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CAS 1559-02-0
diethyl cyclopropane-1,1-dicarboxylate
登记编号：CABO-017、MONT-015
应用背景（按来源药适应症）
神经内分泌瘤苹果酸卡博替尼胰腺神经内分泌肿瘤苹果酸卡博替尼肾细胞癌苹果酸卡博替尼肝细胞癌苹果酸卡博替尼甲状腺瘤苹果酸卡博替尼神经内分泌癌苹果酸卡博替尼过敏性鼻炎孟鲁司特钠哮喘孟鲁司特钠超敏反应孟鲁司特钠季节性过敏性鼻炎孟鲁司特钠常年性变应性鼻炎孟鲁司特钠运动诱发哮喘孟鲁司特钠
来源药（使用该中间体的合成路线）
合成路线中的位置（上下游链）
按路线登记顺序排列，左→右为合成方向；高亮为当前 CAS，其余可点击跳转对应档案。
4-fluoroaniline→4-aminophenol→4-chloro-6,7-dimethoxyquinoline→diethyl cyclopropane-1,1-dicarboxylate→1-(ethoxycarbonyl)cyclopropane-1-carboxylic acid→ethyl 1-((4-hydroxyphenyl)carbamoyl)cyclopropane-1-carboxylate→ethyl 1-((4-((6,7-dimethoxyquinolin-4-yl)oxy)phenyl)carbamoyl)cyclopropane-1-carboxylate→1-((4-((6,7-dimethoxyquinolin-4-yl)oxy)phenyl)carbamoyl)cyclopropane-1-carboxylic acid
7-chloro-2-methylquinoline→isophthalaldehyde→(E)-3-(2-(7-chloroquinolin-2-yl)vinyl)benzaldehyde→(E)-1-(3-(2-(7-chloroquinolin-2-yl)vinyl)phenyl)prop-2-en-1-ol→methyl 2-bromobenzoate→methyl (E)-2-(3-(3-(2-(7-chloroquinolin-2-yl)vinyl)phenyl)-3-oxopropyl)benzoate→methyl (S,E)-2-(3-(3-(2-(7-chloroquinolin-2-yl)vinyl)phenyl)-3-hydroxypropyl)benzoate→(S,E)-1-(3-(2-(7-chloroquinolin-2-yl)vinyl)phenyl)-3-(2-(2-hydroxypropan-2-yl)phenyl)propan-1-ol→(1S)-1-(3-((E)-2-(7-chloroquinolin-2-yl)vinyl)phenyl)-3-(2-(2-((tetrahydro-2H-pyran-2-yl)oxy)propan-2-yl)phenyl)propan-1-ol→(1S)-1-(3-((E)-2-(7-chloroquinolin-2-yl)vinyl)phenyl)-3-(2-(2-((tetrahydro-2H-pyran-2-yl)oxy)propan-2-yl)phenyl)propyl methanesulfonate→methyl 2-(1-((acetylthio)methyl)cyclopropyl)acetate→methyl 2-(1-((((1R)-1-(3-((E)-2-(7-chloroquinolin-2-yl)vinyl)phenyl)-3-(2-(2-((tetrahydro-2H-pyran-2-yl)oxy)propan-2-yl)phenyl)propyl)thio)methyl)cyclopropyl)acetate→pyridine→(R,E)-2-(1-(((1-(3-(2-(7-chloroquinolin-2-yl)vinyl)phenyl)-3-(2-(2-hydroxypropan-2-yl)phenyl)propyl)thio)methyl)cyclopropyl)acetic acid→diethyl cyclopropane-1,1-dicarboxylate→cyclopropane-1,1-diyldimethanol→(1-(hydroxymethyl)cyclopropyl)methyl benzoate→(1-(cyanomethyl)cyclopropyl)methyl benzoate→2-(1-(hydroxymethyl)cyclopropyl)acetic acid
本站可供应的对应中间体
同 CAS 多家在售供应横向对比；价格区间为供应方挂牌口径，实价以询价确认为准。
| 供应商 | 产品 | 价格区间 | 最小起订 | 货期 | 资质 | 操作 |
|---|---|---|---|---|---|---|
| Unibest Nantong cGMP Site | 4-Hydroxy-6,7-dimethoxyqunioline Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Unibest Taizhou GMP-like Site | 4-((6,7-Dimethoxyquinolin -4-yl)oxy)aniline Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Qualified Partner — East China API Works | 1-(4-Fluorophenylcarbamoyl)cyclopropanecarboxylic acid Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
本页为中间体 CAS 注册档案：同 CAS 的多条路线登记已合并；后续供应商报价与买方需求以该 CAS 为主键撮合。