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克拉霉素
Tier C · 观察 / 贸易Clarithromycin
Taisho Pharmaceutical Holdings Co Ltd
原研
1991
首批上市
-
到期年（公开口径）
无销量数据
峰值销售
化学药
类型
靶点：50S ribosomal subunit
商品名：Naxy、Klaricid、Macladin、Klacid、Biaxin、Clarino-500、Clarimax、Cyllind、Clarith、Veclam、Biaxin XL、Minebase
适应症（已批准）：鼻窦炎、扁桃体炎、急性支气管炎、慢性支气管炎、下呼吸道感染、咽炎、传染性疾病、肺炎
各地区研发/上市状态
美国
临床二期
1999-11-02
欧盟
临床三期
2000-04-01
中国
批准上市
1996-01-01
日本
批准上市
1991-03-29
生产该 API 的工厂1
口径：平台供应网络（富通询价明细 + 产品主档）中登记生产该品种的工厂（在产口径），按报价活跃度排序；快照不含成本与客户信息。
已收录 1 家在产工厂名单，登录后可见（工厂信息不对未登录访客展示）。
登录查看工厂名单 →合成路线与中间体8 routes
原研路线 × 0优化路线（非专利）× 7工艺路线 × 1
路线按「原研路线 → 优化路线 / 工艺路线（非专利）」排序。每条路线附本站自绘的路线流程图（中间体 → 原料药）与中间体表（编号 / CAS / 英文名），可直接用于供应商开发与询价。流程图由本站依据已授权的结构化数据自行渲染，未使用任何第三方路线图。
优化Route 1步骤 3 · 总收率 6g(Clarithromycin (Free))
Clarithromycin-001—Clarithromycin-002—Clarithromycin-003—API · 克拉霉素
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Clarithromycin-001 | - | benzyl (2S,3R,4S,6R)-4-{[(benzyloxy)carbonyl](methyl)amino}-2-{[(3R,4S,5S,6R,7S,9R,11R,12R,13S,14R)-14-ethyl-7,12,13-trihydroxy-4-{[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy}-3,5,7,9,11,13-hexamethyl-2,10-dioxo-1-oxacyclotetradecan-6-yl]oxy}-6-methyloxan-3-yl carbonate |
| Clarithromycin-002 | - | benzyl (2S,3R,4S,6R)-4-{[(benzyloxy)carbonyl](methyl)amino}-2-{[(3R,4S,5S,6R,7S,9R,11R,12R,13S,14R)-14-ethyl-12,13-dihydroxy-4-{[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy}-7-methoxy-3,5,7,9,11,13-hexamethyl-2,10-dioxo-1-oxacyclotetradecan-6-yl]oxy}-6-methyloxan-3-yl carbonate |
| Clarithromycin-003 | - | (3R,4S,5S,6R,7S,9R,11R,12R,13S,14R)-14-ethyl-12,13-dihydroxy-4-{[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy}-6-{[(2S,3R,4S,6R)-3-hydroxy-6-methyl-4-(methylamino)oxan-2-yl]oxy}-7-methoxy-3,5,7,9,11,13-hexamethyl-1-oxacyclotetradecane-2,10-dione |
优化Route 3步骤 4 · 总收率 18g(Clarithromycin (Free))
Clarithromycin-006133445-26-8Clarithromycin-007887125-82-8Clarithromycin-008—Clarithromycin-009—Clarithromycin-010—Clarithromycin-011133415-69-7API · 克拉霉素
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Clarithromycin-006 | 133445-26-8 | (3R,4S,5S,6R,7R,9R,10E,11S,12R,13S,14R)-6-[(2S,3R,4S,6R)-4-(Dimethylamino)-3-hydroxy-6-methyltetrahydropyran-2-yloxy]-14-ethyl-7,12,13-trihydroxy-4-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydrpyran-2-yloxy]-3,5,7,9,11,13-hexamethyloxacyclotetradecane-2,10-dione 10-[O-(1-isopropoxycyclohexyl)oxime] |
| Clarithromycin-007 | 887125-82-8 | Acetic acid (2S,3R,4S,6R)-4-(dimethylamino)-2-[((3R,4S,5S,6R,7R,9R,10E,11S,12R,13S,14R)-14-ethyl-7,12,13-trihydroxy-4-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydropyran-2-yloxy]-10-[[(1-isopropoxycyclohexyl)oxy]imino]-3,5,7,9,11,13-hexamethyl-2-oxooxacyclotetradecan-6-yl)oxy]-6-methyltetrahydropyran-3-yl ester |
| Clarithromycin-008 | - | Benzoic acid (2S,3R,4S,6R)-4-(dimethylamino)-2-[((3R,4S,5S,6R,7R,9R,10E,11S,12R,13S,14R)-14-ethyl-7,12,13-trihydroxy-4-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydropyran-2-yloxy]-10-[[(1-isopropoxycyclohexyl)oxy]imino]-3,5,7,9,11,13-hexamethyl-2-oxooxacyclotetradecan-6-yl)oxy]-6-methyltetrahydropyran-3-yl ester |
| Clarithromycin-009 | - | Benzoic acid (2S,3R,4S,6R)-4-(dimethylamino)-2-[(3R,4S,5S,6R,7R,9R,10E,11S,12R,13S,14R)-14-ethyl-12,13-dihydroxy-4-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydropyran-2-yloxy]-10-[[(1-isopropoxycyclohexyl)oxy]imino]-7-methoxy-3,5,7,9,11,13-hexamethyl-2-oxooxacyclotetradecan-6-yloxy]-6-methyltetrahydropyran-3-yl ester |
| Clarithromycin-010 | - | Acetic acid (2S,3R,4S,6R)-4-(dimethylamino)-2-[((3R,4S,5S,6R,7R,9R,10E,11S,12R,13S,14R)-14-ethyl-12,13-dihydroxy-4-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydropyran-2-yloxy]-10-[[(1-isopropoxycyclohexyl)oxy]imino]-7-methoxy-3,5,7,9,11,13-hexamethyl-2-oxooxacyclotetradecan-6-yl)oxy]-6-methyltetrahydropyran-3-yl ester |
| Clarithromycin-011 | 133415-69-7 | (3R,4S,5S,6R,7R,9R,10E,11S,12R,13S,14R)-6-[(2S,3R,4S,6R)-4-(Dimethylamino)-3-hydroxy-6-methyltetrahydropyran-2-yloxy]-14-ethyl-12,13-dihydroxy-4-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydropyran-2-yloxy]-7-methoxy-3,5,7,9,11,13-hexamethyloxacyclotetradecane-2,10-dione 10-[O-(1-isopropoxycyclohexyl)oxime] |
优化Route 4步骤 5 · 总收率 4.2g(Clarithromycin (Free))
Clarithromycin-01213127-18-9Clarithromycin-013611-19-8Clarithromycin-014206997-62-8Clarithromycin-0151395892-49-5Clarithromycin-016—Clarithromycin-017—Clarithromycin-018—Clarithromycin-019149882-99-5API · 克拉霉素
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Clarithromycin-012 | 13127-18-9 | (3R,4S,5S,6R,7R,9R,10Z,11S,12R,13S,14R)-6-[[(2S,3R,4S,6R)-4-(Dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl]oxy]-14-ethyl-7,12,13-trihydroxy-10-(hydroxyimino)-4-[[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydro-2H-pyran-2-yl]oxy]-3,5,7,9,11,13-hexamethyloxacyclotetradecan-2-one |
| Clarithromycin-013 | 611-19-8 | 2-Chlorobenzyl chloride |
| Clarithromycin-014 | 206997-62-8 | (3R,4S,5S,6R,7R,9R,10E,11S,12R,13S,14R)-6-[(2S,3R,4S,6R)-4-(Dimethylamino)-3-hydroxy-6-methyltetrahydropyran-2-yloxy]-14-ethyl-7,12,13-trihydroxy-4- [(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydropyran-2-yloxy]-3,5,7,9,11,13-hexamethyloxacyclotetradecane-2,10-dione 10-[O-(2-chlorobenzyl)oxime] |
| Clarithromycin-015 | 1395892-49-5 | Acetic acid (2S,3R,4S,6R)-2-[((3R,4S,5S,6R,7R,9R,10E,11S,12R,13S,14R)-10-[[(2-chlorobenzyl)oxy]imino]-14-ethyl-7,12,13-trihydroxy-4-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydropyran-2-yloxy]-3,5,7,9,11,13-hexamethyl-2-oxooxacyclotetradecan-6-yl)oxy]-4-(dimethylamino)-6-methyltetrahydropyran-3-yl ester |
| Clarithromycin-016 | - | Benzoic acid (2S,3R,4S,6R)-2-[(3R,4S,5S,6R,7R,9R,10E,11S,12R,13S,14R)-10-[[(2-chlorobenzyloxy]imino]-14-ethyl-7,12,13-trihydroxy-4-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydropyran-2-yloxy]-3,5,7,9,11,13-hexamethyl-2-oxooxacyclotetradecan-6-yloxy]-4-(dimethylamino)-6-methyltetrahydropyran-3-yl ester |
| Clarithromycin-017 | - | Acetic acid (2S,3R,4S,6R)-2-[(3R,4S,5S,6R,7R,9R,10E,11S,12R,13S,14R)-10-[[(2-chlorobenzyloxy]imino]-14-ethyl-12,13-dihydroxy-4-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydropyran-2-yloxy]-7-methoxy-3,5,7,9,11,13-hexamethyl-2-oxooxacyclotetradecan-6-yloxy]-4-(dimethylamino)-6-methyltetrahydropyran-3-yl ester |
| Clarithromycin-018 | - | Benzoic acid (2S,3R,4S,6R)-2-[(3R,4S,5S,6R,7R,9R,10E,11S,12R,13S,14R)-10-[[2-chlorobenzyloxy]imino]-14-ethyl-12,13-dihydroxy-4-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydropyran-2-yloxy]-7-methoxy-3,5,7,9,11,13-hexamethyl-2-oxooxacyclotetradecan-6-yloxy]-4-(dimethylamino)-6-methyltetrahydropyran-3-yl ester |
| Clarithromycin-019 | 149882-99-5 | (3R,4S,5S,6R,7R,9R,10E,11S,12R,13S,14R)-6-[(2S,3R,4S,6R)-4-(Dimethylamino)-3-hydroxy-6-methyltetrahydropyran-2-yloxy]-14-ethyl-12,13-dihydroxy-4-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydropyran-2-yloxy]-7-methoxy-3,5,7,9,11,13-hexamethyloxacyclotetradecane-2,10-dione 10-[O-(2-chlorobenzyl)oxime] |
优化Route 5步骤 1 · 总收率 /
Clarithromycin-01213127-18-9API · 克拉霉素
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Clarithromycin-012 | 13127-18-9 | (3R,4S,5S,6R,7R,9R,10Z,11S,12R,13S,14R)-6-[[(2S,3R,4S,6R)-4-(Dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl]oxy]-14-ethyl-7,12,13-trihydroxy-10-(hydroxyimino)-4-[[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydro-2H-pyran-2-yl]oxy]-3,5,7,9,11,13-hexamethyloxacyclotetradecan-2-one |
优化Route 6步骤 5 · 总收率 17.5g(Clarithromycin (Free))
Clarithromycin-0207704-67-8Clarithromycin-01213127-18-9Clarithromycin-02113127-18-9Clarithromycin-022926-66-9Clarithromycin-023—Clarithromycin-0241253181-38-2Clarithromycin-02574-88-4Clarithromycin-02674-83-9Clarithromycin-0271253181-39-3API · 克拉霉素
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Clarithromycin-020 | 7704-67-8 | (3R,4S,5S,6R,7R,9R,11R,12R,13S,14R)-6-[[(2S,3R,4S,6R)-4-(Dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl]oxy]-14-ethyl-7,12,13-trihydroxy-4-[[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydro-2H-pyran-2-yl]oxy]-3,5,7,9,11,13-hexamethyloxacyclotetradecane-2,10-dione thiocyanate |
| Clarithromycin-012 | 13127-18-9 | Thiocyanic acid--(3R,4S,5S,6R,7R,9R,10E,11S,12R,13S,14R)-6-[[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy]-14-ethyl-7,12,13-trihydroxy-10-(hydroxyimino)-4-[[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy]-3,5,7,9,11,13-hexamethyl-1-oxacyclotetradecan-2-one (1/1) |
| Clarithromycin-021 | 13127-18-9 | (3R,4S,5S,6R,7R,9R,10Z,11S,12R,13S,14R)-6-[[(2S,3R,4S,6R)-4-(Dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl]oxy]-14-ethyl-7,12,13-trihydroxy-10-(hydroxyimino)-4-[[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydro-2H-pyran-2-yl]oxy]-3,5,7,9,11,13-hexamethyloxacyclotetradecan-2-one |
| Clarithromycin-022 | 926-66-9 | 2-Ethoxyprop-1-ene |
| Clarithromycin-023 | - | (3R,4S,5S,6R,7R,9R,10E,11S,12R,13S,14R)-6-[[(2S,3R,4S,6R)-4-(Dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy]-10-[[(2-ethoxypropan-2-yl)oxy]imino]-14-ethyl-7,12,13-trihydroxy-4-[[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy]-3,5,7,9,11,13-hexamethyl-1-oxacyclotetradecan-2-one |
| Clarithromycin-024 | 1253181-38-2 | (3R,4S,5S,6R,7R,9R,10E,11S,12R,13S,14R)-6-([(2S,3R,4S,6R)-4-(Dimethylamino)-6-methyl-3-[(trimethylsilyl)oxy]tetrahydro-2H-pyran-2-yl]oxy)-10-[[(2-ethoxypropan-2-yl)oxy]imino]-14-ethyl-7,12,13-trihydroxy-4-([(2R,4R,5S,6S)-4-methoxy-4,6-dimethyl-5-[(trimethylsilyl)oxy]tetrahydro-2H-pyran-2-yl]oxy)-3,5,7,9,11,13-hexamethyloxacyclotetradecan-2-one |
| Clarithromycin-025 | 74-88-4在售 | Methyl iodide |
| Clarithromycin-026 | 74-83-9 | Bromomethane |
| Clarithromycin-027 | 1253181-39-3 | (3R,4S,5S,6R,7R,9R,10E,11S,12R,13S,14R)-6-([(2S,3R,4S,6R)-4-(Dimethylamino)-6-methyl-3-[(trimethylsilyl)oxy]tetrahydro-2H-pyran-2-yl]oxy)-10-[[(2-ethoxypropan-2-yl)oxy]imino]-14-ethyl-12,13-dihydroxy-7-methoxy-4-([(2R,4R,5S,6S)-4-methoxy-4,6-dimethyl-5-[(trimethylsilyl)oxy]tetrahydro-2H-pyran-2-yl]oxy)-3,5,7,9,11,13-hexamethyloxacyclotetradecan-2-one |
优化Route 7步骤 2 · 总收率 52g(Clarithromycin-028)
Clarithromycin-01213127-18-9Clarithromycin-022926-66-9Clarithromycin-023—Clarithromycin-028—API · 克拉霉素
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Clarithromycin-012 | 13127-18-9 | (3R,4S,5S,6R,7R,9R,10Z,11S,12R,13S,14R)-6-[[(2S,3R,4S,6R)-4-(Dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl]oxy]-14-ethyl-7,12,13-trihydroxy-10-(hydroxyimino)-4-[[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydro-2H-pyran-2-yl]oxy]-3,5,7,9,11,13-hexamethyloxacyclotetradecan-2-one |
| Clarithromycin-022 | 926-66-9 | 2-Ethoxyprop-1-ene |
| Clarithromycin-023 | - | (3R,4S,5S,6R,7R,9R,10E,11S,12R,13S,14R)-6-[[(2S,3R,4S,6R)-4-(Dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy]-10-[[(2-ethoxypropan-2-yl)oxy]imino]-14-ethyl-7,12,13-trihydroxy-4-[[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy]-3,5,7,9,11,13-hexamethyl-1-oxacyclotetradecan-2-one |
| Clarithromycin-028 | - | (3R,4S,5S,6R,7R,9R,10E,11S,12R,13S,14R)-6-[[(2S,3R,4S,6R)-4-(Dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy]-10-[[(2-ethoxypropan-2-yl)oxy]imino]-14-ethyl-7,12,13-trihydroxy-4-([(2R,4R,5S,6S)-4-methoxy-4,6-dimethyl-5-[(trimethylsilyl)oxy]oxan-2-yl]oxy)-3,5,7,9,11,13-hexamethyl-1-oxacyclotetradecan-2-one |
优化Route 8步骤 1 · 总收率 88g(Clarithromycin-012)
Clarithromycin-0207704-67-8Clarithromycin-01213127-18-9API · 克拉霉素
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Clarithromycin-020 | 7704-67-8 | (3R,4S,5S,6R,7R,9R,11R,12R,13S,14R)-6-[[(2S,3R,4S,6R)-4-(Dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl]oxy]-14-ethyl-7,12,13-trihydroxy-4-[[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydro-2H-pyran-2-yl]oxy]-3,5,7,9,11,13-hexamethyloxacyclotetradecane-2,10-dione thiocyanate |
| Clarithromycin-012 | 13127-18-9 | (3R,4S,5S,6R,7R,9R,10Z,11S,12R,13S,14R)-6-[[(2S,3R,4S,6R)-4-(Dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl]oxy]-14-ethyl-7,12,13-trihydroxy-10-(hydroxyimino)-4-[[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydro-2H-pyran-2-yl]oxy]-3,5,7,9,11,13-hexamethyloxacyclotetradecan-2-one |
工艺Route 2步骤 2 · 总收率 429.768g(Clarithromycin (Free))
Clarithromycin-004—Clarithromycin-005—API · 克拉霉素
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Clarithromycin-004 | - | (2R,3R,4R,5R,6R,8R,9E,10S,11R,12R,13S)-5-{[(2S,3R,4S,6R)-4-(dimethylamino)-6-methyl-3-[(trimethylsilyl)oxy]oxan-2-yl]oxy}-13-ethyl-6,11,12-trihydroxy-3-{[(4R,5S,6S)-4-methoxy-4,6-dimethyl-5-[(trimethylsilyl)oxy]oxan-2-yl]oxy}-9-{[(2-methoxypropan-2-yl)oxy]imino}-2,4,6,8,10,12-hexamethylcyclotetradecan-1-one |
| Clarithromycin-005 | - | (2R,3R,4R,5R,6R,8R,9E,10S,11R,12R,13S)-5-{[(2S,3R,4S,6R)-4-(dimethylamino)-6-methyl-3-[(trimethylsilyl)oxy]oxan-2-yl]oxy}-13-ethyl-11,12-dihydroxy-6-methoxy-3-{[(4R,5S,6S)-4-methoxy-4,6-dimethyl-5-[(trimethylsilyl)oxy]oxan-2-yl]oxy}-9-{[(2-methoxypropan-2-yl)oxy]imino}-2,4,6,8,10,12-hexamethylcyclotetradecan-1-one |
常见问题（FAQ）
克拉霉素的适应症有哪些？
已批准的适应症包括：鼻窦炎、扁桃体炎、急性支气管炎、慢性支气管炎、下呼吸道感染、咽炎、传染性疾病、肺炎。
克拉霉素的专利什么时候到期？
克拉霉素的专利到期年暂无公开口径，本页会在数据管道核实后更新。
克拉霉素有几条合成路线？
本站收录 8 条合成路线，最短路线 1 步、总收率 /。每条路线的中间体均带登记编号与 CAS 号。
克拉霉素的关键中间体在哪里可以采购？
克拉霉素的多条路线中间体已挂接 CAS 档案，其中 1 个 CAS 已有优贝德（Unibest）供应网络在售报价，可在本页路线表中直接查看并询价。
如何获取克拉霉素中间体的报价？
在本页选择目标中间体的 CAS 进入档案页，或在询价页直接提交需求；CAS 会自动带入供需撮合流程，由供应网络反馈报价。
数据来源：多源数据交叉核实（仅结构化字段） · 2026-10-22