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CAS 1282516-68-0
9-bromo-2,3-diiodo-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine
登记编号：Inavolisib-005、TASE-005
应用背景（按来源药适应症）
乳腺癌伊那利塞转移性乳腺癌伊那利塞胰腺导管癌伊那利塞二型糖尿病伊那利塞子宫内膜癌伊那利塞卵巢上皮癌伊那利塞乳腺癌Taselisib膀胱癌Taselisib多发性骨髓瘤Taselisib肺癌Taselisib肝癌Taselisib宫颈癌Taselisib
来源药（使用该中间体的合成路线）
合成路线中的位置（上下游链）
按路线登记顺序排列，左→右为合成方向；高亮为当前 CAS，其余可点击跳转对应档案。
3-bromophenol→4-bromo-2-hydroxybenzaldehyde→5-bromo-2-(1H-imidazol-2-yl)phenol→9-bromo-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine→9-bromo-2,3-diiodo-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine→9-bromo-2-iodo-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine→(1S,2S)-1,2-bis((R)-2,2-dimethyl-1,3-dioxolan-4-yl)ethane-1,2-diol→(R)-2,2-dimethyl-1,3-dioxolane-4-carbaldehyde→(R)-4-(difluoromethyl)-2,2-dimethyl-1,3-dioxolane→tert-butylchlorodimethylsilane→(R)-3-((tert-butyldimethylsilyl)oxy)-1,1-difluoropropan-2-ol→(S)-(2-azido-3,3-difluoropropoxy)(tert-butyl)dimethylsilane→(S)-3-((tert-butyldimethylsilyl)oxy)-1,1-difluoropropan-2-amine→(S)-4-(difluoromethyl)oxazolidin-2-one→(1R,2R)-N1,N2-dimethylcyclohexane-1,2-diamine→(S)-3-(9-bromo-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-2-yl)-4-(difluoromethyl)oxazolidin-2-one→L-alanine
9-bromo-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine→9-bromo-2,3-diiodo-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine→9-bromo-2-iodo-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine→(S)-4-(difluoromethyl)oxazolidin-2-one→(1R,2R)-N1,N2-dimethylcyclohexane-1,2-diamine→(S)-3-(9-bromo-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-2-yl)-4-(difluoromethyl)oxazolidin-2-one→L-alanine→8-bromo-2,3-dihydrobenzo[f][1,4]oxazepin-5-aminium→(2-((S)-4-(difluoromethyl)-2-oxooxazolidin-3-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)-L-alaninate
4-bromo-2-hydroxybenzaldehyde→5-bromo-2-(1H-imidazol-2-yl)phenol→1,2-dibromoethane→9-bromo-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine→9-bromo-2,3-diiodo-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine→9-bromo-2-iodo-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine→bis(trimethylsilyl)amine→9-bromo-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine-2-carboxamide→1,1-dimethoxy-N,N-dimethylethanamine→9-bromo-2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine→2-methyl-2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)propanamide
本站可供应的对应中间体
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