1-Chloro-1-methoxymethane（CAS 107-30-2）中间体

应用背景（按来源药适应症）

特应性皮炎克立硼罗皮炎克立硼罗湿疹克立硼罗斑秃克立硼罗局部硬皮病克立硼罗斑块银屑病克立硼罗麻醉盐酸羟甲唑啉/盐酸丁卡因根尖周炎盐酸羟甲唑啉/盐酸丁卡因龋齿盐酸羟甲唑啉/盐酸丁卡因鼻塞盐酸赛洛唑啉鼻炎盐酸赛洛唑啉感冒盐酸赛洛唑啉鼻塞盐酸羟甲唑啉充血盐酸羟甲唑啉眼睑下垂盐酸羟甲唑啉功能性大便失禁盐酸羟甲唑啉酒渣鼻盐酸羟甲唑啉红疹盐酸羟甲唑啉

来源药（使用该中间体的合成路线）

品种	梯队	到期年
右泛醇/盐酸赛洛唑啉Dexpanthenol/Xylometazoline Hydrochloride	Tier C · 观察 / 贸易	-
克立硼罗Crisaborole	Tier C · 观察 / 贸易	-
盐酸羟甲唑啉/盐酸丁卡因Oxymetazoline Hydrochloride/Tetracaine Hydrochloride	Tier C · 观察 / 贸易	-
盐酸赛洛唑啉Xylometazoline Hydrochloride	Tier C · 观察 / 贸易	-
盐酸羟甲唑啉Oxymetazoline Hydrochloride	Tier C · 观察 / 贸易	-

合成路线中的位置（上下游链）

按路线登记顺序排列，左→右为合成方向；高亮为当前 CAS，其余可点击跳转对应档案。

右泛醇/盐酸赛洛唑啉优化路线步数：5总收率：12.4g(Xylometazoline Hydrochloride (API))

1,3-Dimethylbenzene→1,1-Dimethylethanol→1-tert-Butyl-3,5-dimethylbenzene→1-Chloro-1-methoxymethane→5-tert-Butyl-2-(chloromethyl)-1,3-dimethylbenzene→(4-tert-Butyl-2,6-dimethylphenyl)acetonitrile→Ethane-1,2-diamine 4-methylbenzenesulfonate→2-(4-tert-Butyl-2,6-dimethylbenzyl)-4,5-dihydro-1H-imidazole 4-methylbenzenesulfonate

克立硼罗原研路线步数：3总收率：/

4-(4-bromo-3-formylphenoxy)benzonitrile→4-(4-bromo-3-(hydroxymethyl)phenoxy)benzonitrile→chloro(methoxy)methane→4-(4-bromo-3-((methoxymethoxy)methyl)phenoxy)benzonitrile

盐酸羟甲唑啉/盐酸丁卡因优化路线步数：5总收率：7.5g(Oxymetazoline hydrochloride (API))

4-tert-Butyl-2,6-dimethylbenzene-1,3-diol→1-Chloro-1-methoxymethane→6-tert-Butyl-3-(chloromethyl)-2,4-dimethylphenol→(4-tert-Butyl-3-hydroxy-2,6-dimethylphenyl)acetonitrile→4,5-Dihydro-1H-imidazole-2-thiol→6-tert-Butyl-3-(4,5-dihydro-1H-imidazol-2-ylmethyl)-2,4-dimethylphenol→2-(4-tert-Butyl-3-hydroxy-2,6-dimethylphenyl)acetamide→Ethane-1,2-diamine 4-methylbenzenesulfonate→Ethane-1,2-diamine hydrobromide

盐酸赛洛唑啉优化路线步数：5总收率：12.4g(Xylometazoline Hydrochloride (API))

1,3-Dimethylbenzene→1,1-Dimethylethanol→1-tert-Butyl-3,5-dimethylbenzene→1-Chloro-1-methoxymethane→5-tert-Butyl-2-(chloromethyl)-1,3-dimethylbenzene→(4-tert-Butyl-2,6-dimethylphenyl)acetonitrile→Ethane-1,2-diamine 4-methylbenzenesulfonate→2-(4-tert-Butyl-2,6-dimethylbenzyl)-4,5-dihydro-1H-imidazole 4-methylbenzenesulfonate

盐酸羟甲唑啉优化路线步数：5总收率：7.5g(Oxymetazoline hydrochloride (API))

4-tert-Butyl-2,6-dimethylbenzene-1,3-diol→1-Chloro-1-methoxymethane→6-tert-Butyl-3-(chloromethyl)-2,4-dimethylphenol→(4-tert-Butyl-3-hydroxy-2,6-dimethylphenyl)acetonitrile→4,5-Dihydro-1H-imidazole-2-thiol→6-tert-Butyl-3-(4,5-dihydro-1H-imidazol-2-ylmethyl)-2,4-dimethylphenol→2-(4-tert-Butyl-3-hydroxy-2,6-dimethylphenyl)acetamide→Ethane-1,2-diamine 4-methylbenzenesulfonate→Ethane-1,2-diamine hydrobromide

本站可供应的对应中间体

同 CAS 多家在售供应横向对比；价格区间为供应方挂牌口径，实价以询价确认为准。

供应商	产品	价格区间	最小起订	货期	资质
Unibest Taizhou GMP-like Site	2-BROMO-5-HYDROXYBENZALDEHYDE Pharmaceutical Intermediates	询价	询价	询价	—
Qualified Partner — East China API Works	4-(4-Bromo-3-formyl-phenoxy)-benzonitrile Pharmaceutical Intermediates	询价	询价	询价	—
Unibest Nantong cGMP Site	4-[4-bromo-3-(hydroxymethyl)phenoxy]benzonitrile Pharmaceutical Intermediates	询价	询价	询价	—
Unibest Taizhou GMP-like Site	[2-bromo-5-(4-cyanophenoxy)phenyl]methyl acetate Pharmaceutical Intermediates	询价	询价	询价	—