CAS 110-52-1

1,4-dibromobutane

Codes: RP-5063-004, SULFORA-002

Application context (from source-drug indications)

SchizophreniaBrilaroxazineMajor depressive disorderBrilaroxazinePulmonary arterial hypertensionBrilaroxazineIdiopathic pulmonary fibrosisBrilaroxazineManiaBrilaroxazineAttention deficit hyperactivity disorderBrilaroxazineKidney diseaseSulforafan alfadexChronic renal impairmentSulforafan alfadexParkinson's diseaseSulforafan alfadexSchizophreniaSulforafan alfadexLung cancerSulforafan alfadex自闭症Sulforafan alfadex

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
Brilaroxazine	Tier C — Watch / trade	-
Cenerimod	Tier C — Watch / trade	-
Sulforafan alfadex	Tier C — Watch / trade	-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

BrilaroxazineOptimised routesteps: 6total yield: 0.28 g

RP-5063→4-methoxy-2-nitrophenol→ethyl 2-(4-methoxy-2-nitrophenoxy)acetate→ethyl 2-(4-hydroxy-2-nitrophenoxy)acetate→1,4-dibromobutane→ethyl 2-(4-(4-bromobutoxy)-2-nitrophenoxy)acetate→1-(2,3-dichlorophenyl)piperazine hydrochloride→ethyl 2-(4-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butoxy)-2-nitrophenoxy)acetate→6-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butoxy)-2H-benzo[b][1,4]oxazin-3(4H)-one

CenerimodProcess routesteps: 9total yield: 3.3 kg

#1→tert-butyl 3-oxobutanoate→1,4-dibromobutane→1-cyclopentylethanone→6-cyclopentyl-2-oxo-1,2-dihydropyridine-4-carboxylic acid→methyl 6-cyclopentyl-2-oxo-1,2-dihydropyridine-4-carboxylate→methyl 2-chloro-6-cyclopentylisonicotinate→2-cyclopentyl-6-methoxyisonicotinic acid→(R)-4-((2,2-dimethyl-1,3-dioxolan-4-yl)methoxy)-3-ethyl-N-hydroxy-5-methylbenzimidamide→(R)-N-((2-cyclopentyl-6-methoxyisonicotinoyl)oxy)-4-((2,2-dimethyl-1,3-dioxolan-4-yl)methoxy)-3-ethyl-5-methylbenzimidamide→(R)-5-(2-cyclopentyl-6-methoxypyridin-4-yl)-3-(4-((2,2-dimethyl-1,3-dioxolan-4-yl)methoxy)-3-ethyl-5-methylphenyl)-1,2,4-oxadiazole→3-ethyl-4-hydroxy-5-methylbenzonitrile→(R)-(2,2-dimethyl-1,3-dioxolan-4-yl)methanol

Sulforafan alfadexOriginator routesteps: 5total yield: 12.14 g (Sulforadex)

Sulforadex→potassium 1,3-dioxoisoindolin-2-ide→1,4-dibromobutane→2-(4-bromobutyl)isoindoline-1,3-dione→SULFORA-004→SULFORA-005→SULFORA-006

Intermediates available on this site

Side-by-side comparison of all listed offers on this CAS; price bands are list-price ranges, final price subject to RFQ confirmation.

Supplier	Product	Price band	MOQ	Lead time	Qualifications
Qualified Partner — East China API Works	1-(2,3-Dichlorophenyl)piperazine hydrochloride Pharmaceutical Intermediates	On request	On request	On request	—
Unibest Nantong cGMP Site	ethyl 2-(4-(4-(4-(2,3-dichlorophenyl)pipe Pharmaceutical Intermediates	On request	On request	On request	—
Unibest Taizhou GMP-like Site	ethyl 2-(4-(4-bromobutoxy)-2-nitrophenoxy)acetate Pharmaceutical Intermediates	On request	On request	On request	—
Qualified Partner — East China API Works	3,3-dimethyldihydro-2H-pyran-2,6(3H)-dione Pharmaceutical Intermediates	On request	On request	On request	—
Unibest Nantong cGMP Site	methyl (R)-2-((tert-butoxycarbonyl)amino)-3-iodopropanoate Pharmaceutical Intermediates	On request	On request	On request	—
Unibest Taizhou GMP-like Site	(S)-3-(5-bromo-1-ethyl-2-(2-(1-methoxyethyl)pyridin-3-yl)-1H-indol-3-yl)-2,2-dimethylpropan-1-ol Pharmaceutical Intermediates	On request	On request	On request	—

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