← 返回专利悬崖列表
醋酸瑞扎芬净
Tier C · 观察 / 贸易Rezafungin acetate
Seachaid Pharmaceuticals
原研
2023
首批上市
-
到期年（公开口径）
无销量数据
峰值销售
化学药
类型
靶点：1,3-beta-glucan synthase
商品名：Biafungin、REZZAYO
适应症（已批准）：侵袭性念珠菌病、念珠菌病、念珠菌血症
各地区研发/上市状态
美国
批准上市
2023-03-22
欧盟
批准上市
2023-12-22
中国
申请上市
2025-02-26
日本
-
生产该 API 的工厂4
口径：平台供应网络（富通询价明细 + 产品主档）中登记生产该品种的工厂（在产口径），按报价活跃度排序；快照不含成本与客户信息。
已收录 4 家在产工厂名单，登录后可见（工厂信息不对未登录访客展示）。
登录查看工厂名单 →合成路线与中间体5 routes
原研路线 × 0优化路线（非专利）× 5工艺路线 × 0
路线按「原研路线 → 优化路线 / 工艺路线（非专利）」排序。每条路线附本站自绘的路线流程图（中间体 → 原料药）与中间体表（编号 / CAS / 英文名），可直接用于供应商开发与询价。流程图由本站依据已授权的结构化数据自行渲染，未使用任何第三方路线图。
优化Route 1步骤 9 · 总收率 /
(I)796686-1-a90600-20-7(II)796686-1-a107-11-9(III)796686-1-a1152110-39-8(IV)796686-1-a1443528-89-9(V)796686-1-a1443528-80-0(VI)796686-1-a—(VII)796686-1-a—(VIII)796686-1-a—(IX)796686-1-a—(X)796686-1-a—(XI)796686-1-a—(XII)796686-1-a—(XIII)796686-1-a,(XIII)796686-1-b—(XXVa)796686-1-d2401852-68-2API · 醋酸瑞扎芬净
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| (I)796686-1-a | 90600-20-7在售 | (S)-N-Boc-allylglycine |
| (II)796686-1-a | 107-11-9在售 | Allylamine |
| (III)796686-1-a | 1152110-39-8在售 | tert-Butyl [(2S)-1-oxo-1-[(prop-2-en-1-yl)amino]pent-4-en-2-yl]carbamate |
| (IV)796686-1-a | 1443528-89-9在售 | tert-Butyl [(3S)-2-oxo-1,2,3,4-tetrahydropyridin-3-yl]carbamate |
| (V)796686-1-a | 1443528-80-0在售 | tert-Butyl [(3S,5R,6R)-5,6-dihydroxy-2-oxopiperidin-3-yl]carbamate |
| (VI)796686-1-a | - | (4R,5R)-N2-(tert-Butoxycarbonyl)-4,5-dihydroxy-L-ornithine |
| (VII)796686-1-a | - | (4R,5R)-N2-(tert-Butoxycarbonyl)-N5-[[(9H-fluoren-9-yl)oxy]carbonyl]-4,5-dihydroxy-L-ornithine |
| (VIII)796686-1-a | - | (4R,5R)-4,5-Bis(acetyloxy)-N2-(tert-butoxycarbonyl)-N5-[[(9H-fluoren-9-yl)oxy]carbonyl]-L-ornithine |
| (IX)796686-1-a | - | Resin bound (4R,5R)-4,5-bis(acetyloxy)-N2-(tert-butoxycarbonyl)-N5-[[(9H-fluoren-9-yl)oxy]carbonyl]-L-ornithine |
| (X)796686-1-a | - | (3S,4S)-N-Fmoc-3-acetoxy-4-methyl-L-proline |
| (XI)796686-1-a | - | Resin bound N5-[(3S,4S)-3-(acetyloxy)-1-[[(9H-fluoren-9-yl)oxy]carbonyl]-4-methyl-L-prolyl]-(4R,5R)-4,5-bis(acetyloxy)-N2-(tert-butoxycarbonyl)-L-ornithine |
| (XII)796686-1-a | - | O-Acetyl-N-[[(9H-fluoren-9-yl)oxy]carbonyl]-L-threonine |
| (XIII)796686-1-a,(XIII)796686-1-b | - | Resin bound N5-[O-acetyl-N-[[(9H-fluoren-9-yl)oxy]carbonyl]-L-threonyl-(3S,4S)-3-(acetyloxy)-4-methyl-L-prolyl]-(4R,5R)-4,5-bis(acetyloxy)-N2-(tert-butoxycarbonyl)-L-ornithine |
| (XXVa)796686-1-d | 2401852-68-2 | 3(4)-(Pentyloxy)-N-[(2R,6S,9S,11R,12R,14aS,15S,16S,20S,23S,25aS)-2,11,12,15-tetrahydroxy-6,20-bis[(1R)-1-hydroxyethyl]-23-[(4S,5S)-5-(4-hydroxyphenyl)-2-phenyl-1,3,2-dioxaborolan-4-yl]-16-methyl-5,8,14,19,22,25-hexaoxotetracosahydro-1H-dipyrrolo[2,1-c:2',1'-l][1,4,7,10,13,16]hexaazacyclohenicosin-9-yl][1(1),2(1):2(4),3(1)-terphenyl]-1(4)-carboxamide |
优化Route 2步骤 5 · 总收率 /
(XIII)796686-1-a,(XIII)796686-1-b—(XIV)796686-1-b,(XIV)796686-1-e—(XIX)796686-1-b—(XV)796686-1-b—(XVI)796686-1-b178860-12-3(XVII)796686-1-b—(XVIII)796686-1-b181817-14-1(XX)796686-1-b—(XXI)796686-1-b,(XXI)796686-1-c1443528-87-7API · 醋酸瑞扎芬净
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| (XIII)796686-1-a,(XIII)796686-1-b | - | Resin bound N5-[O-acetyl-N-[[(9H-fluoren-9-yl)oxy]carbonyl]-L-threonyl-(3S,4S)-3-(acetyloxy)-4-methyl-L-prolyl]-(4R,5R)-4,5-bis(acetyloxy)-N2-(tert-butoxycarbonyl)-L-ornithine |
| (XIV)796686-1-b,(XIV)796686-1-e | - | (4S)-O-Acetyl-4-(acetyloxy)-4-[4-(acetyloxy)phenyl]-N-[[(9H-fluoren-9-yl)oxy]carbonyl]-L-threonine |
| (XIX)796686-1-b | - | Resin bound N5-[O-acetyl-N-[[(9H-fluoren-9-yl)methoxy]carbonyl]-L-threonyl-(4R)-4-(acetyloxy)-L-prolyl-(4S)-O-acetyl-4-(acetyloxy)-4-[4-(acetyloxy)phenyl]-L-threonyl-O-acetyl-L-threonyl-(3S,4S)-3-(acetyloxy)-4-methyl-L-prolyl]-(4R,5R)-4,5-bis(acetyloxy)-N2-(tert-butoxycarbonyl)-L-ornithine |
| (XV)796686-1-b | - | Resin bound N5-[(4S)-O-acetyl-4-(acetyloxy)-4-[4-(acetyloxy)phenyl]-N-[[(9H-fluoren-9-yl)oxy]carbonyl]-L-threonyl-O-acetyl-L-threonyl-(3S,4S)-3-(acetyloxy)-4-methyl-L-prolyl]-(4R,5R)-4,5-bis(acetyloxy)-N2-(tert-butoxycarbonyl)-L-ornithine |
| (XVI)796686-1-b | 178860-12-3在售 | (4R)-4-(Acetyloxy)-1-[[(9H-fluoren-9-yl)methoxy]carbonyl]-L-proline |
| (XVII)796686-1-b | - | Resin bound N5-[(4R)-4-(acetyloxy)-1-[[(9H-fluoren-9-yl)methoxy]carbonyl]-L-prolyl-(4S)-O-acetyl-4-(acetyloxy)-4-[4-(acetyloxy)phenyl]-L-threonyl-O-acetyl-L-threonyl-(3S,4S)-3-(acetyloxy)-4-methyl-L-prolyl]-(4R,5R)-4,5-bis(acetyloxy)-N2-(tert-butoxycarbonyl)-L-ornithine |
| (XVIII)796686-1-b | 181817-14-1在售 | O-Acetyl-N-[[(9H-fluoren-9-yl)methoxy]carbonyl]-L-threonine |
| (XX)796686-1-b | - | N5-[O-Acetyl-L-threonyl-(4R)-4-(acetyloxy)-L-prolyl-(4S)-O-acetyl-4-(acetyloxy)-4-[4-(acetyloxy)phenyl]-L-threonyl-O-acetyl-L-threonyl-(3S,4S)-3-(acetyloxy)-4-methyl-L-prolyl]-(4R,5R)-4,5-bis(acetyloxy)-N2-(tert-butoxycarbonyl)-L-ornithine |
| (XXI)796686-1-b,(XXI)796686-1-c | 1443528-87-7在售 | (2R,6S,9S,11R,12R,14aS,15S,16S,20S,23S,25aS)-6,20-Bis[(1R)-1-(acetyloxy)ethyl]-9-amino-23-[(1S,2S)-1,2-bis(acetyloxy)-2-[4-(acetyloxy)phenyl]ethyl]-16-methyl-5,8,14,19,22,25-hexaoxotetracosahydro-1H-dipyrrolo[2,1-c:2',1'-l][1,4,7,10,13,16]hexaazacyclohenicosine-2,11,12,15-tetrayl tetraacetate |
优化Route 3步骤 2 · 总收率 /
(XXI)796686-1-b,(XXI)796686-1-c1443528-87-7(XXII)796686-1-c158938-08-0(XXIII)796686-1-c1443528-88-8(XXIV)796686-1-c,(XXIV)796686-1-d166663-25-8(XXVc)796686-1-d2401852-78-4API · 醋酸瑞扎芬净
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| (XXI)796686-1-b,(XXI)796686-1-c | 1443528-87-7在售 | (2R,6S,9S,11R,12R,14aS,15S,16S,20S,23S,25aS)-6,20-Bis[(1R)-1-(acetyloxy)ethyl]-9-amino-23-[(1S,2S)-1,2-bis(acetyloxy)-2-[4-(acetyloxy)phenyl]ethyl]-16-methyl-5,8,14,19,22,25-hexaoxotetracosahydro-1H-dipyrrolo[2,1-c:2',1'-l][1,4,7,10,13,16]hexaazacyclohenicosine-2,11,12,15-tetrayl tetraacetate |
| (XXII)796686-1-c | 158938-08-0在售 | 4''-(Pentyloxy)-1,1':4',1''-terphenyl-4-carboxylic acid |
| (XXIII)796686-1-c | 1443528-88-8在售 | (2R,6S,9S,11R,12R,14aS,15S,16S,20S,23S,25aS)-6,20-Bis[(1R)-1-(acetyloxy)ethyl]-23-[(1S,2S)-1,2-bis(acetyloxy)-2-[4-(acetyloxy)phenyl]ethyl]-16-methyl-5,8,14,19,22,25-hexaoxo-9-[[3(4)-(pentyloxy)[1(1),2(1):2(4),3(1)-terphenyl]-1(4)-carbonyl]amino]tetracosahydro-1H-dipyrrolo[2,1-c:2',1'-l][1,4,7,10,13,16]hexaazacyclohenicosine-2,11,12,15-tetrayl tetraacetate |
| (XXIV)796686-1-c,(XXIV)796686-1-d | 166663-25-8在售 | (11aS,25aS)-N-[9(S)-[1(S),2(S)-Dihydroxy-2-(4-hydroxyphenyl)ethyl]-1(S),13(R),22(R),23(R)-tetrahydroxy-6(S),17(S)-bis[1(R)-hydroxyethyl]-2(S)-methyl-5,8,11,16,19,25-hexaoxoperhydrodipyrrolo[2,1-c:2',1'-l][1,4,7,10,13,16]hexaazacycloheneicosin-20(S)-yl]-4''-pentyloxy-p-terphenyl-4-carboxamide |
| (XXVc)796686-1-d | 2401852-78-4 | N-[(2R,6S,9S,11R,12R,14aS,15S,16S,20S,23S,25aS)-23-[(4S,5S)-2-(3,4-Dimethoxyphenyl)-5-(4-hydroxyphenyl)-1,3,2-dioxaborolan-4-yl]-2,11,12,15-tetrahydroxy-6,20-bis[(1R)-1-hydroxyethyl]-16-methyl-5,8,14,19,22,25-hexaoxotetracosahydro-1H-dipyrrolo[2,1-c:2',1'-l][1,4,7,10,13,16]hexaazacyclohenicosin-9-yl]-3(4)-(pentyloxy)[1(1),2(1):2(4),3(1)-terphenyl]-1(4)-carboxamide |
优化Route 4步骤 2 · 总收率 /
(XXIV)796686-1-c,(XXIV)796686-1-d166663-25-8(XXIX)796686-1-d74-88-4(XXVa)796686-1-d2401852-68-2(XXVb)796686-1-d2401852-73-9(XXVc)796686-1-d2401852-78-4(XXVd)796686-1-d2401852-75-1(XXVI)796686-1-d67-48-1(XXVII)796686-1-d—(XXVIII)796686-1-d2498-25-1API · 醋酸瑞扎芬净
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| (XXIV)796686-1-c,(XXIV)796686-1-d | 166663-25-8在售 | (11aS,25aS)-N-[9(S)-[1(S),2(S)-Dihydroxy-2-(4-hydroxyphenyl)ethyl]-1(S),13(R),22(R),23(R)-tetrahydroxy-6(S),17(S)-bis[1(R)-hydroxyethyl]-2(S)-methyl-5,8,11,16,19,25-hexaoxoperhydrodipyrrolo[2,1-c:2',1'-l][1,4,7,10,13,16]hexaazacycloheneicosin-20(S)-yl]-4''-pentyloxy-p-terphenyl-4-carboxamide |
| (XXIX)796686-1-d | 74-88-4在售 | Methyl iodide |
| (XXVa)796686-1-d | 2401852-68-2 | 3(4)-(Pentyloxy)-N-[(2R,6S,9S,11R,12R,14aS,15S,16S,20S,23S,25aS)-2,11,12,15-tetrahydroxy-6,20-bis[(1R)-1-hydroxyethyl]-23-[(4S,5S)-5-(4-hydroxyphenyl)-2-phenyl-1,3,2-dioxaborolan-4-yl]-16-methyl-5,8,14,19,22,25-hexaoxotetracosahydro-1H-dipyrrolo[2,1-c:2',1'-l][1,4,7,10,13,16]hexaazacyclohenicosin-9-yl][1(1),2(1):2(4),3(1)-terphenyl]-1(4)-carboxamide |
| (XXVb)796686-1-d | 2401852-73-9 | 3(4)-(Pentyloxy)-N-[(2R,6S,9S,11R,12R,14aS,15S,16S,20S,23S,25aS)-2,11,12,15-tetrahydroxy-6,20-bis[(1R)-1-hydroxyethyl]-23-[(4S,5S)-5-(4-hydroxyphenyl)-2-[4-(trifluoromethyl)phenyl]-1,3,2-dioxaborolan-4-yl]-16-methyl-5,8,14,19,22,25-hexaoxotetracosahydro-1H-dipyrrolo[2,1-c:2',1'-l][1,4,7,10,13,16]hexaazacyclohenicosin-9-yl][1(1),2(1):2(4),3(1)-terphenyl]-1(4)-carboxamide |
| (XXVc)796686-1-d | 2401852-78-4 | N-[(2R,6S,9S,11R,12R,14aS,15S,16S,20S,23S,25aS)-23-[(4S,5S)-2-(3,4-Dimethoxyphenyl)-5-(4-hydroxyphenyl)-1,3,2-dioxaborolan-4-yl]-2,11,12,15-tetrahydroxy-6,20-bis[(1R)-1-hydroxyethyl]-16-methyl-5,8,14,19,22,25-hexaoxotetracosahydro-1H-dipyrrolo[2,1-c:2',1'-l][1,4,7,10,13,16]hexaazacyclohenicosin-9-yl]-3(4)-(pentyloxy)[1(1),2(1):2(4),3(1)-terphenyl]-1(4)-carboxamide |
| (XXVd)796686-1-d | 2401852-75-1 | N-[(2R,6S,9S,11R,12R,14aS,15S,16S,20S,23S,25aS)-23-[(4S,5S)-2-(2,6-Dimethylphenyl)-5-(4-hydroxyphenyl)-1,3,2-dioxaborolan-4-yl]-2,11,12,15-tetrahydroxy-6,20-bis[(1R)-1-hydroxyethyl]-16-methyl-5,8,14,19,22,25-hexaoxotetracosahydro-1H-dipyrrolo[2,1-c:2',1'-l][1,4,7,10,13,16]hexaazacyclohenicosin-9-yl]-3(4)-(pentyloxy)[1(1),2(1):2(4),3(1)-terphenyl]-1(4)-carboxamide |
| (XXVI)796686-1-d | 67-48-1 | 2-Hydroxy-N,N,N-trimethylethylammonium chloride |
| (XXVII)796686-1-d | - | 2-[[(2R,6S,9S,11R,12R,14aS,15S,16S,20S,23S,25aS)-23-[(1S,2S)-1,2-Dihydroxy-2-(4-hydroxyphenyl)ethyl]-2,11,15-trihydroxy-6,20-bis[(1R)-1-hydroxyethyl]-16-methyl-5,8,14,19,22,25-hexaoxo-9-[[3(4)-(pentyloxy)[1(1),2(1):2(4),3(1)-terphenyl]-1(4)-carbonyl]amino]tetracosahydro-1H-dipyrrolo[2,1-c:2',1'-l][1,4,7,10,13,16]hexaazacyclohenicosin-12-yl]oxy]-N,N,N-trimethylethan-1-aminium |
| (XXVIII)796686-1-d | 2498-25-1 | 2-(Dimethylamino)ethanol hydrochloride |
优化Route 5步骤 4 · 总收率 /
(XIV)796686-1-b,(XIV)796686-1-e—(XXX)796686-1-e1443528-83-3(XXXI)796686-1-e1894196-63-4(XXXII)796686-1-e106454-67-5(XXXIII)796686-1-e—API · 醋酸瑞扎芬净
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| (XIV)796686-1-b,(XIV)796686-1-e | - | (4S)-O-Acetyl-4-(acetyloxy)-4-[4-(acetyloxy)phenyl]-N-[[(9H-fluoren-9-yl)oxy]carbonyl]-L-threonine |
| (XXX)796686-1-e | 1443528-83-3在售 | (2S,3E)-2-[[(Benzyloxy)carbonyl]amino]-4-[4-(benzyloxy)phenyl]but-3-enoic acid |
| (XXXI)796686-1-e | 1894196-63-4在售 | (4S)-N-[(Benzyloxy)carbonyl]-4-[4-(benzyloxy)phenyl]-4-hydroxy-L-threonine |
| (XXXII)796686-1-e | 106454-67-5在售 | 4(S)-Hydroxy-4-(4-hydroxyphenyl)-L-threonine |
| (XXXIII)796686-1-e | - | (4S)-N-[[(9H-Fluoren-9-yl)oxy]carbonyl]-4-hydroxy-4-(4-hydroxyphenyl)-L-threonine |
常见问题（FAQ）
醋酸瑞扎芬净的适应症有哪些？
已批准的适应症包括：侵袭性念珠菌病、念珠菌病、念珠菌血症。
醋酸瑞扎芬净的专利什么时候到期？
醋酸瑞扎芬净的专利到期年暂无公开口径，本页会在数据管道核实后更新。
醋酸瑞扎芬净有几条合成路线？
本站收录 5 条合成路线，最短路线 2 步、总收率 /。每条路线的中间体均带登记编号与 CAS 号。
醋酸瑞扎芬净的关键中间体在哪里可以采购？
醋酸瑞扎芬净的多条路线中间体已挂接 CAS 档案，其中 15 个 CAS 已有优贝德（Unibest）供应网络在售报价，可在本页路线表中直接查看并询价。
如何获取醋酸瑞扎芬净中间体的报价？
在本页选择目标中间体的 CAS 进入档案页，或在询价页直接提交需求；CAS 会自动带入供需撮合流程，由供应网络反馈报价。
数据来源：多源数据交叉核实（仅结构化字段） · 2026-10-22