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CAS 16450-41-2
(S)-diethyl 2-aminopentanedioate(S)-Glutamic acid diethyl ester
登记编号：PRAL-034、Folic Acid-083、PEME-026
应用背景（按来源药适应症）
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来源药（使用该中间体的合成路线）
| 品种 | 梯队 | 到期年 |
|---|---|---|
| 普拉曲沙Pralatrexate | Tier C · 观察 / 贸易 | - |
| 马来酸依那普利/叶酸Enalapril Maleate/Folic Acid | Tier C · 观察 / 贸易 | - |
| 叶酸Folic Acid | Tier C · 观察 / 贸易 | - |
| 培美曲塞二钠Pemetrexed Disodium Hydrate | Tier B · 提前布局 | - |
合成路线中的位置（上下游链）
按路线登记顺序排列，左→右为合成方向；高亮为当前 CAS，其余可点击跳转对应档案。
methyl 4-(2-methoxy-2-oxoethyl)benzoate→3-bromoprop-1-yne→methyl 4-(1-methoxy-1-oxopent-4-yn-2-yl)benzoate→6-(bromomethyl)pteridine-2,4-diamine→diethyl (4-(1-(2,4-diaminopteridin-6-yl)pent-4-yn-2-yl)benzoyl)-L-glutamate→methyl 4-(2-((2,4-diaminopteridin-6-yl)methyl)-1-methoxy-1-oxopent-4-yn-2-yl)benzoate hydrobromide→4-(2-carboxy-1-(2,4-diaminopteridin-6-yl)pent-4-yn-2-yl)benzoic acid→sodium 4-(1-(2,4-diaminopteridin-6-yl)pent-4-yn-2-yl)benzoate→(S)-diethyl 2-aminopentanedioate
4-(Ethoxycarbonyl)aniline→(+/-)-2-(Chloromethyl)oxirane→Ethyl 4-[(3-chloro-2-hydroxypropyl)amino]benzoate→Ethyl 4-[(tert-butoxycarbonyl)(3-chloro-2-hydroxypropyl)amino]benzoate→Ethyl 4-[(tert-butoxycarbonyl)(3-chloro-2-oxopropyl)amino]benzoate→2,4,5-Triamino-6-hydroxypyrimidine sulfate→Ethyl 4-[[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl](tert-butoxycarbonyl)amino]benzoate→4-[(2-Amino-4-oxo-3H-pteridin-6-yl)methyl-[(2-methylpropan-2-yl)oxycarbonyl]amino]benzoic acid→(S)-Glutamic acid diethyl ester→Diethyl N-(4-[[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl](tert-butoxycarbonyl)amino]benzoyl)-L-glutamate
4-(Ethoxycarbonyl)aniline→(+/-)-2-(Chloromethyl)oxirane→Ethyl 4-[(3-chloro-2-hydroxypropyl)amino]benzoate→Ethyl 4-[(tert-butoxycarbonyl)(3-chloro-2-hydroxypropyl)amino]benzoate→Ethyl 4-[(tert-butoxycarbonyl)(3-chloro-2-oxopropyl)amino]benzoate→2,4,5-Triamino-6-hydroxypyrimidine sulfate→Ethyl 4-[[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl](tert-butoxycarbonyl)amino]benzoate→4-[(2-Amino-4-oxo-3H-pteridin-6-yl)methyl-[(2-methylpropan-2-yl)oxycarbonyl]amino]benzoic acid→(S)-Glutamic acid diethyl ester→Diethyl N-(4-[[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl](tert-butoxycarbonyl)amino]benzoyl)-L-glutamate
dimethyl (4-(2-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzoyl)-L-glutamate→4-(2-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzoic acid→ethyl 4-(3-oxopropyl)benzoate→3-ethylbenzo[d]thiazol-3-ium bromide→ethyl 4-(4-hydroxy-3-oxobutyl)benzoate→malononitrile→ethyl 4-(2-(5-amino-4-cyanofuran-3-yl)ethyl)benzoate→guanidine→ethyl 4-(2-(2,4-diamino-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzoate→(S)-diethyl 2-aminopentanedioate
本站可供应的对应中间体
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