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CAS 372-09-8
2-cyanoacetic acidCyanoacetic acid
登记编号：TOFA-028、TRAT-004、ALOG-017、AZEL-004、Urapidil-023、ENTA-004、TERI-008
应用背景（按来源药适应症）
强直性脊柱炎枸橼酸托法替布幼年型类风湿性关节炎枸橼酸托法替布溃疡性结肠炎枸橼酸托法替布银屑病关节炎枸橼酸托法替布类风湿关节炎枸橼酸托法替布甲状腺瘤曲美替尼胶质瘤曲美替尼毛细胞白血病曲美替尼甲状腺未分化癌曲美替尼实体瘤曲美替尼非小细胞肺癌曲美替尼二型糖尿病苯甲酸阿格列汀糖尿病苯甲酸阿格列汀急性冠脉综合征苯甲酸阿格列汀高血压奥美沙坦酯/阿折地平高血压阿折地平高血压盐酸乌拉地尔帕金森病恩他卡朋立位耐力不良恩他卡朋心动过速恩他卡朋肥胖症恩他卡朋系统性红斑狼疮泰瑞米特钠
来源药（使用该中间体的合成路线）
| 品种 | 梯队 | 到期年 |
|---|---|---|
| 枸橼酸托法替布Tofacitinib Citrate | Tier B · 提前布局 | 2028 |
| 曲美替尼Trametinib | Tier C · 观察 / 贸易 | 2029 |
| 苯甲酸阿格列汀Alogliptin Benzoate | Tier C · 观察 / 贸易 | - |
| 奥美沙坦酯/阿折地平Olmesartan Medoxomil/Azelnidipine | Tier C · 观察 / 贸易 | - |
| 阿折地平Azelnidipine | Tier C · 观察 / 贸易 | - |
| 盐酸乌拉地尔Urapidil hydrochloride | Tier C · 观察 / 贸易 | - |
| 恩他卡朋Entacapone | Tier C · 观察 / 贸易 | - |
| 泰瑞米特钠Teriflunomide Sodium | Tier C · 观察 / 贸易 | - |
合成路线中的位置（上下游链）
按路线登记顺序排列，左→右为合成方向；高亮为当前 CAS，其余可点击跳转对应档案。
methyl (4-methylpyridin-3-yl)carbamate→4-methylpyridin-3-amine→methyl (4-methylpiperidin-3-yl)carbamate→methyl (4-methyl-1-tritylpiperidin-3-yl)carbamate→N,4-dimethyl-1-tritylpiperidin-3-amine hydrochloride→(3R,4R)-N,4-dimethyl-1-tritylpiperidin-3-amine (2R,3R)-2,3-bis((4-methylbenzoyl)oxy)succinate→(3R,4R)-N,4-dimethyl-1-tritylpiperidin-3-amine→2,4-dichloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine→2-chloro-N-methyl-N-((3R,4R)-4-methyl-1-tritylpiperidin-3-yl)-7-tosyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine→2-chloro-N-methyl-N-((3R,4R)-4-methyl-1-tritylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine→2-chloro-N-methyl-N-((3R,4R)-4-methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine→2-cyanoacetic acid
2-fluoro-4-iodoaniline→cyclopropanamine→1-cyclopropyl-3-(2-fluoro-4-iodophenyl)urea→2-cyanoacetic acid→2-cyano-N-cyclopropyl-N-((2-fluoro-4-iodophenyl)carbamoyl)acetamide→6-amino-3-cyclopropyl-1-(2-fluoro-4-iodophenyl)pyrimidine-2,4(1H,3H)-dione→(E)-N'-(1-cyclopropyl-3-(2-fluoro-4-iodophenyl)-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)-N,N-dimethylformimidamide→3-cyclopropyl-1-(2-fluoro-4-iodophenyl)-6-(methylamino)pyrimidine-2,4(1H,3H)-dione→2-methylmalonic acid→3-cyclopropyl-1-(2-fluoro-4-iodophenyl)-5-hydroxy-6,8-dimethylpyrido[2,3-d]pyrimidine-2,4,7(1H,3H,8H)-trione→3-cyclopropyl-1-(2-fluoro-4-iodophenyl)-6,8-dimethyl-2,4,7-trioxo-1,2,3,4,7,8-hexahydropyrido[2,3-d]pyrimidin-5-yl 4-methylbenzenesulfonate→N-(3-aminophenyl)acetamide→N-(3-((3-cyclopropyl-1-(2-fluoro-4-iodophenyl)-6,8-dimethyl-2,4,7-trioxo-1,2,3,4,7,8-hexahydropyrido[2,3-d]pyrimidin-5-yl)amino)phenyl)acetamide
2-(aminomethyl)benzonitrile→1-(2-cyanobenzyl)-3-methylurea→2-cyanoacetic acid→2-cyano-N-((2-cyanobenzyl)carbamoyl)-N-methylacetamide→2-((6-amino-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)benzonitrile→tert-butyl (R)-piperidin-3-ylcarbamate hydrochloride→tert-butyl (R)-(1-(3-(2-cyanobenzyl)-1-methyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)piperidin-3-yl)carbamate
diphenylmethanamine→2-(chloromethyl)oxirane→1-benzhydrylazetidin-3-ol→2-cyanoacetic acid→1-benzhydrylazetidin-3-yl 2-cyanoacetate→1-benzhydrylazetidin-3-yl 3-amino-3-iminopropanoate acetate→isopropyl (E)-2-(3-nitrobenzylidene)-3-oxobutanoate
本站可供应的对应中间体
同 CAS 多家在售供应横向对比；价格区间为供应方挂牌口径，实价以询价确认为准。
| 供应商 | 产品 | 价格区间 | 最小起订 | 货期 | 资质 | 操作 |
|---|---|---|---|---|---|---|
| Unibest Nantong cGMP Site | （3R,4R)-N,4-Dimethyl-1-(phenylmethyl)-3-piperidinamine HCL Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Unibest Taizhou GMP-like Site | 4-Chloro-7-[(4-methylphenyl)sulfonyl]-7H-pyrrolo[2,3-d]pyrimidine Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Qualified Partner — East China API Works | 1-benzyl-4-methylpiperidin-3-one Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Unibest Nantong cGMP Site | N-methyl-N-((3R,4R)-4-methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
本页为中间体 CAS 注册档案：同 CAS 的多条路线登记已合并；后续供应商报价与买方需求以该 CAS 为主键撮合。