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CAS 124-40-3
dimethylamineN-MethylmethanamineDimethylamineDimethylamine anhydrous
登记编号：RIBO-007、Tetracaine-021、SUMAT-007、DESV-002、Desvenlafaxine-012、(XIV)145089-2-a、(XI)145089-4-b、(IV)145089-11-a、(III)145089-21-a
应用背景（按来源药适应症）
乳腺癌琥珀酸瑞波西利麻醉盐酸羟甲唑啉/盐酸丁卡因根尖周炎盐酸羟甲唑啉/盐酸丁卡因龋齿盐酸羟甲唑啉/盐酸丁卡因偏头痛萘普生钠/琥珀酸舒马普坦无先兆偏头痛萘普生钠/琥珀酸舒马普坦抑郁症琥珀酸去甲文拉法辛重度抑郁症琥珀酸去甲文拉法辛抑郁琥珀酸去甲文拉法辛糖尿病神经病变琥珀酸去甲文拉法辛疼痛琥珀酸去甲文拉法辛纤维肌痛琥珀酸去甲文拉法辛重度抑郁症地文拉法辛抑郁症地文拉法辛麻醉盐酸丁卡因色素性视网膜炎盐酸丁卡因疼痛盐酸丁卡因丛集性头痛琥珀酸舒马普坦偏头痛琥珀酸舒马普坦继发性头痛症琥珀酸舒马普坦创伤后头痛琥珀酸舒马普坦阿尔茨海默病重酒石酸卡巴拉汀痴呆重酒石酸卡巴拉汀帕金森病重酒石酸卡巴拉汀抗胆碱能综合征重酒石酸卡巴拉汀神经行为学表现重酒石酸卡巴拉汀认知障碍重酒石酸卡巴拉汀
来源药（使用该中间体的合成路线）
| 品种 | 梯队 | 到期年 |
|---|---|---|
| 琥珀酸瑞波西利Ribociclib Succinate | Tier A · 立即攻坚 | 2029 |
| 盐酸羟甲唑啉/盐酸丁卡因Oxymetazoline Hydrochloride/Tetracaine Hydrochloride | Tier C · 观察 / 贸易 | - |
| 萘普生钠/琥珀酸舒马普坦Naproxen Sodium/Sumatriptan Succinate | Tier C · 观察 / 贸易 | - |
| 琥珀酸去甲文拉法辛Desvenlafaxine Succinate Hydrate | Tier C · 观察 / 贸易 | - |
| 地文拉法辛Desvenlafaxine | Tier C · 观察 / 贸易 | - |
| 盐酸丁卡因Tetracaine Hydrochloride | Tier C · 观察 / 贸易 | - |
| 琥珀酸舒马普坦Sumatriptan Succinate | Tier C · 观察 / 贸易 | - |
| 重酒石酸卡巴拉汀Rivastigmine Tartrate | Tier B · 提前布局 | - |
合成路线中的位置（上下游链）
按路线登记顺序排列，左→右为合成方向；高亮为当前 CAS，其余可点击跳转对应档案。
5-bromo-2,4-dichloropyrimidine→cyclopentanamine→5-bromo-2-chloro-N-cyclopentylpyrimidin-4-amine→prop-2-yn-1-ol→3-(2-chloro-4-(cyclopentylamino)pyrimidin-5-yl)prop-2-yn-1-ol→(2-chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl)methanol→dimethylamine→2-chloro-7-cyclopentyl-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide→tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate→tert-butyl 4-(6-((7-cyclopentyl-6-(dimethylcarbamoyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazine-1-carboxylate→5-chloro-2-nitropyridine→piperazine→1-(6-nitropyridin-3-yl)piperazine→tert-butyl 4-(6-nitropyridin-3-yl)piperazine-1-carboxylate
4-Aminobenzoic acid sodium salt→4-(Butylamino)benzoic acid→p-Chlorobenzoic acid→4-Bromobenzoic acid→4-Iodobenzoic acid→Butylamine→4-(Butylamino)benzoic acid ethyl ester→2-(Dimethylamino)ethanol hydrochloride→2-Chloroethanol→4-(Butylamino)benzoic acid 2-chloroethyl ester→N-Methylmethanamine→n-Butyl bromide→N,N-Dimethylaminoethanol→4-Aminobenzoic acid 2-(dimethylamino)ethyl ester→4-(Butylamino)benzoic acid 2-(dimethylamino)ethyl ester
1-(4-aminophenyl)-N-methylmethanesulfonamide→1-(3-hydrazineylphenyl)-N-methylmethanesulfonamide→2-(phenylthio)acetaldehyde→(E)-N-methyl-1-(3-(2-(2-(phenylthio)ethylidene)hydrazineyl)phenyl)methanesulfonamide→N-methyl-1-(3-(phenylthio)-1H-indol-5-yl)methanesulfonamide→1-(1H-indol-5-yl)-N-methylmethanesulfonamide→dimethylamine→N,N-dimethyl-2-(5-((N-methylsulfamoyl)methyl)-1H-indol-3-yl)-2-oxoacetamide→1-(3-(2-(dimethylamino)ethyl)-1H-indol-5-yl)-N-methylmethanesulfonamide
2-(4-Hydroxyphenyl)acetic acid→2-(4-Hydroxyphenyl)acetyl chloride→Dimethylamine→2-(4-Hydroxyphenyl)-N,N-dimethylacetamide→2-[4-[tert-Butyl(dimethyl)silyloxy]phenyl]-N,N-dimethylacetamide→Cyclohexanone→2-[4-[tert-Butyl(dimethyl)silyloxy]phenyl]-2-(1-hydroxycyclohexyl)-N,N-dimethylacetamide→4-[2-(Dimethylamino)-1-(1-hydroxycyclohexyl)ethyl]phenol→2-(1-Hydroxycyclohexyl)-2-(4-hydroxyphenyl)-N,N-dimethylacetamide
本站可供应的对应中间体
同 CAS 多家在售供应横向对比；价格区间为供应方挂牌口径，实价以询价确认为准。
| 供应商 | 产品 | 价格区间 | 最小起订 | 货期 | 资质 | 操作 |
|---|---|---|---|---|---|---|
| Unibest Nantong cGMP Site | 2-Chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic
acid Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Unibest Taizhou GMP-like Site | 2-Chloro-7-cyclopentyl-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6- carboxamide Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
本页为中间体 CAS 注册档案：同 CAS 的多条路线登记已合并；后续供应商报价与买方需求以该 CAS 为主键撮合。