撮合流程，由供应网络反馈报价。
数据来源：多源数据交叉核实（仅结构化字段） · 2026-10-22