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CAS 1826-67-1
(Vinyl)magnesium bromidevinylmagnesium bromideVinylmagnesium bromide
登记编号：(VIII)101438-67-a、(VII)101438-68-a、DARU-032、Pilocarpine Nitrate-024、(IIb)955428-2-a、Molnupiravir-075、Astaxanthin-040
应用背景（按来源药适应症）
乳腺癌Paclitaxel/Encequidar mesylate腺癌Paclitaxel/Encequidar mesylate血管肉瘤Paclitaxel/Encequidar mesylate实体瘤Paclitaxel/Encequidar mesylateHIV感染乙醇达芦那韦/利托那韦HIV感染乙醇达芦那韦/考比司他青光眼盐酸普索洛尔/盐酸毛果芸香碱HIV感染乙醇达芦那韦胰腺癌紫杉醇非小细胞肺癌紫杉醇霍奇金病紫杉醇精原细胞瘤紫杉醇卵巢癌紫杉醇乳腺癌紫杉醇闭角型青光眼盐酸毛果芸香碱高眼压盐酸毛果芸香碱开角型青光眼盐酸毛果芸香碱瞳孔缩小盐酸毛果芸香碱Sjtoegren综合征盐酸毛果芸香碱虹膜炎盐酸毛果芸香碱外周T细胞淋巴瘤戈利昔替尼EB病毒感染戈利昔替尼病毒感染戈利昔替尼组织细胞增生戈利昔替尼噬血细胞性淋巴组织细胞增多症戈利昔替尼间质性肺疾病戈利昔替尼新型冠状病毒感染莫诺拉韦呼吸道合胞体病毒感染莫诺拉韦流感病毒感染莫诺拉韦肾功能不全莫诺拉韦肝功能衰退莫诺拉韦营养失调虾青素膝关节炎虾青素糖尿病神经病变虾青素中风虾青素
来源药（使用该中间体的合成路线）
| 品种 | 梯队 | 到期年 |
|---|---|---|
| Paclitaxel/Encequidar mesylate | Tier C · 观察 / 贸易 | - |
| 乙醇达芦那韦/利托那韦Darunavir Ethanolate/Ritonavir | Tier C · 观察 / 贸易 | - |
| 乙醇达芦那韦/考比司他Darunavir Ethanolate/Cobicistat | Tier C · 观察 / 贸易 | - |
| 盐酸普索洛尔/盐酸毛果芸香碱Proxodolol hydrochloride/Pilocarpine Hydrochloride | Tier C · 观察 / 贸易 | - |
| 乙醇达芦那韦Darunavir Ethanolate | Tier B · 提前布局 | - |
| 紫杉醇Paclitaxel | Tier B · 提前布局 | - |
| 盐酸毛果芸香碱Pilocarpine Hydrochloride | Tier C · 观察 / 贸易 | - |
| 戈利昔替尼Golidocitinib | Tier C · 观察 / 贸易 | - |
| 莫诺拉韦Molnupiravir | Tier B · 提前布局 | - |
| 虾青素Astaxanthin | Tier C · 观察 / 贸易 | - |
合成路线中的位置（上下游链）
按路线登记顺序排列，左→右为合成方向；高亮为当前 CAS，其余可点击跳转对应档案。
3-Methyl-2-butenal→2-Bromo-3-methylbut-2-enal→(Trimethylsilyl)methyl chloride→3-Bromo-4-methyl-1-(trimethylsilyl)pent-3-en-2-ol→1-[6-(3-Bromo-4-methylpent-3-en-1-yl)-2-chlorocyclohex-1-en-1-yl]prop-2-en-1-ol→3-Bromo-4-methylpenta-1,3-diene→3-Methyl-2-cyclohexen-1-one→6-(3-Bromo-4-methylpent-3-en-1-yl)-2-chlorocyclohex-1-ene-1-carbaldehyde→(Vinyl)magnesium bromide→2-Isopropenyl-4,4,5,5-tetramethyl-1,3,2-dioxaborolane→1-[2-Chloro-6-[4-methyl-3-(prop-1-en-2-yl)pent-3-en-1-yl]cyclohex-1-en-1-yl]prop-2-en-1-ol→1-[2-Chloro-6-[4-methyl-3-(prop-1-en-2-yl)pent-3-en-1-yl]cyclohex-1-en-1-yl]prop-2-en-1-one→(12aS)-4-Chloro-9,12a,13,13-tetramethyl-2,3,6,7,8,11,12,12a-octahydro-6,10-methanobenzo[10]annulen-5(1H)-one
(3S,4aR,6R,11S,12aS)-3-Bromo-9,12a,13,13-tetramethyl-11-[(triethylsilyl)oxy]-2,3,4a,6,7,11,12,12a-octahydro-6,10-methanobenzo[10]annulene-4,5,8(1H)-trione→(3S,4aR,6R,12aR)-3-Bromo-9,12a,13,13-tetramethyl-2,3,4a,6,7,11,12,12a-octahydro-6,10-methanobenzo[10]annulene-4,5,8(1H)-trione→(4aS,6R,11S,12aS)-9,12a,13,13-Tetramethyl-11-[(triethylsilyl)oxy]-4a,6,7,11,12,12a-hexahydro-6,10-methanobenzo[10]annulene-4,5,8(1H)-trione→(4aS,6R,12aS)-9,12a,13,13-Tetramethyl-2,3,4a,6,7,11,12,12a-octahydro-6,10-methanobenzo[10]annulene-4,5,8(1H)-trione→1,1-Dibromo-2,2,3,3-tetramethylcyclopropane→(4aS,6R,12aS)-9,12a,13,13-Tetramethyl-2,3,6,7,8,11,12,12a-octahydro-6,10-methanobenzo[10]annulene-4,5(1H,4aH)-dione→(Vinyl)magnesium bromide→1,1,2,2-Tetramethylethylene→2-Hydroxy-2-methylbutanoic acid→2-Propen-1-one→3-(3-Isopropenyl-4-methyl-3-pentenyl)-2-cyclohexen-1-one→3-Bromo-2,4-dimethylpenta-1,3-diene→3-Ethenylcyclohex-2-en-1-one→3-Ethoxy-2-cyclohexen-1-one→Aluminum trimethanide→Methylmagnesium bromide→Bromoform→Trimethyl([(3S)-3-methyl-3-[4-methyl-3-(prop-1-en-2-yl)pent-3-en-1-yl]cyclohex-1-en-1-yl]oxy)silane→(2beta,4alpha,10beta,13alpha)-10-[(Triethylsilyl)oxy](2-~2~H)taxa-5,11-diene-2,4,13-triol→(2S,3S)-2,3-Dimethyl-3-[4-methyl-3-(prop-1-en-2-yl)pent-3-en-1-yl]-2-(prop-2-enoyl)cyclohexan-1-one→(2S,3S)-3-Methyl-3-[4-methyl-3-(prop-1-en-2-yl)pent-3-en-1-yl]-2-(prop-2-enoyl)cyclohexan-1-one
(2R,3S)-3-iodo-2-(prop-2-yn-1-yloxy)tetrahydrofuran→(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol→bis(2,5-dioxopyrrolidin-1-yl) carbonate→2,5-dioxopyrrolidin-1-yl ((3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl) carbonate→4-amino-N-((2R,3S)-3-amino-2-hydroxy-4-phenylbutyl)-N-isobutylbenzenesulfonamide→2-(benzyloxy)acetaldehyde→vinylmagnesium bromide→1-(benzyloxy)but-3-en-2-ol→prop-1-en-2-yl acetate→(S)-1-(benzyloxy)but-3-en-2-ol→acryloyl chloride→(S)-1-(benzyloxy)but-3-en-2-yl acrylate→(S)-5-((benzyloxy)methyl)furan-2(5H)-one→1,3-dioxolane→(4S,5S)-5-((benzyloxy)methyl)-4-(1,3-dioxolan-2-yl)dihydrofuran-2(3H)-one→(4S,5S)-4-(1,3-dioxolan-2-yl)-5-(hydroxymethyl)dihydrofuran-2(3H)-one→(3S,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol
(2R,3S)-3-iodo-2-(prop-2-yn-1-yloxy)tetrahydrofuran→(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol→bis(2,5-dioxopyrrolidin-1-yl) carbonate→2,5-dioxopyrrolidin-1-yl ((3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl) carbonate→4-amino-N-((2R,3S)-3-amino-2-hydroxy-4-phenylbutyl)-N-isobutylbenzenesulfonamide→2-(benzyloxy)acetaldehyde→vinylmagnesium bromide→1-(benzyloxy)but-3-en-2-ol→prop-1-en-2-yl acetate→(S)-1-(benzyloxy)but-3-en-2-ol→acryloyl chloride→(S)-1-(benzyloxy)but-3-en-2-yl acrylate→(S)-5-((benzyloxy)methyl)furan-2(5H)-one→1,3-dioxolane→(4S,5S)-5-((benzyloxy)methyl)-4-(1,3-dioxolan-2-yl)dihydrofuran-2(3H)-one→(4S,5S)-4-(1,3-dioxolan-2-yl)-5-(hydroxymethyl)dihydrofuran-2(3H)-one→(3S,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol
2-(2,2-Dimethoxyethyl)propane-1,3-diol→2-[(Acetyloxy)methyl]-4,4-dimethoxybutyl acetate→(2R)-2-(Hydroxymethyl)-4,4-dimethoxybutyl acetate→(2S)-2-Formyl-4,4-dimethoxybutyl acetate→Vinylmagnesium bromide→(2S)-2-(2,2-Dimethoxyethyl)pent-4-ene-1,3-diol→(5S)-5-(2,2-Dimethoxyethyl)-4-ethenyl-1,3-dioxan-2-one→(3R,4R)-4-(2,2-Dimethoxyethyl)-3-ethenyldihydrofuran-2(3H)-one→[(3R,4R)-4-Ethenyl-5-oxotetrahydrofuran-3-yl]acetaldehyde→Methylamine→(4R)-3-Ethylidene-4-[(2E)-2-(methylimino)ethyl]dihydrofuran-2(3H)-one→(3E,4R)-3-Ethylidene-4-[(1-methyl-1H-imidazol-5-yl)methyl]dihydrofuran-2(3H)-one
本站可供应的对应中间体
同 CAS 多家在售供应横向对比；价格区间为供应方挂牌口径，实价以询价确认为准。
| 供应商 | 产品 | 价格区间 | 最小起订 | 货期 | 资质 | 操作 |
|---|---|---|---|---|---|---|
| Unibest Taizhou GMP-like Site | ((3aR,4R,6R,6aR)-6-(4-(hydroxyamino)-2-oxopyrimidin-1(2H)-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl isobutyrate Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
本页为中间体 CAS 注册档案：同 CAS 的多条路线登记已合并；后续供应商报价与买方需求以该 CAS 为主键撮合。