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马来酸依那普利/叶酸
Tier C · 观察 / 贸易Enalapril Maleate/Folic Acid
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原研
2008
首批上市
-
到期年（公开口径）
无销量数据
峰值销售
化学药
类型
靶点：ACE
商品名：依叶
适应症（已批准）：原发性高血压
各地区研发/上市状态
美国
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欧盟
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中国
批准上市
2008-03-03
日本
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生产该 API 的工厂16
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登录查看工厂名单 →合成路线与中间体30 routes
原研路线 × 0优化路线（非专利）× 28工艺路线 × 2
路线按「原研路线 → 优化路线 / 工艺路线（非专利）」排序。每条路线附本站自绘的路线流程图（中间体 → 原料药）与中间体表（编号 / CAS / 英文名），可直接用于供应商开发与询价。流程图由本站依据已授权的结构化数据自行渲染，未使用任何第三方路线图。
优化Route 1步骤 1 · 总收率 /
Enalapril-00164920-29-2Enalapril-00213485-59-1API · 马来酸依那普利/叶酸
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Enalapril-001 | 64920-29-2 | Ethyl 2-oxo-4-phenylbutyrate |
| Enalapril-002 | 13485-59-1 | L-Alanyl-L-proline |
优化Route 2步骤 2 · 总收率 4.2g(Enalapril)
Enalapril-00382717-96-2Enalapril-004147-85-3Enalapril-00575847-73-3Enalapril-006110-17-8API · 马来酸依那普利/叶酸
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Enalapril-003 | 82717-96-2 | N-[1-Ethoxy-1-oxo-4-phenylbutan-2(S)-yl]-L-alanine |
| Enalapril-004 | 147-85-3 | (-)-L-Proline<-fgf->L-Proline |
| Enalapril-005 | 75847-73-3 | (S)-1-[N-[1-(Ethoxycarbonyl)-3-phenylpropyl]-L-alanyl]-L-proline |
| Enalapril-006 | 110-17-8在售 | trans-2-Butenedioic acid |
优化Route 3步骤 9 · 总收率 /
Enalapril-00753279-92-8Enalapril-008120999-41-9Enalapril-009138566-24-2Enalapril-010—Enalapril-0111142-20-7Enalapril-01290315-82-5Enalapril-01388767-98-0Enalapril-01429375-30-2Enalapril-015108428-39-3Enalapril-0162812-46-6Enalapril-01727544-35-0API · 马来酸依那普利/叶酸
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Enalapril-007 | 53279-92-8 | 2-Hydroxy-4-phenylbutanenitrile |
| Enalapril-008 | 120999-41-9 | 2(R)-Hydroxy-4-phenylbutanenitrile |
| Enalapril-009 | 138566-24-2 | 4-Phenyl-2(R)-(tetrahydropyran-2-yloxy)butanenitrile |
| Enalapril-010 | - | 4-Phenyl-2(R)-(tetrahydropyran-2-yloxy)butyric acid |
| Enalapril-011 | 1142-20-7 | N-[(Benzyloxy)carbonyl]-L-alanine |
| Enalapril-012 | 90315-82-5 | Ethyl (R)-(-)-2-hydroxy-4-phenylbutyrate |
| Enalapril-013 | 88767-98-0 | 4-Phenyl-2(R)-(trifluoromethylsulfonyloxy)butyric acid ethyl ester |
| Enalapril-014 | 29375-30-2 | L-Alanyl-L-proline tert-butyl ester |
| Enalapril-015 | 108428-39-3 | N-[1-Ethoxy-1-oxo-4-phenylbutan-2(S)-yl]-L-alanyl-L-proline tert-butyl ester |
| Enalapril-016 | 2812-46-6 | N-Boc-proline |
| Enalapril-017 | 27544-35-0 | N-(Benzyloxycarbonyl)-L-alanyl-L-proline tert-butyl ester |
优化Route 4步骤 4 · 总收率 4.11g(Enalapril)
Enalapril-01880828-26-8Enalapril-019103377-40-8Enalapril-02016652-71-4Enalapril-021120924-94-9Enalapril-00382717-96-2API · 马来酸依那普利/叶酸
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Enalapril-018 | 80828-26-8 | N-[(2S)-1-Ethoxy-1-oxo-4-phenylbutan-2-yl]-L-alanine hydrochloride |
| Enalapril-019 | 103377-40-8 | Ethyl (2S)-2-[[(2S)-1-chloro-1-oxopropan-2-yl]amino]-4-phenylbutanoate |
| Enalapril-020 | 16652-71-4 | Benzyl L-prolinate hydrochloride |
| Enalapril-021 | 120924-94-9 | Benzyl N-[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]-L-alanyl-L-prolinate |
| Enalapril-003 | 82717-96-2 | N-[1-Ethoxy-1-oxo-4-phenylbutan-2(S)-yl]-L-alanine |
优化Route 5步骤 1 · 总收率 /
Enalapril-02288098-09-3Enalapril-00575847-73-3API · 马来酸依那普利/叶酸
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Enalapril-022 | 88098-09-3 | N-[(2S)-1-Ethoxy-1,4-dioxo-4-phenylbutan-2-yl]-L-alanyl-L-proline |
| Enalapril-005 | 75847-73-3 | (S)-1-[N-[1-(Ethoxycarbonyl)-3-phenylpropyl]-L-alanyl]-L-proline |
优化Route 6步骤 6 · 总收率 174mg(Enalapril-033)
Enalapril-023103-63-9Enalapril-0243277-89-2Enalapril-02595-92-1Enalapril-02664920-29-2Enalapril-027108607-75-6Enalapril-02856-41-7Enalapril-029877932-98-4Enalapril-0306066-82-6Enalapril-031—Enalapril-032—Enalapril-033—API · 马来酸依那普利/叶酸
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Enalapril-023 | 103-63-9 | (2-Bromoethyl)benzene |
| Enalapril-024 | 3277-89-2 | Bromido(2-phenylethyl)magnesium |
| Enalapril-025 | 95-92-1 | Oxalic acid diethyl diester |
| Enalapril-026 | 64920-29-2 | 2-Oxo-4-phenylbutyric acid ethyl ester |
| Enalapril-027 | 108607-75-6 | 4,5-Ditritium-L-proline |
| Enalapril-028 | 56-41-7 | L-Alanine |
| Enalapril-029 | 877932-98-4 | N-(1-Ethoxy-1-oxo-4-phenylbutan-2-yl)-L-alanine |
| Enalapril-030 | 6066-82-6 | N-Hydroxysuccinimide |
| Enalapril-031 | - | Ethyl 2-([(2S)-1-[(2,5-dioxopyrrolidin-1-yl)oxy]-1-oxopropan-2-yl]amino)-4-phenylbutanoate |
| Enalapril-032 | - | N-(1-Ethoxy-1-oxo-4-phenylbutan-2-yl)-L-alanyl-4,5-ditritium-L-proline |
| Enalapril-033 | - | (2Z)-But-2-enedioic acid N-[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]-L-alanyl-4,5-ditritium-L-proline |
优化Route 7步骤 11 · 总收率 /
Enalapril-03415186-48-8Enalapril-03510065-72-2Enalapril-0361411634-44-0Enalapril-03719810-31-2Enalapril-0381100-88-5Enalapril-039533931-02-1Enalapril-040533931-01-0Enalapril-041533931-03-2Enalapril-04216721-45-2Enalapril-043—Enalapril-044—Enalapril-04541324-66-7Enalapril-046533931-05-4Enalapril-047533931-06-5Enalapril-0481516-08-1,64-17-5Enalapril-00575847-73-3API · 马来酸依那普利/叶酸
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Enalapril-034 | 15186-48-8在售 | 2,2-Dimethyl-1,3-dioxolane-4(R)-carbaldehyde |
| Enalapril-035 | 10065-72-2 | L-Alanine methyl ester |
| Enalapril-036 | 1411634-44-0 | Methyl (Z)-N-[[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]methylidene]-L-alaninate |
| Enalapril-037 | 19810-31-2 | Benzyloxyacetyl chloride |
| Enalapril-038 | 1100-88-5 | Triphenyl(phenylmethyl)phosphonium chloride |
| Enalapril-039 | 533931-02-1 | Methyl (2S)-2-[(2S,3R)-3-(benzyloxy)-2-[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]-4-oxoazetidin-1-yl]propanoate |
| Enalapril-040 | 533931-01-0 | Methyl (2S)-2-[(2S,3R)-3-(benzyloxy)-2-[(1S)-1,2-dihydroxyethyl]-4-oxoazetidin-1-yl]propanoate |
| Enalapril-041 | 533931-03-2 | Methyl (2S)-2-[(2R,3R)-3-(benzyloxy)-2-formyl-4-oxoazetidin-1-yl]propanoate |
| Enalapril-042 | 16721-45-2 | Benzylidene(triphenyl)-lambda5-phosphane |
| Enalapril-043 | - | Methyl (2S)-2-[(3R,4S)-3-(benzyloxy)-2-oxo-4-[(E)-2-phenylethenyl]azetidin-1-yl]propanoate |
| Enalapril-044 | - | (2S)-2-[(3R,4S)-3-Hydroxy-2-oxo-4-(2-phenylethyl)azetidin-1-yl]propanoic acid |
| Enalapril-045 | 41324-66-7 | Benzyl L-prolinate |
| Enalapril-046 | 533931-05-4 | Benzyl 1-[(2S)-2-[(3R,4S)-3-hydroxy-2-oxo-4-(2-phenylethyl)azetidin-1-yl]propanoyl]-L-prolinate |
| Enalapril-047 | 533931-06-5 | Benzyl 1-[(2S)-2-[(4S)-2,5-dioxo-4-(2-phenylethyl)-1,3-oxazolidin-3-yl]propanoyl]-L-prolinate |
| Enalapril-048 | 1516-08-1,64-17-5 | Ethyl alcohol |
| Enalapril-005 | 75847-73-3 | (S)-1-[N-[1-(Ethoxycarbonyl)-3-phenylpropyl]-L-alanyl]-L-proline |
优化Route 8步骤 4 · 总收率 3.28g(Enalapril-054)
Enalapril-049100-52-7Enalapril-050127-17-3Enalapril-051—Enalapril-052128573-54-6Enalapril-05329678-81-7Enalapril-05490315-82-5API · 马来酸依那普利/叶酸
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Enalapril-049 | 100-52-7在售 | Bitter almond |
| Enalapril-050 | 127-17-3 | 2-Oxopropionic acid |
| Enalapril-051 | - | Potassium (3E)-2-oxo-4-phenylbut-3-enoate |
| Enalapril-052 | 128573-54-6 | (2R,3E)-2-Hydroxy-4-phenylbut-3-enoic acid |
| Enalapril-053 | 29678-81-7 | 2(R)-Hydroxy-4-phenylbutyric acid |
| Enalapril-054 | 90315-82-5 | Ethyl (R)-(-)-2-hydroxy-4-phenylbutyrate |
优化Route 9步骤 7 · 总收率 /
Enalapril-05517451-19-3Enalapril-05675-64-9Enalapril-05710017-37-5Enalapril-0581190946-81-6Enalapril-059586396-58-9Enalapril-060586396-61-4Enalapril-061115016-95-0Enalapril-062125639-64-7Enalapril-049100-52-7Enalapril-050127-17-3Enalapril-0481516-08-1,64-17-5API · 马来酸依那普利/叶酸
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Enalapril-055 | 17451-19-3 | (3E)-2-Oxo-4-phenylbut-3-enoic acid |
| Enalapril-056 | 75-64-9在售 | 2-Methylpropan-2-amine |
| Enalapril-057 | 10017-37-5 | 2-Methylpropan-2-amine hydrogen chloride |
| Enalapril-058 | 1190946-81-6 | 3(E)-N-(tert-Butyl)-2-oxo-4-phenylbutenamide |
| Enalapril-059 | 586396-58-9 | (2S,3E)-N-tert-Butyl-2-hydroxy-4-phenylbut-3-enamide |
| Enalapril-060 | 586396-61-4 | (2S)-N-tert-Butyl-2-hydroxy-4-phenylbutanamide |
| Enalapril-061 | 115016-95-0 | (2S)-2-Hydroxy-4-phenylbutanoic acid |
| Enalapril-062 | 125639-64-7 | Ethyl 2(S)-hydroxy-4-phenylbutyrate |
| Enalapril-049 | 100-52-7在售 | Benzaldehyde |
| Enalapril-050 | 127-17-3 | 2-Oxopropanoic acid |
| Enalapril-048 | 1516-08-1,64-17-5 | Non-denatured ethanol |
优化Route 10步骤 5 · 总收率 206.58g(Enalapril)
Enalapril-063123-75-1Enalapril-0642252296-25-4Enalapril-0657364-47-8Enalapril-066273750-74-6Enalapril-00575847-73-3Enalapril-00382717-96-2Enalapril-004147-85-3API · 马来酸依那普利/叶酸
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Enalapril-063 | 123-75-1 | Pyrrolidine |
| Enalapril-064 | 2252296-25-4 | Ethyl (2S)-2-[[(2S)-1-oxo-1-(pyrrolidin-1-yl)propan-2-yl]amino]-4-phenylbutanoate |
| Enalapril-065 | 7364-47-8 | Trimethylsilyl 1-(trimethylsilyl)-L-prolinate |
| Enalapril-066 | 273750-74-6 | Trimethylsilyl N-[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]-L-alanyl-L-prolinate |
| Enalapril-005 | 75847-73-3 | (S)-1-[N-[1-(Ethoxycarbonyl)-3-phenylpropyl]-L-alanyl]-L-proline |
| Enalapril-003 | 82717-96-2 | N-[(S)-(+)-1-(Ethoxycarbonyl)-3-phenylpropyl]-L-alanine |
| Enalapril-004 | 147-85-3 | (S)-(-)-Proline |
优化Route 11步骤 3 · 总收率 20.9g(Enalapril)
Enalapril-00382717-96-2Enalapril-004147-85-3Enalapril-00575847-73-3API · 马来酸依那普利/叶酸
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Enalapril-003 | 82717-96-2 | N-[1-Ethoxy-1-oxo-4-phenylbutan-2(S)-yl]-L-alanine |
| Enalapril-004 | 147-85-3 | (S)-(-)-Proline |
| Enalapril-005 | 75847-73-3 | (S)-1-[N-[1-(Ethoxycarbonyl)-3-phenylpropyl]-L-alanyl]-L-proline |
优化Route 12步骤 5 · 总收率 3.9g(Enalapril-073)
Enalapril-06756-84-8Enalapril-06832213-95-9Enalapril-069116393-72-7Enalapril-070100-39-0Enalapril-071885357-46-0Enalapril-072871123-99-8Enalapril-073943-73-7API · 马来酸依那普利/叶酸
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Enalapril-067 | 56-84-8 | (S)-Aminobutanedioic acid |
| Enalapril-068 | 32213-95-9 | Dimethyl L-aspartate hydrogen chloride |
| Enalapril-069 | 116393-72-7 | Dimethyl N-(triphenylmethyl)-L-aspartate |
| Enalapril-070 | 100-39-0 | 1-(Bromomethyl)benzene |
| Enalapril-071 | 885357-46-0 | Dimethyl 3-benzyl-N-(triphenylmethyl)-L-aspartate |
| Enalapril-072 | 871123-99-8 | (3R)-3-Benzyl-L-aspartic acid |
| Enalapril-073 | 943-73-7 | 2(S)-Amino-4-phenylbutanoic acid |
优化Route 13步骤 8 · 总收率 /
Enalapril-07456-41-7Enalapril-07515761-38-3Enalapril-076—Enalapril-0772133-40-6Enalapril-07833300-71-9Enalapril-07933300-72-0Enalapril-004147-85-3Enalapril-00213485-59-1Enalapril-02664920-29-2Enalapril-00575847-73-3API · 马来酸依那普利/叶酸
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Enalapril-074 | 56-41-7 | L-Alanine |
| Enalapril-075 | 15761-38-3 | N-Boc-2(S)-aminopropanoic acid |
| Enalapril-076 | - | (4R)-4-Amino-1,3-oxazolidine-2,5-dione |
| Enalapril-077 | 2133-40-6 | Methyl L-prolinate hydrogen chloride |
| Enalapril-078 | 33300-71-9 | Methyl N-(tert-butoxycarbonyl)-L-alanyl-L-prolinate |
| Enalapril-079 | 33300-72-0 | N-(tert-Butoxycarbonyl)-L-alanyl-L-proline |
| Enalapril-004 | 147-85-3 | L-Proline |
| Enalapril-002 | 13485-59-1 | L-Alanyl-L-proline |
| Enalapril-026 | 64920-29-2 | 2-Oxo-4-phenylbutyric acid ethyl ester |
| Enalapril-005 | 75847-73-3 | (S)-1-[N-[1-(Ethoxycarbonyl)-3-phenylpropyl]-L-alanyl]-L-proline |
优化Route 14步骤 3 · 总收率 37.9g(Enalapril-054)
Enalapril-080104-53-0Enalapril-081—Enalapril-008120999-41-9Enalapril-05490315-82-5API · 马来酸依那普利/叶酸
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Enalapril-080 | 104-53-0 | 3-Phenylpropionaldehyde |
| Enalapril-081 | - | Ethyl 2-oxo-4-phenylbut-3-enoate |
| Enalapril-008 | 120999-41-9 | 2(R)-Hydroxy-4-phenylbutanenitrile |
| Enalapril-054 | 90315-82-5 | Ethyl (R)-(-)-2-hydroxy-4-phenylbutyrate |
优化Route 1步骤 5 · 总收率 /
Folic Acid-001684258-65-9Folic Acid-002876508-38-2Folic Acid-003—Folic Acid-004873397-19-4Folic Acid-00589794-15-0Folic Acid-00613726-52-8Folic Acid-00752534-76-6API · 马来酸依那普利/叶酸
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Folic Acid-001 | 684258-65-9 | 1-(2-Amino-4-oxo-3,4-dihydropteridin-6-ylmethyl)pyridinium iodide |
| Folic Acid-002 | 876508-38-2 | 2-Amino-6-methyl-3,4,5,8-tetrahydropteridin-4-one |
| Folic Acid-003 | - | 2-Amino-6-methylpteridin-4(3H)-one |
| Folic Acid-004 | 873397-19-4 | 2-Amino-6-(chloromethyl)pteridin-4(3H)-one |
| Folic Acid-005 | 89794-15-0 | 2-Amino-6-(bromomethyl)pteridin-4(3H)-one |
| Folic Acid-006 | 13726-52-8 | N-(4-Aminobenzoyl)-L-glutamic acid diethyl diester |
| Folic Acid-007 | 52534-76-6 | N-[4-(2-Amino-4-oxo-1,4-dihydropteridin-6-ylmethylamino)benzoyl]-L-glutamic acid diethyl diester |
优化Route 2步骤 2 · 总收率 /
Folic Acid-00829769-49-1Folic Acid-009—Folic Acid-010—API · 马来酸依那普利/叶酸
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Folic Acid-008 | 29769-49-1 | N-(6-Formyl-4-oxo-1,4-dihydropteridin-2-yl)acetamide |
| Folic Acid-009 | - | 4(S)-(4-Aminobenzamido)-5-ethoxy-5-oxopentanoic acid |
| Folic Acid-010 | - | 4(S)-[4-(2-Acetamido-4-oxo-1,4-dihydropteridin-6-ylmethyleneamino)benzamido]-5-ethoxy-5-oxopentanoic acid |
优化Route 3步骤 3 · 总收率 /
Folic Acid-0115221-17-0Folic Acid-012110-86-1Folic Acid-013878776-10-4Folic Acid-0141004-75-7Folic Acid-001684258-65-9Folic Acid-0154271-30-1API · 马来酸依那普利/叶酸
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Folic Acid-011 | 5221-17-0 | 2,3-Dibromopropanal |
| Folic Acid-012 | 110-86-1 | Azabenzene |
| Folic Acid-013 | 878776-10-4 | 1-(2-Bromo-3-oxopropyl)pyridinium bromide |
| Folic Acid-014 | 1004-75-7 | 2,5,6-Triaminopyrimidin-4(5H)-one |
| Folic Acid-001 | 684258-65-9 | 1-(2-Amino-4-oxo-3,4-dihydropteridin-6-ylmethyl)pyridinium iodide |
| Folic Acid-015 | 4271-30-1 | N-(4-Aminobenzoyl)-L-glutamic acid |
优化Route 4步骤 2 · 总收率 /
Folic Acid-016636-38-4Folic Acid-00613726-52-8Folic Acid-017—Folic Acid-0141004-75-7API · 马来酸依那普利/叶酸
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Folic Acid-016 | 636-38-4 | 2,3-Dihydroxy-2-propenal |
| Folic Acid-006 | 13726-52-8 | N-(4-Aminobenzoyl)-L-glutamic acid diethyl diester |
| Folic Acid-017 | - | N-[4-[2,3-Dihydroxy-2-propenylideneamino]benzoyl]-L-glutamic acid diethyl diester |
| Folic Acid-014 | 1004-75-7 | 2,5,6-Triaminopyrimidin-4(5H)-one |
优化Route 5步骤 4 · 总收率 /
Folic Acid-018712-30-1Folic Acid-019—Folic Acid-02052407-60-0Folic Acid-02159091-92-8Folic Acid-02252407-61-1API · 马来酸依那普利/叶酸
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Folic Acid-018 | 712-30-1 | 2-Amino-4-oxo-3,4-dihydropteridine-6-carbaldehyde |
| Folic Acid-019 | - | N-(6-Formyl-4-oxo-1,4-dihydropteridin-2-yl)acetamide dihydrate |
| Folic Acid-020 | 52407-60-0 | N-(4-Aminobenzoyl)-L-glutamic acid dimethyl diester |
| Folic Acid-021 | 59091-92-8 | N-[4-(2-Acetamido-4-oxo-1,4-dihydropteridin-6-ylmethyleneamino)benzoyl]-L-glutamic acid dimethyl diester |
| Folic Acid-022 | 52407-61-1 | N-[4-(2-Acetamido-4-oxo-1,4-dihydropteridin-6-ylmethylamino)benzoyl]-L-glutamic acid dimethyl diester |
优化Route 6步骤 4 · 总收率 /
Folic Acid-0154271-30-1Folic Acid-00613726-52-8Folic Acid-0115221-17-0Folic Acid-024—Folic Acid-0141004-75-7Folic Acid-00752534-76-6API · 马来酸依那普利/叶酸
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Folic Acid-015 | 4271-30-1 | N-(4-Aminobenzoyl)-L-glutamic acid |
| Folic Acid-006 | 13726-52-8 | N-(4-Aminobenzoyl)-L-glutamic acid diethyl diester |
| Folic Acid-011 | 5221-17-0 | 2,3-Dibromopropanal |
| Folic Acid-024 | - | N-[4-(2,3-Dibromopropylideneamino)benzoyl]-L-glutamic acid diethyl diester |
| Folic Acid-014 | 1004-75-7 | 2,5,6-Triaminopyrimidin-4(5H)-one |
| Folic Acid-007 | 52534-76-6 | N-[4-(2-Amino-4-oxo-1,4-dihydropteridin-6-ylmethylamino)benzoyl]-L-glutamic acid diethyl diester |
优化Route 7步骤 1 · 总收率 /
Folic Acid-0141004-75-7Folic Acid-0154271-30-1Folic Acid-02510140-89-3Folic Acid-0115221-17-0API · 马来酸依那普利/叶酸
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Folic Acid-014 | 1004-75-7 | 2,5,6-Triaminopyrimidin-4(5H)-one |
| Folic Acid-015 | 4271-30-1 | N-(4-Aminobenzoyl)-L-glutamic acid |
| Folic Acid-025 | 10140-89-3 | 2,3-Dichloropropanal |
| Folic Acid-011 | 5221-17-0 | 2,3-Dibromopropanal |
优化Route 8步骤 1 · 总收率 /
Folic Acid-0262536-53-0Folic Acid-02753053-54-6API · 马来酸依那普利/叶酸
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Folic Acid-026 | 2536-53-0 | N-[4-(2-Amino-4-oxo-1,4-dihydropteridin-6-ylmethylamino)-3,5-dibromobenzoyl]-L-glutamic acid |
| Folic Acid-027 | 53053-54-6 | N-[4-(2-Amino-4-oxo-1,4-dihydropteridin-6-ylmethylamino)-3,5-dideuterobenzoyl]-L-glutamic acid |
优化Route 9步骤 8 · 总收率 /
Folic Acid-028—Folic Acid-029171777-66-5Folic Acid-030171777-67-6Folic Acid-0311118-89-4Folic Acid-032171777-68-7Folic Acid-033171777-69-8Folic Acid-00829769-49-1Folic Acid-018712-30-1Folic Acid-034—Folic Acid-035171777-71-2Folic Acid-036171777-72-3API · 马来酸依那普利/叶酸
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Folic Acid-028 | - | 1,2,3,4,5-Pentadeutero-6-trideuteromethylbenzene |
| Folic Acid-029 | 171777-66-5 | 2,3,5,6-Tetradeutero-4-nitrobenzoic acid |
| Folic Acid-030 | 171777-67-6 | 2,3,5,6-Tetradeutero-4-nitrobenzoyl chloride |
| Folic Acid-031 | 1118-89-4 | Diethyl L-glutamate hydrochloride |
| Folic Acid-032 | 171777-68-7 | Diethyl N-[(2,3,5,6-tetradeutero-4-nitrophenyl)carbonyl]-L-glutamate |
| Folic Acid-033 | 171777-69-8 | Diethyl N-[(4-amino-2,3,5,6-tetradeuterophenyl)carbonyl]-L-glutamate |
| Folic Acid-008 | 29769-49-1 | N-(6-Formyl-4-oxo-1,4-dihydropteridin-2-yl)acetamide |
| Folic Acid-018 | 712-30-1 | 2-Amino-4-oxo-3,4-dihydropteridine-6-carbaldehyde |
| Folic Acid-034 | - | Diethyl N-[[4-([[2-(acetylamino)-4-oxo-1,4-dihydropteridin-6-yl]methylidene]amino)-2,3,5,6-tetradeuterophenyl]carbonyl]-L-glutamate |
| Folic Acid-035 | 171777-71-2 | Diethyl N-[[4-([[2-(acetylamino)-4-oxo-1,4-dihydropteridin-6-yl]methyl]amino)-2,3,5,6-tetradeuterophenyl]carbonyl]-L-glutamate |
| Folic Acid-036 | 171777-72-3 | N-[(4-[[(2-Amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino]-2,3,5,6-tetradeuterophenyl)carbonyl]-L-glutamic acid |
优化Route 10步骤 2 · 总收率 /
Folic Acid-037—Folic Acid-038156045-54-4Folic Acid-039156045-55-5Folic Acid-0141004-75-7Folic Acid-0154271-30-1Folic Acid-040—API · 马来酸依那普利/叶酸
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Folic Acid-037 | - | [1,3-13C]Propan-2-one |
| Folic Acid-038 | 156045-54-4 | 1,1,3-Trichloro[1,3-13C]propan-2-one |
| Folic Acid-039 | 156045-55-5 | 1,3-Dichloro[1,3-13C]propan-2-one |
| Folic Acid-014 | 1004-75-7 | 2,5,6-Triaminopyrimidin-4(5H)-one |
| Folic Acid-015 | 4271-30-1 | N-(4-Aminobenzoyl)-L-glutamic acid |
| Folic Acid-040 | - | N-[[4-([[2-Amino-4-oxo[7-13C]-4,4a-dihydropteridin-6-yl][13C]methyl]amino)phenyl]carbonyl]-L-glutamic acid |
优化Route 11步骤 12 · 总收率 /
Folic Acid-041107-02-8Folic Acid-0115221-17-0Folic Acid-0426630-39-3Folic Acid-043125072-36-8Folic Acid-044100707-85-5Folic Acid-04528621-39-8Folic Acid-046—Folic Acid-0474227-30-9Folic Acid-04892104-52-4Folic Acid-00829769-49-1Folic Acid-0154271-30-1Folic Acid-049883451-68-1Folic Acid-050233600-79-8API · 马来酸依那普利/叶酸
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Folic Acid-041 | 107-02-8 | 2-Propenal |
| Folic Acid-011 | 5221-17-0 | 2,3-Dibromopropanal |
| Folic Acid-042 | 6630-39-3 | 2-Bromo-1,1,3-triethoxypropane |
| Folic Acid-043 | 125072-36-8 | 1,3,3-Triethoxyprop-1-ene |
| Folic Acid-044 | 100707-85-5 | 1,2-Dibromo-1,3,3-triethoxypropane |
| Folic Acid-045 | 28621-39-8 | 2-Bromo-3,3-diethoxypropanal |
| Folic Acid-046 | - | 2,5,6-Triaminopyrimidin-4(5H)-one hydrochloride |
| Folic Acid-047 | 4227-30-9 | 2-Amino-6-(diethoxymethyl)pteridin-4(1H)-one |
| Folic Acid-048 | 92104-52-4 | N-[6-(Diethoxymethyl)-4-oxo-1,4-dihydropteridin-2-yl]acetamide |
| Folic Acid-008 | 29769-49-1 | N-(6-Formyl-4-oxo-1,4-dihydropteridin-2-yl)acetamide |
| Folic Acid-015 | 4271-30-1 | N-(4-Aminobenzoyl)-L-glutamic acid |
| Folic Acid-049 | 883451-68-1 | N-([4-[[[2-(Acetylamino)-4-oxo-1,4-dihydropteridin-6-yl]methyl](formyl)amino]phenyl]carbonyl)-L-glutamic acid |
| Folic Acid-050 | 233600-79-8 | N-[[4-([[2-(Acetylamino)-4-oxo-1,4-dihydropteridin-6-yl]methyl]amino)phenyl]carbonyl]-L-glutamic acid |
优化Route 12步骤 4 · 总收率 38.92g(Folic Acid (Free))
Folic Acid-051122-04-3Folic Acid-05256-86-0Folic Acid-0536758-40-3Folic Acid-054—Folic Acid-0154271-30-1Folic Acid-0141004-75-7Folic Acid-055—Folic Acid-056921-03-9API · 马来酸依那普利/叶酸
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Folic Acid-051 | 122-04-3 | 4-Nitrobenzoyl chloride |
| Folic Acid-052 | 56-86-0 | (S)-(+)-Glutamic acid |
| Folic Acid-053 | 6758-40-3 | (2S)-[(4-Nitrobenzoyl)amino]pentanedioic acid |
| Folic Acid-054 | - | Sodium 1-[[(1S)-1-carboxy-3-carboxylatopropyl]carbamoyl]-4-nitrobenzene |
| Folic Acid-015 | 4271-30-1 | N-(4-Aminobenzoyl)-L-glutamic acid |
| Folic Acid-014 | 1004-75-7 | 2,5,6-Triaminopyrimidin-4(5H)-one |
| Folic Acid-055 | - | 2,5,6-Triaminopyrimidin-4-one sulfate |
| Folic Acid-056 | 921-03-9 | 1,1,3-Trichloroacetone |
优化Route 13步骤 7 · 总收率 18.76g(Folic Acid (Free))
Folic Acid-057105-34-0Folic Acid-058—Folic Acid-05956-06-4Folic Acid-0602387-48-6Folic Acid-061—Folic Acid-06235011-47-3Folic Acid-0632035099-30-8Folic Acid-06451324-37-9Folic Acid-065112740-59-7Folic Acid-06614337-41-8Folic Acid-067—Folic Acid-068—Folic Acid-0154271-30-1API · 马来酸依那普利/叶酸
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Folic Acid-057 | 105-34-0在售 | (Methoxycarbonyl)acetonitrile |
| Folic Acid-058 | - | Guanidine sulfate |
| Folic Acid-059 | 56-06-4 | 2,4-Diamino-6-hydroxypyrimidine |
| Folic Acid-060 | 2387-48-6 | 2,4-Diamino-6-hydroxy-5-nitrosopyrimidine |
| Folic Acid-061 | - | 2,5,6-Triaminopyrimidin-4-ol |
| Folic Acid-062 | 35011-47-3 | Sulfuric acid 2,5,6-triaminopyrimidin-4(1H)-one |
| Folic Acid-063 | 2035099-30-8 | 2,5,6-Triaminopyrimidin-4-ol dihydrobromide |
| Folic Acid-064 | 51324-37-9 | 2,5,6-Triaminopyrimidin-4-one dihydrochloride |
| Folic Acid-065 | 112740-59-7 | 3-Bromo-2-oxopropanal oxime |
| Folic Acid-066 | 14337-41-8 | 1-Chloro-3-(hydroxyimino)propan-2-one |
| Folic Acid-067 | - | 2-Amino-6-(bromomethyl)-4-pteridinol |
| Folic Acid-068 | - | 2-Amino-6-(chloromethyl)-4-pteridinol |
| Folic Acid-015 | 4271-30-1 | N-(4-Aminobenzoyl)-L-glutamic acid |
优化Route 16步骤 7 · 总收率 1.5g(Folic Acid (Free))
Folic Acid-07594-09-7Folic Acid-076106-89-8Folic Acid-077—Folic Acid-078—Folic Acid-079—Folic Acid-080—Folic Acid-081—Folic Acid-082—Folic Acid-08316450-41-2Folic Acid-084—API · 马来酸依那普利/叶酸
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Folic Acid-075 | 94-09-7 | 4-(Ethoxycarbonyl)aniline |
| Folic Acid-076 | 106-89-8 | (+/-)-2-(Chloromethyl)oxirane |
| Folic Acid-077 | - | Ethyl 4-[(3-chloro-2-hydroxypropyl)amino]benzoate |
| Folic Acid-078 | - | Ethyl 4-[(tert-butoxycarbonyl)(3-chloro-2-hydroxypropyl)amino]benzoate |
| Folic Acid-079 | - | Ethyl 4-[(tert-butoxycarbonyl)(3-chloro-2-oxopropyl)amino]benzoate |
| Folic Acid-080 | - | 2,4,5-Triamino-6-hydroxypyrimidine sulfate |
| Folic Acid-081 | - | Ethyl 4-[[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl](tert-butoxycarbonyl)amino]benzoate |
| Folic Acid-082 | - | 4-[(2-Amino-4-oxo-3H-pteridin-6-yl)methyl-[(2-methylpropan-2-yl)oxycarbonyl]amino]benzoic acid |
| Folic Acid-083 | 16450-41-2 | (S)-Glutamic acid diethyl ester |
| Folic Acid-084 | - | Diethyl N-(4-[[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl](tert-butoxycarbonyl)amino]benzoyl)-L-glutamate |
工艺Route 14步骤 1 · 总收率 1898.52g(Folic Acid (Free))
Folic Acid-0536758-40-3Folic Acid-0602387-48-6Folic Acid-069—API · 马来酸依那普利/叶酸
工艺Route 15步骤 5 · 总收率 20.58-21.35kg(Folic Acid (Free))
Folic Acid-070105-56-6Folic Acid-07150-01-1Folic Acid-0591956-06-04Folic Acid-0602387-48-6Folic Acid-0141004-75-7Folic Acid-041107-02-8Folic Acid-072619-45-4Folic Acid-07334794-87-1Folic Acid-074142-47-2,138-15-8API · 马来酸依那普利/叶酸
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Folic Acid-070 | 105-56-6在售 | 2-Cyanoacetic acid ethyl ester |
| Folic Acid-071 | 50-01-1 | Aminoformamidine hydrochloride |
| Folic Acid-059 | 1956-06-04 | 2,4-Diamino-6-hydroxypyrimidine |
| Folic Acid-060 | 2387-48-6 | 2,4-Diamino-6-hydroxy-5-nitrosopyrimidine |
| Folic Acid-014 | 1004-75-7 | 2,5,6-Triaminopyrimidin-4(5H)-one |
| Folic Acid-041 | 107-02-8 | 2-Propenal |
| Folic Acid-072 | 619-45-4 | Methyl 4-aminobenzoate |
| Folic Acid-073 | 34794-87-1 | Methyl 4-[[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino]benzoate |
| Folic Acid-074 | 142-47-2,138-15-8 | L-Glutamic acid monosodium salt |
常见问题（FAQ）
马来酸依那普利/叶酸的适应症有哪些？
已批准的适应症包括：原发性高血压。
马来酸依那普利/叶酸的专利什么时候到期？
马来酸依那普利/叶酸的专利到期年暂无公开口径，本页会在数据管道核实后更新。
马来酸依那普利/叶酸有几条合成路线？
本站收录 30 条合成路线，最短路线 1 步、总收率 /。每条路线的中间体均带登记编号与 CAS 号。
马来酸依那普利/叶酸的关键中间体在哪里可以采购？
马来酸依那普利/叶酸的多条路线中间体已挂接 CAS 档案，其中 6 个 CAS 已有优贝德（Unibest）供应网络在售报价，可在本页路线表中直接查看并询价。
如何获取马来酸依那普利/叶酸中间体的报价？
在本页选择目标中间体的 CAS 进入档案页，或在询价页直接提交需求；CAS 会自动带入供需撮合流程，由供应网络反馈报价。
数据来源：多源数据交叉核实（仅结构化字段） · 2026-10-22