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他唑巴坦钠
Tier C · 观察 / 贸易Tazobactam Sodium
大鹏药品工业株式会社
原研
1999
首批上市
-
到期年（公开口径）
无销量数据
峰值销售
化学药
类型
靶点：Beta Lactamase
适应症（已批准）：细菌感染
各地区研发/上市状态
美国
-
欧盟
-
中国
批准上市
1999-01-01
日本
-
合成路线与中间体13 routes
原研路线 × 0优化路线（非专利）× 12工艺路线 × 1
路线按「原研路线 → 优化路线 / 工艺路线（非专利）」排序。每条路线附本站自绘的路线流程图（中间体 → 原料药）与中间体表（编号 / CAS / 英文名），可直接用于供应商开发与询价。流程图由本站依据已授权的结构化数据自行渲染，未使用任何第三方路线图。
优化Route 1步骤 8 · 总收率 181.68g(Tazobactam (Free))
Tazobactam Sodium-00187579-78-0Tazobactam Sodium-002149-30-4Tazobactam Sodium-00387579-79-1Tazobactam Sodium-00485573-73-5Tazobactam Sodium-00589051-47-8Tazobactam Sodium-00689051-49-0Tazobactam Sodium-0071066-54-2Tazobactam Sodium-008—Tazobactam Sodium-00989789-07-1Tazobactam Sodium-01074-86-2Tazobactam Sodium-011108-05-4Tazobactam Sodium-01289786-04-9API · 他唑巴坦钠
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Tazobactam Sodium-001 | 87579-78-0在售 | (2S,5R)-2beta-[(Benzhydryloxy)carbonyl]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane4-oxide |
| Tazobactam Sodium-002 | 149-30-4在售 | 1,3-Benzothiazole-2-thiol |
| Tazobactam Sodium-003 | 87579-79-1在售 | (2R)-2-[(2R)-2-[(Benzothiazol-2-yl)dithio]-4-oxoazetidin-1-yl]-3-methyl-3-butenoic acid benzhydryl ester |
| Tazobactam Sodium-004 | 85573-73-5在售 | (2S-(2alpha,3beta,5alpha))-3-(Chloromethyl)-3-methyl-7-oxo-4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid diphenylmethyl ester |
| Tazobactam Sodium-005 | 89051-47-8在售 | Benzhydryl (2S,3S,5R)-3-(azidomethyl)-3-methyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate |
| Tazobactam Sodium-006 | 89051-49-0在售 | Benzhydryl (2S,3S,5R)-3-(azidomethyl)-3-methyl-4,4,7-trioxo-4lambda6-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate |
| Tazobactam Sodium-007 | 1066-54-2在售 | 1-Trimethylsilylethyne |
| Tazobactam Sodium-008 | - | Benzhydryl 2a-methyl-2beta-(4-trimethylsilyl-1,2,3-triazol-1 ylmethyl)penam-3a-carboxylate-1,1-dioxide |
| Tazobactam Sodium-009 | 89789-07-1在售 | Benzhydryl (2S,3S,5R)-3-((1H-1,2,3-triazol-1-yl)methyl)-3-methyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate 4,4-dioxide |
| Tazobactam Sodium-010 | 74-86-2在售 | Acetylene |
| Tazobactam Sodium-011 | 108-05-4在售 | 1-Acetoxyethylene |
| Tazobactam Sodium-012 | 89786-04-9在售 | (2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-(triazol-1-ylmethyl)-4lambda6-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid |
优化Route 3步骤 14 · 总收率 17g(Tazobactam Sodium-029)
Tazobactam Sodium-021551-16-6Tazobactam Sodium-02224158-88-1Tazobactam Sodium-02375527-84-3Tazobactam Sodium-024113891-01-3Tazobactam Sodium-00187579-78-0Tazobactam Sodium-02569126-86-9Tazobactam Sodium-02613257-88-0Tazobactam Sodium-027288-36-8Tazobactam Sodium-028120241-79-4Tazobactam Sodium-020125949-72-6Tazobactam Sodium-029—Tazobactam Sodium-03079703-02-9Tazobactam Sodium-0315350-57-2Tazobactam Sodium-03287-53-6Tazobactam Sodium-03379702-81-1Tazobactam Sodium-03473968-83-9Tazobactam Sodium-002149-30-4Tazobactam Sodium-00387579-79-1Tazobactam Sodium-03572118-49-1Tazobactam Sodium-03689051-48-9Tazobactam Sodium-00485573-73-5Tazobactam Sodium-037—API · 他唑巴坦钠
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Tazobactam Sodium-021 | 551-16-6在售 | (+)-6-Aminopenicillanic acid |
| Tazobactam Sodium-022 | 24158-88-1在售 | (2S,5R)-6,6-Dibromo-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid |
| Tazobactam Sodium-023 | 75527-84-3在售 | Diphenylmethyl (2S,5R)-6,6-dibromo-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate |
| Tazobactam Sodium-024 | 113891-01-3在售 | Diphenylmethyl (2S,5R)-6,6-dibromo-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate 4-oxide |
| Tazobactam Sodium-001 | 87579-78-0在售 | (2S,5R)-2beta-[(Benzhydryloxy)carbonyl]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane4-oxide |
| Tazobactam Sodium-025 | 69126-86-9在售 | Methyl (2S,5R)-3,3-dimethyl-4,7-dioxo-4lambda4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate |
| Tazobactam Sodium-026 | 13257-88-0在售 | 1-(Trimethylsilyl)-1,2,3-triazole |
| Tazobactam Sodium-027 | 288-36-8在售 | 1,2,3-Triazole |
| Tazobactam Sodium-028 | 120241-79-4在售 | 3-(1,2,3-Triazol-4-yl)pyridine |
| Tazobactam Sodium-020 | 125949-72-6在售 | (2S,3S,5R)-2-Methyl-2-(1H-1,2,3-triazol-1-ylmethyl)penam-3-carboxylic acid diphenylmethyl ester |
| Tazobactam Sodium-029 | - | Methyl (2S,3S,5R)-3-methyl-7-oxo-3-[(1H-1,2,3-triazol-1-yl)methyl]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate |
| Tazobactam Sodium-030 | 79703-02-9在售 | (2S,4R,6S)-6-Bromo-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid 4-oxide |
| Tazobactam Sodium-031 | 5350-57-2在售 | (Diphenylmethylidene)hydrazine |
| Tazobactam Sodium-032 | 87-53-6在售 | (2S,5R)-3,3-Dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid |
| Tazobactam Sodium-033 | 79702-81-1在售 | (2S,5R)-3,3-Dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid 4-oxide |
| Tazobactam Sodium-034 | 73968-83-9在售 | Benzhydryl (2S,5R)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate |
| Tazobactam Sodium-002 | 149-30-4在售 | 1,3-Benzothiazole-2-thiol |
| Tazobactam Sodium-003 | 87579-79-1在售 | (2R)-2-[(2R)-2-[(Benzothiazol-2-yl)dithio]-4-oxoazetidin-1-yl]-3-methyl-3-butenoic acid benzhydryl ester |
| Tazobactam Sodium-035 | 72118-49-1在售 | Methyl (2R)-2-[(2R)-2-[(1,3-benzothiazol-2-yl)disulfanyl]-4-oxoazetidin-1-yl]-3-methylbut-3-enoate |
| Tazobactam Sodium-036 | 89051-48-9在售 | Diphenylmethyl (2S,3R,5R)-3-(bromomethyl)-3-methyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate |
| Tazobactam Sodium-004 | 85573-73-5在售 | (2S-(2alpha,3beta,5alpha))-3-(Chloromethyl)-3-methyl-7-oxo-4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid diphenylmethyl ester |
| Tazobactam Sodium-037 | - | Methyl (2S,3R,5R)-3-(chloromethyl)-3-methyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate |
优化Route 4步骤 7 · 总收率 5g(Tazobactam (Free))
Tazobactam Sodium-027288-36-8Tazobactam Sodium-038—Tazobactam Sodium-020125949-72-6Tazobactam Sodium-029—Tazobactam Sodium-00989789-07-1Tazobactam Sodium-039—Tazobactam Sodium-01289786-04-9Tazobactam Sodium-03689051-48-9Tazobactam Sodium-040—Tazobactam Sodium-0412775432-22-7Tazobactam Sodium-042—API · 他唑巴坦钠
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Tazobactam Sodium-027 | 288-36-8在售 | 1,2,3-Triazole |
| Tazobactam Sodium-038 | - | Silver(1+) 1,2,3-triazol-1-ide |
| Tazobactam Sodium-020 | 125949-72-6在售 | (2S,3S,5R)-2-Methyl-2-(1H-1,2,3-triazol-1-ylmethyl)penam-3-carboxylic acid diphenylmethyl ester |
| Tazobactam Sodium-029 | - | Methyl (2S,3S,5R)-3-methyl-7-oxo-3-[(1H-1,2,3-triazol-1-yl)methyl]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate |
| Tazobactam Sodium-009 | 89789-07-1在售 | Benzhydryl (2S,3S,5R)-3-((1H-1,2,3-triazol-1-yl)methyl)-3-methyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate 4,4-dioxide |
| Tazobactam Sodium-039 | - | Methyl (2S,3S,5R)-3-methyl-4,4,7-trioxo-3-[(1H-1,2,3-triazol-1-yl)methyl]-4lambda6-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate |
| Tazobactam Sodium-012 | 89786-04-9在售 | (2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-(triazol-1-ylmethyl)-4lambda6-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid |
| Tazobactam Sodium-036 | 89051-48-9在售 | Diphenylmethyl (2S,3R,5R)-3-(bromomethyl)-3-methyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate |
| Tazobactam Sodium-040 | - | Diphenylmethyl (2S,3R,4R,5R)-3-(bromomethyl)-3-methyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate 4-oxide |
| Tazobactam Sodium-041 | 2775432-22-7在售 | (Z)-Ethene-1,2-diamine hydrogen chloride |
| Tazobactam Sodium-042 | - | Diphenylmethyl (2S,3S,4R,5R)-3-methyl-7-oxo-3-(1H-1,2,3-triazol-1-ylmethyl)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate 4-oxide |
优化Route 5步骤 15 · 总收率 4.6g(Tazobactam (Free))
Tazobactam Sodium-021551-16-6Tazobactam Sodium-04324138-28-1Tazobactam Sodium-03079703-02-9Tazobactam Sodium-0315350-57-2Tazobactam Sodium-044883-40-9Tazobactam Sodium-04580353-26-0Tazobactam Sodium-04674189-25-6Tazobactam Sodium-00187579-78-0Tazobactam Sodium-002149-30-4Tazobactam Sodium-00387579-79-1Tazobactam Sodium-00485573-73-5Tazobactam Sodium-047—Tazobactam Sodium-048—Tazobactam Sodium-00689051-49-0Tazobactam Sodium-049104893-87-0Tazobactam Sodium-00589051-47-8Tazobactam Sodium-01074-86-2Tazobactam Sodium-00989789-07-1Tazobactam Sodium-01289786-04-9API · 他唑巴坦钠
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Tazobactam Sodium-021 | 551-16-6在售 | (+)-6-Aminopenicillanic acid |
| Tazobactam Sodium-043 | 24138-28-1在售 | (2S,5R,6S)-6-Bromo-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid |
| Tazobactam Sodium-030 | 79703-02-9在售 | (2S,4R,6S)-6-Bromo-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid 4-oxide |
| Tazobactam Sodium-031 | 5350-57-2在售 | (Diphenylmethylidene)hydrazine |
| Tazobactam Sodium-044 | 883-40-9在售 | [Diazo(phenyl)methyl]benzene |
| Tazobactam Sodium-045 | 80353-26-0在售 | (2S,5R,6S)-Benzhydryl 6-bromo-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate 4-oxide |
| Tazobactam Sodium-046 | 74189-25-6在售 | Diphenylmethyl (2S,5R,6S)-6-bromo-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate |
| Tazobactam Sodium-001 | 87579-78-0在售 | (2S,5R)-2beta-[(Benzhydryloxy)carbonyl]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane4-oxide |
| Tazobactam Sodium-002 | 149-30-4在售 | 1,3-Benzothiazole-2-thiol |
| Tazobactam Sodium-003 | 87579-79-1在售 | (2R)-2-[(2R)-2-[(Benzothiazol-2-yl)dithio]-4-oxoazetidin-1-yl]-3-methyl-3-butenoic acid benzhydryl ester |
| Tazobactam Sodium-004 | 85573-73-5在售 | (2S-(2alpha,3beta,5alpha))-3-(Chloromethyl)-3-methyl-7-oxo-4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid diphenylmethyl ester |
| Tazobactam Sodium-047 | - | Diphenylmethyl (2S,3R,4R,5R)-3-(chloromethyl)-3-methyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate 4-oxide |
| Tazobactam Sodium-048 | - | Diphenylmethyl (2S,3S,4R,5R)-3-(azidomethyl)-3-methyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate 4-oxide |
| Tazobactam Sodium-006 | 89051-49-0在售 | Benzhydryl (2S,3S,5R)-3-(azidomethyl)-3-methyl-4,4,7-trioxo-4lambda6-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate |
| Tazobactam Sodium-049 | 104893-87-0在售 | Diphenylmethyl (2R,3S,6R)-3-azido-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]octane-2-carboxylate |
| Tazobactam Sodium-005 | 89051-47-8在售 | Benzhydryl (2S,3S,5R)-3-(azidomethyl)-3-methyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate |
| Tazobactam Sodium-010 | 74-86-2在售 | Acetylene |
| Tazobactam Sodium-009 | 89789-07-1在售 | Benzhydryl (2S,3S,5R)-3-((1H-1,2,3-triazol-1-yl)methyl)-3-methyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate 4,4-dioxide |
| Tazobactam Sodium-012 | 89786-04-9在售 | (2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-(triazol-1-ylmethyl)-4lambda6-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid |
优化Route 6步骤 3 · 总收率 27.8g(Tazobactam Sodium-009)
Tazobactam Sodium-00485573-73-5Tazobactam Sodium-00689051-49-0Tazobactam Sodium-00989789-07-1Tazobactam Sodium-05085573-74-6Tazobactam Sodium-027288-36-8API · 他唑巴坦钠
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Tazobactam Sodium-004 | 85573-73-5在售 | (2S-(2alpha,3beta,5alpha))-3-(Chloromethyl)-3-methyl-7-oxo-4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid diphenylmethyl ester |
| Tazobactam Sodium-006 | 89051-49-0在售 | Benzhydryl (2S,3S,5R)-3-(azidomethyl)-3-methyl-4,4,7-trioxo-4lambda6-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate |
| Tazobactam Sodium-009 | 89789-07-1在售 | Benzhydryl (2S,3S,5R)-3-((1H-1,2,3-triazol-1-yl)methyl)-3-methyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate 4,4-dioxide |
| Tazobactam Sodium-050 | 85573-74-6在售 | Diphenylmethyl (2S,3R,5R)-3-(chloromethyl)-3-methyl-4,4,7-trioxo-4lambda6-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate |
| Tazobactam Sodium-027 | 288-36-8在售 | 1,2,3-Triazole |
优化Route 7步骤 5 · 总收率 167g(Tazobactam Sodium-001)
Tazobactam Sodium-021551-16-6Tazobactam Sodium-0315350-57-2Tazobactam Sodium-00187579-78-0Tazobactam Sodium-05199395-86-5Tazobactam Sodium-052134866-13-0Tazobactam Sodium-053134866-14-1API · 他唑巴坦钠
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Tazobactam Sodium-021 | 551-16-6在售 | (+)-6-Aminopenicillanic acid |
| Tazobactam Sodium-031 | 5350-57-2在售 | (Diphenylmethylidene)hydrazine |
| Tazobactam Sodium-001 | 87579-78-0在售 | (2S,5R)-2beta-[(Benzhydryloxy)carbonyl]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane4-oxide |
| Tazobactam Sodium-051 | 99395-86-5在售 | Diphenylmethyl (2S,4R,5R,6R)-6-amino-3,3-dimethyl-4,7-dioxo-4lambda4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate |
| Tazobactam Sodium-052 | 134866-13-0在售 | (2S,5R,6R)-6-[(tert-Butoxycarbonyl)amino]-3,3-dimethyl-4,7-dioxo-4lambda4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid |
| Tazobactam Sodium-053 | 134866-14-1在售 | Diphenylmethyl (2S,5R,6R)-6-[(tert-butoxycarbonyl)amino]-3,3-dimethyl-4,7-dioxo-4lambda4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate |
优化Route 8步骤 1 · 总收率 /
Tazobactam Sodium-05425232-41-1API · 他唑巴坦钠
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Tazobactam Sodium-054 | 25232-41-1在售 | alpha,omega-Dimethylpoly[1-(pyridin-4-yl)ethane-1,2-diyl] |
优化Route 9步骤 1 · 总收率 12.0916g(Tazobactam (Free))
Tazobactam Sodium-055117030-11-2Tazobactam Sodium-015471-25-0Tazobactam Sodium-01289786-04-9API · 他唑巴坦钠
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Tazobactam Sodium-055 | 117030-11-2在售 | (2S,3S,5R)-3-(Azidomethyl)-3-methyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid 4,4-dioxide |
| Tazobactam Sodium-015 | 471-25-0在售 | 2-Propynoic acid |
| Tazobactam Sodium-012 | 89786-04-9在售 | (2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-(triazol-1-ylmethyl)-4lambda6-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid |
优化Route 10步骤 2 · 总收率 /
Tazobactam Sodium-01289786-04-9API · 他唑巴坦钠
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Tazobactam Sodium-012 | 89786-04-9在售 | (2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-(triazol-1-ylmethyl)-4lambda6-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid |
优化Route 11步骤 9 · 总收率 7.4g(Tazobactam (Free))
Tazobactam Sodium-03079703-02-9Tazobactam Sodium-05674367-78-5Tazobactam Sodium-057618-85-9Tazobactam Sodium-05880078-08-6Tazobactam Sodium-059—Tazobactam Sodium-06076911-22-3Tazobactam Sodium-061—Tazobactam Sodium-002149-30-4Tazobactam Sodium-0622375589-54-9Tazobactam Sodium-063—Tazobactam Sodium-0642375589-55-0Tazobactam Sodium-065—Tazobactam Sodium-0662375589-56-1Tazobactam Sodium-0672376815-36-8Tazobactam Sodium-068117030-09-8Tazobactam Sodium-069—Tazobactam Sodium-01074-86-2Tazobactam Sodium-070117030-07-6Tazobactam Sodium-0712376815-35-7Tazobactam Sodium-01289786-04-9API · 他唑巴坦钠
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Tazobactam Sodium-030 | 79703-02-9在售 | (2S,4R,6S)-6-Bromo-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid 4-oxide |
| Tazobactam Sodium-056 | 74367-78-5在售 | 1-(Chloromethyl)-3,5-dinitrobenzene |
| Tazobactam Sodium-057 | 618-85-9在售 | 1-Methyl-3,5-dinitrobenzene |
| Tazobactam Sodium-058 | 80078-08-6在售 | Benzyl (2S,4R,5R,6S)-6-bromo-3,3-dimethyl-4,7-dioxo-4lambda4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate |
| Tazobactam Sodium-059 | - | (3,5-Dinitrophenyl)methyl (2S,4R,5R,6S)-6-bromo-3,3-dimethyl-4,7-dioxo-4lambda4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate |
| Tazobactam Sodium-060 | 76911-22-3在售 | Benzyl (2S,4R,5R)-3,3-dimethyl-4,7-dioxo-4lambda4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate |
| Tazobactam Sodium-061 | - | (3,5-Dinitrophenyl)methyl (2S,4R,5R)-3,3-dimethyl-4,7-dioxo-4lambda4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate |
| Tazobactam Sodium-002 | 149-30-4在售 | 1,3-Benzothiazole-2-thiol |
| Tazobactam Sodium-062 | 2375589-54-9在售 | Benzyl (2R)-2-[(2R)-2-[(1,3-benzothiazol-2-yl)disulfanyl]-4-oxoazetidin-1-yl]-3-methylbut-3-enoate |
| Tazobactam Sodium-063 | - | (3,5-Dinitrophenyl)methyl (2R)-2-[(2R)-2-[(1,3-benzothiazol-2-yl)disulfanyl]-4-oxoazetidin-1-yl]-3-methylbut-3-enoate |
| Tazobactam Sodium-064 | 2375589-55-0在售 | Benzyl (2S,3R,5R)-3-(chloromethyl)-3-methyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate |
| Tazobactam Sodium-065 | - | (3,5-Dinitrophenyl)methyl (2S,3R,5R)-3-(chloromethyl)-3-methyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate |
| Tazobactam Sodium-066 | 2375589-56-1在售 | Benzyl (2S,3S,5R)-3-(azidomethyl)-3-methyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate |
| Tazobactam Sodium-067 | 2376815-36-8在售 | (3,5-Dinitrophenyl)methyl (2S,3S,5R)-3-(azidomethyl)-3-methyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate |
| Tazobactam Sodium-068 | 117030-09-8在售 | Benzyl (2S,3S,5R)-3-(azidomethyl)-3-methyl-4,4,7-trioxo-4lambda6-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate |
| Tazobactam Sodium-069 | - | (3,5-Dinitrophenyl)methyl (2S,3S,5R)-3-(azidomethyl)-3-methyl-4,4,7-trioxo-4lambda6-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate |
| Tazobactam Sodium-010 | 74-86-2在售 | Acetylene |
| Tazobactam Sodium-070 | 117030-07-6在售 | Benzyl (2S,3S,5R)-3-methyl-4,4,7-trioxo-3-[(1H-1,2,3-triazol-1-yl)methyl]-4lambda6-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate |
| Tazobactam Sodium-071 | 2376815-35-7在售 | (3,5-Dinitrophenyl)methyl (2S,3S,5R)-3-methyl-4,4,7-trioxo-3-[(1H-1,2,3-triazol-1-yl)methyl]-4lambda6-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate |
| Tazobactam Sodium-012 | 89786-04-9在售 | (2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-(triazol-1-ylmethyl)-4lambda6-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid |
优化Route 12步骤 3 · 总收率 43.6g(Tazobactam Sodium-027)
Tazobactam Sodium-013107-22-2Tazobactam Sodium-0725470-11-1Tazobactam Sodium-07317016-13-6Tazobactam Sodium-017584-14-5Tazobactam Sodium-027288-36-8API · 他唑巴坦钠
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Tazobactam Sodium-013 | 107-22-2在售 | Ethanedial |
| Tazobactam Sodium-072 | 5470-11-1在售 | Hydroxylamine hydrochloric acid salt |
| Tazobactam Sodium-073 | 17016-13-6在售 | N,N'-(1E,2E)-Ethane-1,2-diylidenedihydroxylamine |
| Tazobactam Sodium-017 | 584-14-5在售 | 1H-1,2,3-Triazol-1-amine |
| Tazobactam Sodium-027 | 288-36-8在售 | 1,2,3-Triazole |
优化Route 13步骤 5 · 总收率 25.72g(Tazobactam (Free))
Tazobactam Sodium-03379702-81-1Tazobactam Sodium-074—Tazobactam Sodium-075—Tazobactam Sodium-076—Tazobactam Sodium-027288-36-8Tazobactam Sodium-077132182-82-2Tazobactam Sodium-01289786-04-9API · 他唑巴坦钠
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Tazobactam Sodium-033 | 79702-81-1在售 | (2S,5R)-3,3-Dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid 4-oxide |
| Tazobactam Sodium-074 | - | (2S,5R)-3-[(Acetyloxy)methyl]-3-methyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid |
| Tazobactam Sodium-075 | - | (2S,5R)-3-(Hydroxymethyl)-3-methyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid |
| Tazobactam Sodium-076 | - | (2S,5R)-3-[[(Methanesulfonyl)oxy]methyl]-3-methyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid |
| Tazobactam Sodium-027 | 288-36-8在售 | 1,2,3-Triazole |
| Tazobactam Sodium-077 | 132182-82-2在售 | (2S,3S,5R)-3-Methyl-7-oxo-3-[(1H-1,2,3-triazol-1-yl)methyl]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid |
| Tazobactam Sodium-012 | 89786-04-9在售 | (2S,3S,5R)-3-Methyl-4,4,7-trioxo-3-(triazol-1-ylmethyl)-4lambda6-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid |
工艺Route 2步骤 7 · 总收率 1046.36g(Tazobactam Sodium-009)
Tazobactam Sodium-00485573-73-5Tazobactam Sodium-00989789-07-1Tazobactam Sodium-013107-22-2Tazobactam Sodium-014302-01-2Tazobactam Sodium-0167677-13-6Tazobactam Sodium-017584-14-5Tazobactam Sodium-018—Tazobactam Sodium-019—Tazobactam Sodium-015471-25-0Tazobactam Sodium-020125949-72-6API · 他唑巴坦钠
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Tazobactam Sodium-004 | 85573-73-5在售 | (2S-(2alpha,3beta,5alpha))-3-(Chloromethyl)-3-methyl-7-oxo-4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid diphenylmethyl ester |
| Tazobactam Sodium-009 | 89789-07-1在售 | Benzhydryl (2S,3S,5R)-3-((1H-1,2,3-triazol-1-yl)methyl)-3-methyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate 4,4-dioxide |
| Tazobactam Sodium-013 | 107-22-2在售 | Ethanedial |
| Tazobactam Sodium-014 | 302-01-2在售 | Diamine |
| Tazobactam Sodium-016 | 7677-13-6在售 | 1,1'-(Ethane-1,2-diylidene)dihydrazine |
| Tazobactam Sodium-017 | 584-14-5在售 | 1H-1,2,3-Triazol-1-amine |
| Tazobactam Sodium-018 | - | 3-Amino-1-([(2S,3S,5R)-2-[(diphenylmethoxy)carbonyl]-3-methyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptan-3-yl]methyl)-1H-1,2,3-triazol-3-ium chloride |
| Tazobactam Sodium-019 | - | 3-Amino-1-([(2S,3S,5R)-2-[(diphenylmethoxy)carbonyl]-3-methyl-4,4,7-trioxo-4lambda6-thia-1-azabicyclo[3.2.0]heptan-3-yl]methyl)-1H-1,2,3-triazol-3-ium chloride |
| Tazobactam Sodium-015 | 471-25-0在售 | 2-Propynoic acid |
| Tazobactam Sodium-020 | 125949-72-6在售 | (2S,3S,5R)-2-Methyl-2-(1H-1,2,3-triazol-1-ylmethyl)penam-3-carboxylic acid diphenylmethyl ester |
常见问题（FAQ）
他唑巴坦钠的适应症有哪些？
已批准的适应症包括：细菌感染。
他唑巴坦钠的专利什么时候到期？
他唑巴坦钠的专利到期年暂无公开口径，本页会在数据管道核实后更新。
他唑巴坦钠有几条合成路线？
本站收录 13 条合成路线，最短路线 1 步、总收率 /。每条路线的中间体均带登记编号与 CAS 号。
他唑巴坦钠的关键中间体在哪里可以采购？
他唑巴坦钠的多条路线中间体已挂接 CAS 档案，其中 58 个 CAS 已有优贝德（Unibest）供应网络在售报价，可在本页路线表中直接查看并询价。
如何获取他唑巴坦钠中间体的报价？
在本页选择目标中间体的 CAS 进入档案页，或在询价页直接提交需求；CAS 会自动带入供需撮合流程，由供应网络反馈报价。
数据来源：多源数据交叉核实（仅结构化字段） · 2026-10-22