达格列净丙二醇一水化物/盐酸沙格列汀

Q: 达格列净丙二醇一水化物/盐酸沙格列汀的适应症有哪些？

已批准的适应症包括：二型糖尿病。

Tier C · 观察 / 贸易

Dapagliflozin Propanediol Monohydrate/Saxagliptin Hydrochloride

阿斯利康

原研

2016

首批上市

到期年（公开口径）

无销量数据

峰值销售

化学药

类型

靶点：SGLT2、DPP4

商品名：Qtern

适应症（已批准）：二型糖尿病

各地区研发/上市状态

美国

撤市

欧盟

批准上市

2016-07-15

中国

日本

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合成路线与中间体4 routes

原研路线 × 1优化路线（非专利）× 3工艺路线 × 0

路线按「原研路线 → 优化路线 / 工艺路线（非专利）」排序。每条路线附本站自绘的路线流程图（中间体 → 原料药）与中间体表（编号 / CAS / 英文名），可直接用于供应商开发与询价。流程图由本站依据已授权的结构化数据自行渲染，未使用任何第三方路线图。

原研Route 1步骤 11 · 总收率 /

SAXA-00198-79-3SAXA-0027149-65-7SAXA-003144978-12-1SAXA-004178172-26-4SAXA-00590104-21-5SAXA-006709031-38-9SAXA-007361440-67-7SAXA-008709031-45-8SAXA-009361442-01-5SAXA-0101194836-75-3SAXA-011709031-43-6SAXA-012361442-00-4SAXA-013768-90-1SAXA-01469097-20-7SAXA-01530074-09-0SAXA-016128665-98-5SAXA-017709031-32-3SAXA-018709031-33-4SAXA-019709031-28-7SAXA-020709031-29-8SAXA-021598-99-2SAXA-022199783-35-2SAXA-023709031-34-5SAXA-024709031-35-6SAXA-025709031-36-7SAXA-0264942-47-6SAXA-02759768-70-6SAXA-028317375-33-0SAXA-029709031-30-1SAXA-030—API · 达格列净丙二醇一水化物/盐酸沙格列汀

编号	CAS 号	中间体名称
SAXA-001	98-79-3 在售	(S)-5-oxopyrrolidine-2-carboxylic acid
SAXA-002	7149-65-7	(S)-ethyl 5-oxopyrrolidine-2-carboxylate
SAXA-003	144978-12-1	1-(tert-butyl) 2-ethyl (S)-5-oxopyrrolidine-1,2-dicarboxylate
SAXA-004	178172-26-4 在售	1-(tert-butyl) 2-ethyl (S)-2,3-dihydro-1H-pyrrole-1,2-dicarboxylate
SAXA-005	90104-21-5	(S)-1-(tert-butoxycarbonyl)-2,3-dihydro-1H-pyrrole-2-carboxylic acid
SAXA-006	709031-38-9	tert-butyl (S)-2-carbamoyl-2,3-dihydro-1H-pyrrole-1-carboxylate
SAXA-007	361440-67-7 在售	tert-butyl (1S,3S,5S)-3-carbamoyl-2-azabicyclo[3.1.0]hexane-2-carboxylate
SAXA-008	709031-45-8 在售	(1S,3S,5S)-2-azabicyclo[3.1.0]hexane-3-carboxamide methanesulfonate
SAXA-009	361442-01-5	tert-butyl ((S)-2-((1S,3S,5S)-3-carbamoyl-2-azabicyclo[3.1.0]hexan-2-yl)-1-((1r,3R,5R,7S)-3-hydroxyadamantan-1-yl)-2-oxoethyl)carbamate
SAXA-010	1194836-75-3	(1R,3r,5R,7S)-3-((S)-1-((tert-butoxycarbonyl)amino)-2-((1S,3S,5S)-3-cyano-2-azabicyclo[3.1.0]hexan-2-yl)-2-oxoethyl)adamantan-1-yl 2,2,2-trifluoroacetate
SAXA-011	709031-43-6	tert-butyl ((S)-2-((1S,3S,5S)-3-cyano-2-azabicyclo[3.1.0]hexan-2-yl)-1-((1r,3R,5R,7S)-3-hydroxyadamantan-1-yl)-2-oxoethyl)carbamate
SAXA-012	361442-00-4 在售	(S)-2-((tert-butoxycarbonyl)amino)-2-((1r,3R,5R,7S)-3-hydroxyadamantan-1-yl)acetic acid
SAXA-013	768-90-1	(3s,5s,7s)-1-bromoadamantane
SAXA-014	69097-20-7	2,2,7,7-tetramethyl-4-((trimethylsilyl)oxy)-3,6-dioxa-2,7-disilaoct-4-ene
SAXA-015	30074-09-0	2-((3r,5r,7r)-adamantan-1-yl)-2-hydroxyacetic acid
SAXA-016	128665-98-5	methyl 2-((3r,5r,7r)-adamantan-1-yl)-2-hydroxyacetate
SAXA-017	709031-32-3	methyl 2-((3r,5r,7r)-adamantan-1-yl)-2-oxoacetate
SAXA-018	709031-33-4	methyl 2-((1r,3s,5R,7S)-3-hydroxyadamantan-1-yl)-2-oxoacetate
SAXA-019	709031-28-7	2-((1r,3s,5R,7S)-3-hydroxyadamantan-1-yl)-2-oxoacetic acid
SAXA-020	709031-29-8	(S)-2-amino-2-((1r,3R,5R,7S)-3-hydroxyadamantan-1-yl)acetic acid
SAXA-021	598-99-2	methyl 2,2,2-trichloroacetate
SAXA-022	199783-35-2	((2,2-dichloro-1-methoxyvinyl)oxy)trimethylsilane
SAXA-023	709031-34-5	methyl 2-((3r,5r,7r)-adamantan-1-yl)-2,2-dichloroacetate
SAXA-024	709031-35-6	methyl 2,2-dichloro-2-((1r,3s,5R,7S)-3-hydroxyadamantan-1-yl)acetate
SAXA-025	709031-36-7	2,2-dichloro-2-((1r,3s,5R,7S)-3-hydroxyadamantan-1-yl)acetic acid
SAXA-026	4942-47-6	2-((3r,5r,7r)-adamantan-1-yl)acetic acid
SAXA-027	59768-70-6	2-((3r,5r,7r)-adamantan-1-yl)-2-bromoacetic acid
SAXA-028	317375-33-0	2-bromo-2-((1r,3s,5R,7S)-3-hydroxyadamantan-1-yl)acetic acid
SAXA-029	709031-30-1	2-amino-2-((1r,3s,5R,7S)-3-hydroxyadamantan-1-yl)acetic acid
SAXA-030	-	2-((tert-butoxycarbonyl)amino)-2-((1r,3s,5R,7S)-3-hydroxyadamantan-1-yl)acetic acid

优化Route 2步骤 11 · 总收率 /

SAXA-009361442-01-5SAXA-031828-51-3SAXA-032711-01-3SAXA-033770-71-8SAXA-0342094-74-8SAXA-035—SAXA-036361441-95-4SAXA-037361441-96-5SAXA-03895853-35-3SAXA-039361441-97-6SAXA-040361442-00-4SAXA-041361440-69-9API · 达格列净丙二醇一水化物/盐酸沙格列汀

编号	CAS 号	中间体名称
SAXA-009	361442-01-5	tert-butyl ((S)-2-((1S,3S,5S)-3-carbamoyl-2-azabicyclo[3.1.0]hexan-2-yl)-1-((1r,3R,5R,7S)-3-hydroxyadamantan-1-yl)-2-oxoethyl)carbamate
SAXA-031	828-51-3	(3r,5r,7r)-adamantane-1-carboxylic acid
SAXA-032	711-01-3	methyl (3r,5r,7r)-adamantane-1-carboxylate
SAXA-033	770-71-8	((3r,5r,7r)-adamantan-1-yl)methanol
SAXA-034	2094-74-8	(3r,5r,7r)-adamantane-1-carbaldehyde
SAXA-035	-	(R)-2-amino-2-phenylethan-1-ol
SAXA-036	361441-95-4	(S)-2-((3S,5S,7S)-adamantan-1-yl)-2-(((R)-2-hydroxy-1-phenylethyl)amino)acetonitrile
SAXA-037	361441-96-5	(S)-2-((3S,5S,7S)-adamantan-1-yl)-2-(((R)-2-hydroxy-1-phenylethyl)amino)acetic acid hydrochloride
SAXA-038	95853-35-3	(S)-2-((3S,5S,7S)-adamantan-1-yl)-2-aminoacetic acid
SAXA-039	361441-97-6	(S)-2-((3S,5S,7S)-adamantan-1-yl)-2-((tert-butoxycarbonyl)amino)acetic acid
SAXA-040	361442-00-4 在售	(S)-2-((tert-butoxycarbonyl)amino)-2-((1r,3R,5R,7S)-3-hydroxyadamantan-1-yl)acetic acid
SAXA-041	361440-69-9	(1S,3S,5S)-2-azabicyclo[3.1.0]hexane-3-carboxamide 2,2,2-trifluoroacetate

优化Route 3步骤 6 · 总收率 /

SAXA-042865999-64-0SAXA-043859202-35-0SAXA-044865999-65-1SAXA-045865999-66-2SAXA-046865999-67-3SAXA-047865999-68-4SAXA-048865999-70-8API · 达格列净丙二醇一水化物/盐酸沙格列汀

编号	CAS 号	中间体名称
SAXA-042	865999-64-0	(S)-2-amino-2-((1r,3R,5R,7S)-3-hydroxyadamantan-1-yl)acetic acid hydrochloride
SAXA-043	859202-35-0	(S)-2-((1r,3R,5R,7S)-3-hydroxyadamantan-1-yl)-2-(2,2,2-trifluoroacetamido)acetic acid
SAXA-044	865999-65-1	(S)-2-(2,2,2-trifluoroacetamido)-2-((1r,3R,5R,7S)-3-(2,2,2-trifluoroacetoxy)adamantan-1-yl)acetic acid
SAXA-045	865999-66-2	(1R,3r,5R,7S)-3-((S)-2-chloro-2-oxo-1-(2,2,2-trifluoroacetamido)ethyl)adamantan-1-yl 2,2,2-trifluoroacetate
SAXA-046	865999-67-3	(1S,3S,5S)-2-azabicyclo[3.1.0]hexane-3-carbonitrile hydrochloride
SAXA-047	865999-68-4	(1R,3r,5R,7S)-3-((S)-2-((1S,3S,5S)-3-cyano-2-azabicyclo[3.1.0]hexan-2-yl)-2-oxo-1-(2,2,2-trifluoroacetamido)ethyl)adamantan-1-yl 2,2,2-trifluoroacetate
SAXA-048	865999-70-8	N-((S)-2-((1S,3S,5S)-3-cyano-2-azabicyclo[3.1.0]hexan-2-yl)-1-((1r,3R,5R,7S)-3-hydroxyadamantan-1-yl)-2-oxoethyl)-2,2,2-trifluoroacetamide

优化Route 4步骤 10 · 总收率 /

SAXA-004178172-26-4SAXA-006709031-38-9SAXA-007361440-67-7SAXA-009361442-01-5SAXA-011709031-43-6SAXA-020709031-29-8SAXA-03895853-35-3SAXA-040361442-00-4SAXA-049709031-39-0SAXA-0501660-04-4SAXA-05116091-98-8API · 达格列净丙二醇一水化物/盐酸沙格列汀

编号	CAS 号	中间体名称
SAXA-004	178172-26-4 在售	1-(tert-butyl) 2-ethyl (S)-2,3-dihydro-1H-pyrrole-1,2-dicarboxylate
SAXA-006	709031-38-9	tert-butyl (S)-2-carbamoyl-2,3-dihydro-1H-pyrrole-1-carboxylate
SAXA-007	361440-67-7 在售	tert-butyl (1S,3S,5S)-3-carbamoyl-2-azabicyclo[3.1.0]hexane-2-carboxylate
SAXA-009	361442-01-5	tert-butyl ((S)-2-((1S,3S,5S)-3-carbamoyl-2-azabicyclo[3.1.0]hexan-2-yl)-1-((1r,3R,5R,7S)-3-hydroxyadamantan-1-yl)-2-oxoethyl)carbamate
SAXA-011	709031-43-6	tert-butyl ((S)-2-((1S,3S,5S)-3-cyano-2-azabicyclo[3.1.0]hexan-2-yl)-1-((1r,3R,5R,7S)-3-hydroxyadamantan-1-yl)-2-oxoethyl)carbamate
SAXA-020	709031-29-8	(S)-2-amino-2-((1r,3R,5R,7S)-3-hydroxyadamantan-1-yl)acetic acid
SAXA-038	95853-35-3	(S)-2-((3S,5S,7S)-adamantan-1-yl)-2-aminoacetic acid
SAXA-040	361442-00-4 在售	(S)-2-((tert-butoxycarbonyl)amino)-2-((1r,3R,5R,7S)-3-hydroxyadamantan-1-yl)acetic acid
SAXA-049	709031-39-0	(1S,3S,5S)-2-azabicyclo[3.1.0]hexane-3-carboxamide hydrochloride
SAXA-050	1660-04-4	1-((3r,5r,7r)-adamantan-1-yl)ethanone
SAXA-051	16091-98-8	2-((3r,5r,7r)-adamantan-1-yl)-2-oxoacetic acid

常见问题（FAQ）

达格列净丙二醇一水化物/盐酸沙格列汀的适应症有哪些？

已批准的适应症包括：二型糖尿病。

达格列净丙二醇一水化物/盐酸沙格列汀的专利什么时候到期？

达格列净丙二醇一水化物/盐酸沙格列汀的专利到期年暂无公开口径，本页会在数据管道核实后更新。

达格列净丙二醇一水化物/盐酸沙格列汀有几条合成路线？

本站收录 4 条合成路线，最短路线 6 步、总收率 /。每条路线的中间体均带登记编号与 CAS 号。

达格列净丙二醇一水化物/盐酸沙格列汀的关键中间体在哪里可以采购？

达格列净丙二醇一水化物/盐酸沙格列汀的多条路线中间体已挂接 CAS 档案，其中 5 个 CAS 已有优贝德（Unibest）供应网络在售报价，可在本页路线表中直接查看并询价。

如何获取达格列净丙二醇一水化物/盐酸沙格列汀中间体的报价？

在本页选择目标中间体的 CAS 进入档案页，或在询价页直接提交需求；CAS 会自动带入供需撮合流程，由供应网络反馈报价。

数据来源：多源数据交叉核实（仅结构化字段） · 2026-10-22