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莫诺拉韦
Tier B · 提前布局Molnupiravir
埃默里大学
原研
2021
首批上市
-
到期年（公开口径）
$5.68B ▲
峰值销售
化学药
类型
靶点：RdRp
商品名：Molxvir、Lagevrio、利卓瑞、Movfor、LAGEVRIO
适应症（已批准）：新型冠状病毒感染
各地区研发/上市状态
美国
临床三期
2020-10-19
欧盟
批准上市
2021-11-04
中国
批准上市
2022-12-30
日本
批准上市
2021-12-24
合成路线与中间体23 routes
原研路线 × 1优化路线（非专利）× 22工艺路线 × 0
路线按「原研路线 → 优化路线 / 工艺路线（非专利）」排序。每条路线附本站自绘的路线流程图（中间体 → 原料药）与中间体表（编号 / CAS / 英文名），可直接用于供应商开发与询价。流程图由本站依据已授权的结构化数据自行渲染，未使用任何第三方路线图。
原研Route 1步骤 10 · 总收率 /
Molnupiravir-00158-96-8Molnupiravir-002362-43-6Molnupiravir-00397-72-3Molnupiravir-0042346620-53-7Molnupiravir-005—Molnupiravir-006288-88-0Molnupiravir-0072346620-54-8Molnupiravir-008—Molnupiravir-009104105-73-9Molnupiravir-010138421-23-5Molnupiravir-011—API · 莫诺拉韦
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Molnupiravir-001 | 58-96-8在售 | 1-(beta-D-Ribofuranosyl)uracil |
| Molnupiravir-002 | 362-43-6在售 | 1-[(3aR,4R,6R,6aR)-6-(Hydroxymethyl)-2,2-dimethyl-tetrahydro-2H-furo[3,4-d][1,3]dioxol-4-yl]-1,2,3,4-tetrahydropyrimidine-2,4-dione<-fgf->2',3'-O-Isopropylideneuridine |
| Molnupiravir-003 | 97-72-3在售 | 2-Methylpropionic anhydride |
| Molnupiravir-004 | 2346620-53-7在售 | 2',3'-O-(1-Methylethylidene)-5'-O-(2-methylpropanoyl)uridine |
| Molnupiravir-005 | - | N-Hydroxy-2',3'-O-(1-methylethylidene)-5'-O-(2-methylpropanoyl)cytidine |
| Molnupiravir-006 | 288-88-0在售 | 1H-1,2,4-Triazole |
| Molnupiravir-007 | 2346620-54-8在售 | 1-[2,3-O-(1-Methylethylidene)-5-O-(2-methylpropanoyl)-beta-D-ribofuranosyl]-4-(1H-1,2,4-triazol-1-yl)pyrimidin-2(1H)-one |
| Molnupiravir-008 | - | 1-beta-D-Ribofuranosyl-4-(1H-1,2,4-triazol-1-yl)-3,4-dihydropyrimidin-2(1H)-one |
| Molnupiravir-009 | 104105-73-9在售 | 1-[2,3-O-(1-Methylethylidene)-beta-D-ribofuranosyl]-4-(1H-1,2,4-triazol-1-yl)pyrimidin-2(1H)-one |
| Molnupiravir-010 | 138421-23-5在售 | Acetone O-isobutyryloxime |
| Molnupiravir-011 | - | 1-[(2xi)-5-O-(2-Methylpropanoyl)-beta-D-erythro-pentofuranosyl]-4-(1H-1,2,4-triazol-1-yl)-3,4-dihydropyrimidin-2(1H)-one |
优化Route 2步骤 12 · 总收率 /
Molnupiravir-01250-69-1Molnupiravir-013—Molnupiravir-014—Molnupiravir-015—Molnupiravir-01679-30-1Molnupiravir-01714631-20-0Molnupiravir-018—Molnupiravir-01965-46-3Molnupiravir-0201955522-00-5Molnupiravir-021—Molnupiravir-0222634757-84-7Molnupiravir-0237803-49-8Molnupiravir-0245470-11-1Molnupiravir-02510039-54-0Molnupiravir-005—Molnupiravir-00397-72-3API · 莫诺拉韦
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Molnupiravir-012 | 50-69-1在售 | - |
| Molnupiravir-013 | - | Methyl 2,3-O-isopropylidene-beta-D-ribofuranoside |
| Molnupiravir-014 | - | Methyl 5-O-benzoyl-2,3-O-(1-methylethylidene)-beta-D-ribofuranoside |
| Molnupiravir-015 | - | 1,2,3-Tri-O-acetyl-5-O-benzoyl-beta-D-ribofuranose |
| Molnupiravir-016 | 79-30-1在售 | 2-Methylpropionyl chloride |
| Molnupiravir-017 | 14631-20-0在售 | N-(2-Oxo-1,2-dihydropyrimidin-4-yl)acetamide |
| Molnupiravir-018 | - | N-Acetyl-2',3'-di-O-acetyl-5'-O-benzoylcytidine |
| Molnupiravir-019 | 65-46-3在售 | Cytosine-1-beta-D-ribofuranoside |
| Molnupiravir-020 | 1955522-00-5在售 | Sulfuric acid 2',3'-O-(1-methylethylidene)cytidine |
| Molnupiravir-021 | - | 2',3'-O-(1-Methylethylidene)cytidine |
| Molnupiravir-022 | 2634757-84-7在售 | 2',3'-O-(1-Methylethylidene)-N-(2-methylpropanoyl)-5'-O-(2-methylpropanoyl)cytidine |
| Molnupiravir-023 | 7803-49-8在售 | Hydroxylamine |
| Molnupiravir-024 | 5470-11-1在售 | Hydroxylamine hydrochloride |
| Molnupiravir-025 | 10039-54-0在售 | Hydroxylamine sulfate |
| Molnupiravir-005 | - | N-Hydroxy-2',3'-O-(1-methylethylidene)-5'-O-(2-methylpropanoyl)cytidine |
| Molnupiravir-003 | 97-72-3在售 | 2-Methylpropionic anhydride |
优化Route 3步骤 11 · 总收率 /
Molnupiravir-026127-06-0Molnupiravir-0271686124-74-2Molnupiravir-028886538-46-1Molnupiravir-02967-64-1Molnupiravir-03079-31-2Molnupiravir-0201955522-00-5Molnupiravir-00397-72-3Molnupiravir-01965-46-3Molnupiravir-010138421-23-5Molnupiravir-005—API · 莫诺拉韦
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Molnupiravir-026 | 127-06-0在售 | Acetone oxime |
| Molnupiravir-027 | 1686124-74-2在售 | 2',3'-O-(1-Methylethylidene)-5'-O-(2-methylpropanoyl)cytidine |
| Molnupiravir-028 | 886538-46-1在售 | 5'-O-Isobutyryl cytidine |
| Molnupiravir-029 | 67-64-1在售 | Acetone |
| Molnupiravir-030 | 79-31-2在售 | 2-Methylpropionic acid |
| Molnupiravir-020 | 1955522-00-5在售 | Sulfuric acid 2',3'-O-(1-methylethylidene)cytidine |
| Molnupiravir-003 | 97-72-3在售 | Isobutyric anhydride |
| Molnupiravir-019 | 65-46-3在售 | 1-(beta-D-Ribofuranosyl)cytosine |
| Molnupiravir-010 | 138421-23-5在售 | Acetone O-isobutyryloxime |
| Molnupiravir-005 | - | N-Hydroxy-2',3'-O-(1-methylethylidene)-5'-O-(2-methylpropanoyl)cytidine |
优化Route 4步骤 8 · 总收率 77.1g(Molnupiravir)
Molnupiravir-03185373-26-8,3258-02-4Molnupiravir-03297-85-8Molnupiravir-0332424-98-8Molnupiravir-01965-46-3Molnupiravir-010138421-23-5Molnupiravir-01679-30-1Molnupiravir-028886538-46-1Molnupiravir-00397-72-3API · 莫诺拉韦
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Molnupiravir-031 | 85373-26-8,3258-02-4在售 | N4-Hydroxycytidine |
| Molnupiravir-032 | 97-85-8在售 | 2-Methylpropyl 2-methylpropanoate |
| Molnupiravir-033 | 2424-98-8在售 | Ethenyl 2-methylpropanoate |
| Molnupiravir-019 | 65-46-3在售 | 1-(beta-D-Ribofuranosyl)cytosine |
| Molnupiravir-010 | 138421-23-5在售 | Acetone O-isobutyryloxime |
| Molnupiravir-016 | 79-30-1在售 | 2-Methylpropionyl chloride |
| Molnupiravir-028 | 886538-46-1在售 | 5'-O-Isobutyryl cytidine |
| Molnupiravir-003 | 97-72-3在售 | 2-Methylpropionic anhydride |
优化Route 5步骤 2 · 总收率 /
Molnupiravir-010138421-23-5Molnupiravir-01679-30-1Molnupiravir-03079-31-2Molnupiravir-02967-64-1Molnupiravir-026127-06-0API · 莫诺拉韦
优化Route 6步骤 5 · 总收率 7.10g(Molnupiravir-031)
Molnupiravir-03464898-15-3Molnupiravir-0351955521-90-0Molnupiravir-03185373-26-8,3258-02-4Molnupiravir-00158-96-8Molnupiravir-008—API · 莫诺拉韦
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Molnupiravir-034 | 64898-15-3在售 | 1-[(2R,3R,4R,5R)-3,4-Bis[(tert-butyldimethylsilyl)oxy]-5-{[(tert-butyldimethylsilyl)oxy]methyl}oxolan-2-yl]-1,2,3,4-tetrahydropyrimidine-2,4-dione |
| Molnupiravir-035 | 1955521-90-0在售 | 2',3',5'-Tris-O-[tert-butyl(dimethyl)silyl]-N-hydroxycytidine |
| Molnupiravir-031 | 85373-26-8,3258-02-4在售 | N4-Hydroxycytidine |
| Molnupiravir-001 | 58-96-8在售 | Uracil-1-beta-D-ribofuranoside |
| Molnupiravir-008 | - | 1-beta-D-Ribofuranosyl-4-(1H-1,2,4-triazol-1-yl)-3,4-dihydropyrimidin-2(1H)-one |
优化Route 7步骤 6 · 总收率 3.5g(Molnupiravir-031)
Molnupiravir-03666-22-8Molnupiravir-03713035-61-5Molnupiravir-0384105-38-8Molnupiravir-039—Molnupiravir-040—Molnupiravir-03185373-26-8,3258-02-4API · 莫诺拉韦
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Molnupiravir-036 | 66-22-8在售 | 2,4(1H,3H)-Pyrimidinedione |
| Molnupiravir-037 | 13035-61-5在售 | D-Ribofuranose 1,2,3,5-tetraacetate |
| Molnupiravir-038 | 4105-38-8在售 | Triacetyl uridine |
| Molnupiravir-039 | - | 4-Chloro-1-(2,3,5-tri-O-acetyl-beta-D-ribofuranosyl)pyrimidin-2(1H)-one |
| Molnupiravir-040 | - | 2',3',5'-Tri-O-acetyl-N-hydroxycytidine |
| Molnupiravir-031 | 85373-26-8,3258-02-4在售 | N4-Hydroxycytidine |
优化Route 8步骤 7 · 总收率 30.72g(Molnupiravir)
Molnupiravir-041—Molnupiravir-042102096-25-3Molnupiravir-002362-43-6Molnupiravir-0245470-11-1Molnupiravir-010138421-23-5Molnupiravir-0332424-98-8Molnupiravir-005—Molnupiravir-0042346620-53-7API · 莫诺拉韦
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Molnupiravir-041 | - | N-Hydroxy-2',3'-O-(1-methylethylidene)cytidine |
| Molnupiravir-042 | 102096-25-3在售 | 2,2,2-Trifluoroethyl 2-methylpropanoate |
| Molnupiravir-002 | 362-43-6在售 | 1-[(3aR,4R,6R,6aR)-6-(Hydroxymethyl)-2,2-dimethyl-tetrahydro-2H-furo[3,4-d][1,3]dioxol-4-yl]-1,2,3,4-tetrahydropyrimidine-2,4-dione<-fgf->2',3'-O-Isopropylideneuridine |
| Molnupiravir-024 | 5470-11-1在售 | Hydroxylammonium chloride |
| Molnupiravir-010 | 138421-23-5在售 | Acetone O-isobutyryloxime |
| Molnupiravir-033 | 2424-98-8在售 | Ethenyl 2-methylpropanoate |
| Molnupiravir-005 | - | N-Hydroxy-2',3'-O-(1-methylethylidene)-5'-O-(2-methylpropanoyl)cytidine |
| Molnupiravir-004 | 2346620-53-7在售 | 2',3'-O-(1-Methylethylidene)-5'-O-(2-methylpropanoyl)uridine |
优化Route 9步骤 1 · 总收率 76g(Molnupiravir-043)
Molnupiravir-0432752491-44-2Molnupiravir-01965-46-3API · 莫诺拉韦
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Molnupiravir-043 | 2752491-44-2在售 | Methanesulfonic acid 2',3'-O-(1-methylethylidene)cytidine (1/1) |
| Molnupiravir-019 | 65-46-3在售 | Cytosine-1-beta-D-ribofuranoside |
优化Route 10步骤 6 · 总收率 5.14g(Molnupiravir)
Molnupiravir-044—Molnupiravir-045—Molnupiravir-046—Molnupiravir-01965-46-3Molnupiravir-010138421-23-5Molnupiravir-01679-30-1Molnupiravir-03079-31-2Molnupiravir-028886538-46-1Molnupiravir-00397-72-3API · 莫诺拉韦
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Molnupiravir-044 | - | N-[(Dimethylamino)methylidene]cytidine |
| Molnupiravir-045 | - | 5'-O-(2-Methylpropanoyl)cytidine oxalate |
| Molnupiravir-046 | - | N,O2',O3'-Tris[(dimethylamino)methylidene]cytidine |
| Molnupiravir-019 | 65-46-3在售 | 1-(beta-D-Ribofuranosyl)cytosine |
| Molnupiravir-010 | 138421-23-5在售 | Acetone O-isobutyryloxime |
| Molnupiravir-016 | 79-30-1在售 | Isobutyryl chloride |
| Molnupiravir-030 | 79-31-2在售 | 2-Methylpropionic acid |
| Molnupiravir-028 | 886538-46-1在售 | 5'-O-Isobutyryl cytidine |
| Molnupiravir-003 | 97-72-3在售 | Dimethylacetic anhydride |
优化Route 11步骤 3 · 总收率 245g(Molnupiravir)
Molnupiravir-047—Molnupiravir-048105-60-2Molnupiravir-049107-13-1Molnupiravir-050—API · 莫诺拉韦
优化Route 12步骤 2 · 总收率 147g(Molnupiravir)
Molnupiravir-051—Molnupiravir-00158-96-8Molnupiravir-00397-72-3API · 莫诺拉韦
优化Route 13步骤 3 · 总收率 /
Molnupiravir-052—Molnupiravir-01250-69-1Molnupiravir-00397-72-3Molnupiravir-03666-22-8Molnupiravir-051—API · 莫诺拉韦
优化Route 14步骤 7 · 总收率 343mg(Molnupiravir)
Molnupiravir-053—Molnupiravir-054—Molnupiravir-055—Molnupiravir-01965-46-3Molnupiravir-046—Molnupiravir-00397-72-3API · 莫诺拉韦
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Molnupiravir-053 | - | N-[(Dimethylamino)methylidene]-2',3'-O-[(dimethylamino)methylidene]-5'-O-(2-methylpropanoyl)cytidine |
| Molnupiravir-054 | - | N-[(Dimethylamino)methylidene]-5'-O-(2-methylpropanoyl)cytidine |
| Molnupiravir-055 | - | N-[(Hydroxyimino)methyl]-5'-O-(2-methylpropanoyl)cytidine |
| Molnupiravir-019 | 65-46-3在售 | Cytosine beta-D-riboside |
| Molnupiravir-046 | - | N,O2',O3'-Tris[(dimethylamino)methylidene]cytidine |
| Molnupiravir-003 | 97-72-3在售 | Dimethylacetic anhydride |
优化Route 15步骤 5 · 总收率 /
Molnupiravir-0564099-88-1Molnupiravir-057—Molnupiravir-05871-30-7Molnupiravir-0271686124-74-2Molnupiravir-05250-69-1Molnupiravir-01679-30-1API · 莫诺拉韦
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Molnupiravir-056 | 4099-88-1在售 | 2,3-O-Isopropylidene-D-ribofuranose |
| Molnupiravir-057 | - | 2,3-O-(1-Methylethylidene)-1,5-bis-O-(2-methylpropanoyl)-D-ribofuranose |
| Molnupiravir-058 | 71-30-7在售 | 4-Aminopyrimidin-2(1H)-one |
| Molnupiravir-027 | 1686124-74-2在售 | 2',3'-O-(1-Methylethylidene)-5'-O-(2-methylpropanoyl)cytidine |
| Molnupiravir-052 | 50-69-1在售 | - |
| Molnupiravir-016 | 79-30-1在售 | Isobutyryl chloride |
优化Route 16步骤 4 · 总收率 42.9g(Molnupiravir)
Molnupiravir-059—Molnupiravir-060—Molnupiravir-01965-46-3Molnupiravir-03185373-26-8,3258-02-4Molnupiravir-00397-72-3API · 莫诺拉韦
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Molnupiravir-059 | - | 2',3'-O-[(Dimethylamino)methylidene]-N-hydroxycytidine |
| Molnupiravir-060 | - | 2',3'-O-[(Dimethylamino)methylidene]-N-hydroxy-5'-O-(2-methylpropanoyl)cytidine |
| Molnupiravir-019 | 65-46-3在售 | Cytosine-1-beta-D-ribofuranoside |
| Molnupiravir-031 | 85373-26-8,3258-02-4在售 | N4-Hydroxycytidine |
| Molnupiravir-003 | 97-72-3在售 | Isobutyric anhydride |
优化Route 17步骤 1 · 总收率 /
Molnupiravir-05250-69-1Molnupiravir-03666-22-8Molnupiravir-00158-96-8API · 莫诺拉韦
优化Route 18步骤 3 · 总收率 /
Molnupiravir-061—Molnupiravir-062—Molnupiravir-041—Molnupiravir-00397-72-3API · 莫诺拉韦
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Molnupiravir-061 | - | 2',3'-O-(1-Methylethylidene)-5'-O-(2-methylpropanoyl)-N-[(2-methylpropanoyl)oxy]cytidine |
| Molnupiravir-062 | - | 5'-O-(2-Methylpropanoyl)-N-[(2-methylpropanoyl)oxy]cytidine |
| Molnupiravir-041 | - | N-Hydroxy-2',3'-O-(1-methylethylidene)cytidine |
| Molnupiravir-003 | 97-72-3在售 | alpha-Methylpropionic anhydride |
优化Route 19步骤 7 · 总收率 1.65g(Molnupiravir)
Molnupiravir-063—Molnupiravir-06429108-90-5Molnupiravir-065—Molnupiravir-066—Molnupiravir-05250-69-1Molnupiravir-03666-22-8Molnupiravir-00397-72-3Molnupiravir-0245470-11-1API · 莫诺拉韦
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Molnupiravir-063 | - | 1,2,3-Tri-O-acetyl-5-O-(triphenylmethyl)-D-ribofuranose |
| Molnupiravir-064 | 29108-90-5在售 | 2',3'-Di-O-acetyluridine |
| Molnupiravir-065 | - | 2',3'-Di-O-acetyl-5'-O-(2-methylpropanoyl)uridine |
| Molnupiravir-066 | - | 1-[2,3-Di-O-acetyl-5-O-(2-methylpropanoyl)-beta-D-ribofuranosyl]-4-[[2,4,6-tri(propan-2-yl)benzene-1-sulfonyl]oxy]pyrimidin-2(1H)-one |
| Molnupiravir-052 | 50-69-1在售 | - |
| Molnupiravir-036 | 66-22-8在售 | 2,4(1H,3H)-Pyrimidinedione |
| Molnupiravir-003 | 97-72-3在售 | 2-Methylpropionic anhydride |
| Molnupiravir-024 | 5470-11-1在售 | Hydroxylamine hydrochloride |
优化Route 20步骤 4 · 总收率 /
Molnupiravir-067—Molnupiravir-068—Molnupiravir-069—Molnupiravir-070—Molnupiravir-071—Molnupiravir-072—Molnupiravir-01965-46-3Molnupiravir-00397-72-3Molnupiravir-02510039-54-0API · 莫诺拉韦
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Molnupiravir-067 | - | Sulfuric acid 2',3'-O-benzylidenecytidine (1/1) |
| Molnupiravir-068 | - | Sulfuric acid 2',3'-O-methylidenecytidine (1/1) |
| Molnupiravir-069 | - | 2',3'-O-Benzylidene-5'-O-(2-methylpropanoyl)cytidine |
| Molnupiravir-070 | - | 2',3'-O-Methylidene-5'-O-(2-methylpropanoyl)cytidine |
| Molnupiravir-071 | - | 2',3'-O-Benzylidene-N-hydroxy-5'-O-(2-methylpropanoyl)cytidine |
| Molnupiravir-072 | - | N-Hydroxy-2',3'-O-methylidene-5'-O-(2-methylpropanoyl)cytidine |
| Molnupiravir-019 | 65-46-3在售 | 1-(beta-D-Ribofuranosyl)cytosine |
| Molnupiravir-003 | 97-72-3在售 | 2-Methylpropionic anhydride |
| Molnupiravir-025 | 10039-54-0在售 | Hydroxylamine sulfate |
优化Route 21步骤 5 · 总收率 4.15g(Molnupiravir)
Molnupiravir-073—Molnupiravir-00158-96-8Molnupiravir-002362-43-6Molnupiravir-00397-72-3Molnupiravir-0042346620-53-7Molnupiravir-0237803-49-8Molnupiravir-005—API · 莫诺拉韦
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Molnupiravir-073 | - | 1-[2,3-O-(1-Methylethylidene)-5-O-(2-methylpropanoyl)-beta-D-ribofuranosyl]-4-sulfanylidene-3,4-dihydropyrimidin-2(1H)-one |
| Molnupiravir-001 | 58-96-8在售 | 1-(beta-D-Ribofuranosyl)uracil |
| Molnupiravir-002 | 362-43-6在售 | 1-[(3aR,4R,6R,6aR)-6-(Hydroxymethyl)-2,2-dimethyl-tetrahydro-2H-furo[3,4-d][1,3]dioxol-4-yl]-1,2,3,4-tetrahydropyrimidine-2,4-dione<-fgf->2',3'-O-Isopropylideneuridine |
| Molnupiravir-003 | 97-72-3在售 | 2-Methylpropionic anhydride |
| Molnupiravir-004 | 2346620-53-7在售 | 2',3'-O-(1-Methylethylidene)-5'-O-(2-methylpropanoyl)uridine |
| Molnupiravir-023 | 7803-49-8在售 | Hydroxylamine |
| Molnupiravir-005 | - | N-Hydroxy-2',3'-O-(1-methylethylidene)-5'-O-(2-methylpropanoyl)cytidine |
优化Route 22步骤 10 · 总收率 /
Molnupiravir-074129940-50-7Molnupiravir-0751826-67-1Molnupiravir-076170277-82-4Molnupiravir-077—Molnupiravir-078—Molnupiravir-07975-47-8Molnupiravir-080—Molnupiravir-081—Molnupiravir-082—Molnupiravir-083—Molnupiravir-03666-22-8Molnupiravir-00397-72-3Molnupiravir-051—Molnupiravir-02510039-54-0API · 莫诺拉韦
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Molnupiravir-074 | 129940-50-7在售 | 2(S)-(1,1,1-Triphenylmethoxymethyl)oxirane |
| Molnupiravir-075 | 1826-67-1在售 | (Vinyl)magnesium bromide |
| Molnupiravir-076 | 170277-82-4在售 | (2S)-1-(Triphenylmethoxy)pent-4-en-2-ol |
| Molnupiravir-077 | - | (3S)-3-[[tert-Butyl(diphenyl)silyl]oxy]-4-(triphenylmethoxy)butanal |
| Molnupiravir-078 | - | (2S,3aS,9aR)-2-[(Triphenylmethoxy)methyl]-2,3,3a,9a-tetrahydro-6H-furo[2',3':4,5][1,3]oxazolo[3,2-a]pyrimidin-6-one |
| Molnupiravir-079 | 75-47-8在售 | Iodoform |
| Molnupiravir-080 | - | tert-Butyl[[(2S,4E)-5-iodo-1-(triphenylmethoxy)pent-4-en-2-yl]oxy]diphenylsilane |
| Molnupiravir-081 | - | 1-[(1E,4S)-4-Hydroxy-5-(triphenylmethoxy)pent-1-en-1-yl]pyrimidine-2,4(1H,3H)-dione |
| Molnupiravir-082 | - | 1-[(2R,5S)-5-(Trityloxymethyl)-2,5-dihydrofuran-2-yl]pyrimidine-2,4-dione |
| Molnupiravir-083 | - | [(2S,5R)-5-(2,4-Dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2,5-dihydrofuran-2-yl]methyl 2-methylpropanoate |
| Molnupiravir-036 | 66-22-8在售 | 2,4(1H,3H)-Pyrimidinedione |
| Molnupiravir-003 | 97-72-3在售 | 2-Methylpropionic anhydride |
| Molnupiravir-051 | - | 5'-O-(2-Methylpropanoyl)uridine |
| Molnupiravir-025 | 10039-54-0在售 | Hydroxylamine sulfate |
优化Route 23步骤 6 · 总收率 85mg(Molnupiravir)
Molnupiravir-01965-46-3Molnupiravir-08485373-26-8,3258-02-4Molnupiravir-00397-72-3Molnupiravir-086—Molnupiravir-085—API · 莫诺拉韦
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Molnupiravir-019 | 65-46-3在售 | 1-(beta-D-Ribofuranosyl)cytosine<-fgf-> |
| Molnupiravir-084 | 85373-26-8,3258-02-4在售 | N4-Hydroxycytidine |
| Molnupiravir-003 | 97-72-3在售 | Isobutyric anhydride |
| Molnupiravir-086 | - | 5'-O-(2-Methylpropanoyl)-N-[(2-methylpropanoyl)oxy]cytidine |
| Molnupiravir-085 | - | N-[(2-Methylpropanoyl)oxy]cytidine |
常见问题（FAQ）
莫诺拉韦的适应症有哪些？
已批准的适应症包括：新型冠状病毒感染。
莫诺拉韦的专利什么时候到期？
莫诺拉韦的专利到期年暂无公开口径，本页会在数据管道核实后更新。
莫诺拉韦有几条合成路线？
本站收录 23 条合成路线，最短路线 1 步、总收率 76g(Molnupiravir-043)。每条路线的中间体均带登记编号与 CAS 号。
莫诺拉韦的关键中间体在哪里可以采购？
莫诺拉韦的多条路线中间体已挂接 CAS 档案，其中 41 个 CAS 已有优贝德（Unibest）供应网络在售报价，可在本页路线表中直接查看并询价。
如何获取莫诺拉韦中间体的报价？
在本页选择目标中间体的 CAS 进入档案页，或在询价页直接提交需求；CAS 会自动带入供需撮合流程，由供应网络反馈报价。
数据来源：多源数据交叉核实（仅结构化字段） · 2026-10-22