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CAS 1034305-11-7
benzo[b]thiophen-2-yl(5-bromo-2-fluorophenyl)methanol
登记编号：IPRA-003
应用背景（按来源药适应症）
二型糖尿病磷酸西格列汀一水合物/伊格列净L-脯氨酸盐二型糖尿病伊格列净L-脯氨酸盐一型糖尿病伊格列净L-脯氨酸盐糖尿病伊格列净L-脯氨酸盐肝脏疾病伊格列净L-脯氨酸盐
来源药（使用该中间体的合成路线）
| 品种 | 梯队 | 到期年 |
|---|---|---|
| 磷酸西格列汀一水合物/伊格列净L-脯氨酸盐Sitagliptin Phosphate Monohydrate/Ipragliflozin L-Proline | Tier C · 观察 / 贸易 | - |
| 伊格列净L-脯氨酸盐Ipragliflozin L-Proline | Tier C · 观察 / 贸易 | - |
合成路线中的位置（上下游链）
按路线登记顺序排列，左→右为合成方向；高亮为当前 CAS，其余可点击跳转对应档案。
5-bromo-2-fluorobenzaldehyde→benzo[b]thiophene→benzo[b]thiophen-2-yl(5-bromo-2-fluorophenyl)methanol→(benzo[b]thiophen-2-yl(5-bromo-2-fluorophenyl)methoxy)(tert-butyl)dimethylsilane→(3R,4S,5R,6R)-3,4,5-tris(benzyloxy)-6-((benzyloxy)methyl)tetrahydro-2H-pyran-2-one→(3R,4S,5R,6R)-2-(3-(benzo[b]thiophen-2-yl((tert-butyldimethylsilyl)oxy)methyl)-4-fluorophenyl)-3,4,5-tris(benzyloxy)-6-((benzyloxy)methyl)tetrahydro-2H-pyran-2-ol→(3R,4S,5R,6R)-2-(3-(benzo[b]thiophen-2-yl(hydroxy)methyl)-4-fluorophenyl)-3,4,5-tris(benzyloxy)-6-((benzyloxy)methyl)tetrahydro-2H-pyran-2-ol→(2S,3S,4R,5R,6R)-2-(3-(benzo[b]thiophen-2-ylmethyl)-4-fluorophenyl)-3,4,5-tris(benzyloxy)-6-((benzyloxy)methyl)tetrahydro-2H-pyran
5-bromo-2-fluorobenzaldehyde→benzo[b]thiophene→benzo[b]thiophen-2-yl(5-bromo-2-fluorophenyl)methanol→(3R,4S,5R,6R)-3,4,5-tris(benzyloxy)-6-((benzyloxy)methyl)tetrahydro-2H-pyran-2-one→(2S,3S,4R,5R,6R)-2-(3-(benzo[b]thiophen-2-ylmethyl)-4-fluorophenyl)-3,4,5-tris(benzyloxy)-6-((benzyloxy)methyl)tetrahydro-2H-pyran→2-(5-bromo-2-fluorobenzyl)benzo[b]thiophene→(3R,4S,5R,6R)-2-(3-(benzo[b]thiophen-2-ylmethyl)-4-fluorophenyl)-3,4,5-tris(benzyloxy)-6-((benzyloxy)methyl)tetrahydro-2H-pyran-2-ol
5-bromo-2-fluorobenzaldehyde→benzo[b]thiophene→benzo[b]thiophen-2-yl(5-bromo-2-fluorophenyl)methanol→2-(5-bromo-2-fluorobenzyl)benzo[b]thiophene→2-((5-bromo-2-fluorophenyl)chloromethyl)benzo[b]thiophene→(3R,4S,5R,6R)-3,4,5-tris((trimethylsilyl)oxy)-6-(((trimethylsilyl)oxy)methyl)tetrahydro-2H-pyran-2-one→(2S,3R,4S,5S,6R)-2-(3-(benzo[b]thiophen-2-ylmethyl)-4-fluorophenyl)-6-(hydroxymethyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triol→(2S,3R,4S,5R,6R)-6-(acetoxymethyl)-2-(3-(benzo[b]thiophen-2-ylmethyl)-4-fluorophenyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triyl triacetate→(2R,3R,4R,5S,6S)-2-(acetoxymethyl)-6-(3-(benzo[b]thiophen-2-ylmethyl)-4-fluorophenyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate→(S)-pyrrolidine-2-carboxylic acid
5-bromo-2-fluorobenzaldehyde→benzo[b]thiophene→benzo[b]thiophen-2-yl(5-bromo-2-fluorophenyl)methanol→(benzo[b]thiophen-2-yl(5-bromo-2-fluorophenyl)methoxy)(tert-butyl)dimethylsilane→(3R,4S,5R,6R)-3,4,5-tris(benzyloxy)-6-((benzyloxy)methyl)tetrahydro-2H-pyran-2-one→(3R,4S,5R,6R)-2-(3-(benzo[b]thiophen-2-yl((tert-butyldimethylsilyl)oxy)methyl)-4-fluorophenyl)-3,4,5-tris(benzyloxy)-6-((benzyloxy)methyl)tetrahydro-2H-pyran-2-ol→(3R,4S,5R,6R)-2-(3-(benzo[b]thiophen-2-yl(hydroxy)methyl)-4-fluorophenyl)-3,4,5-tris(benzyloxy)-6-((benzyloxy)methyl)tetrahydro-2H-pyran-2-ol→(2S,3S,4R,5R,6R)-2-(3-(benzo[b]thiophen-2-ylmethyl)-4-fluorophenyl)-3,4,5-tris(benzyloxy)-6-((benzyloxy)methyl)tetrahydro-2H-pyran
5-bromo-2-fluorobenzaldehyde→benzo[b]thiophene→benzo[b]thiophen-2-yl(5-bromo-2-fluorophenyl)methanol→(3R,4S,5R,6R)-3,4,5-tris(benzyloxy)-6-((benzyloxy)methyl)tetrahydro-2H-pyran-2-one→(2S,3S,4R,5R,6R)-2-(3-(benzo[b]thiophen-2-ylmethyl)-4-fluorophenyl)-3,4,5-tris(benzyloxy)-6-((benzyloxy)methyl)tetrahydro-2H-pyran→2-(5-bromo-2-fluorobenzyl)benzo[b]thiophene→(3R,4S,5R,6R)-2-(3-(benzo[b]thiophen-2-ylmethyl)-4-fluorophenyl)-3,4,5-tris(benzyloxy)-6-((benzyloxy)methyl)tetrahydro-2H-pyran-2-ol
本站可供应的对应中间体
同 CAS 多家在售供应横向对比；价格区间为供应方挂牌口径，实价以询价确认为准。
| 供应商 | 产品 | 价格区间 | 最小起订 | 货期 | 资质 | 操作 |
|---|---|---|---|---|---|---|
| Qualified Partner — East China API Works | Benzo[b]thiophen-2-yl(5-bromo-2-fluorophenyl)methano Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
本页为中间体 CAS 注册档案：同 CAS 的多条路线登记已合并；后续供应商报价与买方需求以该 CAS 为主键撮合。