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盐酸羟甲唑啉/盐酸丁卡因
Tier C · 观察 / 贸易Oxymetazoline Hydrochloride/Tetracaine Hydrochloride
St. Renatus Llc
原研
2016
首批上市
-
到期年（公开口径）
无销量数据
峰值销售
化学药
类型
靶点：ADRA1A
商品名：Kovanaze
适应症（已批准）：麻醉
各地区研发/上市状态
美国
批准上市
2016-06-29
欧盟
-
中国
-
日本
-
生产该 API 的工厂9
口径：平台供应网络（富通询价明细 + 产品主档）中登记生产该品种的工厂（在产口径），按报价活跃度排序；快照不含成本与客户信息。
已收录 9 家在产工厂名单，登录后可见（工厂信息不对未登录访客展示）。
登录查看工厂名单 →合成路线与中间体7 routes
原研路线 × 0优化路线（非专利）× 7工艺路线 × 0
路线按「原研路线 → 优化路线 / 工艺路线（非专利）」排序。每条路线附本站自绘的路线流程图（中间体 → 原料药）与中间体表（编号 / CAS / 英文名），可直接用于供应商开发与询价。流程图由本站依据已授权的结构化数据自行渲染，未使用任何第三方路线图。
优化Route 1步骤 5 · 总收率 7.5g(Oxymetazoline hydrochloride (API))
Oxymetazoline Hydrochloride-001—Oxymetazoline Hydrochloride-002107-30-2Oxymetazoline Hydrochloride-00323500-79-0Oxymetazoline Hydrochloride-00455699-10-0Oxymetazoline Hydrochloride-0051191945-77-3Oxymetazoline Hydrochloride-0061491-59-4Oxymetazoline Hydrochloride-00755699-13-3Oxymetazoline Hydrochloride-00814034-59-4Oxymetazoline Hydrochloride-00943702-89-2API · 盐酸羟甲唑啉/盐酸丁卡因
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Oxymetazoline Hydrochloride-001 | - | 4-tert-Butyl-2,6-dimethylbenzene-1,3-diol |
| Oxymetazoline Hydrochloride-002 | 107-30-2在售 | 1-Chloro-1-methoxymethane |
| Oxymetazoline Hydrochloride-003 | 23500-79-0 | 6-tert-Butyl-3-(chloromethyl)-2,4-dimethylphenol |
| Oxymetazoline Hydrochloride-004 | 55699-10-0 | (4-tert-Butyl-3-hydroxy-2,6-dimethylphenyl)acetonitrile |
| Oxymetazoline Hydrochloride-005 | 1191945-77-3 | 4,5-Dihydro-1H-imidazole-2-thiol |
| Oxymetazoline Hydrochloride-006 | 1491-59-4 | 6-tert-Butyl-3-(4,5-dihydro-1H-imidazol-2-ylmethyl)-2,4-dimethylphenol |
| Oxymetazoline Hydrochloride-007 | 55699-13-3 | 2-(4-tert-Butyl-3-hydroxy-2,6-dimethylphenyl)acetamide |
| Oxymetazoline Hydrochloride-008 | 14034-59-4 | Ethane-1,2-diamine 4-methylbenzenesulfonate |
| Oxymetazoline Hydrochloride-009 | 43702-89-2 | Ethane-1,2-diamine hydrobromide |
优化Route 2步骤 6 · 总收率 26g(Oxymetazoline hydrochloride (API))
Oxymetazoline Hydrochloride-00455699-10-0Oxymetazoline Hydrochloride-010107-15-3Oxymetazoline Hydrochloride-011871-78-3Oxymetazoline Hydrochloride-0061491-59-4Oxymetazoline Hydrochloride-01255699-17-7Oxymetazoline Hydrochloride-01355699-12-2Oxymetazoline Hydrochloride-00814034-59-4Oxymetazoline Hydrochloride-00755699-13-3Oxymetazoline Hydrochloride-0142576-47-8Oxymetazoline Hydrochloride-015106-93-4Oxymetazoline Hydrochloride-016—API · 盐酸羟甲唑啉/盐酸丁卡因
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Oxymetazoline Hydrochloride-004 | 55699-10-0 | (4-tert-Butyl-3-hydroxy-2,6-dimethylphenyl)acetonitrile |
| Oxymetazoline Hydrochloride-010 | 107-15-3 | Ethane-1,2-diamine |
| Oxymetazoline Hydrochloride-011 | 871-78-3 | N-[2-(Acetamido)ethyl]acetamide |
| Oxymetazoline Hydrochloride-006 | 1491-59-4 | 6-tert-Butyl-3-(4,5-dihydro-1H-imidazol-2-ylmethyl)-2,4-dimethylphenol |
| Oxymetazoline Hydrochloride-012 | 55699-17-7 | (4-tert-Butyl-3-hydroxy-2,6-dimethylphenyl)acetyl chloride |
| Oxymetazoline Hydrochloride-013 | 55699-12-2 | (4-tert-Butyl-3-hydroxy-2,6-dimethylphenyl)acetic acid |
| Oxymetazoline Hydrochloride-008 | 14034-59-4 | Ethane-1,2-diamine 4-methylbenzenesulfonate |
| Oxymetazoline Hydrochloride-007 | 55699-13-3 | 2-(4-tert-Butyl-3-hydroxy-2,6-dimethylphenyl)acetamide |
| Oxymetazoline Hydrochloride-014 | 2576-47-8 | 2-Bromoethanamine hydrobromide |
| Oxymetazoline Hydrochloride-015 | 106-93-4在售 | Ethylene dibromide |
| Oxymetazoline Hydrochloride-016 | - | Ethyl 2-(4-tert-butyl-3-hydroxy-2,6-dimethylphenyl)ethanimidoate hydrochloride |
优化Route 1步骤 6 · 总收率 /
Tetracaine-00162-23-7Tetracaine-002122-04-3Tetracaine-003108-01-0Tetracaine-00454288-75-4Tetracaine-00538152-22-6Tetracaine-00617599-02-9Tetracaine-00710012-47-2Tetracaine-008123-72-8Tetracaine-009109-65-9Tetracaine-01094-24-6API · 盐酸羟甲唑啉/盐酸丁卡因
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Tetracaine-001 | 62-23-7 | 4-Nitrobenzoic acid |
| Tetracaine-002 | 122-04-3 | 4-Nitrobenzoyl chloride |
| Tetracaine-003 | 108-01-0 | N,N-Dimethylaminoethanol |
| Tetracaine-004 | 54288-75-4 | 2-(Dimethylamino)ethyl 4-nitrobenzoate hydrogen chloride |
| Tetracaine-005 | 38152-22-6 | 2-(Dimethylamino)ethyl 4-nitrobenzoate |
| Tetracaine-006 | 17599-02-9 | 2-(Dimethylamino)ethyl 4-aminobenzoate hydrogen chloride |
| Tetracaine-007 | 10012-47-2 | 4-Aminobenzoic acid 2-(dimethylamino)ethyl ester |
| Tetracaine-008 | 123-72-8 | Butanal |
| Tetracaine-009 | 109-65-9 | 1-Bromobutane |
| Tetracaine-010 | 94-24-6 | 4-(Butylamino)benzoic acid 2-(dimethylamino)ethyl ester |
优化Route 2步骤 10 · 总收率 /
Tetracaine-011555-06-6Tetracaine-0124740-24-3Tetracaine-01374-11-3Tetracaine-014586-76-5Tetracaine-015619-58-9Tetracaine-016109-73-9Tetracaine-01794-32-6Tetracaine-0182498-25-1Tetracaine-019107-07-3Tetracaine-020—Tetracaine-021124-40-3Tetracaine-009109-65-9Tetracaine-003108-01-0Tetracaine-00710012-47-2Tetracaine-01094-24-6API · 盐酸羟甲唑啉/盐酸丁卡因
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Tetracaine-011 | 555-06-6 | 4-Aminobenzoic acid sodium salt |
| Tetracaine-012 | 4740-24-3 | 4-(Butylamino)benzoic acid |
| Tetracaine-013 | 74-11-3在售 | p-Chlorobenzoic acid |
| Tetracaine-014 | 586-76-5在售 | 4-Bromobenzoic acid |
| Tetracaine-015 | 619-58-9在售 | 4-Iodobenzoic acid |
| Tetracaine-016 | 109-73-9 | Butylamine |
| Tetracaine-017 | 94-32-6 | 4-(Butylamino)benzoic acid ethyl ester |
| Tetracaine-018 | 2498-25-1 | 2-(Dimethylamino)ethanol hydrochloride |
| Tetracaine-019 | 107-07-3 | 2-Chloroethanol |
| Tetracaine-020 | - | 4-(Butylamino)benzoic acid 2-chloroethyl ester |
| Tetracaine-021 | 124-40-3在售 | N-Methylmethanamine |
| Tetracaine-009 | 109-65-9 | n-Butyl bromide |
| Tetracaine-003 | 108-01-0 | N,N-Dimethylaminoethanol |
| Tetracaine-007 | 10012-47-2 | 4-Aminobenzoic acid 2-(dimethylamino)ethyl ester |
| Tetracaine-010 | 94-24-6 | 4-(Butylamino)benzoic acid 2-(dimethylamino)ethyl ester |
优化Route 3步骤 3 · 总收率 93.5g(Tetracaine)
Tetracaine-022150-13-0Tetracaine-008123-72-8Tetracaine-003108-01-0API · 盐酸羟甲唑啉/盐酸丁卡因
优化Route 4步骤 5 · 总收率 /
Tetracaine-023586-75-4Tetracaine-02438152-18-0Tetracaine-02594-09-7Tetracaine-009109-65-9Tetracaine-003108-01-0Tetracaine-016109-73-9Tetracaine-01094-24-6Tetracaine-01794-32-6Tetracaine-022150-13-0API · 盐酸羟甲唑啉/盐酸丁卡因
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Tetracaine-023 | 586-75-4 | 4-Bromobenzoyl chloride |
| Tetracaine-024 | 38152-18-0 | 2-(Dimethylamino)ethyl 4-bromobenzoate |
| Tetracaine-025 | 94-09-7 | Ethyl 4-aminobenzoate |
| Tetracaine-009 | 109-65-9 | n-Butyl bromide |
| Tetracaine-003 | 108-01-0 | N,N-Dimethylaminoethanol |
| Tetracaine-016 | 109-73-9 | Monobutylamine |
| Tetracaine-010 | 94-24-6 | 4-(Butylamino)benzoic acid 2-(dimethylamino)ethyl ester |
| Tetracaine-017 | 94-32-6 | 4-(Butylamino)benzoic acid ethyl ester |
| Tetracaine-022 | 150-13-0 | 4-Aminobenzoic acid |
优化Route 5步骤 3 · 总收率 /
Tetracaine-02699-77-4Tetracaine-02594-09-7Tetracaine-008123-72-8Tetracaine-01794-32-6Tetracaine-003108-01-0Tetracaine-01094-24-6API · 盐酸羟甲唑啉/盐酸丁卡因
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Tetracaine-026 | 99-77-4 | Ethyl 4-nitrobenzoate |
| Tetracaine-025 | 94-09-7 | 4-Aminobenzoic acid ethyl ester |
| Tetracaine-008 | 123-72-8 | Butyraldehyde |
| Tetracaine-017 | 94-32-6 | 4-(Butylamino)benzoic acid ethyl ester |
| Tetracaine-003 | 108-01-0 | N,N-Dimethyl-2-hydroxyethylamine |
| Tetracaine-010 | 94-24-6 | 4-(Butylamino)benzoic acid 2-(dimethylamino)ethyl ester |
常见问题（FAQ）
盐酸羟甲唑啉/盐酸丁卡因的适应症有哪些？
已批准的适应症包括：麻醉。
盐酸羟甲唑啉/盐酸丁卡因的专利什么时候到期？
盐酸羟甲唑啉/盐酸丁卡因的专利到期年暂无公开口径，本页会在数据管道核实后更新。
盐酸羟甲唑啉/盐酸丁卡因有几条合成路线？
本站收录 7 条合成路线，最短路线 3 步、总收率 93.5g(Tetracaine)。每条路线的中间体均带登记编号与 CAS 号。
盐酸羟甲唑啉/盐酸丁卡因的关键中间体在哪里可以采购？
盐酸羟甲唑啉/盐酸丁卡因的多条路线中间体已挂接 CAS 档案，其中 6 个 CAS 已有优贝德（Unibest）供应网络在售报价，可在本页路线表中直接查看并询价。
如何获取盐酸羟甲唑啉/盐酸丁卡因中间体的报价？
在本页选择目标中间体的 CAS 进入档案页，或在询价页直接提交需求；CAS 会自动带入供需撮合流程，由供应网络反馈报价。
数据来源：多源数据交叉核实（仅结构化字段） · 2026-10-22