CAS 106-94-5

1-bromopropane

登记编号：TICA-044、SOLIF-017、ROTI-037

应用背景（按来源药适应症）

中风替格瑞洛急性冠脉综合征替格瑞洛心肌梗塞替格瑞洛外周血管疾病替格瑞洛下尿路症状琥珀酸索利那新/盐酸坦洛新前列腺增生琥珀酸索利那新/盐酸坦洛新膀胱过度活动症琥珀酸索利那新/盐酸坦洛新药物相关的副作用和不良反应琥珀酸索利那新/盐酸坦洛新膀胱颈梗阻琥珀酸索利那新/盐酸坦洛新不宁腿综合征罗替高汀帕金森病罗替高汀物质相关性障碍罗替高汀药物相关的副作用和不良反应罗替高汀组织粘连罗替高汀术后疼痛罗替高汀膀胱过度活动症琥珀酸索利那新急迫性尿失禁琥珀酸索利那新泌尿系疾病琥珀酸索利那新

来源药（使用该中间体的合成路线）

品种	梯队	到期年
替格瑞洛Ticagrelor	Tier B · 提前布局	2029
琥珀酸索利那新/盐酸坦洛新Solifenacin Succinate/Tamsulosin Hydrochloride	Tier C · 观察 / 贸易	-
罗替高汀Rotigotine	Tier C · 观察 / 贸易	-
琥珀酸索利那新Solifenacin Succinate	Tier B · 提前布局	-

合成路线中的位置（上下游链）

按路线登记顺序排列，左→右为合成方向；高亮为当前 CAS，其余可点击跳转对应档案。

替格瑞洛优化路线步数：5总收率：192 mg

4,6-dichloro-2-(propylthio)pyrimidin-5-amine→diethyl 2-acetamidomalonate→thiourea→sodium 5-acetamido-4,6-dihydroxypyrimidine-2-thiolate→N-(4,6-dihydroxy-2-mercaptopyrimidin-5-yl)acetamide→1-bromopropane→N-(4,6-dihydroxy-2-(propylthio)pyrimidin-5-yl)acetamide→5-amino-2-(propylthio)pyrimidine-4,6-diol hydrochloride

琥珀酸索利那新/盐酸坦洛新优化路线步数：2总收率：1.1 g

(S)-1-phenyl-1,2,3,4-tetrahydroisoquinoline→(R)-quinuclidin-3-ol→1-bromopropane→propyl (S)-1-phenyl-3,4-dihydroisoquinoline-2(1H)-carboxylate

罗替高汀优化路线步数：4总收率：79.8 g

5-methoxy-1,2,3,4-tetrahydronaphthalen-2-amine→(S)-5-methoxy-1,2,3,4-tetrahydronaphthalen-2-amine→(S)-5-methoxy-N-propyl-1,2,3,4-tetrahydronaphthalen-2-amine→1-bromopropane→2-(2-bromoethyl)thiophene→(S)-5-methoxy-N-propyl-N-(2-(thiophen-2-yl)ethyl)-1,2,3,4-tetrahydronaphthalen-2-amine

琥珀酸索利那新优化路线步数：2总收率：1.1 g

(S)-1-phenyl-1,2,3,4-tetrahydroisoquinoline→(R)-quinuclidin-3-ol→1-bromopropane→propyl (S)-1-phenyl-3,4-dihydroisoquinoline-2(1H)-carboxylate

本站可供应的对应中间体

同 CAS 多家在售供应横向对比；价格区间为供应方挂牌口径，实价以询价确认为准。

供应商	产品	价格区间	最小起订	货期	资质
Qualified Partner — East China API Works	5-Methoxy-2-tetralone Pharmaceutical Intermediates	询价	询价	询价	—
Unibest Nantong cGMP Site	(S)-2-AMINO-5-METHOXYTETRALIN HYDROCHLORIDE Pharmaceutical Intermediates	询价	询价	询价	—
Unibest Taizhou GMP-like Site	(S)-2-Amino-5-methoxytetralin Hydrochloride Pharmaceutical Intermediates	询价	询价	询价	—
Qualified Partner — East China API Works	(S)-1,2,3,4-Tetrahydro-5-methoxy-N-propyl-2-naphthalenamine hydrochloride Pharmaceutical Intermediates	询价	询价	询价	—
Unibest Nantong cGMP Site	(S)-2-Amino-5-methoxytetralin (S)-mandelate Pharmaceutical Intermediates	询价	询价	询价	—
Qualified Partner — East China API Works	4,6-Dichloro-2-(propylthio)pyrimidin -5-amine Pharmaceutical Intermediates	询价	询价	询价	—
Unibest Nantong cGMP Site	2-((3aR,4S,6R,6aS)-6-amino-2,2-dimethyltetrahydro -3aH-cyclopenta[d][1,3]dioxol -4-yloxy)ethanol L-tataric acid Pharmaceutical Intermediates	询价	询价	询价	—
Unibest Taizhou GMP-like Site	(1R,2S)-2-(3,4-Difluorophenyl)cyclopropanaminium(2R)hydroxy(phenyl)ethanoate Pharmaceutical Intermediates	询价	询价	询价	—
Qualified Partner — East China API Works	Ethanol, 2-[[(3aR,4S,6R,6aS)-6-[[5-aMino-6-chloro-2-(propylthio)-4-pyriMidinyl]aMino]tetrahydro-2,2-diMethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]- Pharmaceutical Intermediates	询价	询价	询价	—
Unibest Nantong cGMP Site	(1R,2S)-2-(3,4-difluorophenyl)cyclopropanamine hydrochloride Pharmaceutical Intermediates	询价	询价	询价	—
Unibest Taizhou GMP-like Site	Cyclopropanamine,2-(3,4-difluorophenyl)-(1R,2S) -(2R,3R)-2,3-dihydroxybutanedioate (1:1) Pharmaceutical Intermediates	询价	询价	询价	—
Qualified Partner — East China API Works	2-[[(3aS,4R,6S,6aR)-4-[7-[[(1R,2S)-2-(3,4-Difluorophenyl)cyclopropyl]amino]-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl]-2,2-dimethyl-tetrahydro-3aH-cyclopenta[d][1,3]dioxol-6-yl]oxy]ethanol Pharmaceutical Intermediates	询价	询价	询价	—

本页为中间体 CAS 注册档案：同 CAS 的多条路线登记已合并；后续供应商报价与买方需求以该 CAS 为主键撮合。