← 返回专利悬崖列表
CAS 74-88-4
Iodomethaneiodomethane-11CMethyl iodide
登记编号：(I)270899-4-a、LACO-011、(XXXIV)638294-1-d、(XXXVI)101438-55-d、Ephedrine Sulfate-019、Clarithromycin-025、Desvenlafaxine-024、(X)1225102-1-a、(IV)909096-2-a、(XXIX)796686-1-d、(XXXIII)145089-2-d、Granisetron-009 等 15 个
应用背景（按来源药适应症）
重度抑郁症盐酸艾司氯胺酮自杀意念盐酸艾司氯胺酮抑郁症盐酸艾司氯胺酮麻醉盐酸艾司氯胺酮难治性抑郁症盐酸艾司氯胺酮疼痛盐酸艾司氯胺酮强直阵挛性癫痫拉考沙胺癫痫拉考沙胺癫痫部分性发作拉考沙胺癫痫发作拉考沙胺收缩性心力衰竭非奈利酮舒张期心力衰竭非奈利酮心脏衰竭非奈利酮慢性肾功能不全非奈利酮糖尿病肾病非奈利酮二型糖尿病非奈利酮乳腺癌Paclitaxel/Encequidar mesylate腺癌Paclitaxel/Encequidar mesylate血管肉瘤Paclitaxel/Encequidar mesylate实体瘤Paclitaxel/Encequidar mesylate低血压硫酸麻黄碱边缘带B细胞淋巴瘤克拉霉素/雷贝拉唑钠/阿莫西林十二指肠溃疡克拉霉素/雷贝拉唑钠/阿莫西林特发性血小板减少性紫癜克拉霉素/雷贝拉唑钠/阿莫西林胃溃疡克拉霉素/雷贝拉唑钠/阿莫西林胃炎克拉霉素/雷贝拉唑钠/阿莫西林幽门螺杆菌感染克拉霉素/雷贝拉唑钠/阿莫西林重度抑郁症地文拉法辛抑郁症地文拉法辛胰腺癌紫杉醇非小细胞肺癌紫杉醇霍奇金病紫杉醇精原细胞瘤紫杉醇卵巢癌紫杉醇乳腺癌紫杉醇鼻窦炎克拉霉素扁桃体炎克拉霉素急性支气管炎克拉霉素慢性支气管炎克拉霉素下呼吸道感染克拉霉素咽炎克拉霉素非小细胞肺癌氟泽雷塞结直肠癌氟泽雷塞实体瘤氟泽雷塞非小细胞肺癌伊鲁阿克侵袭性念珠菌病醋酸瑞扎芬净念珠菌病醋酸瑞扎芬净念珠菌血症醋酸瑞扎芬净卡氏肺囊虫感染醋酸瑞扎芬净侵袭性真菌感染醋酸瑞扎芬净曲霉菌属感染醋酸瑞扎芬净阿尔茨海默病重酒石酸卡巴拉汀痴呆重酒石酸卡巴拉汀帕金森病重酒石酸卡巴拉汀抗胆碱能综合征重酒石酸卡巴拉汀神经行为学表现重酒石酸卡巴拉汀认知障碍重酒石酸卡巴拉汀化疗导致的恶心和呕吐格拉司琼恶心格拉司琼呕吐格拉司琼手术后恶心呕吐格拉司琼术后疼痛格拉司琼胃肌轻瘫格拉司琼非小细胞肺癌宗艾替尼肺癌宗艾替尼食道腺癌宗艾替尼食管胃结合部肿瘤宗艾替尼胃癌宗艾替尼转移性乳腺癌宗艾替尼热潮红依林奈坦血管舒缩症依林奈坦HR阳性乳腺癌依林奈坦睡眠障碍依林奈坦绝经期症状依林奈坦阿片类依赖依林奈坦
来源药（使用该中间体的合成路线）
| 品种 | 梯队 | 到期年 |
|---|---|---|
| 盐酸艾司氯胺酮Esketamine Hydrochloride | Tier B · 提前布局 | 2029 |
| 拉考沙胺Lacosamide | Tier B · 提前布局 | 2028 |
| 非奈利酮Finerenone | Tier C · 观察 / 贸易 | 2030 |
| Paclitaxel/Encequidar mesylate | Tier C · 观察 / 贸易 | - |
| 硫酸麻黄碱Ephedrine Sulfate | Tier C · 观察 / 贸易 | - |
| 克拉霉素/雷贝拉唑钠/阿莫西林Clarithromycin/Rabeprazole Sodium/Amoxicillin | Tier C · 观察 / 贸易 | - |
| 地文拉法辛Desvenlafaxine | Tier C · 观察 / 贸易 | - |
| 紫杉醇Paclitaxel | Tier B · 提前布局 | - |
| 克拉霉素Clarithromycin | Tier C · 观察 / 贸易 | - |
| 氟泽雷塞Fulzerasib | Tier C · 观察 / 贸易 | - |
| 伊鲁阿克Iruplinalkib | Tier C · 观察 / 贸易 | - |
| 醋酸瑞扎芬净Rezafungin acetate | Tier C · 观察 / 贸易 | - |
| 重酒石酸卡巴拉汀Rivastigmine Tartrate | Tier B · 提前布局 | - |
| 格拉司琼Granisetron | Tier C · 观察 / 贸易 | - |
| 宗艾替尼Zongertinib | Tier C · 观察 / 贸易 | - |
| 依林奈坦Elinzanetant | Tier C · 观察 / 贸易 | - |
| 氢溴酸依他佐辛Eptazocine hydrobromide | Tier C · 观察 / 贸易 | - |
合成路线中的位置（上下游链）
按路线登记顺序排列，左→右为合成方向；高亮为当前 CAS，其余可点击跳转对应档案。
Iodomethane→Chlorocyclopentane→1-Chloro-2-cyanobenzene→(2-Chlorophenyl)(cyclopentyl)methanone→2-Chlorobenzoyl chloride→Cyclopentene→(1-Bromocyclopentyl)(2-chlorophenyl) ketone→Aminomethane→1-[(E)-(2-Chlorophenyl)(methylimino)methyl]cyclopentan-1-ol hydrogen chloride→(±)-2-(2-Chlorophenyl)-2-(methylamino)cyclohexanone hydrochloride→2-(2-Chlorophenyl)-2-(methylamino)cyclohexan-1-one→(2S)-2-(2-Chlorophenyl)-2-(methylamino)cyclohexanone
1,3-Dihydroxy-2,2-dimethylpropane→2,2-Dimethylcyclohexane-1,3-dione→2,2,4-Trimethylcyclohex-3-en-1-one→2,4,6-Triisopropyl-N'-[(1Z)-2,2,4-trimethylcyclohex-3-en-1-ylidene]benzenesulfonohydrazide→2,4,6-Triisopropylbenzenesulfonohydrazide→3,3,7,7-Tetramethyl-1,5-dioxaspiro[5.5]undecan-8-one→3,3,7,7,9-Pentamethyl-1,5-dioxaspiro[5.5]undec-8-ene→3,5-Cyclohexanedione→4-Methyl-N'-[(8E)-3,3,7,7-tetramethyl-1,5-dioxaspiro[5.5]undec-8-ylidene]benzenesulfonohydrazide→4-Methylbenzenesulfonhydrazide→Iodomethane
Cinnamyl alcohol→(±)-3-(Benzyloxy)-2-bromo-3-phenylpropan-1-ol→(±)-2-[(Benzyloxy)(phenyl)methyl]oxirane→(2R)-2-[(R)-(Benzyloxy)(phenyl)methyl]oxirane→(1R,2R)-1-(Benzyloxy)-1-phenylpropan-2-ol→(1R,2R)-1-(Benzyloxy)-1-phenylpropan-2-yl methanesulfonate→[(1R,2S)-2-Azido-1-(benzyloxy)propyl]benzene→Benzyl [(1R,2S)-1-(benzyloxy)-1-phenylpropan-2-yl]carbamate→Methyl iodide→Benzyl [(1R,2S)-1-(benzyloxy)-1-phenylpropan-2-yl]methylcarbamate→(-)-2(S)-(Methylamino)-1(R)-phenylpropan-1-ol
本站可供应的对应中间体
同 CAS 多家在售供应横向对比；价格区间为供应方挂牌口径，实价以询价确认为准。
| 供应商 | 产品 | 价格区间 | 最小起订 | 货期 | 资质 | 操作 |
|---|---|---|---|---|---|---|
| Unibest Taizhou GMP-like Site | N-Boc-O-Benzyl-D-serine Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Qualified Partner — East China API Works | 6-chloro-4-(4-fluoro-2-methylphenyl)pyridin-3-amine hydrochloride Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Unibest Nantong cGMP Site | N-[6-Chloro-4-(4-fluoro-2-methylp henyl)-3-pyridinyl]-N,a,a-trimethy Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Unibest Taizhou GMP-like Site | 3-Morpholinemethanol, 4-(phenylmethyl)-, hydrochloride Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Qualified Partner — East China API Works | (7S,9aS)-7-((Benzyloxy)methyl)octahydropyrazino[2,1-c][1,4]oxazine dioxalate salt Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Unibest Nantong cGMP Site | 2-(3,5-bis(trifluoroMethyl)phenyl)-2-Methyl propanoic acid Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Unibest Taizhou GMP-like Site | ((7S)-octahydropyrazino[2,1-c][1,4]oxazin-7-yl)methanol Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Qualified Partner — East China API Works | 4-Boc-3-morpholinecarboxylic Acid Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Unibest Nantong cGMP Site | 2-(3,5-bis-trifluoromethylphenyl)-2-methyl-propionyl chloride Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Unibest Nantong cGMP Site | 4-Bromo-2-methoxybenzaldehyde Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Unibest Taizhou GMP-like Site | 4-formyl-3-methoxybenzonitrile Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Qualified Partner — East China API Works | 4-AMino-5-Methylpyridin-2-ol Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Unibest Nantong cGMP Site | 2-chloro-5-methylpyridin-4-amine Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Unibest Taizhou GMP-like Site | 2-Cyanoethyl 3-oxobutanoate Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Qualified Partner — East China API Works | 2-cyanoethyl 4-(4-cyano-2-methoxyphenyl)-2,8-dimethyl-5-oxo-1,4,5,6-tetrahydro-1,6-naphthyridine-3-carboxylate Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
本页为中间体 CAS 注册档案：同 CAS 的多条路线登记已合并；后续供应商报价与买方需求以该 CAS 为主键撮合。