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CAS 106-95-6
3-bromoprop-1-ene1-Bromo-2-propene
登记编号：MRIO-001、MRIO-002、Atorvastatin-157、METOPR-011、DOLU-016、LEVO-021、PRUC-025、IXAB-054、PACR-005、TREP-032、ERTA-002、EPTI-061
应用背景（按来源药适应症）
糖尿病神经病变苯磺酸美洛加巴林疱疹后神经痛苯磺酸美洛加巴林周围神经系统疾病苯磺酸美洛加巴林心脏和血管疾病阿托伐他汀/氢氯噻嗪/阿司匹林/依那普利高血压阿托伐他汀/氢氯噻嗪/阿司匹林/依那普利高脂血症阿托伐他汀/氢氯噻嗪/阿司匹林/依那普利心脏病阿托伐他汀/氢氯噻嗪/阿司匹林/依那普利心绞痛盐酸伊伐布雷定/酒石酸美托洛尔HIV感染多替拉韦钠分娩多替拉韦钠结核分枝杆菌感染多替拉韦钠肝炎多替拉韦钠疱疹病毒感染多替拉韦钠肝功能衰退多替拉韦钠重度抑郁症盐酸左米那普仑缺血性卒中盐酸左米那普仑抑郁盐酸左米那普仑便秘琥珀酸普芦卡必利术后并发症琥珀酸普芦卡必利肠内喂养不耐受琥珀酸普芦卡必利阿片类药物引起的便秘琥珀酸普芦卡必利疼痛琥珀酸普芦卡必利假性肠梗阻琥珀酸普芦卡必利高脂血症阿托伐他汀锶蛛网膜下腔出血阿托伐他汀锶高血压阿托伐他汀锶乳腺癌伊沙匹隆转移性乳腺癌伊沙匹隆宫颈癌伊沙匹隆前列腺癌伊沙匹隆实体瘤伊沙匹隆中性粒细胞减少伊沙匹隆高血压琥珀酸美托洛尔心绞痛琥珀酸美托洛尔心脏衰竭琥珀酸美托洛尔甲状腺功能亢进症琥珀酸美托洛尔心律失常琥珀酸美托洛尔心脏神经官能症琥珀酸美托洛尔骨髓纤维化枸橼酸帕克替尼血小板减少枸橼酸帕克替尼急性髓细胞样白血病枸橼酸帕克替尼原发性血小板增多症枸橼酸帕克替尼真性红细胞增多症枸橼酸帕克替尼慢性骨髓单核细胞性白血病枸橼酸帕克替尼间质性肺疾病曲前列尼尔肺性高血压曲前列尼尔肺动脉高压曲前列尼尔特发性肺纤维化曲前列尼尔肺纤维化曲前列尼尔特发性肺动脉高压曲前列尼尔复杂皮肤和皮肤结构感染厄他培南钠腹腔感染厄他培南钠菌血症厄他培南钠泌尿系统感染厄他培南钠社区获得性肺炎厄他培南钠肾盂肾炎厄他培南钠不稳定型心绞痛依替巴肽心肌梗塞依替巴肽缺血性卒中依替巴肽急性冠脉综合征依替巴肽镰状细胞血症依替巴肽ST段抬高型心肌梗死依替巴肽
来源药（使用该中间体的合成路线）
| 品种 | 梯队 | 到期年 |
|---|---|---|
| 苯磺酸美洛加巴林Mirogabalin besilate | Tier C · 观察 / 贸易 | 2030 |
| 阿托伐他汀/氢氯噻嗪/阿司匹林/依那普利Atorvastatin/Hydrochlorothiazide/Aspirin/Enalapril | Tier C · 观察 / 贸易 | - |
| 盐酸伊伐布雷定/酒石酸美托洛尔Ivabradine Hydrochloride/Metoprolol Tartrate | Tier C · 观察 / 贸易 | - |
| 多替拉韦钠Dolutegravir Sodium | Tier B · 提前布局 | - |
| 盐酸左米那普仑Levomilnacipran Hydrochloride | Tier C · 观察 / 贸易 | - |
| 琥珀酸普芦卡必利Prucalopride Succinate | Tier C · 观察 / 贸易 | - |
| 阿托伐他汀锶Atorvastatin strontium | Tier C · 观察 / 贸易 | - |
| 伊沙匹隆Ixabepilone | Tier C · 观察 / 贸易 | - |
| 琥珀酸美托洛尔Metoprolol Succinate | Tier C · 观察 / 贸易 | - |
| 枸橼酸帕克替尼Pacritinib Citrate | Tier C · 观察 / 贸易 | - |
| 曲前列尼尔Treprostinil | Tier B · 提前布局 | - |
| 厄他培南钠Ertapenem Sodium | Tier C · 观察 / 贸易 | - |
| 依替巴肽Eptifibatide | Tier C · 观察 / 贸易 | - |
合成路线中的位置（上下游链）
按路线登记顺序排列，左→右为合成方向；高亮为当前 CAS，其余可点击跳转对应档案。
3-bromoprop-1-ene→3-bromoprop-1-ene→ethyl 4-ethyl-3-hydroxyhept-6-enoate→4-ethyl-3-hydroxyhept-6-enoic acid→tert-butyl 2-(dimethoxyphosphoryl)acetate→(E)-tert-butyl 2-(3-ethylbicyclo[3.2.0]hept-3-en-6-ylidene)acetate→tert-butyl 2-(3-ethyl-6-(nitromethyl)bicyclo[3.2.0]hept-3-en-6-yl)acetate→tert-butyl 2-((1R,5S,6S)-3-ethyl-6-(nitromethyl)bicyclo[3.2.0]hept-3-en-6-yl)acetate→tert-butyl 2-((1R,5S,6S)-6-(((tert-butoxycarbonyl)amino)methyl)-3-ethylbicyclo[3.2.0]hept-3-en-6-yl)acetate
1,1-Dimethylethyl cyanoacetate→1-Bromo-2-propene→tert-Butyl 3-oxohex-5-enoate→tert-Butyl (3R)-3-hydroxyhex-5-enoate→tert-Butyl [(4R,6S)-6-(bromomethyl)-2-oxo-1,3-dioxan-4-yl]acetate→[(4S,6R)-6-[2-(tert-Butoxy)-2-oxoethyl]-2,2-dimethyl-1,3-dioxan-4-yl]methyl acetate→(4R,6S)-6-Hydroxymethyl-2,2-dimethyl-1,3-dioxane-4-acetic Acid 1,1-dimethylethyl ester
3-hydroxy-2-methyl-4H-pyran-4-one→3-(benzyloxy)-2-methyl-4H-pyran-4-one→3-(benzyloxy)-2-methylpyridin-4(1H)-one→3-(benzyloxy)-5-bromo-2-methylpyridin-4-ol→methyl 5-(benzyloxy)-4-hydroxy-6-methylnicotinate→methyl 4-acetoxy-5-(benzyloxy)-6-methylnicotinate→4-acetoxy-3-(benzyloxy)-5-(methoxycarbonyl)-2-methylpyridine 1-oxide→methyl 4-acetoxy-6-(acetoxymethyl)-5-(benzyloxy)nicotinate→6-(acetoxymethyl)-5-(benzyloxy)-4-oxo-1,4-dihydropyridine-3-carboxylic acid→(2,4-difluorophenyl)methanamine→5-(benzyloxy)-N-(2,4-difluorobenzyl)-6-(hydroxymethyl)-4-oxo-1,4-dihydropyridine-3-carboxamide→5-(benzyloxy)-N-(2,4-difluorobenzyl)-6-formyl-4-oxo-1,4-dihydropyridine-3-carboxamide→3-(benzyloxy)-5-((2,4-difluorobenzyl)carbamoyl)-4-oxo-1,4-dihydropyridine-2-carboxylic acid→methyl 3-(benzyloxy)-5-((2,4-difluorobenzyl)carbamoyl)-4-oxo-1,4-dihydropyridine-2-carboxylate→methyl 3-(benzyloxy)-5-((2,4-difluorobenzyl)carbamoyl)-4-oxo-1,4-dihydropyridine-2-carboxylate→3-bromoprop-1-ene→methyl 1-allyl-3-(benzyloxy)-5-((2,4-difluorobenzyl)carbamoyl)-4-oxo-1,4-dihydropyridine-2-carboxylate→methyl 3-(benzyloxy)-5-((2,4-difluorobenzyl)carbamoyl)-4-oxo-1-(2-oxoethyl)-1,4-dihydropyridine-2-carboxylate→(R)-3-aminobutan-1-ol→(4R,12aS)-7-(benzyloxy)-N-(2,4-difluorobenzyl)-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide
本站可供应的对应中间体
同 CAS 多家在售供应横向对比；价格区间为供应方挂牌口径，实价以询价确认为准。
| 供应商 | 产品 | 价格区间 | 最小起订 | 货期 | 资质 | 操作 |
|---|---|---|---|---|---|---|
| Qualified Partner — East China API Works | (1R,5S)-3-ethyl-Bicyclo[3.2.0]hept-3-en-6-one Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Unibest Nantong cGMP Site | 3-ethylbicyclo[3.2.0]hept-3-en-6-one Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Qualified Partner — East China API Works | (1R,2R,3aS,9aS)-2,3,3a,4,9,9a-Hexahydro-1-[(3S)-3-hydroxyoctyl]-1H-benz[f]indene-2,5-diol Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Unibest Nantong cGMP Site | 1-broMo-5-fluoro-2-Methyl-3-nitrobenzene Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Unibest Taizhou GMP-like Site | methyl 4-cyclopropyl-2-fluorobenzoate Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Qualified Partner — East China API Works | tert-butyl 2-(4-amino-6-chloropyrimidin-5-yloxy)ethylmethylcarbamate Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Unibest Nantong cGMP Site | 2H-Benz[f]inden-2-one, 9-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3,3a,4,9-tetrahydro-5-methoxy-1-[(3S)-3-[(tetrahydro-2H-pyran-2-yl)oxy]octyl]-, (3aS,9R)- Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Unibest Taizhou GMP-like Site | 2-allyl-3-methoxybenzaldehyde Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Qualified Partner — East China API Works | (5S)-1-Decyn-5-ol Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
本页为中间体 CAS 注册档案：同 CAS 的多条路线登记已合并；后续供应商报价与买方需求以该 CAS 为主键撮合。