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CAS 98-79-3
(S)-5-oxopyrrolidine-2-carboxylic acid
登记编号：ERTU-018、SAXA-001
应用背景（按来源药适应症）
二型糖尿病艾托格列净二尖瓣闭锁不全艾托格列净左心室功能不全艾托格列净心脏衰竭艾托格列净动脉粥样硬化艾托格列净胰岛素抵抗艾托格列净二型糖尿病达格列净丙二醇一水化物/盐酸沙格列汀二型糖尿病沙格列汀水合物低血糖症沙格列汀水合物一型糖尿病沙格列汀水合物糖尿病沙格列汀水合物
来源药（使用该中间体的合成路线）
| 品种 | 梯队 | 到期年 |
|---|---|---|
| 艾托格列净Ertugliflozin | Tier C · 观察 / 贸易 | - |
| 达格列净丙二醇一水化物/盐酸沙格列汀Dapagliflozin Propanediol Monohydrate/Saxagliptin Hydrochloride | Tier C · 观察 / 贸易 | - |
| 沙格列汀水合物Saxagliptin Hydrate | Tier B · 提前布局 | - |
合成路线中的位置（上下游链）
按路线登记顺序排列，左→右为合成方向；高亮为当前 CAS，其余可点击跳转对应档案。
4-bromo-1-chloro-2-(4-ethoxybenzyl)benzene→(3R,4S,5R,6R)-3,4,5-tris((trimethylsilyl)oxy)-6-(((trimethylsilyl)oxy)methyl)tetrahydro-2H-pyran-2-one→(2S,3R,4S,5S,6R)-2-(4-chloro-3-(4-ethoxybenzyl)phenyl)-6-(hydroxymethyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triol→((2R,3R,4S,5R,6S)-6-(4-chloro-3-(4-ethoxybenzyl)phenyl)-6-methoxy-3,4,5-tris((trimethylsilyl)oxy)tetrahydro-2H-pyran-2-yl)methanol→(2S,3R,4S,5R,6S)-6-(4-chloro-3-(4-ethoxybenzyl)phenyl)-6-methoxy-3,4,5-tris((trimethylsilyl)oxy)tetrahydro-2H-pyran-2-carbaldehyde→(2S,3R,4S,5S)-2-(4-chloro-3-(4-ethoxybenzyl)phenyl)-6,6-bis(hydroxymethyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triol→(S)-5-oxopyrrolidine-2-carboxylic acid
(S)-5-oxopyrrolidine-2-carboxylic acid→(S)-ethyl 5-oxopyrrolidine-2-carboxylate→1-(tert-butyl) 2-ethyl (S)-5-oxopyrrolidine-1,2-dicarboxylate→1-(tert-butyl) 2-ethyl (S)-2,3-dihydro-1H-pyrrole-1,2-dicarboxylate→(S)-1-(tert-butoxycarbonyl)-2,3-dihydro-1H-pyrrole-2-carboxylic acid→tert-butyl (S)-2-carbamoyl-2,3-dihydro-1H-pyrrole-1-carboxylate→tert-butyl (1S,3S,5S)-3-carbamoyl-2-azabicyclo[3.1.0]hexane-2-carboxylate→(1S,3S,5S)-2-azabicyclo[3.1.0]hexane-3-carboxamide methanesulfonate→tert-butyl ((S)-2-((1S,3S,5S)-3-carbamoyl-2-azabicyclo[3.1.0]hexan-2-yl)-1-((1r,3R,5R,7S)-3-hydroxyadamantan-1-yl)-2-oxoethyl)carbamate→(1R,3r,5R,7S)-3-((S)-1-((tert-butoxycarbonyl)amino)-2-((1S,3S,5S)-3-cyano-2-azabicyclo[3.1.0]hexan-2-yl)-2-oxoethyl)adamantan-1-yl 2,2,2-trifluoroacetate→tert-butyl ((S)-2-((1S,3S,5S)-3-cyano-2-azabicyclo[3.1.0]hexan-2-yl)-1-((1r,3R,5R,7S)-3-hydroxyadamantan-1-yl)-2-oxoethyl)carbamate→(S)-2-((tert-butoxycarbonyl)amino)-2-((1r,3R,5R,7S)-3-hydroxyadamantan-1-yl)acetic acid→(3s,5s,7s)-1-bromoadamantane→2,2,7,7-tetramethyl-4-((trimethylsilyl)oxy)-3,6-dioxa-2,7-disilaoct-4-ene→2-((3r,5r,7r)-adamantan-1-yl)-2-hydroxyacetic acid→methyl 2-((3r,5r,7r)-adamantan-1-yl)-2-hydroxyacetate→methyl 2-((3r,5r,7r)-adamantan-1-yl)-2-oxoacetate→methyl 2-((1r,3s,5R,7S)-3-hydroxyadamantan-1-yl)-2-oxoacetate→2-((1r,3s,5R,7S)-3-hydroxyadamantan-1-yl)-2-oxoacetic acid→(S)-2-amino-2-((1r,3R,5R,7S)-3-hydroxyadamantan-1-yl)acetic acid→methyl 2,2,2-trichloroacetate→((2,2-dichloro-1-methoxyvinyl)oxy)trimethylsilane→methyl 2-((3r,5r,7r)-adamantan-1-yl)-2,2-dichloroacetate→methyl 2,2-dichloro-2-((1r,3s,5R,7S)-3-hydroxyadamantan-1-yl)acetate→2,2-dichloro-2-((1r,3s,5R,7S)-3-hydroxyadamantan-1-yl)acetic acid→2-((3r,5r,7r)-adamantan-1-yl)acetic acid→2-((3r,5r,7r)-adamantan-1-yl)-2-bromoacetic acid→2-bromo-2-((1r,3s,5R,7S)-3-hydroxyadamantan-1-yl)acetic acid→2-amino-2-((1r,3s,5R,7S)-3-hydroxyadamantan-1-yl)acetic acid→2-((tert-butoxycarbonyl)amino)-2-((1r,3s,5R,7S)-3-hydroxyadamantan-1-yl)acetic acid
(S)-5-oxopyrrolidine-2-carboxylic acid→(S)-ethyl 5-oxopyrrolidine-2-carboxylate→1-(tert-butyl) 2-ethyl (S)-5-oxopyrrolidine-1,2-dicarboxylate→1-(tert-butyl) 2-ethyl (S)-2,3-dihydro-1H-pyrrole-1,2-dicarboxylate→(S)-1-(tert-butoxycarbonyl)-2,3-dihydro-1H-pyrrole-2-carboxylic acid→tert-butyl (S)-2-carbamoyl-2,3-dihydro-1H-pyrrole-1-carboxylate→tert-butyl (1S,3S,5S)-3-carbamoyl-2-azabicyclo[3.1.0]hexane-2-carboxylate→(1S,3S,5S)-2-azabicyclo[3.1.0]hexane-3-carboxamide methanesulfonate→tert-butyl ((S)-2-((1S,3S,5S)-3-carbamoyl-2-azabicyclo[3.1.0]hexan-2-yl)-1-((1r,3R,5R,7S)-3-hydroxyadamantan-1-yl)-2-oxoethyl)carbamate→(1R,3r,5R,7S)-3-((S)-1-((tert-butoxycarbonyl)amino)-2-((1S,3S,5S)-3-cyano-2-azabicyclo[3.1.0]hexan-2-yl)-2-oxoethyl)adamantan-1-yl 2,2,2-trifluoroacetate→tert-butyl ((S)-2-((1S,3S,5S)-3-cyano-2-azabicyclo[3.1.0]hexan-2-yl)-1-((1r,3R,5R,7S)-3-hydroxyadamantan-1-yl)-2-oxoethyl)carbamate→(S)-2-((tert-butoxycarbonyl)amino)-2-((1r,3R,5R,7S)-3-hydroxyadamantan-1-yl)acetic acid→(3s,5s,7s)-1-bromoadamantane→2,2,7,7-tetramethyl-4-((trimethylsilyl)oxy)-3,6-dioxa-2,7-disilaoct-4-ene→2-((3r,5r,7r)-adamantan-1-yl)-2-hydroxyacetic acid→methyl 2-((3r,5r,7r)-adamantan-1-yl)-2-hydroxyacetate→methyl 2-((3r,5r,7r)-adamantan-1-yl)-2-oxoacetate→methyl 2-((1r,3s,5R,7S)-3-hydroxyadamantan-1-yl)-2-oxoacetate→2-((1r,3s,5R,7S)-3-hydroxyadamantan-1-yl)-2-oxoacetic acid→(S)-2-amino-2-((1r,3R,5R,7S)-3-hydroxyadamantan-1-yl)acetic acid→methyl 2,2,2-trichloroacetate→((2,2-dichloro-1-methoxyvinyl)oxy)trimethylsilane→methyl 2-((3r,5r,7r)-adamantan-1-yl)-2,2-dichloroacetate→methyl 2,2-dichloro-2-((1r,3s,5R,7S)-3-hydroxyadamantan-1-yl)acetate→2,2-dichloro-2-((1r,3s,5R,7S)-3-hydroxyadamantan-1-yl)acetic acid→2-((3r,5r,7r)-adamantan-1-yl)acetic acid→2-((3r,5r,7r)-adamantan-1-yl)-2-bromoacetic acid→2-bromo-2-((1r,3s,5R,7S)-3-hydroxyadamantan-1-yl)acetic acid→2-amino-2-((1r,3s,5R,7S)-3-hydroxyadamantan-1-yl)acetic acid→2-((tert-butoxycarbonyl)amino)-2-((1r,3s,5R,7S)-3-hydroxyadamantan-1-yl)acetic acid
本站可供应的对应中间体
同 CAS 多家在售供应横向对比；价格区间为供应方挂牌口径，实价以询价确认为准。
| 供应商 | 产品 | 价格区间 | 最小起订 | 货期 | 资质 | 操作 |
|---|---|---|---|---|---|---|
| Unibest Taizhou GMP-like Site | 2-((benzyloxy)(4-ethoxyphenyl)methyl)-4-bromo-1-chlorobenzene Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Qualified Partner — East China API Works | (2R, 3S.4S)-2, 3, 4-tris(benzyloxy)-4-((R)-4-((benzyloxy)meth yl)-2, 2-dimeth yl-1, 3- dioxolan-4-yl)-1-(4-methylDiDerazin-1-yl)butan-1-one Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
本页为中间体 CAS 注册档案：同 CAS 的多条路线登记已合并；后续供应商报价与买方需求以该 CAS 为主键撮合。