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克拉霉素/雷贝拉唑钠/阿莫西林
Tier C · 观察 / 贸易Clarithromycin/Rabeprazole Sodium/Amoxicillin
卫材株式会社
原研
2013
首批上市
-
到期年（公开口径）
无销量数据
峰值销售
化学药
类型
靶点：50S ribosomal subunit、Proton pump、PBPs
商品名：Rabecure
适应症（已批准）：边缘带B细胞淋巴瘤、十二指肠溃疡、特发性血小板减少性紫癜、胃溃疡、胃炎、幽门螺杆菌感染
各地区研发/上市状态
美国
-
欧盟
-
中国
-
日本
批准上市
2013-08-15
生产该 API 的工厂10
口径：平台供应网络（富通询价明细 + 产品主档）中登记生产该品种的工厂（在产口径），按报价活跃度排序；快照不含成本与客户信息。
已收录 10 家在产工厂名单，登录后可见（工厂信息不对未登录访客展示）。
登录查看工厂名单 →合成路线与中间体20 routes
原研路线 × 1优化路线（非专利）× 18工艺路线 × 1
路线按「原研路线 → 优化路线 / 工艺路线（非专利）」排序。每条路线附本站自绘的路线流程图（中间体 → 原料药）与中间体表（编号 / CAS / 英文名），可直接用于供应商开发与询价。流程图由本站依据已授权的结构化数据自行渲染，未使用任何第三方路线图。
原研Route 1步骤 4 · 总收率 530 mg
RABE-0011589-49-7RABE-00259886-90-7RABE-003117977-18-1RABE-004117977-20-5RABE-005583-39-1RABE-006117977-21-6API · 克拉霉素/雷贝拉唑钠/阿莫西林
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| RABE-001 | 1589-49-7 | 3-methoxypropan-1-ol |
| RABE-002 | 59886-90-7 | 4-chloro-2,3-dimethylpyridine 1-oxide |
| RABE-003 | 117977-18-1 | 4-(3-methoxypropoxy)-2,3-dimethylpyridine 1-oxide |
| RABE-004 | 117977-20-5 | 2-(chloromethyl)-4-(3-methoxypropoxy)-3-methylpyridine |
| RABE-005 | 583-39-1 | 1H-benzo[d]imidazole-2-thiol |
| RABE-006 | 117977-21-6 | 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)thio)-1H-benzo[d]imidazole |
优化Route 1步骤 6 · 总收率 /
Amoxicillin-001922-68-9Amoxicillin-0022627-86-3Amoxicillin-0033082-62-0Amoxicillin-004—Amoxicillin-005—Amoxicillin-006108-95-2Amoxicillin-007—Amoxicillin-008—Amoxicillin-009—Amoxicillin-010—Amoxicillin-01157591-61-4Amoxicillin-01237763-23-8Amoxicillin-013551-16-6API · 克拉霉素/雷贝拉唑钠/阿莫西林
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Amoxicillin-001 | 922-68-9 | Methyl glyoxylate |
| Amoxicillin-002 | 2627-86-3 | (S)-(-)-1-Phenylethylamine |
| Amoxicillin-003 | 3082-62-0 | (1S)-1-(2-Naphthyl)ethanamine |
| Amoxicillin-004 | - | Methyl (2Z)-[[(1S)-1-phenylethyl]imino]acetate |
| Amoxicillin-005 | - | Methyl (2Z)-[[(1S)-1-(naphthalen-2-yl)ethyl]imino]acetate |
| Amoxicillin-006 | 108-95-2在售 | Carbolic acid |
| Amoxicillin-007 | - | Methyl (2R)-(4-hydroxyphenyl)[(1-phenylethyl)amino]acetate |
| Amoxicillin-008 | - | Methyl (2R)-(4-hydroxyphenyl)[[1-(naphthalen-2-yl)ethyl]amino]acetate |
| Amoxicillin-009 | - | Methyl (2R)-(4-hydroxyphenyl)[(1-phenylethyl)amino]acetate hydrogen chloride (1/1) |
| Amoxicillin-010 | - | Methyl (2R)-(4-hydroxyphenyl)[[1-(naphthalen-2-yl)ethyl]amino]acetate hydrogen chloride (1/1) |
| Amoxicillin-011 | 57591-61-4 | D-p-Hydroxyphenylglycine methyl ester hydrochloride |
| Amoxicillin-012 | 37763-23-8 | D-p-yHdroxyphenylglycine methyl ester |
| Amoxicillin-013 | 551-16-6在售 | (+)-6-Aminopenicillanic acid |
优化Route 2步骤 4 · 总收率 /
Amoxicillin-01436747-66-7Amoxicillin-01526787-75-7Amoxicillin-013551-16-6Amoxicillin-01676953-81-6Amoxicillin-017—API · 克拉霉素/雷贝拉唑钠/阿莫西林
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Amoxicillin-014 | 36747-66-7 | [[(Benzyloxy)carbonyl]amino](4-hydroxyphenyl)acetic acid |
| Amoxicillin-015 | 26787-75-7 | (2R)-[[(Benzyloxy)carbonyl]amino](4-hydroxyphenyl)acetic acid |
| Amoxicillin-013 | 551-16-6在售 | (+)-6-Aminopenicillanic acid |
| Amoxicillin-016 | 76953-81-6 | (2S,5R,6R)-6-[[(2R)-2-[[(Benzyloxy)carbonyl]amino]-2-(4-hydroxyphenyl)acetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid |
| Amoxicillin-017 | - | Sodium (2S,5R,6R)-6-[[(2R)-2-[[(benzyloxy)carbonyl]amino]-2-(4-hydroxyphenyl)acetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate |
优化Route 3步骤 5 · 总收率 /
Amoxicillin-01526787-75-7Amoxicillin-01822818-40-2Amoxicillin-019105-45-3Amoxicillin-020—Amoxicillin-021—Amoxicillin-022—Amoxicillin-013551-16-6API · 克拉霉素/雷贝拉唑钠/阿莫西林
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Amoxicillin-015 | 26787-75-7 | (2R)-[[(Benzyloxy)carbonyl]amino](4-hydroxyphenyl)acetic acid |
| Amoxicillin-018 | 22818-40-2 | (2R)-2-Amino-2-(4-hydroxyphenyl)acetic acid |
| Amoxicillin-019 | 105-45-3在售 | 1-Methoxybutane-1,3-dione |
| Amoxicillin-020 | - | Sodium (2R)-(4-hydroxyphenyl)[[(2E)-4-methoxy-4-oxobut-2-en-2-yl]amino]acetate |
| Amoxicillin-021 | - | Sodium (2S,5R,6R)-6-amino-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate |
| Amoxicillin-022 | - | Potassium (2S,5R,6R)-6-amino-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate |
| Amoxicillin-013 | 551-16-6在售 | (+)-6-Aminopenicillanic acid |
优化Route 4步骤 6 · 总收率 /
Amoxicillin-01526787-75-7Amoxicillin-02126889-95-2Amoxicillin-013551-16-6Amoxicillin-02228645-17-2Amoxicillin-01822818-40-2Amoxicillin-02351431-08-4API · 克拉霉素/雷贝拉唑钠/阿莫西林
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Amoxicillin-015 | 26787-75-7 | (2R)-[[(Benzyloxy)carbonyl]amino](4-hydroxyphenyl)acetic acid |
| Amoxicillin-021 | 26889-95-2 | (2R)-[[(Benzyloxy)carbonyl]amino](4-[[(benzyloxy)carbonyl]oxy]phenyl)acetic acid |
| Amoxicillin-013 | 551-16-6在售 | (+)-6-Aminopenicillanic acid |
| Amoxicillin-022 | 28645-17-2 | (2S,5R,6R)-6-[[(2R)-2-Amino-2-(4-[[(benzyloxy)carbonyl]oxy]phenyl)acetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid |
| Amoxicillin-018 | 22818-40-2 | (2R)-2-Amino-2-(4-hydroxyphenyl)acetic acid |
| Amoxicillin-023 | 51431-08-4 | (2R)-Amino(4-hydroxyphenyl)acetyl chloride hydrogen chloride |
优化Route 5步骤 3 · 总收率 /
Amoxicillin-02432401-82-4Amoxicillin-013551-16-6Amoxicillin-02553726-38-8Amoxicillin-026—Amoxicillin-02738083-36-2API · 克拉霉素/雷贝拉唑钠/阿莫西林
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Amoxicillin-024 | 32401-82-4 | [[(Benzyloxy)carbonyl]amino](4-[[(benzyloxy)carbonyl]oxy]phenyl)acetic acid |
| Amoxicillin-013 | 551-16-6在售 | (+)-6-Aminopenicillanic acid |
| Amoxicillin-025 | 53726-38-8 | (2S,5R,6R)-6-[[[[(Benzyloxy)carbonyl]amino](4-[[(benzyloxy)carbonyl]oxy]phenyl)acetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid |
| Amoxicillin-026 | - | Sodium (2S,5R,6R)-6-[[[[(benzyloxy)carbonyl]amino](4-[[(benzyloxy)carbonyl]oxy]phenyl)acetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate |
| Amoxicillin-027 | 38083-36-2 | (2S,5R,6R)-6-[[Amino(4-hydroxyphenyl)acetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid |
优化Route 6步骤 3 · 总收率 /
Amoxicillin-01822818-40-2Amoxicillin-028178119-93-2Amoxicillin-013551-16-6Amoxicillin-0292171277-86-2API · 克拉霉素/雷贝拉唑钠/阿莫西林
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Amoxicillin-018 | 22818-40-2 | (2R)-2-Amino-2-(4-hydroxyphenyl)acetic acid |
| Amoxicillin-028 | 178119-93-2 | (2R)-([[(9H-Fluoren-9-yl)methoxy]carbonyl]amino)(4-hydroxyphenyl)acetic acid |
| Amoxicillin-013 | 551-16-6在售 | (+)-6-Aminopenicillanic acid |
| Amoxicillin-029 | 2171277-86-2 | (2S,5R,6R)-6-[[(2R)-2-([[(9H-Fluoren-9-yl)methoxy]carbonyl]amino)-2-(4-hydroxyphenyl)acetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid |
优化Route 7步骤 1 · 总收率 /
Amoxicillin-030113-98-4Amoxicillin-03147294-44-0,47294-41-7,70019-71-5,61-33-6,30411-69-9,7005-30-3Amoxicillin-01157591-61-4Amoxicillin-01237763-23-8Amoxicillin-03254397-23-8API · 克拉霉素/雷贝拉唑钠/阿莫西林
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Amoxicillin-030 | 113-98-4 | (2S,5R,6R)-3,3-Dimethyl-7-oxo-6-(2-phenylacetamido)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid potassium salt |
| Amoxicillin-031 | 47294-44-0,47294-41-7,70019-71-5,61-33-6,30411-69-9,7005-30-3 | (2S-(2alpha,5alpha,6beta))-3,3-Dimethyl-7-oxo-6-((phenylacetyl)amino)-4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid |
| Amoxicillin-011 | 57591-61-4 | D-p-Hydroxyphenylglycine methyl ester hydrochloride |
| Amoxicillin-012 | 37763-23-8 | D-p-yHdroxyphenylglycine methyl ester |
| Amoxicillin-032 | 54397-23-8 | (2R)-2-Amino-2-(4-hydroxyphenyl)acetamide |
优化Route 2步骤 3 · 总收率 40.32 kg
RABE-005583-39-1RABE-006117977-21-6RABE-007153259-31-5RABE-008117976-89-3API · 克拉霉素/雷贝拉唑钠/阿莫西林
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| RABE-005 | 583-39-1 | 1H-benzo[d]imidazole-2-thiol |
| RABE-006 | 117977-21-6 | 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)thio)-1H-benzo[d]imidazole |
| RABE-007 | 153259-31-5 | 2-(chloromethyl)-4-(3-methoxypropoxy)-3-methylpyridine hydrochloride |
| RABE-008 | 117976-89-3 | 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)-1H-benzo[d]imidazole |
优化Route 3步骤 1 · 总收率 /
RABE-006117977-21-6API · 克拉霉素/雷贝拉唑钠/阿莫西林
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| RABE-006 | 117977-21-6 | 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)thio)-1H-benzo[d]imidazole |
优化Route 4步骤 1 · 总收率 92.4 g
RABE-005583-39-1RABE-009117977-20-5API · 克拉霉素/雷贝拉唑钠/阿莫西林
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| RABE-005 | 583-39-1 | 1H-benzo[d]imidazole-2-thiol |
| RABE-009 | 117977-20-5 | 2-(chloromethyl)-4-(3-methoxypropoxy)-3-methylpyridine |
优化Route 5步骤 2 · 总收率 /
RABE-004117977-20-5RABE-005583-39-1RABE-008117976-89-3RABE-010924663-39-8API · 克拉霉素/雷贝拉唑钠/阿莫西林
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| RABE-004 | 117977-20-5 | 2-(chloromethyl)-4-(3-methoxypropoxy)-3-methylpyridine |
| RABE-005 | 583-39-1 | 1H-benzo[d]imidazole-2-thiol |
| RABE-008 | 117976-89-3 | 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)-1H-benzo[d]imidazole |
| RABE-010 | 924663-39-8 | 2-(chloromethyl)-4-(3-methoxypropoxy)-3-methylpyridine 1-oxide |
优化Route 1步骤 3 · 总收率 6g(Clarithromycin (Free))
Clarithromycin-001—Clarithromycin-002—Clarithromycin-003—API · 克拉霉素/雷贝拉唑钠/阿莫西林
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Clarithromycin-001 | - | benzyl (2S,3R,4S,6R)-4-{[(benzyloxy)carbonyl](methyl)amino}-2-{[(3R,4S,5S,6R,7S,9R,11R,12R,13S,14R)-14-ethyl-7,12,13-trihydroxy-4-{[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy}-3,5,7,9,11,13-hexamethyl-2,10-dioxo-1-oxacyclotetradecan-6-yl]oxy}-6-methyloxan-3-yl carbonate |
| Clarithromycin-002 | - | benzyl (2S,3R,4S,6R)-4-{[(benzyloxy)carbonyl](methyl)amino}-2-{[(3R,4S,5S,6R,7S,9R,11R,12R,13S,14R)-14-ethyl-12,13-dihydroxy-4-{[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy}-7-methoxy-3,5,7,9,11,13-hexamethyl-2,10-dioxo-1-oxacyclotetradecan-6-yl]oxy}-6-methyloxan-3-yl carbonate |
| Clarithromycin-003 | - | (3R,4S,5S,6R,7S,9R,11R,12R,13S,14R)-14-ethyl-12,13-dihydroxy-4-{[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy}-6-{[(2S,3R,4S,6R)-3-hydroxy-6-methyl-4-(methylamino)oxan-2-yl]oxy}-7-methoxy-3,5,7,9,11,13-hexamethyl-1-oxacyclotetradecane-2,10-dione |
优化Route 3步骤 4 · 总收率 18g(Clarithromycin (Free))
Clarithromycin-006133445-26-8Clarithromycin-007887125-82-8Clarithromycin-008—Clarithromycin-009—Clarithromycin-010—Clarithromycin-011133415-69-7API · 克拉霉素/雷贝拉唑钠/阿莫西林
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Clarithromycin-006 | 133445-26-8 | (3R,4S,5S,6R,7R,9R,10E,11S,12R,13S,14R)-6-[(2S,3R,4S,6R)-4-(Dimethylamino)-3-hydroxy-6-methyltetrahydropyran-2-yloxy]-14-ethyl-7,12,13-trihydroxy-4-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydrpyran-2-yloxy]-3,5,7,9,11,13-hexamethyloxacyclotetradecane-2,10-dione 10-[O-(1-isopropoxycyclohexyl)oxime] |
| Clarithromycin-007 | 887125-82-8 | Acetic acid (2S,3R,4S,6R)-4-(dimethylamino)-2-[((3R,4S,5S,6R,7R,9R,10E,11S,12R,13S,14R)-14-ethyl-7,12,13-trihydroxy-4-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydropyran-2-yloxy]-10-[[(1-isopropoxycyclohexyl)oxy]imino]-3,5,7,9,11,13-hexamethyl-2-oxooxacyclotetradecan-6-yl)oxy]-6-methyltetrahydropyran-3-yl ester |
| Clarithromycin-008 | - | Benzoic acid (2S,3R,4S,6R)-4-(dimethylamino)-2-[((3R,4S,5S,6R,7R,9R,10E,11S,12R,13S,14R)-14-ethyl-7,12,13-trihydroxy-4-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydropyran-2-yloxy]-10-[[(1-isopropoxycyclohexyl)oxy]imino]-3,5,7,9,11,13-hexamethyl-2-oxooxacyclotetradecan-6-yl)oxy]-6-methyltetrahydropyran-3-yl ester |
| Clarithromycin-009 | - | Benzoic acid (2S,3R,4S,6R)-4-(dimethylamino)-2-[(3R,4S,5S,6R,7R,9R,10E,11S,12R,13S,14R)-14-ethyl-12,13-dihydroxy-4-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydropyran-2-yloxy]-10-[[(1-isopropoxycyclohexyl)oxy]imino]-7-methoxy-3,5,7,9,11,13-hexamethyl-2-oxooxacyclotetradecan-6-yloxy]-6-methyltetrahydropyran-3-yl ester |
| Clarithromycin-010 | - | Acetic acid (2S,3R,4S,6R)-4-(dimethylamino)-2-[((3R,4S,5S,6R,7R,9R,10E,11S,12R,13S,14R)-14-ethyl-12,13-dihydroxy-4-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydropyran-2-yloxy]-10-[[(1-isopropoxycyclohexyl)oxy]imino]-7-methoxy-3,5,7,9,11,13-hexamethyl-2-oxooxacyclotetradecan-6-yl)oxy]-6-methyltetrahydropyran-3-yl ester |
| Clarithromycin-011 | 133415-69-7 | (3R,4S,5S,6R,7R,9R,10E,11S,12R,13S,14R)-6-[(2S,3R,4S,6R)-4-(Dimethylamino)-3-hydroxy-6-methyltetrahydropyran-2-yloxy]-14-ethyl-12,13-dihydroxy-4-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydropyran-2-yloxy]-7-methoxy-3,5,7,9,11,13-hexamethyloxacyclotetradecane-2,10-dione 10-[O-(1-isopropoxycyclohexyl)oxime] |
优化Route 4步骤 5 · 总收率 4.2g(Clarithromycin (Free))
Clarithromycin-01213127-18-9Clarithromycin-013611-19-8Clarithromycin-014206997-62-8Clarithromycin-0151395892-49-5Clarithromycin-016—Clarithromycin-017—Clarithromycin-018—Clarithromycin-019149882-99-5API · 克拉霉素/雷贝拉唑钠/阿莫西林
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Clarithromycin-012 | 13127-18-9 | (3R,4S,5S,6R,7R,9R,10Z,11S,12R,13S,14R)-6-[[(2S,3R,4S,6R)-4-(Dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl]oxy]-14-ethyl-7,12,13-trihydroxy-10-(hydroxyimino)-4-[[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydro-2H-pyran-2-yl]oxy]-3,5,7,9,11,13-hexamethyloxacyclotetradecan-2-one |
| Clarithromycin-013 | 611-19-8 | 2-Chlorobenzyl chloride |
| Clarithromycin-014 | 206997-62-8 | (3R,4S,5S,6R,7R,9R,10E,11S,12R,13S,14R)-6-[(2S,3R,4S,6R)-4-(Dimethylamino)-3-hydroxy-6-methyltetrahydropyran-2-yloxy]-14-ethyl-7,12,13-trihydroxy-4- [(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydropyran-2-yloxy]-3,5,7,9,11,13-hexamethyloxacyclotetradecane-2,10-dione 10-[O-(2-chlorobenzyl)oxime] |
| Clarithromycin-015 | 1395892-49-5 | Acetic acid (2S,3R,4S,6R)-2-[((3R,4S,5S,6R,7R,9R,10E,11S,12R,13S,14R)-10-[[(2-chlorobenzyl)oxy]imino]-14-ethyl-7,12,13-trihydroxy-4-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydropyran-2-yloxy]-3,5,7,9,11,13-hexamethyl-2-oxooxacyclotetradecan-6-yl)oxy]-4-(dimethylamino)-6-methyltetrahydropyran-3-yl ester |
| Clarithromycin-016 | - | Benzoic acid (2S,3R,4S,6R)-2-[(3R,4S,5S,6R,7R,9R,10E,11S,12R,13S,14R)-10-[[(2-chlorobenzyloxy]imino]-14-ethyl-7,12,13-trihydroxy-4-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydropyran-2-yloxy]-3,5,7,9,11,13-hexamethyl-2-oxooxacyclotetradecan-6-yloxy]-4-(dimethylamino)-6-methyltetrahydropyran-3-yl ester |
| Clarithromycin-017 | - | Acetic acid (2S,3R,4S,6R)-2-[(3R,4S,5S,6R,7R,9R,10E,11S,12R,13S,14R)-10-[[(2-chlorobenzyloxy]imino]-14-ethyl-12,13-dihydroxy-4-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydropyran-2-yloxy]-7-methoxy-3,5,7,9,11,13-hexamethyl-2-oxooxacyclotetradecan-6-yloxy]-4-(dimethylamino)-6-methyltetrahydropyran-3-yl ester |
| Clarithromycin-018 | - | Benzoic acid (2S,3R,4S,6R)-2-[(3R,4S,5S,6R,7R,9R,10E,11S,12R,13S,14R)-10-[[2-chlorobenzyloxy]imino]-14-ethyl-12,13-dihydroxy-4-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydropyran-2-yloxy]-7-methoxy-3,5,7,9,11,13-hexamethyl-2-oxooxacyclotetradecan-6-yloxy]-4-(dimethylamino)-6-methyltetrahydropyran-3-yl ester |
| Clarithromycin-019 | 149882-99-5 | (3R,4S,5S,6R,7R,9R,10E,11S,12R,13S,14R)-6-[(2S,3R,4S,6R)-4-(Dimethylamino)-3-hydroxy-6-methyltetrahydropyran-2-yloxy]-14-ethyl-12,13-dihydroxy-4-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydropyran-2-yloxy]-7-methoxy-3,5,7,9,11,13-hexamethyloxacyclotetradecane-2,10-dione 10-[O-(2-chlorobenzyl)oxime] |
优化Route 5步骤 1 · 总收率 /
Clarithromycin-01213127-18-9API · 克拉霉素/雷贝拉唑钠/阿莫西林
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Clarithromycin-012 | 13127-18-9 | (3R,4S,5S,6R,7R,9R,10Z,11S,12R,13S,14R)-6-[[(2S,3R,4S,6R)-4-(Dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl]oxy]-14-ethyl-7,12,13-trihydroxy-10-(hydroxyimino)-4-[[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydro-2H-pyran-2-yl]oxy]-3,5,7,9,11,13-hexamethyloxacyclotetradecan-2-one |
优化Route 6步骤 5 · 总收率 17.5g(Clarithromycin (Free))
Clarithromycin-0207704-67-8Clarithromycin-01213127-18-9Clarithromycin-02113127-18-9Clarithromycin-022926-66-9Clarithromycin-023—Clarithromycin-0241253181-38-2Clarithromycin-02574-88-4Clarithromycin-02674-83-9Clarithromycin-0271253181-39-3API · 克拉霉素/雷贝拉唑钠/阿莫西林
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Clarithromycin-020 | 7704-67-8 | (3R,4S,5S,6R,7R,9R,11R,12R,13S,14R)-6-[[(2S,3R,4S,6R)-4-(Dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl]oxy]-14-ethyl-7,12,13-trihydroxy-4-[[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydro-2H-pyran-2-yl]oxy]-3,5,7,9,11,13-hexamethyloxacyclotetradecane-2,10-dione thiocyanate |
| Clarithromycin-012 | 13127-18-9 | Thiocyanic acid--(3R,4S,5S,6R,7R,9R,10E,11S,12R,13S,14R)-6-[[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy]-14-ethyl-7,12,13-trihydroxy-10-(hydroxyimino)-4-[[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy]-3,5,7,9,11,13-hexamethyl-1-oxacyclotetradecan-2-one (1/1) |
| Clarithromycin-021 | 13127-18-9 | (3R,4S,5S,6R,7R,9R,10Z,11S,12R,13S,14R)-6-[[(2S,3R,4S,6R)-4-(Dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl]oxy]-14-ethyl-7,12,13-trihydroxy-10-(hydroxyimino)-4-[[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydro-2H-pyran-2-yl]oxy]-3,5,7,9,11,13-hexamethyloxacyclotetradecan-2-one |
| Clarithromycin-022 | 926-66-9 | 2-Ethoxyprop-1-ene |
| Clarithromycin-023 | - | (3R,4S,5S,6R,7R,9R,10E,11S,12R,13S,14R)-6-[[(2S,3R,4S,6R)-4-(Dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy]-10-[[(2-ethoxypropan-2-yl)oxy]imino]-14-ethyl-7,12,13-trihydroxy-4-[[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy]-3,5,7,9,11,13-hexamethyl-1-oxacyclotetradecan-2-one |
| Clarithromycin-024 | 1253181-38-2 | (3R,4S,5S,6R,7R,9R,10E,11S,12R,13S,14R)-6-([(2S,3R,4S,6R)-4-(Dimethylamino)-6-methyl-3-[(trimethylsilyl)oxy]tetrahydro-2H-pyran-2-yl]oxy)-10-[[(2-ethoxypropan-2-yl)oxy]imino]-14-ethyl-7,12,13-trihydroxy-4-([(2R,4R,5S,6S)-4-methoxy-4,6-dimethyl-5-[(trimethylsilyl)oxy]tetrahydro-2H-pyran-2-yl]oxy)-3,5,7,9,11,13-hexamethyloxacyclotetradecan-2-one |
| Clarithromycin-025 | 74-88-4在售 | Methyl iodide |
| Clarithromycin-026 | 74-83-9 | Bromomethane |
| Clarithromycin-027 | 1253181-39-3 | (3R,4S,5S,6R,7R,9R,10E,11S,12R,13S,14R)-6-([(2S,3R,4S,6R)-4-(Dimethylamino)-6-methyl-3-[(trimethylsilyl)oxy]tetrahydro-2H-pyran-2-yl]oxy)-10-[[(2-ethoxypropan-2-yl)oxy]imino]-14-ethyl-12,13-dihydroxy-7-methoxy-4-([(2R,4R,5S,6S)-4-methoxy-4,6-dimethyl-5-[(trimethylsilyl)oxy]tetrahydro-2H-pyran-2-yl]oxy)-3,5,7,9,11,13-hexamethyloxacyclotetradecan-2-one |
优化Route 7步骤 2 · 总收率 52g(Clarithromycin-028)
Clarithromycin-01213127-18-9Clarithromycin-022926-66-9Clarithromycin-023—Clarithromycin-028—API · 克拉霉素/雷贝拉唑钠/阿莫西林
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Clarithromycin-012 | 13127-18-9 | (3R,4S,5S,6R,7R,9R,10Z,11S,12R,13S,14R)-6-[[(2S,3R,4S,6R)-4-(Dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl]oxy]-14-ethyl-7,12,13-trihydroxy-10-(hydroxyimino)-4-[[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydro-2H-pyran-2-yl]oxy]-3,5,7,9,11,13-hexamethyloxacyclotetradecan-2-one |
| Clarithromycin-022 | 926-66-9 | 2-Ethoxyprop-1-ene |
| Clarithromycin-023 | - | (3R,4S,5S,6R,7R,9R,10E,11S,12R,13S,14R)-6-[[(2S,3R,4S,6R)-4-(Dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy]-10-[[(2-ethoxypropan-2-yl)oxy]imino]-14-ethyl-7,12,13-trihydroxy-4-[[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy]-3,5,7,9,11,13-hexamethyl-1-oxacyclotetradecan-2-one |
| Clarithromycin-028 | - | (3R,4S,5S,6R,7R,9R,10E,11S,12R,13S,14R)-6-[[(2S,3R,4S,6R)-4-(Dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy]-10-[[(2-ethoxypropan-2-yl)oxy]imino]-14-ethyl-7,12,13-trihydroxy-4-([(2R,4R,5S,6S)-4-methoxy-4,6-dimethyl-5-[(trimethylsilyl)oxy]oxan-2-yl]oxy)-3,5,7,9,11,13-hexamethyl-1-oxacyclotetradecan-2-one |
优化Route 8步骤 1 · 总收率 88g(Clarithromycin-012)
Clarithromycin-0207704-67-8Clarithromycin-01213127-18-9API · 克拉霉素/雷贝拉唑钠/阿莫西林
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Clarithromycin-020 | 7704-67-8 | (3R,4S,5S,6R,7R,9R,11R,12R,13S,14R)-6-[[(2S,3R,4S,6R)-4-(Dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl]oxy]-14-ethyl-7,12,13-trihydroxy-4-[[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydro-2H-pyran-2-yl]oxy]-3,5,7,9,11,13-hexamethyloxacyclotetradecane-2,10-dione thiocyanate |
| Clarithromycin-012 | 13127-18-9 | (3R,4S,5S,6R,7R,9R,10Z,11S,12R,13S,14R)-6-[[(2S,3R,4S,6R)-4-(Dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl]oxy]-14-ethyl-7,12,13-trihydroxy-10-(hydroxyimino)-4-[[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydro-2H-pyran-2-yl]oxy]-3,5,7,9,11,13-hexamethyloxacyclotetradecan-2-one |
工艺Route 2步骤 2 · 总收率 429.768g(Clarithromycin (Free))
Clarithromycin-004—Clarithromycin-005—API · 克拉霉素/雷贝拉唑钠/阿莫西林
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Clarithromycin-004 | - | (2R,3R,4R,5R,6R,8R,9E,10S,11R,12R,13S)-5-{[(2S,3R,4S,6R)-4-(dimethylamino)-6-methyl-3-[(trimethylsilyl)oxy]oxan-2-yl]oxy}-13-ethyl-6,11,12-trihydroxy-3-{[(4R,5S,6S)-4-methoxy-4,6-dimethyl-5-[(trimethylsilyl)oxy]oxan-2-yl]oxy}-9-{[(2-methoxypropan-2-yl)oxy]imino}-2,4,6,8,10,12-hexamethylcyclotetradecan-1-one |
| Clarithromycin-005 | - | (2R,3R,4R,5R,6R,8R,9E,10S,11R,12R,13S)-5-{[(2S,3R,4S,6R)-4-(dimethylamino)-6-methyl-3-[(trimethylsilyl)oxy]oxan-2-yl]oxy}-13-ethyl-11,12-dihydroxy-6-methoxy-3-{[(4R,5S,6S)-4-methoxy-4,6-dimethyl-5-[(trimethylsilyl)oxy]oxan-2-yl]oxy}-9-{[(2-methoxypropan-2-yl)oxy]imino}-2,4,6,8,10,12-hexamethylcyclotetradecan-1-one |
常见问题（FAQ）
克拉霉素/雷贝拉唑钠/阿莫西林的适应症有哪些？
已批准的适应症包括：边缘带B细胞淋巴瘤、十二指肠溃疡、特发性血小板减少性紫癜、胃溃疡、胃炎、幽门螺杆菌感染。
克拉霉素/雷贝拉唑钠/阿莫西林的专利什么时候到期？
克拉霉素/雷贝拉唑钠/阿莫西林的专利到期年暂无公开口径，本页会在数据管道核实后更新。
克拉霉素/雷贝拉唑钠/阿莫西林有几条合成路线？
本站收录 20 条合成路线，最短路线 1 步、总收率 /。每条路线的中间体均带登记编号与 CAS 号。
克拉霉素/雷贝拉唑钠/阿莫西林的关键中间体在哪里可以采购？
克拉霉素/雷贝拉唑钠/阿莫西林的多条路线中间体已挂接 CAS 档案，其中 4 个 CAS 已有优贝德（Unibest）供应网络在售报价，可在本页路线表中直接查看并询价。
如何获取克拉霉素/雷贝拉唑钠/阿莫西林中间体的报价？
在本页选择目标中间体的 CAS 进入档案页，或在询价页直接提交需求；CAS 会自动带入供需撮合流程，由供应网络反馈报价。
数据来源：多源数据交叉核实（仅结构化字段） · 2026-10-22