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CAS 106-93-4
Ethylene dibromide1,2-dibromoethane1,2-Dibromoethane
登记编号：Oxymetazoline Hydrochloride-015、BAZE-024、SITAF-015、SILO-022、CHIG-004、(IV)919110-1-a、TASE-003
应用背景（按来源药适应症）
麻醉盐酸羟甲唑啉/盐酸丁卡因根尖周炎盐酸羟甲唑啉/盐酸丁卡因龋齿盐酸羟甲唑啉/盐酸丁卡因雌激素缺乏综合征结合雌激素/醋酸巴多昔芬骨质疏松症结合雌激素/醋酸巴多昔芬血管舒缩症结合雌激素/醋酸巴多昔芬非浸润性导管癌结合雌激素/醋酸巴多昔芬焦虑结合雌激素/醋酸巴多昔芬绝经期症状结合雌激素/醋酸巴多昔芬膀胱炎西他沙星鼻窦炎西他沙星扁桃体炎西他沙星肺炎西他沙星宫颈炎西他沙星冠周炎西他沙星前列腺增生赛洛多辛下尿路症状赛洛多辛尿路结石症赛洛多辛肾结石赛洛多辛避孕行为赛洛多辛尿路结石赛洛多辛鼻塞盐酸羟甲唑啉充血盐酸羟甲唑啉眼睑下垂盐酸羟甲唑啉功能性大便失禁盐酸羟甲唑啉酒渣鼻盐酸羟甲唑啉红疹盐酸羟甲唑啉绝经期后骨质疏松醋酸巴多昔芬乳腺癌醋酸巴多昔芬骨质疏松症醋酸巴多昔芬绝经期症状醋酸巴多昔芬二型糖尿病西格列他钠非酒精性脂肪性肝炎西格列他钠胰岛素抵抗西格列他钠肝功能衰退西格列他钠肾功能不全西格列他钠糖尿病西格列他钠非小细胞肺癌地罗阿克乳腺癌Taselisib膀胱癌Taselisib多发性骨髓瘤Taselisib肺癌Taselisib肝癌Taselisib宫颈癌Taselisib
来源药（使用该中间体的合成路线）
| 品种 | 梯队 | 到期年 |
|---|---|---|
| 盐酸羟甲唑啉/盐酸丁卡因Oxymetazoline Hydrochloride/Tetracaine Hydrochloride | Tier C · 观察 / 贸易 | - |
| 结合雌激素/醋酸巴多昔芬Conjugated Estrogens/Bazedoxifene Acetate | Tier C · 观察 / 贸易 | - |
| 西他沙星Sitafloxacin Hydrate | Tier C · 观察 / 贸易 | - |
| 赛洛多辛Silodosin | Tier C · 观察 / 贸易 | - |
| 盐酸羟甲唑啉Oxymetazoline Hydrochloride | Tier C · 观察 / 贸易 | - |
| 醋酸巴多昔芬Bazedoxifene Acetate | Tier C · 观察 / 贸易 | - |
| 西格列他钠Chiglitazar Sodium | Tier C · 观察 / 贸易 | - |
| 地罗阿克Dirozalkib | Tier C · 观察 / 贸易 | - |
| Taselisib | Tier C · 观察 / 贸易 | - |
合成路线中的位置（上下游链）
按路线登记顺序排列，左→右为合成方向；高亮为当前 CAS，其余可点击跳转对应档案。
(4-tert-Butyl-3-hydroxy-2,6-dimethylphenyl)acetonitrile→Ethane-1,2-diamine→N-[2-(Acetamido)ethyl]acetamide→6-tert-Butyl-3-(4,5-dihydro-1H-imidazol-2-ylmethyl)-2,4-dimethylphenol→(4-tert-Butyl-3-hydroxy-2,6-dimethylphenyl)acetyl chloride→(4-tert-Butyl-3-hydroxy-2,6-dimethylphenyl)acetic acid→Ethane-1,2-diamine 4-methylbenzenesulfonate→2-(4-tert-Butyl-3-hydroxy-2,6-dimethylphenyl)acetamide→2-Bromoethanamine hydrobromide→Ethylene dibromide→Ethyl 2-(4-tert-butyl-3-hydroxy-2,6-dimethylphenyl)ethanimidoate hydrochloride
1-(4-(benzyloxy)phenyl)-2-bromopropan-1-one→1-(4-(2-(azepan-1-yl)ethoxy)benzyl)-5-(benzyloxy)-2-(4-(benzyloxy)phenyl)-3-methyl-1H-indole→4-hydroxybenzaldehyde→4-(2-(azepan-1-yl)ethoxy)benzaldehyde→azepane→1,2-dibromoethane→1-(2-bromoethyl)azepane→4-(benzyloxy)aniline→N-(4-(2-(azepan-1-yl)ethoxy)benzyl)-4-(benzyloxy)aniline
ethyl 3-(3-chloro-2,4,5-trifluorophenyl)-3-oxopropanoate→(Z)-ethyl 2-(3-chloro-2,4,5-trifluorobenzoyl)-3-ethoxyacrylate→tert-butyl ((1R,2S)-2-fluorocyclopropyl)carbamate→ethyl (Z)-2-(3-chloro-2,4,5-trifluorobenzoyl)-3-(((1R,2S)-2-fluorocyclopropyl)amino)acrylate→ethyl 8-chloro-6,7-difluoro-1-((1R,2S)-2-fluorocyclopropyl)-4-oxo-1,4-dihydroquinoline-3-carboxylate→8-chloro-6,7-difluoro-1-((1R,2S)-2-fluorocyclopropyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid→SITAF-007→7-((S)-7-((tert-butoxycarbonyl)amino)-5-azaspiro[2.4]heptan-5-yl)-8-chloro-6-fluoro-1-((1R,2S)-2-fluorocyclopropyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid→2-fluorocyclopropane-1-carboxylic acid→(R)-1-phenylethan-1-amine→2-fluoro-N-((R)-1-phenylethyl)cyclopropane-1-carboxamide→2-fluoro-N-((R)-1-phenylethyl)cyclopropane-1-carboxamide→(1S,2S)-2-fluoro-N-((R)-1-phenylethyl)cyclopropane-1-carboxamide→ethyl 3-oxobutanoate→1,2-dibromoethane→ethyl 1-acetylcyclopropane-1-carboxylate→ethyl 1-(2-bromoacetyl)cyclopropane-1-carboxylate→(R)-5-(1-phenylethyl)-5-azaspiro[2.4]heptane-4,7-dione→(R,Z)-7-(hydroxyimino)-5-(1-phenylethyl)-5-azaspiro[2.4]heptan-4-one→(S)-7-amino-5-((R)-1-phenylethyl)-5-azaspiro[2.4]heptan-4-one→(S)-5-((R)-1-phenylethyl)-5-azaspiro[2.4]heptan-7-amine→tert-butyl ((S)-5-((R)-1-phenylethyl)-5-azaspiro[2.4]heptan-7-yl)carbamate
SITAF-007→1,2-dibromoethane→benzylglycine→N-benzyl-N-(tert-butoxycarbonyl)glycine→potassium 3-ethoxy-3-oxopropanoate→ethyl 4-(benzyl(tert-butoxycarbonyl)amino)-3-oxobutanoate→ethyl 1-(N-benzyl-N-(tert-butoxycarbonyl)glycyl)cyclopropane-1-carboxylate→5-benzyl-5-azaspiro[2.4]heptane-4,7-dione→(S)-5-benzyl-7-hydroxy-5-azaspiro[2.4]heptan-4-one→(S)-5-benzyl-5-azaspiro[2.4]heptan-7-amine→tert-butyl (S)-(5-benzyl-5-azaspiro[2.4]heptan-7-yl)carbamate
1-(1-acetylindolin-5-yl)propan-1-one→1-(1-acetylindolin-5-yl)-2-bromopropan-1-one→1-(5-(2-bromopropyl)indolin-1-yl)ethan-1-one→1-(5-(2-bromopropyl)-7-nitroindolin-1-yl)ethan-1-one→1-(7-amino-5-(2-bromopropyl)indolin-1-yl)ethan-1-one→1-acetyl-5-(2-bromopropyl)indoline-7-carbonitrile→1-acetyl-5-(2-azidopropyl)indoline-7-carbonitrile→1-acetyl-5-(2-aminopropyl)indoline-7-carbonitrile→1-(2-bromoethoxy)-2-(2,2,2-trifluoroethoxy)benzene→1-acetyl-5-(2-((2-(2-(2,2,2-trifluoroethoxy)phenoxy)ethyl)amino)propyl)indoline-7-carbonitrile→(R)-1-acetyl-5-(2-((2-(2-(2,2,2-trifluoroethoxy)phenoxy)ethyl)amino)propyl)indoline-7-carbonitrile→tert-butyl (R)-(1-(1-acetyl-7-cyanoindolin-5-yl)propan-2-yl)(2-(2-(2,2,2-trifluoroethoxy)phenoxy)ethyl)carbamate→tert-butyl (R)-(1-(7-cyanoindolin-5-yl)propan-2-yl)(2-(2-(2,2,2-trifluoroethoxy)phenoxy)ethyl)carbamate→tert-butyl (R)-(1-(7-carbamoylindolin-5-yl)propan-2-yl)(2-(2-(2,2,2-trifluoroethoxy)phenoxy)ethyl)carbamate→3-((tert-butyldimethylsilyl)oxy)propyl 4-nitrobenzenesulfonate→tert-butyl (R)-(1-(1-(3-((tert-butyldimethylsilyl)oxy)propyl)-7-carbamoylindolin-5-yl)propan-2-yl)(2-(2-(2,2,2-trifluoroethoxy)phenoxy)ethyl)carbamate→tert-butyl (R)-(1-(7-carbamoyl-1-(3-hydroxypropyl)indolin-5-yl)propan-2-yl)(2-(2-(2,2,2-trifluoroethoxy)phenoxy)ethyl)carbamate→2-methoxyphenol→1,1,1-trifluoro-2-iodoethane→1-methoxy-2-(2,2,2-trifluoroethoxy)benzene→2-(2,2,2-trifluoroethoxy)phenol→1,2-dibromoethane
本站可供应的对应中间体
同 CAS 多家在售供应横向对比；价格区间为供应方挂牌口径，实价以询价确认为准。
| 供应商 | 产品 | 价格区间 | 最小起订 | 货期 | 资质 | 操作 |
|---|---|---|---|---|---|---|
| Unibest Nantong cGMP Site | Carbamic acid, (7S)-5-azaspiro[2.4]hept-7-yl-, 1,1-dimethylethyl ester (9CI) Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
本页为中间体 CAS 注册档案：同 CAS 的多条路线登记已合并；后续供应商报价与买方需求以该 CAS 为主键撮合。