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奥美沙坦酯/阿折地平
Tier C · 观察 / 贸易Olmesartan Medoxomil/Azelnidipine
第一三共株式会社
原研
2010
首批上市
-
到期年（公开口径）
$0.15B ▲
峰值销售
化学药
类型
靶点：AT1、Voltage-gated L-type calcium channel
商品名：Rezaltas
适应症（已批准）：高血压
各地区研发/上市状态
美国
-
欧盟
-
中国
-
日本
批准上市
2010-01-20
生产该 API 的工厂11
口径：平台供应网络（富通询价明细 + 产品主档）中登记生产该品种的工厂（在产口径），按报价活跃度排序；快照不含成本与客户信息。
已收录 11 家在产工厂名单，登录后可见（工厂信息不对未登录访客展示）。
登录查看工厂名单 →合成路线与中间体6 routes
原研路线 × 2优化路线（非专利）× 4工艺路线 × 0
路线按「原研路线 → 优化路线 / 工艺路线（非专利）」排序。每条路线附本站自绘的路线流程图（中间体 → 原料药）与中间体表（编号 / CAS / 英文名），可直接用于供应商开发与询价。流程图由本站依据已授权的结构化数据自行渲染，未使用任何第三方路线图。
原研Route 1步骤 7 · 总收率 16.6 g
OLME-0011187-42-4OLME-00243083-12-1OLME-00351802-42-7OLME-004144689-94-1OLME-005144689-93-0OLME-006124750-51-2OLME-007144690-33-5OLME-0081114761-92-0OLME-00980841-78-7OLME-010144690-92-6API · 奥美沙坦酯/阿折地平
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| OLME-001 | 1187-42-4 | (2R,3R,4R,5S)-2-((benzoyloxy)methyl)-5-bromotetrahydrofuran-3,4-diyl dibenzoate |
| OLME-002 | 43083-12-1 | 1,1,1-trimethoxybutane |
| OLME-003 | 51802-42-7 | 2-propyl-1H-imidazole-4,5-dicarbonitrile |
| OLME-004 | 144689-94-1 | diethyl 2-propyl-1H-imidazole-4,5-dicarboxylate |
| OLME-005 | 144689-93-0 | ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate |
| OLME-006 | 124750-51-2 | 5-(4'-(bromomethyl)-[1,1'-biphenyl]-2-yl)-1-trityl-1H-tetrazole |
| OLME-007 | 144690-33-5 | ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1-((2'-(1-trityl-1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-imidazole-5-carboxylate |
| OLME-008 | 1114761-92-0 | lithium 4-(2-hydroxypropan-2-yl)-2-propyl-1-((2'-(1-trityl-1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-imidazole-5-carboxylate |
| OLME-009 | 80841-78-7 | 4-(chloromethyl)-5-methyl-1,3-dioxol-2-one |
| OLME-010 | 144690-92-6 | (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 4-(2-hydroxypropan-2-yl)-2-propyl-1-((2'-(1-trityl-1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-imidazole-5-carboxylate |
原研Route 1步骤 4 · 总收率 2.17 g
AZEL-00191-00-9AZEL-002106-89-8AZEL-00318621-17-5AZEL-004372-09-8AZEL-005116574-14-2AZEL-006170749-59-4AZEL-007—API · 奥美沙坦酯/阿折地平
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| AZEL-001 | 91-00-9 | diphenylmethanamine |
| AZEL-002 | 106-89-8 | 2-(chloromethyl)oxirane |
| AZEL-003 | 18621-17-5在售 | 1-benzhydrylazetidin-3-ol |
| AZEL-004 | 372-09-8在售 | 2-cyanoacetic acid |
| AZEL-005 | 116574-14-2 | 1-benzhydrylazetidin-3-yl 2-cyanoacetate |
| AZEL-006 | 170749-59-4 | 1-benzhydrylazetidin-3-yl 3-amino-3-iminopropanoate acetate |
| AZEL-007 | - | isopropyl (E)-2-(3-nitrobenzylidene)-3-oxobutanoate |
优化Route 2步骤 5 · 总收率 /
OLME-004144689-94-1OLME-005144689-93-0OLME-00980841-78-7OLME-010144690-92-6OLME-011114772-54-2OLME-012144690-96-0OLME-013144689-24-7API · 奥美沙坦酯/阿折地平
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| OLME-004 | 144689-94-1 | diethyl 2-propyl-1H-imidazole-4,5-dicarboxylate |
| OLME-005 | 144689-93-0 | ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate |
| OLME-009 | 80841-78-7 | 4-(chloromethyl)-5-methyl-1,3-dioxol-2-one |
| OLME-010 | 144690-92-6 | (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 4-(2-hydroxypropan-2-yl)-2-propyl-1-((2'-(1-trityl-1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-imidazole-5-carboxylate |
| OLME-011 | 114772-54-2 | 4'-(bromomethyl)-[1,1'-biphenyl]-2-carbonitrile |
| OLME-012 | 144690-96-0 | ethyl 1-((2'-cyano-[1,1'-biphenyl]-4-yl)methyl)-4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate |
| OLME-013 | 144689-24-7 | 1-((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylic acid |
优化Route 3步骤 3 · 总收率 /
OLME-005144689-93-0OLME-006124750-51-2OLME-00980841-78-7OLME-010144690-92-6OLME-014144690-04-0OLME-015—API · 奥美沙坦酯/阿折地平
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| OLME-005 | 144689-93-0 | ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate |
| OLME-006 | 124750-51-2 | 5-(4'-(bromomethyl)-[1,1'-biphenyl]-2-yl)-1-trityl-1H-tetrazole |
| OLME-009 | 80841-78-7 | 4-(chloromethyl)-5-methyl-1,3-dioxol-2-one |
| OLME-010 | 144690-92-6 | (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 4-(2-hydroxypropan-2-yl)-2-propyl-1-((2'-(1-trityl-1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-imidazole-5-carboxylate |
| OLME-014 | 144690-04-0 | 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylic acid |
| OLME-015 | - | (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate |
优化Route 4步骤 5 · 总收率 40 mg
OLME-005144689-93-0OLME-00980841-78-7OLME-016589-15-1OLME-017685091-51-4OLME-018—OLME-019—OLME-020—OLME-021—API · 奥美沙坦酯/阿折地平
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| OLME-005 | 144689-93-0 | ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate |
| OLME-009 | 80841-78-7 | 4-(chloromethyl)-5-methyl-1,3-dioxol-2-one |
| OLME-016 | 589-15-1 | 1-bromo-4-(bromomethyl)benzene |
| OLME-017 | 685091-51-4 | ethyl 1-(4-bromobenzyl)-4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate |
| OLME-018 | - | (2-(1-(2-phenylpropan-2-yl)-1H-tetrazol-5-yl)phenyl)boronic acid |
| OLME-019 | - | ethyl 4-(2-hydroxypropan-2-yl)-1-((2'-(1-(2-phenylpropan-2-yl)-1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-propyl-1H-imidazole-5-carboxylate |
| OLME-020 | - | 4-(2-hydroxypropan-2-yl)-1-((2'-(1-(2-phenylpropan-2-yl)-1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-propyl-1H-imidazole-5-carboxylic acid |
| OLME-021 | - | (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 4-(2-hydroxypropan-2-yl)-1-((2'-(1-(2-phenylpropan-2-yl)-1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-propyl-1H-imidazole-5-carboxylate |
优化Route 5步骤 5 · 总收率 /
OLME-00980841-78-7OLME-011114772-54-2OLME-022—OLME-023—OLME-0241309566-95-7OLME-0251199807-52-7OLME-0261993494-83-9API · 奥美沙坦酯/阿折地平
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| OLME-009 | 80841-78-7 | 4-(chloromethyl)-5-methyl-1,3-dioxol-2-one |
| OLME-011 | 114772-54-2 | 4'-(bromomethyl)-[1,1'-biphenyl]-2-carbonitrile |
| OLME-022 | - | 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carbonitrile |
| OLME-023 | - | 4,4-dimethyl-2-propyl-4,6-dihydro-1H-furo[3,4-d]imidazol-6-ol |
| OLME-024 | 1309566-95-7 | 4'-((6-hydroxy-4,4-dimethyl-2-propyl-4,6-dihydro-1H-furo[3,4-d]imidazol-1-yl)methyl)-[1,1'-biphenyl]-2-carbonitrile |
| OLME-025 | 1199807-52-7 | 1-((2'-cyano-[1,1'-biphenyl]-4-yl)methyl)-4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylic acid |
| OLME-026 | 1993494-83-9 | (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 1-((2'-cyano-[1,1'-biphenyl]-4-yl)methyl)-4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate |
常见问题（FAQ）
奥美沙坦酯/阿折地平的适应症有哪些？
已批准的适应症包括：高血压。
奥美沙坦酯/阿折地平的专利什么时候到期？
奥美沙坦酯/阿折地平的专利到期年暂无公开口径，本页会在数据管道核实后更新。
奥美沙坦酯/阿折地平有几条合成路线？
本站收录 6 条合成路线，最短路线 3 步、总收率 /。每条路线的中间体均带登记编号与 CAS 号。
奥美沙坦酯/阿折地平的关键中间体在哪里可以采购？
奥美沙坦酯/阿折地平的多条路线中间体已挂接 CAS 档案，其中 2 个 CAS 已有优贝德（Unibest）供应网络在售报价，可在本页路线表中直接查看并询价。
如何获取奥美沙坦酯/阿折地平中间体的报价？
在本页选择目标中间体的 CAS 进入档案页，或在询价页直接提交需求；CAS 会自动带入供需撮合流程，由供应网络反馈报价。
数据来源：多源数据交叉核实（仅结构化字段） · 2026-10-22