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阿托伐他汀/氢氯噻嗪/阿司匹林/依那普利
Tier C · 观察 / 贸易Atorvastatin/Hydrochlorothiazide/Aspirin/Enalapril
Alborz Darou Pharmaceutical
原研
2018
首批上市
-
到期年（公开口径）
无销量数据
峰值销售
化学药
类型
靶点：Thiazide-sensitive sodium-chloride cotransporter、ACE、HMGCR、COXs
商品名：Polypill-E、PolyPill 4-1
适应症（已批准）：心脏和血管疾病
各地区研发/上市状态
美国
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欧盟
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中国
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日本
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生产该 API 的工厂11
口径：平台供应网络（富通询价明细 + 产品主档）中登记生产该品种的工厂（在产口径），按报价活跃度排序；快照不含成本与客户信息。
已收录 11 家在产工厂名单，登录后可见（工厂信息不对未登录访客展示）。
登录查看工厂名单 →合成路线与中间体34 routes
原研路线 × 0优化路线（非专利）× 34工艺路线 × 0
路线按「原研路线 → 优化路线 / 工艺路线（非专利）」排序。每条路线附本站自绘的路线流程图（中间体 → 原料药）与中间体表（编号 / CAS / 英文名），可直接用于供应商开发与询价。流程图由本站依据已授权的结构化数据自行渲染，未使用任何第三方路线图。
优化Route 1步骤 1 · 总收率 /
Enalapril-00164920-29-2Enalapril-00213485-59-1API · 阿托伐他汀/氢氯噻嗪/阿司匹林/依那普利
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Enalapril-001 | 64920-29-2 | Ethyl 2-oxo-4-phenylbutyrate |
| Enalapril-002 | 13485-59-1 | L-Alanyl-L-proline |
优化Route 2步骤 2 · 总收率 4.2g(Enalapril)
Enalapril-00382717-96-2Enalapril-004147-85-3Enalapril-00575847-73-3Enalapril-006110-17-8API · 阿托伐他汀/氢氯噻嗪/阿司匹林/依那普利
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Enalapril-003 | 82717-96-2 | N-[1-Ethoxy-1-oxo-4-phenylbutan-2(S)-yl]-L-alanine |
| Enalapril-004 | 147-85-3 | (-)-L-Proline<-fgf->L-Proline |
| Enalapril-005 | 75847-73-3 | (S)-1-[N-[1-(Ethoxycarbonyl)-3-phenylpropyl]-L-alanyl]-L-proline |
| Enalapril-006 | 110-17-8在售 | trans-2-Butenedioic acid |
优化Route 3步骤 9 · 总收率 /
Enalapril-00753279-92-8Enalapril-008120999-41-9Enalapril-009138566-24-2Enalapril-010—Enalapril-0111142-20-7Enalapril-01290315-82-5Enalapril-01388767-98-0Enalapril-01429375-30-2Enalapril-015108428-39-3Enalapril-0162812-46-6Enalapril-01727544-35-0API · 阿托伐他汀/氢氯噻嗪/阿司匹林/依那普利
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Enalapril-007 | 53279-92-8 | 2-Hydroxy-4-phenylbutanenitrile |
| Enalapril-008 | 120999-41-9 | 2(R)-Hydroxy-4-phenylbutanenitrile |
| Enalapril-009 | 138566-24-2 | 4-Phenyl-2(R)-(tetrahydropyran-2-yloxy)butanenitrile |
| Enalapril-010 | - | 4-Phenyl-2(R)-(tetrahydropyran-2-yloxy)butyric acid |
| Enalapril-011 | 1142-20-7 | N-[(Benzyloxy)carbonyl]-L-alanine |
| Enalapril-012 | 90315-82-5 | Ethyl (R)-(-)-2-hydroxy-4-phenylbutyrate |
| Enalapril-013 | 88767-98-0 | 4-Phenyl-2(R)-(trifluoromethylsulfonyloxy)butyric acid ethyl ester |
| Enalapril-014 | 29375-30-2 | L-Alanyl-L-proline tert-butyl ester |
| Enalapril-015 | 108428-39-3 | N-[1-Ethoxy-1-oxo-4-phenylbutan-2(S)-yl]-L-alanyl-L-proline tert-butyl ester |
| Enalapril-016 | 2812-46-6 | N-Boc-proline |
| Enalapril-017 | 27544-35-0 | N-(Benzyloxycarbonyl)-L-alanyl-L-proline tert-butyl ester |
优化Route 4步骤 4 · 总收率 4.11g(Enalapril)
Enalapril-01880828-26-8Enalapril-019103377-40-8Enalapril-02016652-71-4Enalapril-021120924-94-9Enalapril-00382717-96-2API · 阿托伐他汀/氢氯噻嗪/阿司匹林/依那普利
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Enalapril-018 | 80828-26-8 | N-[(2S)-1-Ethoxy-1-oxo-4-phenylbutan-2-yl]-L-alanine hydrochloride |
| Enalapril-019 | 103377-40-8 | Ethyl (2S)-2-[[(2S)-1-chloro-1-oxopropan-2-yl]amino]-4-phenylbutanoate |
| Enalapril-020 | 16652-71-4 | Benzyl L-prolinate hydrochloride |
| Enalapril-021 | 120924-94-9 | Benzyl N-[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]-L-alanyl-L-prolinate |
| Enalapril-003 | 82717-96-2 | N-[1-Ethoxy-1-oxo-4-phenylbutan-2(S)-yl]-L-alanine |
优化Route 5步骤 1 · 总收率 /
Enalapril-02288098-09-3Enalapril-00575847-73-3API · 阿托伐他汀/氢氯噻嗪/阿司匹林/依那普利
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Enalapril-022 | 88098-09-3 | N-[(2S)-1-Ethoxy-1,4-dioxo-4-phenylbutan-2-yl]-L-alanyl-L-proline |
| Enalapril-005 | 75847-73-3 | (S)-1-[N-[1-(Ethoxycarbonyl)-3-phenylpropyl]-L-alanyl]-L-proline |
优化Route 6步骤 6 · 总收率 174mg(Enalapril-033)
Enalapril-023103-63-9Enalapril-0243277-89-2Enalapril-02595-92-1Enalapril-02664920-29-2Enalapril-027108607-75-6Enalapril-02856-41-7Enalapril-029877932-98-4Enalapril-0306066-82-6Enalapril-031—Enalapril-032—Enalapril-033—API · 阿托伐他汀/氢氯噻嗪/阿司匹林/依那普利
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Enalapril-023 | 103-63-9 | (2-Bromoethyl)benzene |
| Enalapril-024 | 3277-89-2 | Bromido(2-phenylethyl)magnesium |
| Enalapril-025 | 95-92-1 | Oxalic acid diethyl diester |
| Enalapril-026 | 64920-29-2 | 2-Oxo-4-phenylbutyric acid ethyl ester |
| Enalapril-027 | 108607-75-6 | 4,5-Ditritium-L-proline |
| Enalapril-028 | 56-41-7 | L-Alanine |
| Enalapril-029 | 877932-98-4 | N-(1-Ethoxy-1-oxo-4-phenylbutan-2-yl)-L-alanine |
| Enalapril-030 | 6066-82-6 | N-Hydroxysuccinimide |
| Enalapril-031 | - | Ethyl 2-([(2S)-1-[(2,5-dioxopyrrolidin-1-yl)oxy]-1-oxopropan-2-yl]amino)-4-phenylbutanoate |
| Enalapril-032 | - | N-(1-Ethoxy-1-oxo-4-phenylbutan-2-yl)-L-alanyl-4,5-ditritium-L-proline |
| Enalapril-033 | - | (2Z)-But-2-enedioic acid N-[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]-L-alanyl-4,5-ditritium-L-proline |
优化Route 7步骤 11 · 总收率 /
Enalapril-03415186-48-8Enalapril-03510065-72-2Enalapril-0361411634-44-0Enalapril-03719810-31-2Enalapril-0381100-88-5Enalapril-039533931-02-1Enalapril-040533931-01-0Enalapril-041533931-03-2Enalapril-04216721-45-2Enalapril-043—Enalapril-044—Enalapril-04541324-66-7Enalapril-046533931-05-4Enalapril-047533931-06-5Enalapril-0481516-08-1,64-17-5Enalapril-00575847-73-3API · 阿托伐他汀/氢氯噻嗪/阿司匹林/依那普利
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Enalapril-034 | 15186-48-8在售 | 2,2-Dimethyl-1,3-dioxolane-4(R)-carbaldehyde |
| Enalapril-035 | 10065-72-2 | L-Alanine methyl ester |
| Enalapril-036 | 1411634-44-0 | Methyl (Z)-N-[[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]methylidene]-L-alaninate |
| Enalapril-037 | 19810-31-2 | Benzyloxyacetyl chloride |
| Enalapril-038 | 1100-88-5 | Triphenyl(phenylmethyl)phosphonium chloride |
| Enalapril-039 | 533931-02-1 | Methyl (2S)-2-[(2S,3R)-3-(benzyloxy)-2-[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]-4-oxoazetidin-1-yl]propanoate |
| Enalapril-040 | 533931-01-0 | Methyl (2S)-2-[(2S,3R)-3-(benzyloxy)-2-[(1S)-1,2-dihydroxyethyl]-4-oxoazetidin-1-yl]propanoate |
| Enalapril-041 | 533931-03-2 | Methyl (2S)-2-[(2R,3R)-3-(benzyloxy)-2-formyl-4-oxoazetidin-1-yl]propanoate |
| Enalapril-042 | 16721-45-2 | Benzylidene(triphenyl)-lambda5-phosphane |
| Enalapril-043 | - | Methyl (2S)-2-[(3R,4S)-3-(benzyloxy)-2-oxo-4-[(E)-2-phenylethenyl]azetidin-1-yl]propanoate |
| Enalapril-044 | - | (2S)-2-[(3R,4S)-3-Hydroxy-2-oxo-4-(2-phenylethyl)azetidin-1-yl]propanoic acid |
| Enalapril-045 | 41324-66-7 | Benzyl L-prolinate |
| Enalapril-046 | 533931-05-4 | Benzyl 1-[(2S)-2-[(3R,4S)-3-hydroxy-2-oxo-4-(2-phenylethyl)azetidin-1-yl]propanoyl]-L-prolinate |
| Enalapril-047 | 533931-06-5 | Benzyl 1-[(2S)-2-[(4S)-2,5-dioxo-4-(2-phenylethyl)-1,3-oxazolidin-3-yl]propanoyl]-L-prolinate |
| Enalapril-048 | 1516-08-1,64-17-5 | Ethyl alcohol |
| Enalapril-005 | 75847-73-3 | (S)-1-[N-[1-(Ethoxycarbonyl)-3-phenylpropyl]-L-alanyl]-L-proline |
优化Route 8步骤 4 · 总收率 3.28g(Enalapril-054)
Enalapril-049100-52-7Enalapril-050127-17-3Enalapril-051—Enalapril-052128573-54-6Enalapril-05329678-81-7Enalapril-05490315-82-5API · 阿托伐他汀/氢氯噻嗪/阿司匹林/依那普利
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Enalapril-049 | 100-52-7在售 | Bitter almond |
| Enalapril-050 | 127-17-3 | 2-Oxopropionic acid |
| Enalapril-051 | - | Potassium (3E)-2-oxo-4-phenylbut-3-enoate |
| Enalapril-052 | 128573-54-6 | (2R,3E)-2-Hydroxy-4-phenylbut-3-enoic acid |
| Enalapril-053 | 29678-81-7 | 2(R)-Hydroxy-4-phenylbutyric acid |
| Enalapril-054 | 90315-82-5 | Ethyl (R)-(-)-2-hydroxy-4-phenylbutyrate |
优化Route 9步骤 7 · 总收率 /
Enalapril-05517451-19-3Enalapril-05675-64-9Enalapril-05710017-37-5Enalapril-0581190946-81-6Enalapril-059586396-58-9Enalapril-060586396-61-4Enalapril-061115016-95-0Enalapril-062125639-64-7Enalapril-049100-52-7Enalapril-050127-17-3Enalapril-0481516-08-1,64-17-5API · 阿托伐他汀/氢氯噻嗪/阿司匹林/依那普利
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Enalapril-055 | 17451-19-3 | (3E)-2-Oxo-4-phenylbut-3-enoic acid |
| Enalapril-056 | 75-64-9在售 | 2-Methylpropan-2-amine |
| Enalapril-057 | 10017-37-5 | 2-Methylpropan-2-amine hydrogen chloride |
| Enalapril-058 | 1190946-81-6 | 3(E)-N-(tert-Butyl)-2-oxo-4-phenylbutenamide |
| Enalapril-059 | 586396-58-9 | (2S,3E)-N-tert-Butyl-2-hydroxy-4-phenylbut-3-enamide |
| Enalapril-060 | 586396-61-4 | (2S)-N-tert-Butyl-2-hydroxy-4-phenylbutanamide |
| Enalapril-061 | 115016-95-0 | (2S)-2-Hydroxy-4-phenylbutanoic acid |
| Enalapril-062 | 125639-64-7 | Ethyl 2(S)-hydroxy-4-phenylbutyrate |
| Enalapril-049 | 100-52-7在售 | Benzaldehyde |
| Enalapril-050 | 127-17-3 | 2-Oxopropanoic acid |
| Enalapril-048 | 1516-08-1,64-17-5 | Non-denatured ethanol |
优化Route 10步骤 5 · 总收率 206.58g(Enalapril)
Enalapril-063123-75-1Enalapril-0642252296-25-4Enalapril-0657364-47-8Enalapril-066273750-74-6Enalapril-00575847-73-3Enalapril-00382717-96-2Enalapril-004147-85-3API · 阿托伐他汀/氢氯噻嗪/阿司匹林/依那普利
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Enalapril-063 | 123-75-1 | Pyrrolidine |
| Enalapril-064 | 2252296-25-4 | Ethyl (2S)-2-[[(2S)-1-oxo-1-(pyrrolidin-1-yl)propan-2-yl]amino]-4-phenylbutanoate |
| Enalapril-065 | 7364-47-8 | Trimethylsilyl 1-(trimethylsilyl)-L-prolinate |
| Enalapril-066 | 273750-74-6 | Trimethylsilyl N-[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]-L-alanyl-L-prolinate |
| Enalapril-005 | 75847-73-3 | (S)-1-[N-[1-(Ethoxycarbonyl)-3-phenylpropyl]-L-alanyl]-L-proline |
| Enalapril-003 | 82717-96-2 | N-[(S)-(+)-1-(Ethoxycarbonyl)-3-phenylpropyl]-L-alanine |
| Enalapril-004 | 147-85-3 | (S)-(-)-Proline |
优化Route 11步骤 3 · 总收率 20.9g(Enalapril)
Enalapril-00382717-96-2Enalapril-004147-85-3Enalapril-00575847-73-3API · 阿托伐他汀/氢氯噻嗪/阿司匹林/依那普利
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Enalapril-003 | 82717-96-2 | N-[1-Ethoxy-1-oxo-4-phenylbutan-2(S)-yl]-L-alanine |
| Enalapril-004 | 147-85-3 | (S)-(-)-Proline |
| Enalapril-005 | 75847-73-3 | (S)-1-[N-[1-(Ethoxycarbonyl)-3-phenylpropyl]-L-alanyl]-L-proline |
优化Route 12步骤 5 · 总收率 3.9g(Enalapril-073)
Enalapril-06756-84-8Enalapril-06832213-95-9Enalapril-069116393-72-7Enalapril-070100-39-0Enalapril-071885357-46-0Enalapril-072871123-99-8Enalapril-073943-73-7API · 阿托伐他汀/氢氯噻嗪/阿司匹林/依那普利
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Enalapril-067 | 56-84-8 | (S)-Aminobutanedioic acid |
| Enalapril-068 | 32213-95-9 | Dimethyl L-aspartate hydrogen chloride |
| Enalapril-069 | 116393-72-7 | Dimethyl N-(triphenylmethyl)-L-aspartate |
| Enalapril-070 | 100-39-0 | 1-(Bromomethyl)benzene |
| Enalapril-071 | 885357-46-0 | Dimethyl 3-benzyl-N-(triphenylmethyl)-L-aspartate |
| Enalapril-072 | 871123-99-8 | (3R)-3-Benzyl-L-aspartic acid |
| Enalapril-073 | 943-73-7 | 2(S)-Amino-4-phenylbutanoic acid |
优化Route 13步骤 8 · 总收率 /
Enalapril-07456-41-7Enalapril-07515761-38-3Enalapril-076—Enalapril-0772133-40-6Enalapril-07833300-71-9Enalapril-07933300-72-0Enalapril-004147-85-3Enalapril-00213485-59-1Enalapril-02664920-29-2Enalapril-00575847-73-3API · 阿托伐他汀/氢氯噻嗪/阿司匹林/依那普利
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Enalapril-074 | 56-41-7 | L-Alanine |
| Enalapril-075 | 15761-38-3 | N-Boc-2(S)-aminopropanoic acid |
| Enalapril-076 | - | (4R)-4-Amino-1,3-oxazolidine-2,5-dione |
| Enalapril-077 | 2133-40-6 | Methyl L-prolinate hydrogen chloride |
| Enalapril-078 | 33300-71-9 | Methyl N-(tert-butoxycarbonyl)-L-alanyl-L-prolinate |
| Enalapril-079 | 33300-72-0 | N-(tert-Butoxycarbonyl)-L-alanyl-L-proline |
| Enalapril-004 | 147-85-3 | L-Proline |
| Enalapril-002 | 13485-59-1 | L-Alanyl-L-proline |
| Enalapril-026 | 64920-29-2 | 2-Oxo-4-phenylbutyric acid ethyl ester |
| Enalapril-005 | 75847-73-3 | (S)-1-[N-[1-(Ethoxycarbonyl)-3-phenylpropyl]-L-alanyl]-L-proline |
优化Route 14步骤 3 · 总收率 37.9g(Enalapril-054)
Enalapril-080104-53-0Enalapril-081—Enalapril-008120999-41-9Enalapril-05490315-82-5API · 阿托伐他汀/氢氯噻嗪/阿司匹林/依那普利
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Enalapril-080 | 104-53-0 | 3-Phenylpropionaldehyde |
| Enalapril-081 | - | Ethyl 2-oxo-4-phenylbut-3-enoate |
| Enalapril-008 | 120999-41-9 | 2(R)-Hydroxy-4-phenylbutanenitrile |
| Enalapril-054 | 90315-82-5 | Ethyl (R)-(-)-2-hydroxy-4-phenylbutyrate |
优化Route 1步骤 10 · 总收率 /
Atorvastatin-001—Atorvastatin-00288-95-9Atorvastatin-003—Atorvastatin-004108998-83-0Atorvastatin-005540-88-5Atorvastatin-006222406-66-8Atorvastatin-007110862-46-9Atorvastatin-008222406-69-1Atorvastatin-009222406-71-5Atorvastatin-010222406-73-7Atorvastatin-011134395-00-9Atorvastatin-012793652-69-4Atorvastatin-013222406-80-6Atorvastatin-014—API · 阿托伐他汀/氢氯噻嗪/阿司匹林/依那普利
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Atorvastatin-001 | - | [14C]-Sodium acetate |
| Atorvastatin-002 | 88-95-9 | ortho-Phthaloyl chloride |
| Atorvastatin-003 | - | [14C=O]Acetyl chloride |
| Atorvastatin-004 | 108998-83-0 | (2S)-1,1,2-Triphenylethane-1,2-diol |
| Atorvastatin-005 | 540-88-5 | 1,1-Dimethylethyl acetate |
| Atorvastatin-006 | 222406-66-8 | (1S)-2-hydroxy-1,2,2-triphenylethyl acetate |
| Atorvastatin-007 | 110862-46-9 | 5-(4-Fluorophenyl)-1-(3-oxopropyl)-N,4-diphenyl-2-(propan-2-yl)-1H-pyrrole-3-carboxamide |
| Atorvastatin-008 | 222406-69-1 | (1S)-2-hydroxy-1,2,2-triphenylethyl (3R)-5-[2-(4-fluorophenyl)-3-phenyl-4-(phenylcarbamoyl)-5-(propan-2-yl)-1H-pyrrol-1-yl]-3-hydroxypentanoate |
| Atorvastatin-009 | 222406-71-5 | methyl (3R)-5-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl]-3-hydroxypentanoate |
| Atorvastatin-010 | 222406-73-7 | tert-butyl (5R)-7-[2-(4-fluorophenyl)-3-phenyl-4-(phenylcarbamoyl)-5-(propan-2-yl)-1H-pyrrol-1-yl]-5-hydroxy-3-oxoheptanoate |
| Atorvastatin-011 | 134395-00-9 | Atorvastatin tert-butyl ester |
| Atorvastatin-012 | 793652-69-4 | (3R,5R)-7-[2-(4-fluorophenyl)-3-phenyl-4-(phenylcarbamoyl)-5-(propan-2-yl)-1H-pyrrol-1-yl]-3,5-dihydroxyheptanoic acid |
| Atorvastatin-013 | 222406-80-6 | 5-(4-fluorophenyl)-1-{2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl}-2-isopropyl-N,4-diphenyl-1H-pyrrole-3-carboxamide |
| Atorvastatin-014 | - | sodium (3R,5R)-7-[2-(4-fluorophenyl)-3-phenyl-4-(phenylcarbamoyl)-5-(propan-2-yl)-1H-pyrrol-1-yl]-3,5-dihydroxyheptanoate |
优化Route 2步骤 7 · 总收率 1.21kg(Atorvastatin Strontium)
Atorvastatin-015—Atorvastatin-016—Atorvastatin-017—Atorvastatin-0181353049-81-6Atorvastatin-019—Atorvastatin-020—Atorvastatin-021—Atorvastatin-011134395-00-9API · 阿托伐他汀/氢氯噻嗪/阿司匹林/依那普利
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Atorvastatin-015 | - | 2-[2-(4-Fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxo-N-phenylpentanamide |
| Atorvastatin-016 | - | Methyl [(4R,6R)-6-(2-aminoethyl)-2,2-dimethyl-1,3-dioxan-4-yl]acetate |
| Atorvastatin-017 | - | (4R,6R)-6-(2-Aminoethyl)-2,2-dimethyl-1,3-Dioxane-4-acetic acid 1,1-dimethylethyl ester |
| Atorvastatin-018 | 1353049-81-6 | Methyl [(4R,6R)-6-[2-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl]ethyl]-2,2-dimethyl-1,3-dioxan-4-yl]acetate |
| Atorvastatin-019 | - | (4R,6R)-6-[2-[2-(4-Fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrol-1-yl]ethyl]-2,2-dimethyl-1,3-dioxane-4-acetic acid 1,1-dimethylethyl ester |
| Atorvastatin-020 | - | Methyl (3R,5R)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl]-3,5-dihydroxyheptanoate |
| Atorvastatin-021 | - | 7-[2-(4-Fluorophenyl)-5-isopropyl-3-phenyl-4-(N-phenylcarbamoyl)-1H-pyrrol-1-yl]-3(R),5(R)-dihydroxyheptanoic acid sodium salt |
| Atorvastatin-011 | 134395-00-9 | Atorvastatin tert-butyl ester |
优化Route 3步骤 11 · 总收率 /
Atorvastatin-022838906-36-8Atorvastatin-023—Atorvastatin-024838906-52-8Atorvastatin-0251404189-41-8Atorvastatin-026112904-69-5Atorvastatin-027—Atorvastatin-0281443774-74-0Atorvastatin-0291443774-76-2Atorvastatin-0301417187-90-6Atorvastatin-031676260-68-7Atorvastatin-032714963-28-7Atorvastatin-033—Atorvastatin-016—Atorvastatin-017—API · 阿托伐他汀/氢氯噻嗪/阿司匹林/依那普利
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Atorvastatin-022 | 838906-36-8 | 4-(Benzyloxy)dihydro-2H-pyran-2,6(3H)-dione |
| Atorvastatin-023 | - | 3-Hydroxypentanedioic acid 1,5-diethyl ester |
| Atorvastatin-024 | 838906-52-8 | Diethyl 3-(benzyloxy)pentanedioate |
| Atorvastatin-025 | 1404189-41-8 | 3-(Benzyloxy)pentanedioic acid |
| Atorvastatin-026 | 112904-69-5 | (3R)-3-(Benzyloxy)-5-methoxy-5-oxopentanoic acid |
| Atorvastatin-027 | - | (Methoxycarbonyl)acetonitrile |
| Atorvastatin-028 | 1443774-74-0 | Dimethyl (5R)-5-(benzyloxy)-2-cyano-3-oxoheptanedioate |
| Atorvastatin-029 | 1443774-76-2 | Methyl (3R)-3-(benzyloxy)-6-cyano-5-oxohexanoate |
| Atorvastatin-030 | 1417187-90-6 | Methyl (3R)-6-cyano-3-hydroxy-5-oxohexanoate |
| Atorvastatin-031 | 676260-68-7 | Methyl (3R,5R)-6-cyano-3,5-dihydroxyhexanoate |
| Atorvastatin-032 | 714963-28-7 | Methyl [(4R,6R)-6-(cyanomethyl)-2,2-dimethyl-1,3-dioxan-4-yl]acetate |
| Atorvastatin-033 | - | - |
| Atorvastatin-016 | - | Methyl [(4R,6R)-6-(2-aminoethyl)-2,2-dimethyl-1,3-dioxan-4-yl]acetate |
| Atorvastatin-017 | - | (4R,6R)-6-(2-Aminoethyl)-2,2-dimethyl-1,3-Dioxane-4-acetic acid 1,1-dimethylethyl ester |
优化Route 4步骤 5 · 总收率 /
Atorvastatin-03465564-05-8Atorvastatin-03575-07-0Atorvastatin-036916852-78-3Atorvastatin-037916852-79-4Atorvastatin-038676260-70-1Atorvastatin-039125995-03-1Atorvastatin-015—API · 阿托伐他汀/氢氯噻嗪/阿司匹林/依那普利
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Atorvastatin-034 | 65564-05-8 | Benzyl (3-oxopropyl)carbamate |
| Atorvastatin-035 | 75-07-0 | Ethanal |
| Atorvastatin-036 | 916852-78-3 | Benzyl [2-[(2R,4R)-4,6-dihydroxytetrahydro-2H-pyran-2-yl]ethyl]carbamate |
| Atorvastatin-037 | 916852-79-4 | Benzyl [2-[(2R,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl]carbamate |
| Atorvastatin-038 | 676260-70-1 | (4R,6R)-6-(2-aminoethyl)-4-hydroxyoxan-2-one |
| Atorvastatin-039 | 125995-03-1 | 5-(4-Fluorophenyl)-1-[2-[4(R)-hydroxy-6-oxotetrahydropyran-2(R)-yl]ethyl]-2-isopropyl-N,4-diphenyl-1H-pyrrole-3-carboxamide |
| Atorvastatin-015 | - | 2-[2-(4-Fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxo-N-phenylpentanamide |
优化Route 5步骤 1 · 总收率 50.7g(Atorvastatin Strontium)
Atorvastatin-039125995-03-1API · 阿托伐他汀/氢氯噻嗪/阿司匹林/依那普利
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Atorvastatin-039 | 125995-03-1 | 5-(4-Fluorophenyl)-1-[2-[4(R)-hydroxy-6-oxotetrahydropyran-2(R)-yl]ethyl]-2-isopropyl-N,4-diphenyl-1H-pyrrole-3-carboxamide |
优化Route 6步骤 7 · 总收率 /
Atorvastatin-04042558-54-3Atorvastatin-0411146977-84-5Atorvastatin-042100-52-7Atorvastatin-043—Atorvastatin-0441146977-88-9Atorvastatin-045—Atorvastatin-0461146977-86-7Atorvastatin-0471146977-83-4Atorvastatin-0481146977-87-8Atorvastatin-04962-53-3Atorvastatin-0501146977-89-0Atorvastatin-0511146978-02-0API · 阿托伐他汀/氢氯噻嗪/阿司匹林/依那普利
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Atorvastatin-040 | 42558-54-3 | 4-Methyl-3-oxopentanoic acid methyl ester |
| Atorvastatin-041 | 1146977-84-5 | 4-Methyl-3-oxopentanoic acid 4-methoxybenzyl ester |
| Atorvastatin-042 | 100-52-7在售 | Benzaldehyde |
| Atorvastatin-043 | - | 2-Benzylidene-4-methyl-3-oxopentanoic acid 4-methoxybenzyl ester |
| Atorvastatin-044 | 1146977-88-9 | 1-[3(R)-[tert-Butyl(dimethyl)silyloxy]-5-hydroxypentyl]-5-(4-fluorophenyl)-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid |
| Atorvastatin-045 | - | (4-Fluorophenyl)methanone |
| Atorvastatin-046 | 1146977-86-7 | 2-[2-(4-Fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxopentanoic acid 4-methoxybenzyl ester |
| Atorvastatin-047 | 1146977-83-4 | 5-Amino-3(R)-[tert-butyl(dimethyl)silyloxy]pentan-1-ol |
| Atorvastatin-048 | 1146977-87-8 | 1-[3(R)-[tert-Butyl(dimethyl)silyloxy]-5-hydroxypentyl]-5-(4-fluorophenyl)-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid 4-methoxybenzyl ester |
| Atorvastatin-049 | 62-53-3在售 | Aminobenzene |
| Atorvastatin-050 | 1146977-89-0 | 1-[3(R)-[tert-butyl(dimethyl)silyloxy]-5-hydroxypentyl]-5-(4-fluorophenyl)-2-isopropyl-N,4-diphenyl-1H-pyrrole-3-carboxamide |
| Atorvastatin-051 | 1146978-02-0 | 1-[3(R)-[tert-Butyl(dimethyl)silyloxy]-5-oxopentyl]-5-(4-fluorophenyl)-2-isopropyl-N,4-diphenyl-1H-pyrrole-3-carboxamide |
优化Route 7步骤 6 · 总收率 /
Atorvastatin-05298684-92-5Atorvastatin-0531146977-91-4Atorvastatin-0541146977-92-5Atorvastatin-0551146977-93-6Atorvastatin-056616201-27-5Atorvastatin-057134523-07-2Atorvastatin-0511146978-02-0API · 阿托伐他汀/氢氯噻嗪/阿司匹林/依那普利
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Atorvastatin-052 | 98684-92-5 | 2-Ethoxy-2-oxoethanediazonium |
| Atorvastatin-053 | 1146977-91-4 | 5(R)-[tert-Butyl(dimethyl)silyloxy]-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(N-phenylcarbamoyl)-1H-pyrrol-1-yl]-3-oxoheptanoic acid ethyl ester |
| Atorvastatin-054 | 1146977-92-5 | 7-[2-(4-Fluorophenyl)-5-isopropyl-3-phenyl-4-(N-phenylcarbamoyl)-1H-pyrrol-1-yl]-5(R)-hydroxy-3-oxoheptanoic acid ethyl ester |
| Atorvastatin-055 | 1146977-93-6 | 7-[2-(4-Fluorophenyl)-5-isopropyl-3-phenyl-4-(N-phenylcarbamoyl)-1H-pyrrol-1-yl]-3(R),5(R)-dihydroxyheptanoic acid ethyl ester |
| Atorvastatin-056 | 616201-27-5 | Ethyl [(4R,6R)-6-[2-[2-(4-fluorophenyl)-3-phenyl-4-(phenylcarbamoyl)-5-(propan-2-yl)-1H-pyrrol-1-yl]ethyl]-2,2-dimethyl-1,3-dioxan-4-yl]acetate |
| Atorvastatin-057 | 134523-07-2 | 5-(4-Fluorophenyl)-1-[2-[4(S)-hydroxy-6-oxotetrahydropyran-2(S)-yl]ethyl]-2-isopropyl-N,4-diphenyl-1H-pyrrole-3-carboxamide |
| Atorvastatin-051 | 1146978-02-0 | 1-[3(R)-[tert-Butyl(dimethyl)silyloxy]-5-oxopentyl]-5-(4-fluorophenyl)-2-isopropyl-N,4-diphenyl-1H-pyrrole-3-carboxamide |
优化Route 8步骤 4 · 总收率 41.5g(Atorvastatin-047)
Atorvastatin-058141942-84-9Atorvastatin-059105876-27-5Atorvastatin-060105876-28-6Atorvastatin-0611146977-82-3Atorvastatin-0471146977-83-4API · 阿托伐他汀/氢氯噻嗪/阿司匹林/依那普利
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Atorvastatin-058 | 141942-84-9 | 4-Cyano-3(R)-hydroxybutyric acid methyl ester |
| Atorvastatin-059 | 105876-27-5 | 3(R)-[tert-Butyl(dimethyl)silyloxy]-4-cyanobutyric acid methyl ester |
| Atorvastatin-060 | 105876-28-6 | (3R)-3-[[tert-Butyl(dimethyl)silyl]oxy]-4-cyanobutanoic acid |
| Atorvastatin-061 | 1146977-82-3 | 3(R)-[tert-Butyl(dimethyl)silyloxy]-5-hydroxypentanenitrile |
| Atorvastatin-047 | 1146977-83-4 | 5-Amino-3(R)-[tert-butyl(dimethyl)silyloxy]pentan-1-ol |
优化Route 9步骤 11 · 总收率 /
Atorvastatin-062—Atorvastatin-06380667-81-8Atorvastatin-06421870-79-1Atorvastatin-0654613-62-1Atorvastatin-0661092527-73-5Atorvastatin-0674494-96-6Atorvastatin-068—Atorvastatin-069—Atorvastatin-070—Atorvastatin-0711092527-75-7Atorvastatin-0721092527-77-9Atorvastatin-073—Atorvastatin-015—API · 阿托伐他汀/氢氯噻嗪/阿司匹林/依那普利
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Atorvastatin-062 | - | (3aR,5S,6S,6aR)-5-[(4R)-2,2-Dimethyl-1,3-dioxolan-4-yl]-2,2-dimethyltetrahydro-2H-furo[2,3-d][1,3]dioxol-6-ol |
| Atorvastatin-063 | 80667-81-8 | 1,2:5,6-Di-O-isopropylidene-3-O-(imidazol-1-ylsulfonyl)-alpha-D-glucofuranose |
| Atorvastatin-064 | 21870-79-1 | 3-S-Acetyl-1,2:5,6-Di-O-isopropylidene-3-thio-alpha-D-allofuranose |
| Atorvastatin-065 | 4613-62-1 | 3-Deoxy-1,2:5,6-Di-O-isopropylidene-alpha-D-ribo-hexofuranose |
| Atorvastatin-066 | 1092527-73-5 | (3aR,5R,6aR)-2,2-Dimethyl-5-(2-nitroethyl)perhydrofuro[2,3-d][1,3]dioxole |
| Atorvastatin-067 | 4494-96-6 | 3-Deoxy-1,2-O-isopropylidene-alpha-D-ribo-hexofuranose |
| Atorvastatin-068 | - | (3aR,6aR)-2,2-Dimethylperhydrofuro[2,3-d][1,3]dioxole-5-carbaldehyde |
| Atorvastatin-069 | - | 1-[(3aR,6aR)-2,2-Dimethylperhydrofuro[2,3-d][1,3]dioxol-5-yl]-2-nitroethanol |
| Atorvastatin-070 | - | (3aR,6aR)-2,2-Dimethyl-5-(2-nitrovinyl)perhydrofuro[2,3-d][1,3]dioxole |
| Atorvastatin-071 | 1092527-75-7 | 2-[(3aR,5R,6aR)-2,2-Dimethylperhydrofuro[2,3-d][1,3]dioxol-5-yl]ethylamine |
| Atorvastatin-072 | 1092527-77-9 | 1-[2-[(3aR,5R,6aR)-2,2-Dimethylperhydrofuro[2,3-d][1,3]dioxol-5-yl]ethyl]-5-(4-fluorophenyl)-2-isopropyl-N,4-diphenyl-1H-pyrrole-3-carboxamide |
| Atorvastatin-073 | - | 1-[2-[4(R),5-Dihydroxytetrahydrofuran-2(R)-yl]ethyl]-5-(4-fluorophenyl)-2-isopropyl-N,4-diphenyl-1H-pyrrole-3-carboxamide |
| Atorvastatin-015 | - | 2-[2-(4-Fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxo-N-phenylpentanamide |
优化Route 10步骤 5 · 总收率 /
Atorvastatin-074—Atorvastatin-075896110-02-4Atorvastatin-0761092527-64-4Atorvastatin-0771092527-66-6Atorvastatin-0781092527-68-8Atorvastatin-068—Atorvastatin-0711092527-75-7API · 阿托伐他汀/氢氯噻嗪/阿司匹林/依那普利
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Atorvastatin-074 | - | Ethyl (diethoxyphosphoryl)acetate |
| Atorvastatin-075 | 896110-02-4 | 3-[(3aR,5S,6aR)-2,2-Dimethylperhydrofuro[2,3-d][1,3]dioxol-5-yl]-2-propenoic acid ethyl ester |
| Atorvastatin-076 | 1092527-64-4 | 3-[(3aR,5R,6aR)-2,2-Dimethylperhydrofuro[2,3-d][1,3]dioxol-5-yl]propionic acid ethyl ester |
| Atorvastatin-077 | 1092527-66-6 | 3-[(3aR,5R,6aR)-2,2-Dimethylperhydrofuro[2,3-d][1,3]dioxol-5-yl]propionamide |
| Atorvastatin-078 | 1092527-68-8 | 1,2-O-Isopropylidene-6-(methoxycarbonylamino)-3,5,6-trideoxy-alpha-D-erythro-hexofuranose |
| Atorvastatin-068 | - | (3aR,5S,6aR)-2,2-Dimethylperhydrofuro[2,3-d][1,3]dioxole-5-carbaldehyde |
| Atorvastatin-071 | 1092527-75-7 | 2-[(3aR,5R,6aR)-2,2-Dimethylperhydrofuro[2,3-d][1,3]dioxol-5-yl]ethylamine |
优化Route 11步骤 11 · 总收率 232.6g(Atorvastatin-017)
Atorvastatin-079—Atorvastatin-080—Atorvastatin-0811370478-50-4Atorvastatin-0821192308-67-0Atorvastatin-083—Atorvastatin-084—Atorvastatin-085—Atorvastatin-0861011476-83-7Atorvastatin-0871370478-51-5Atorvastatin-088619261-21-1Atorvastatin-089—Atorvastatin-090154026-96-7Atorvastatin-091154026-97-8Atorvastatin-092154026-98-9Atorvastatin-017—Atorvastatin-005—API · 阿托伐他汀/氢氯噻嗪/阿司匹林/依那普利
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Atorvastatin-079 | - | (2R)-2-(Chloromethyl)oxirane |
| Atorvastatin-080 | - | - |
| Atorvastatin-081 | 1370478-50-4 | (2R)-1-Chloro-4-nitrobutan-2-ol |
| Atorvastatin-082 | 1192308-67-0 | (3R)-3-Hydroxy-5-nitropentanenitrile |
| Atorvastatin-083 | - | 1-Methoxy-1-methylethyl methyl ether |
| Atorvastatin-084 | - | (2-(tert-Butoxy)-2-oxoethyl)zinc(II) bromide |
| Atorvastatin-085 | - | 1,1-Dimethylethyl monobromoacetate |
| Atorvastatin-086 | 1011476-83-7 | tert-Butyl (5R)-5-hydroxy-7-nitro-3-oxoheptanoate |
| Atorvastatin-087 | 1370478-51-5 | 3(R),5(R)-Dihydroxy-7-nitroheptanoic acid tert-butyl ester |
| Atorvastatin-088 | 619261-21-1 | tert-Butyl [(4R,6R)-2,2-dimethyl-6-(2-nitroethyl)-1,3-dioxan-4-yl]acetate |
| Atorvastatin-089 | - | Ethyl (3S)-4-bromo-3-hydroxybutanoate |
| Atorvastatin-090 | 154026-96-7 | tert-Butyl (5S)-6-bromo-5-hydroxy-3-oxohexanoate |
| Atorvastatin-091 | 154026-97-8 | tert-Butyl (3R,5S)-6-bromo-3,5-dihydroxyhexanoate |
| Atorvastatin-092 | 154026-98-9 | tert-Butyl [(4R,6S)-6-(bromomethyl)-2,2-dimethyl-1,3-dioxan-4-yl]acetate |
| Atorvastatin-017 | - | (4R,6R)-6-(2-Aminoethyl)-2,2-dimethyl-1,3-Dioxane-4-acetic acid 1,1-dimethylethyl ester |
| Atorvastatin-005 | - | 1,1-Dimethylethyl acetate |
优化Route 12步骤 15 · 总收率 3.83g(Atorvastatin-017)
Atorvastatin-093181272-46-8Atorvastatin-0943536-96-7Atorvastatin-095—Atorvastatin-0961622324-73-5Atorvastatin-097950513-91-4Atorvastatin-0981622324-77-9Atorvastatin-0991622324-74-6Atorvastatin-1001622324-75-7Atorvastatin-1011622324-76-8Atorvastatin-102—Atorvastatin-1031173184-84-3Atorvastatin-1041380521-21-0Atorvastatin-105682356-88-3Atorvastatin-07951594-55-9Atorvastatin-083—Atorvastatin-085—Atorvastatin-017—Atorvastatin-005540-88-5Atorvastatin-040—API · 阿托伐他汀/氢氯噻嗪/阿司匹林/依那普利
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Atorvastatin-093 | 181272-46-8 | (3R)-3-Hydroxyhex-5-enenitrile |
| Atorvastatin-094 | 3536-96-7 | Chlorido(ethenyl)magnesium |
| Atorvastatin-095 | - | (2R)-1-Chloropent-4-en-2-ol |
| Atorvastatin-096 | 1622324-73-5 | (3R)-3-[(Trimethylsilyl)oxy]hex-5-enenitrile |
| Atorvastatin-097 | 950513-91-4 | tert-Butyl (5R)-5-hydroxy-3-oxooct-7-enoate |
| Atorvastatin-098 | 1622324-77-9 | tert-Butyl [(4R,6R)-6-[(2E)-2-(hydroxyimino)ethyl]-2,2-dimethyl-1,3-dioxan-4-yl]acetate |
| Atorvastatin-099 | 1622324-74-6 | tert-Butyl (3R,5R)-3,5-dihydroxyoct-7-enoate |
| Atorvastatin-100 | 1622324-75-7 | tert-Butyl [(4R,6R)-6-allyl-2,2-dimethyl-1,3-dioxan-4-yl]acetate |
| Atorvastatin-101 | 1622324-76-8 | tert-Butyl [(4R,6S)-2,2-dimethyl-6-(2-oxoethyl)-1,3-dioxan-4-yl]acetate |
| Atorvastatin-102 | - | Hydroxylamine hydrochloric acid |
| Atorvastatin-103 | 1173184-84-3 | (4R)-2,2-Dimethyl-6beta-(2-hydroxyethyl)-1,3-dioxane-4beta-acetic acid tert-butyl ester |
| Atorvastatin-104 | 1380521-21-0 | tert-Butyl [(4R,6R)-6-[2-[(methanesulfonyl)oxy]ethyl]-2,2-dimethyl-1,3-dioxan-4-yl]acetate |
| Atorvastatin-105 | 682356-88-3 | tert-Butyl [(4R,6R)-6-(2-azidoethyl)-2,2-dimethyl-1,3-dioxan-4-yl]acetate |
| Atorvastatin-079 | 51594-55-9 | (2R)-2-(Chloromethyl)oxirane |
| Atorvastatin-083 | - | 1-Methoxy-1-methylethyl methyl ether |
| Atorvastatin-085 | - | 1,1-Dimethylethyl monobromoacetate |
| Atorvastatin-017 | - | (4R,6R)-6-(2-Aminoethyl)-2,2-dimethyl-1,3-Dioxane-4-acetic acid 1,1-dimethylethyl ester |
| Atorvastatin-005 | 540-88-5 | 1,1-Dimethylethyl acetate |
| Atorvastatin-040 | - | Methyl (3R)-3-hydroxyhex-5-enoate |
优化Route 13步骤 3 · 总收率 /
Atorvastatin-106—Atorvastatin-107112100-39-7Atorvastatin-108130158-22-4Atorvastatin-109430434-51-8Atorvastatin-094—API · 阿托伐他汀/氢氯噻嗪/阿司匹林/依那普利
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Atorvastatin-106 | - | (S)-4-Chloro-3-hydroxybutanoic acid ethyl ester |
| Atorvastatin-107 | 112100-39-7 | Ethyl (3S)-3-hydroxy-4-iodobutanoate |
| Atorvastatin-108 | 130158-22-4 | Ethyl (3S)-3-[[tert-butyl(dimethyl)silyl]oxy]-4-iodobutanoate |
| Atorvastatin-109 | 430434-51-8 | Ethyl (3R)-3-[[tert-butyl(dimethyl)silyl]oxy]hex-5-enoate |
| Atorvastatin-094 | - | Chlorido(ethenyl)magnesium<-fgf->Chloro(vinyl)magnesium<-fgf->Vinylmagnesium chloride |
优化Route 14步骤 11 · 总收率 /
Atorvastatin-1101375257-29-6Atorvastatin-111—Atorvastatin-1121375257-24-1Atorvastatin-11319790-60-4Atorvastatin-114—Atorvastatin-1151824037-91-3Atorvastatin-116—Atorvastatin-117104713-29-3Atorvastatin-1181256553-72-6Atorvastatin-1191824037-92-4Atorvastatin-1201824037-97-9Atorvastatin-1211824037-93-5Atorvastatin-122119146-87-1Atorvastatin-1231824037-94-6API · 阿托伐他汀/氢氯噻嗪/阿司匹林/依那普利
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Atorvastatin-110 | 1375257-29-6 | (4S)-1-[(1R)-1-Phenylethyl]-4-(propan-2-yl)imidazolidin-2-one |
| Atorvastatin-111 | - | Acetic acid chloride |
| Atorvastatin-112 | 1375257-24-1 | (4S)-3-Acetyl-1-[(1R)-1-phenylethyl]-4-(propan-2-yl)imidazolidin-2-one |
| Atorvastatin-113 | 19790-60-4 | 3-Benzyloxy-1-propanal |
| Atorvastatin-114 | - | (3R)-5-(Benzyloxy)-3-[[tert-butyl(dimethyl)silyl]oxy]pentanoic acid |
| Atorvastatin-115 | 1824037-91-3 | (4S)-3-[(3R)-5-(Benzyloxy)-3-hydroxypentanoyl]-4-isopropyl-1-[(1R)-1-phenylethyl]imidazolidin-2-one |
| Atorvastatin-116 | - | (3R)-5-(Benzyloxy)-3-hydroxypentanoic acid |
| Atorvastatin-117 | 104713-29-3 | Methyl (3R)-5-(benzyloxy)-3-hydroxypentanoate |
| Atorvastatin-118 | 1256553-72-6 | Methyl (3R)-5-(benzyloxy)-3-[[tert-butyl(dimethyl)silyl]oxy]pentanoate |
| Atorvastatin-119 | 1824037-92-4 | (4S)-3-[(3R,5R)-7-(Benzyloxy)-5-[[tert-butyl(dimethyl)silyl]oxy]-3-hydroxyheptanoyl]-4-isopropyl-1-[(1R)-1-phenylethyl]imidazolidin-2-one |
| Atorvastatin-120 | 1824037-97-9 | (3R,5R)-7-(Benzyloxy)-5-[[tert-butyl(dimethyl)silyl]oxy]-3-hydroxyheptanoic acid |
| Atorvastatin-121 | 1824037-93-5 | Methyl (3R,5R)-7-(benzyloxy)-3,5-bis[[tert-butyl(dimethyl)silyl]oxy]heptanoate |
| Atorvastatin-122 | 119146-87-1 | Methyl (3R,5R)-3,5-bis[[tert-butyl(dimethyl)silyl]oxy]-7-hydroxyheptanoate |
| Atorvastatin-123 | 1824037-94-6 | Methyl (3R,5R)-7-azido-3,5-bis[[tert-butyl(dimethyl)silyl]oxy]heptanoate |
优化Route 15步骤 3 · 总收率 /
Atorvastatin-124—Atorvastatin-1251824037-95-7Atorvastatin-039125995-03-1Atorvastatin-1231824037-94-6Atorvastatin-015—API · 阿托伐他汀/氢氯噻嗪/阿司匹林/依那普利
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Atorvastatin-124 | - | Methyl (3R,5R)-7-amino-3,5-bis[[tert-butyl(dimethyl)silyl]oxy]heptanoate |
| Atorvastatin-125 | 1824037-95-7 | Methyl (3R,5R)-3,5-bis[[tert-butyl(dimethyl)silyl]oxy]-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl]heptanoate |
| Atorvastatin-039 | 125995-03-1 | 5-(4-Fluorophenyl)-1-[2-[4(R)-hydroxy-6-oxotetrahydropyran-2(R)-yl]ethyl]-2-isopropyl-N,4-diphenyl-1H-pyrrole-3-carboxamide |
| Atorvastatin-123 | 1824037-94-6 | Methyl (3R,5R)-7-azido-3,5-bis[[tert-butyl(dimethyl)silyl]oxy]heptanoate |
| Atorvastatin-015 | - | 2-[2-(4-Fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxo-N-phenylpentanamide |
优化Route 16步骤 11 · 总收率 25g(Atorvastatin-017)
Atorvastatin-126110-00-9Atorvastatin-127—Atorvastatin-12857673-84-8Atorvastatin-12975-52-5Atorvastatin-130—Atorvastatin-131162972-45-4Atorvastatin-132300720-95-0Atorvastatin-133675201-91-9Atorvastatin-134—Atorvastatin-1351841131-83-6Atorvastatin-136674-82-8Atorvastatin-1371841131-84-7Atorvastatin-13867-64-1Atorvastatin-1391841131-85-8Atorvastatin-017—API · 阿托伐他汀/氢氯噻嗪/阿司匹林/依那普利
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Atorvastatin-126 | 110-00-9在售 | 1,4-Epoxy-1,3-butadiene |
| Atorvastatin-127 | - | (2E)-1,1,4,4-Tetramethoxybut-2-ene |
| Atorvastatin-128 | 57673-84-8 | 2,2-Dimethoxyacetaldehyde |
| Atorvastatin-129 | 75-52-5在售 | Nitrocarbol |
| Atorvastatin-130 | - | tert-Butyl 4-bromo-3-oxobutanoate |
| Atorvastatin-131 | 162972-45-4 | 1,1-Dimethoxy-3-nitropropan-2-ol |
| Atorvastatin-132 | 300720-95-0 | (1E)-3,3-Dimethoxy-1-nitroprop-1-ene |
| Atorvastatin-133 | 675201-91-9 | (2E)-3-Nitroprop-2-enal |
| Atorvastatin-134 | - | Bromido(4-tert-butoxy-2,4-dioxobutyl)zinc |
| Atorvastatin-135 | 1841131-83-6 | tert-Butyl (5S,6E)-5-hydroxy-7-nitro-3-oxohept-6-enoate |
| Atorvastatin-136 | 674-82-8在售 | 4-Methylene-2-oxetanone |
| Atorvastatin-137 | 1841131-84-7 | tert-Butyl (3R,5S,6E)-3,5-dihydroxy-7-nitrohept-6-enoate |
| Atorvastatin-138 | 67-64-1在售 | 2-Propanone |
| Atorvastatin-139 | 1841131-85-8 | tert-Butyl [(4R,6S)-2,2-dimethyl-6-[(E)-2-nitroethenyl]-1,3-dioxan-4-yl]acetate |
| Atorvastatin-017 | - | (4R,6R)-6-(2-Aminoethyl)-2,2-dimethyl-1,3-Dioxane-4-acetic acid 1,1-dimethylethyl ester |
优化Route 17步骤 15 · 总收率 36.3gAtorvastatin-152)
Atorvastatin-1401783-96-6Atorvastatin-1414198-33-8Atorvastatin-142101021-57-2Atorvastatin-143—Atorvastatin-1442089224-18-8Atorvastatin-145—Atorvastatin-14691285-62-0Atorvastatin-147204448-48-6Atorvastatin-1482089224-19-9Atorvastatin-1492089224-20-2Atorvastatin-150114861-21-1Atorvastatin-151106799-15-9Atorvastatin-1521262052-10-7Atorvastatin-1532089224-21-3Atorvastatin-1542089224-22-4Atorvastatin-1552089224-23-5Atorvastatin-13867-64-1Atorvastatin-12975-52-5Atorvastatin-0943536-96-7API · 阿托伐他汀/氢氯噻嗪/阿司匹林/依那普利
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Atorvastatin-140 | 1783-96-6 | (2R)-2-Aminobutanedioic acid |
| Atorvastatin-141 | 4198-33-8 | (2R)-2-Chlorobutanedioic acid |
| Atorvastatin-142 | 101021-57-2 | (2R)-2-Chlorobutane-1,4-diol |
| Atorvastatin-143 | - | 2-[(2S)-Oxiran-2-yl]ethan-1-ol |
| Atorvastatin-144 | 2089224-18-8 | (4S,6S)-4-[2-(Benzyloxy)ethyl]-6-(bromomethyl)-1,3-dioxan-2-one |
| Atorvastatin-145 | - | (2S)-2-[2-(Benzyloxy)ethyl]oxirane |
| Atorvastatin-146 | 91285-62-0 | (3R)-1-(Benzyloxy)hex-5-en-3-ol |
| Atorvastatin-147 | 204448-48-6 | (3R)-1-(Benzyloxy)hex-5-en-3-yl tert-butyl carbonate |
| Atorvastatin-148 | 2089224-19-9 | (4S,6S)-4-[2-(Benzyloxy)ethyl]-6-(bromomethyl)-2,2-dimethyl-1,3-dioxane |
| Atorvastatin-149 | 2089224-20-2 | 6-O-Acetyl-1-O-benzyl-2,4-dideoxy-3,5-O-(1-methylethylidene)-D-erythro-hexitol |
| Atorvastatin-150 | 114861-21-1 | 1-O-Benzyl-2,4-dideoxy-3,5-O-(1-methylethylidene)-D-erythro-hexitol |
| Atorvastatin-151 | 106799-15-9 | 6-O-Benzyl-3,5-dideoxy-2,4-O-(1-methylethylidene)-L-erythro-hexose |
| Atorvastatin-152 | 1262052-10-7 | 2-[(4R,6S)-6-[2-(Benzyloxy)ethyl]-2,2-dimethyl-1,3-dioxan-4-yl]ethanamine |
| Atorvastatin-153 | 2089224-21-3 | (6xi)-1-O-Benzyl-2,4,7-trideoxy-3,5-O-(1-methylethylidene)-7-nitro-D-erythro-heptitol |
| Atorvastatin-154 | 2089224-22-4 | (6xi)-6-O-Acetyl-1-O-benzyl-2,4,7-trideoxy-3,5-O-(1-methylethylidene)-7-nitro-D-erythro-heptitol |
| Atorvastatin-155 | 2089224-23-5 | (4S,6R)-4-[2-(Benzyloxy)ethyl]-2,2-dimethyl-6-(2-nitroethyl)-1,3-dioxane |
| Atorvastatin-138 | 67-64-1在售 | 2-Propanone |
| Atorvastatin-129 | 75-52-5在售 | Nitrocarbol |
| Atorvastatin-094 | 3536-96-7 | Chlorido(ethenyl)magnesium |
优化Route 18步骤 5 · 总收率 /
Atorvastatin-1561116-98-9Atorvastatin-157106-95-6Atorvastatin-1582770108-45-5Atorvastatin-159554432-27-8Atorvastatin-1601660128-90-4Atorvastatin-161—Atorvastatin-162—API · 阿托伐他汀/氢氯噻嗪/阿司匹林/依那普利
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Atorvastatin-156 | 1116-98-9 | 1,1-Dimethylethyl cyanoacetate |
| Atorvastatin-157 | 106-95-6在售 | 1-Bromo-2-propene |
| Atorvastatin-158 | 2770108-45-5 | tert-Butyl 3-oxohex-5-enoate |
| Atorvastatin-159 | 554432-27-8 | tert-Butyl (3R)-3-hydroxyhex-5-enoate |
| Atorvastatin-160 | 1660128-90-4 | tert-Butyl [(4R,6S)-6-(bromomethyl)-2-oxo-1,3-dioxan-4-yl]acetate |
| Atorvastatin-161 | - | [(4S,6R)-6-[2-(tert-Butoxy)-2-oxoethyl]-2,2-dimethyl-1,3-dioxan-4-yl]methyl acetate |
| Atorvastatin-162 | - | (4R,6S)-6-Hydroxymethyl-2,2-dimethyl-1,3-dioxane-4-acetic Acid 1,1-dimethylethyl ester |
优化Route 19步骤 6 · 总收率 206.7g(Atorvastatin-161)
Atorvastatin-16386728-85-0Atorvastatin-164—Atorvastatin-165—Atorvastatin-166154026-93-4Atorvastatin-167154026-94-5Atorvastatin-161—Atorvastatin-005540-88-5Atorvastatin-08377-76-9API · 阿托伐他汀/氢氯噻嗪/阿司匹林/依那普利
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Atorvastatin-163 | 86728-85-0 | Methyl (3S)-4-chloro-3-hydroxybutanoate |
| Atorvastatin-164 | - | Methyl (3S)-4-chloro-3-[(trimethylsilyl)oxy]butanoate |
| Atorvastatin-165 | - | (3S)-4-Chloro-3-[(trimethylsilyl)oxy]butanal |
| Atorvastatin-166 | 154026-93-4 | tert-Butyl (3R,5S)-6-chloro-3,5-dihydroxyhexanoate |
| Atorvastatin-167 | 154026-94-5 | tert-Butyl [(4R,6S)-6-(chloromethyl)-2,2-dimethyl-1,3-dioxan-4-yl]acetate |
| Atorvastatin-161 | - | [(4S,6R)-6-[2-(tert-Butoxy)-2-oxoethyl]-2,2-dimethyl-1,3-dioxan-4-yl]methyl acetate |
| Atorvastatin-005 | 540-88-5 | 1,1-Dimethylethyl acetate |
| Atorvastatin-083 | 77-76-9在售 | 1-Methoxy-1-methylethyl methyl ether |
优化Route 20步骤 1 · 总收率 57g(Atorvastatin-169)
Atorvastatin-16884367-31-7Atorvastatin-169—API · 阿托伐他汀/氢氯噻嗪/阿司匹林/依那普利
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Atorvastatin-168 | 84367-31-7 | (R)-(+)-4-Chloro-3-hydroxybutyronitrile |
| Atorvastatin-169 | - | tert-Butyl [(3R)-4-chloro-3-hydroxybutyl]carbamate |
常见问题（FAQ）
阿托伐他汀/氢氯噻嗪/阿司匹林/依那普利的适应症有哪些？
已批准的适应症包括：心脏和血管疾病。
阿托伐他汀/氢氯噻嗪/阿司匹林/依那普利的专利什么时候到期？
阿托伐他汀/氢氯噻嗪/阿司匹林/依那普利的专利到期年暂无公开口径，本页会在数据管道核实后更新。
阿托伐他汀/氢氯噻嗪/阿司匹林/依那普利有几条合成路线？
本站收录 34 条合成路线，最短路线 1 步、总收率 /。每条路线的中间体均带登记编号与 CAS 号。
阿托伐他汀/氢氯噻嗪/阿司匹林/依那普利的关键中间体在哪里可以采购？
阿托伐他汀/氢氯噻嗪/阿司匹林/依那普利的多条路线中间体已挂接 CAS 档案，其中 11 个 CAS 已有优贝德（Unibest）供应网络在售报价，可在本页路线表中直接查看并询价。
如何获取阿托伐他汀/氢氯噻嗪/阿司匹林/依那普利中间体的报价？
在本页选择目标中间体的 CAS 进入档案页，或在询价页直接提交需求；CAS 会自动带入供需撮合流程，由供应网络反馈报价。
数据来源：多源数据交叉核实（仅结构化字段） · 2026-10-22