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CAS 2295-31-0
thiazolidine-2,4-dione
登记编号：LOBE-008、PIOG-012、HYPIL-008
应用背景（按来源药适应症）
二型糖尿病洛贝格列酮硫酸盐胃肌轻瘫洛贝格列酮硫酸盐肾功能不全洛贝格列酮硫酸盐肝功能异常洛贝格列酮硫酸盐二型糖尿病苯甲酸阿格列汀/盐酸吡格列酮二型糖尿病盐酸吡格列酮肺性高血压盐酸吡格列酮乳腺癌盐酸吡格列酮非酒精性脂肪性肝炎盐酸吡格列酮可卡因成瘾盐酸吡格列酮酗酒盐酸吡格列酮肾上腺脑白质营养不良Leriglitazone弗里德赖希共济失调Leriglitazone
来源药（使用该中间体的合成路线）
| 品种 | 梯队 | 到期年 |
|---|---|---|
| 洛贝格列酮硫酸盐Lobeglitazone Sulfate | Tier C · 观察 / 贸易 | - |
| 苯甲酸阿格列汀/盐酸吡格列酮Alogliptin Benzoate/Pioglitazone Hydrochloride | Tier C · 观察 / 贸易 | - |
| 盐酸吡格列酮Pioglitazone Hydrochloride | Tier B · 提前布局 | - |
| Leriglitazone | Tier C · 观察 / 贸易 | - |
合成路线中的位置（上下游链）
按路线登记顺序排列，左→右为合成方向；高亮为当前 CAS，其余可点击跳转对应档案。
4,6-dichloropyrimidine→4-methoxyphenol→4-chloro-6-(4-methoxyphenoxy)pyrimidine→2-(methylamino)ethan-1-ol→2-((6-(4-methoxyphenoxy)pyrimidin-4-yl)(methyl)amino)ethanol→4-fluorobenzaldehyde→4-(2-((6-(4-methoxyphenoxy)pyrimidin-4-yl)(methyl)amino)ethoxy)benzaldehyde→thiazolidine-2,4-dione→(Z)-5-(4-(2-((6-(4-methoxyphenoxy)pyrimidin-4-yl)(methyl)amino)ethoxy)benzylidene)thiazolidine-2,4-dione
thiazolidine-2,4-dione→4-hydroxybenzaldehyde→5-ethyl-2-vinylpyridine→2-bromo-1-(5-ethylpyridin-2-yl)ethan-1-ol→4-(2-(5-ethylpyridin-2-yl)-2-hydroxyethoxy)benzaldehyde→(Z)-5-(4-(2-(5-ethylpyridin-2-yl)-2-hydroxyethoxy)benzylidene)thiazolidine-2,4-dione→5-(4-(2-(5-ethylpyridin-2-yl)-2-hydroxyethoxy)benzyl)thiazolidine-2,4-dione→5-(4-(2-chloro-2-(5-ethylpyridin-2-yl)ethoxy)benzyl)thiazolidine-2,4-dione
2-(5-ethylpyridin-2-yl)ethan-1-ol→thiazolidine-2,4-dione→4-hydroxybenzaldehyde→4-(2-(5-ethylpyridin-2-yl)-2-hydroxyethoxy)benzaldehyde→5-ethyl-2-(2-hydroxyethyl)pyridine 1-oxide→1-(5-ethylpyridin-2-yl)ethane-1,2-diyl diacetate→1-(5-ethylpyridin-2-yl)ethane-1,2-diol→4-(5-ethylpyridin-2-yl)-1,3,2-dioxathiolane 2-oxide→1-(5-ethylpyridin-2-yl)-2-(4-formylphenoxy)ethyl 4-methylbenzenesulfonate→(Z)-2-(4-((2,4-dioxothiazolidin-5-ylidene)methyl)phenoxy)-1-(5-ethylpyridin-2-yl)ethyl 4-methylbenzenesulfonate→2-(4-((2,4-dioxothiazolidin-5-yl)methyl)phenoxy)-1-(5-ethylpyridin-2-yl)ethyl 4-methylbenzenesulfonate
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