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CAS 110-52-1
1,4-dibromobutane
登记编号：RP-5063-004、SULFORA-002
应用背景（按来源药适应症）
精神分裂症Brilaroxazine重度抑郁症Brilaroxazine肺动脉高压Brilaroxazine特发性肺纤维化Brilaroxazine躁狂症Brilaroxazine注意力缺陷障碍伴多动Brilaroxazine肾脏疾病Sulforafan alfadex慢性肾功能不全Sulforafan alfadex帕金森病Sulforafan alfadex精神分裂症Sulforafan alfadex肺癌Sulforafan alfadex自闭症Sulforafan alfadex
来源药（使用该中间体的合成路线）
| 品种 | 梯队 | 到期年 |
|---|---|---|
| Brilaroxazine | Tier C · 观察 / 贸易 | - |
| Cenerimod | Tier C · 观察 / 贸易 | - |
| Sulforafan alfadex | Tier C · 观察 / 贸易 | - |
合成路线中的位置（上下游链）
按路线登记顺序排列，左→右为合成方向；高亮为当前 CAS，其余可点击跳转对应档案。
RP-5063→4-methoxy-2-nitrophenol→ethyl 2-(4-methoxy-2-nitrophenoxy)acetate→ethyl 2-(4-hydroxy-2-nitrophenoxy)acetate→1,4-dibromobutane→ethyl 2-(4-(4-bromobutoxy)-2-nitrophenoxy)acetate→1-(2,3-dichlorophenyl)piperazine hydrochloride→ethyl 2-(4-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butoxy)-2-nitrophenoxy)acetate→6-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butoxy)-2H-benzo[b][1,4]oxazin-3(4H)-one
#1→tert-butyl 3-oxobutanoate→1,4-dibromobutane→1-cyclopentylethanone→6-cyclopentyl-2-oxo-1,2-dihydropyridine-4-carboxylic acid→methyl 6-cyclopentyl-2-oxo-1,2-dihydropyridine-4-carboxylate→methyl 2-chloro-6-cyclopentylisonicotinate→2-cyclopentyl-6-methoxyisonicotinic acid→(R)-4-((2,2-dimethyl-1,3-dioxolan-4-yl)methoxy)-3-ethyl-N-hydroxy-5-methylbenzimidamide→(R)-N-((2-cyclopentyl-6-methoxyisonicotinoyl)oxy)-4-((2,2-dimethyl-1,3-dioxolan-4-yl)methoxy)-3-ethyl-5-methylbenzimidamide→(R)-5-(2-cyclopentyl-6-methoxypyridin-4-yl)-3-(4-((2,2-dimethyl-1,3-dioxolan-4-yl)methoxy)-3-ethyl-5-methylphenyl)-1,2,4-oxadiazole→3-ethyl-4-hydroxy-5-methylbenzonitrile→(R)-(2,2-dimethyl-1,3-dioxolan-4-yl)methanol
本站可供应的对应中间体
同 CAS 多家在售供应横向对比；价格区间为供应方挂牌口径，实价以询价确认为准。
| 供应商 | 产品 | 价格区间 | 最小起订 | 货期 | 资质 | 操作 |
|---|---|---|---|---|---|---|
| Qualified Partner — East China API Works | 1-(2,3-Dichlorophenyl)piperazine hydrochloride Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Unibest Nantong cGMP Site | ethyl 2-(4-(4-(4-(2,3-dichlorophenyl)pipe Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Unibest Taizhou GMP-like Site | ethyl 2-(4-(4-bromobutoxy)-2-nitrophenoxy)acetate Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Qualified Partner — East China API Works | 3,3-dimethyldihydro-2H-pyran-2,6(3H)-dione Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Unibest Nantong cGMP Site | methyl (R)-2-((tert-butoxycarbonyl)amino)-3-iodopropanoate Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Unibest Taizhou GMP-like Site | (S)-3-(5-bromo-1-ethyl-2-(2-(1-methoxyethyl)pyridin-3-yl)-1H-indol-3-yl)-2,2-dimethylpropan-1-ol Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
本页为中间体 CAS 注册档案：同 CAS 的多条路线登记已合并；后续供应商报价与买方需求以该 CAS 为主键撮合。