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CAS 459-57-4
4-fluorobenzaldehyde(4-Fluorophenyl)methanone4-Fluorobenzaldehyde
登记编号：PIMAV-014、Tamsulosin Hydrochloride-023、ROSU-001、LOBE-006、ESCI-021、Mosapride Citrate-017、(IV)1078735-2-a、BASM-001
应用背景（按来源药适应症）
妄想酒石酸匹莫范色林幻觉酒石酸匹莫范色林勃起功能障碍他达拉非/坦洛新前列腺增生他达拉非/坦洛新高血压瑞舒伐他汀钙/非马沙坦钾三水合物血脂障碍瑞舒伐他汀钙/非马沙坦钾三水合物高血压瑞舒伐他汀钙/替米沙坦高脂血症瑞舒伐他汀钙/替米沙坦下尿路症状琥珀酸索利那新/盐酸坦洛新前列腺增生琥珀酸索利那新/盐酸坦洛新膀胱过度活动症琥珀酸索利那新/盐酸坦洛新药物相关的副作用和不良反应琥珀酸索利那新/盐酸坦洛新膀胱颈梗阻琥珀酸索利那新/盐酸坦洛新二型糖尿病洛贝格列酮硫酸盐胃肌轻瘫洛贝格列酮硫酸盐肾功能不全洛贝格列酮硫酸盐肝功能异常洛贝格列酮硫酸盐前列腺增生度他雄胺/盐酸坦洛新前列腺增生盐酸坦洛新泌尿系统感染盐酸坦洛新尿潴留盐酸坦洛新腹股沟疝盐酸坦洛新排尿功能障碍盐酸坦洛新下尿路症状盐酸坦洛新纯合子家族性高胆固醇血症瑞舒伐他汀钙杂合子家族性高胆固醇血症瑞舒伐他汀钙高脂蛋白血症Ⅲ型瑞舒伐他汀钙动脉粥样硬化瑞舒伐他汀钙II型高脂蛋白血症瑞舒伐他汀钙高胆固醇血症瑞舒伐他汀钙社交恐惧症草酸艾司西酞普兰重度抑郁症草酸艾司西酞普兰惊恐病草酸艾司西酞普兰抑郁草酸艾司西酞普兰焦虑症草酸艾司西酞普兰肠易激综合征草酸艾司西酞普兰胃炎枸橼酸莫沙必利肠内喂养不耐受枸橼酸莫沙必利肠易激综合征枸橼酸莫沙必利消化不良枸橼酸莫沙必利便秘枸橼酸莫沙必利乳腺癌甲苯磺酸依仑司群转移性乳腺癌甲苯磺酸依仑司群转移癌甲苯磺酸依仑司群卵巢癌甲苯磺酸依仑司群子宫内膜癌甲苯磺酸依仑司群结直肠癌甲苯磺酸依仑司群Dup15q综合征Basmisanil中风Basmisanil唐氏综合征Basmisanil精神分裂症Basmisanil
来源药（使用该中间体的合成路线）
| 品种 | 梯队 | 到期年 |
|---|---|---|
| 酒石酸匹莫范色林Pimavanserin Tartrate | Tier C · 观察 / 贸易 | 2029 |
| 他达拉非/坦洛新Tadalafil/Tamsulosin | Tier C · 观察 / 贸易 | - |
| 瑞舒伐他汀钙/非马沙坦钾三水合物Fimasartan potassium trihydrate/Rosuvastatin calcium | Tier C · 观察 / 贸易 | - |
| 瑞舒伐他汀钙/替米沙坦Rosuvastatin Calcium/Telmisartan | Tier C · 观察 / 贸易 | - |
| 琥珀酸索利那新/盐酸坦洛新Solifenacin Succinate/Tamsulosin Hydrochloride | Tier C · 观察 / 贸易 | - |
| 洛贝格列酮硫酸盐Lobeglitazone Sulfate | Tier C · 观察 / 贸易 | - |
| 度他雄胺/盐酸坦洛新Dutasteride/Tamsulosin Hydrochloride | Tier C · 观察 / 贸易 | - |
| 盐酸坦洛新Tamsulosin Hydrochloride | Tier C · 观察 / 贸易 | - |
| 瑞舒伐他汀钙Rosuvastatin Calcium | Tier B · 提前布局 | - |
| 草酸艾司西酞普兰Escitalopram Oxalate | Tier B · 提前布局 | - |
| 枸橼酸莫沙必利Mosapride Citrate | Tier C · 观察 / 贸易 | - |
| 甲苯磺酸依仑司群Imlunestrant Tosylate | Tier C · 观察 / 贸易 | - |
| Basmisanil | Tier C · 观察 / 贸易 | - |
合成路线中的位置（上下游链）
按路线登记顺序排列，左→右为合成方向；高亮为当前 CAS，其余可点击跳转对应档案。
5-(2(R)-Aminopropyl)-2-methoxybenzenesulfonamide→Benzaldehyde→4-Methoxybenzaldehyde→4-Formylphenol→(4-Fluorophenyl)methanone→2-methoxy-5-[(2R)-2-[(E)-(phenylmethylidene)amino]propyl]benzene-1-sulfonamide→2-Methoxy-5-[(2R)-2-[(E)-[(4-methoxyphenyl)methylidene]amino]propyl]benzene-1-sulfonamide→5-[(2R)-2-[(E)-[(4-Hydroxyphenyl)methylidene]amino]propyl]-2-methoxybenzene-1-sulfonamide→5-[(2R)-2-[(E)-[(4-Fluorophenyl)methylidene]amino]propyl]-2-methoxybenzene-1-sulfonamide→1-ethoxy-2-(2-iodoethoxy)benzene→(E)-[2-(2-ethoxyphenoxy)ethyl][(2R)-1-(4-methoxy-3-sulfamoylphenyl)propan-2-yl](phenylmethylidene)azanium iodide→(2R)-N-[2-(2-Ethoxyphenoxy)ethyl]-N-[(E)-(4-methoxyphenyl)methylidene]-1-(4-methoxy-3-sulfamoylphenyl)propan-2-iminium iodide→(2R)-N-[2-(2-Ethoxyphenoxy)ethyl]-N-[(E)-(4-hydroxyphenyl)methylidene]-1-(4-methoxy-3-sulfamoylphenyl)propan-2-iminium iodide→(2R)-N-[2-(2-Ethoxyphenoxy)ethyl]-N-[(E)-(4-fluorophenyl)methylidene]-1-(4-methoxy-3-sulfamoylphenyl)propan-2-iminium iodide→(-)-5-[2(R)-[2-(2-Ethoxyphenoxy)ethylamino]propyl]-2-methoxybenzenesulfonamide
4-fluorobenzaldehyde→ethyl 4-methyl-3-oxopentanoate→(Z)-ethyl 2-(4-fluorobenzylidene)-4-methyl-3-oxopentanoate→(methyleneamino)(methylthio)methanamine→ethyl 4-(4-fluorophenyl)-6-isopropyl-2-(methylthio)pyrimidine-5-carboxylate→ethyl 4-(4-fluorophenyl)-6-isopropyl-2-(methylsulfonyl)pyrimidine-5-carboxylate→ethyl 4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidine-5-carboxylate→N-(4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl)-N-methylmethanesulfonamide→methyl (R)-3-((tert-butyldimethylsilyl)oxy)-5-oxo-6-(triphenyl-l5-phosphanylidene)hexanoate→methyl (R,E)-3-((tert-butyldimethylsilyl)oxy)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-5-oxohept-6-enoate→methyl (R,E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-3-hydroxy-5-oxohept-6-enoate→methyl (3R,5S,E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoate→sodium (3R,5S,E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoate
4-fluorobenzaldehyde→N-(5-((diphenylphosphoryl)methyl)-4-(4-fluorophenyl)-6-isopropylpyrimidin-2-yl)-N-methylmethanesulfonamide→N-(4-(4-fluorophenyl)-5-((E)-2-((2S,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl)vinyl)-6-isopropylpyrimidin-2-yl)-N-methylmethanesulfonamide→methyl 4-methyl-3-oxopentanoate→urea→methyl 4-(4-fluorophenyl)-6-isopropyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate→methyl 4-(4-fluorophenyl)-2-hydroxy-6-isopropylpyrimidine-5-carboxylate→N-methylmethanesulfonamide→methyl 4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidine-5-carboxylate→N-(4-(4-fluorophenyl)-5-(hydroxymethyl)-6-isopropylpyrimidin-2-yl)-N-methylmethanesulfonamide→N-(5-(bromomethyl)-4-(4-fluorophenyl)-6-isopropylpyrimidin-2-yl)-N-methylmethanesulfonamide→tert-butyl (4S,6S)-6-formyl-2,2-dimethyl-1,3-dioxane-4-carboxylate→tert-butyl (4S,6S)-6-((E)-2-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)vinyl)-2,2-dimethyl-1,3-dioxane-4-carboxylate
4-fluorobenzaldehyde→ethyl 4-methyl-3-oxopentanoate→(Z)-ethyl 2-(4-fluorobenzylidene)-4-methyl-3-oxopentanoate→(methyleneamino)(methylthio)methanamine→ethyl 4-(4-fluorophenyl)-6-isopropyl-2-(methylthio)pyrimidine-5-carboxylate→ethyl 4-(4-fluorophenyl)-6-isopropyl-2-(methylsulfonyl)pyrimidine-5-carboxylate→ethyl 4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidine-5-carboxylate→N-(4-(4-fluorophenyl)-5-formyl-6-isopropylpyrimidin-2-yl)-N-methylmethanesulfonamide→methyl (R)-3-((tert-butyldimethylsilyl)oxy)-5-oxo-6-(triphenyl-l5-phosphanylidene)hexanoate→methyl (R,E)-3-((tert-butyldimethylsilyl)oxy)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-5-oxohept-6-enoate→methyl (R,E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-3-hydroxy-5-oxohept-6-enoate→methyl (3R,5S,E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoate→sodium (3R,5S,E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoate
本站可供应的对应中间体
目录暂未收录该靶点的在售中间体 —— 可直接发起询价，需求会进入撮合池。
本页为中间体 CAS 注册档案：同 CAS 的多条路线登记已合并；后续供应商报价与买方需求以该 CAS 为主键撮合。