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CAS 123-30-8
4-aminophenol4-Hydroxyaniline
登记编号：CABO-011、Ceftazidime-035、SORF-004
应用背景（按来源药适应症）
神经内分泌瘤苹果酸卡博替尼胰腺神经内分泌肿瘤苹果酸卡博替尼肾细胞癌苹果酸卡博替尼肝细胞癌苹果酸卡博替尼甲状腺瘤苹果酸卡博替尼神经内分泌癌苹果酸卡博替尼膀胱炎阿维巴坦钠/头孢他啶胆囊炎阿维巴坦钠/头孢他啶腹膜炎阿维巴坦钠/头孢他啶腹腔感染阿维巴坦钠/头孢他啶肝脓肿阿维巴坦钠/头孢他啶脓毒病阿维巴坦钠/头孢他啶细菌感染头孢他啶/他唑巴坦钠呼吸道感染头孢他啶/他唑巴坦钠泌尿系统感染头孢他啶/他唑巴坦钠甲状腺瘤甲苯磺酸索拉非尼肝细胞癌甲苯磺酸索拉非尼肾细胞癌甲苯磺酸索拉非尼侵袭性纤维瘤病甲苯磺酸索拉非尼肝癌甲苯磺酸索拉非尼骨髓增生性疾病甲苯磺酸索拉非尼细菌感染头孢他啶革兰氏阳性细菌感染头孢他啶革兰氏阴性细菌感染头孢他啶妇科疾病头孢他啶腹腔感染头孢他啶骨关节炎头孢他啶
来源药（使用该中间体的合成路线）
| 品种 | 梯队 | 到期年 |
|---|---|---|
| 苹果酸卡博替尼Cabozantinib S-malate | Tier B · 提前布局 | 2029 |
| 阿维巴坦钠/头孢他啶Avibactam Sodium/Ceftazidime | Tier C · 观察 / 贸易 | - |
| 头孢他啶/他唑巴坦钠Ceftazidime/Tazobactam Sodium | Tier C · 观察 / 贸易 | - |
| 甲苯磺酸索拉非尼Sorafenib Tosylate | Tier B · 提前布局 | - |
| 头孢他啶Ceftazidime | Tier C · 观察 / 贸易 | - |
合成路线中的位置（上下游链）
按路线登记顺序排列，左→右为合成方向；高亮为当前 CAS，其余可点击跳转对应档案。
1-(3,4-dimethoxyphenyl)ethan-1-one→1-(4,5-dimethoxy-2-nitrophenyl)ethanone→1-(2-amino-4,5-dimethoxyphenyl)ethanone→ethyl formate→6,7-dimethoxyquinolin-4-ol→6,7-dimethoxyquinolin-4-yl trifluoromethanesulfonate→N-(4-fluorophenyl)-N-(4-hydroxyphenyl)cyclopropane-1,1-dicarboxamide→cyclopropane-1,1-dicarboxylic acid→4-fluoroaniline→methyl 1-((4-fluorophenyl)carbamoyl)cyclopropanecarboxylate→4-aminophenol
4-fluoroaniline→4-aminophenol→4-chloro-6,7-dimethoxyquinoline→diethyl cyclopropane-1,1-dicarboxylate→1-(ethoxycarbonyl)cyclopropane-1-carboxylic acid→ethyl 1-((4-hydroxyphenyl)carbamoyl)cyclopropane-1-carboxylate→ethyl 1-((4-((6,7-dimethoxyquinolin-4-yl)oxy)phenyl)carbamoyl)cyclopropane-1-carboxylate→1-((4-((6,7-dimethoxyquinolin-4-yl)oxy)phenyl)carbamoyl)cyclopropane-1-carboxylic acid
4-(Dimethylamino)phenol→tert-Butyl (5Z)-5-(2-amino-1,3-thiazol-4-yl)-8,8-dimethyl-4-oxo-3,7-dioxa-2-thia-6-azanon-5-en-9-oate 2,2-dioxide→4-Methoxybenzyl (6R,7R)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-[[(1-tert-butoxy-2-methyl-1-oxopropan-2-yl)oxy]imino]acetyl]amino]-3-(chloromethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate→1-[[(6R,7R)-7-[[(2Z)-2-(2-Amino-1,3-thiazol-4-yl)-2-[[(1-tert-butoxy-2-methyl-1-oxopropan-2-yl)oxy]imino]acetyl]amino]-2-[[(4-methoxybenzyl)oxy]carbonyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl]pyridinium chloride→4-Hydroxyaniline→(2Z)-(2-Amino-1,3-thiazol-4-yl)[[(1-tert-butoxy-2-methyl-1-oxopropan-2-yl)oxy]imino]acetic acid→Pyridine→4-Methoxybenzyl (6R,7R)-7-amino-3-(chloromethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate hydrochloride
4-(Dimethylamino)phenol→tert-Butyl (5Z)-5-(2-amino-1,3-thiazol-4-yl)-8,8-dimethyl-4-oxo-3,7-dioxa-2-thia-6-azanon-5-en-9-oate 2,2-dioxide→4-Methoxybenzyl (6R,7R)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-[[(1-tert-butoxy-2-methyl-1-oxopropan-2-yl)oxy]imino]acetyl]amino]-3-(chloromethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate→1-[[(6R,7R)-7-[[(2Z)-2-(2-Amino-1,3-thiazol-4-yl)-2-[[(1-tert-butoxy-2-methyl-1-oxopropan-2-yl)oxy]imino]acetyl]amino]-2-[[(4-methoxybenzyl)oxy]carbonyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl]pyridinium chloride→4-Hydroxyaniline→(2Z)-(2-Amino-1,3-thiazol-4-yl)[[(1-tert-butoxy-2-methyl-1-oxopropan-2-yl)oxy]imino]acetic acid→Pyridine→4-Methoxybenzyl (6R,7R)-7-amino-3-(chloromethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate hydrochloride
本站可供应的对应中间体
同 CAS 多家在售供应横向对比；价格区间为供应方挂牌口径，实价以询价确认为准。
| 供应商 | 产品 | 价格区间 | 最小起订 | 货期 | 资质 | 操作 |
|---|---|---|---|---|---|---|
| Unibest Nantong cGMP Site | 4-Hydroxy-6,7-dimethoxyqunioline Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Unibest Taizhou GMP-like Site | 4-((6,7-Dimethoxyquinolin -4-yl)oxy)aniline Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Qualified Partner — East China API Works | 1-(4-Fluorophenylcarbamoyl)cyclopropanecarboxylic acid Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
本页为中间体 CAS 注册档案：同 CAS 的多条路线登记已合并；后续供应商报价与买方需求以该 CAS 为主键撮合。