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CAS 2316-64-5
4-bromo-2-(hydroxymethyl)phenol
登记编号：SALM-011、VILA-009
应用背景（按来源药适应症）
哮喘布地奈德/昔萘酸沙美特罗慢性阻塞性肺疾病昔萘酸沙美特罗哮喘昔萘酸沙美特罗运动诱发哮喘昔萘酸沙美特罗支气管痉挛昔萘酸沙美特罗局部颏下脂肪增多昔萘酸沙美特罗哮喘三苯乙酸维兰特罗慢性阻塞性肺疾病三苯乙酸维兰特罗
来源药（使用该中间体的合成路线）
| 品种 | 梯队 | 到期年 |
|---|---|---|
| 布地奈德/昔萘酸沙美特罗Budesonide/Salmeterol xinafoate | Tier C · 观察 / 贸易 | - |
| 昔萘酸沙美特罗Salmeterol xinafoate | Tier C · 观察 / 贸易 | - |
| 三苯乙酸维兰特罗Vilanterol Trifenatate | Tier C · 观察 / 贸易 | - |
合成路线中的位置（上下游链）
按路线登记顺序排列，左→右为合成方向；高亮为当前 CAS，其余可点击跳转对应档案。
1,6-dibromohexane→4-phenylbutan-1-ol→(4-((6-bromohexyl)oxy)butyl)benzene→2,2-dimethoxyethanamine→N-(2,2-dimethoxyethyl)-6-(4-phenylbutoxy)hexan-1-amine→benzyl (2,2-dimethoxyethyl)(6-(4-phenylbutoxy)hexyl)carbamate→benzyl (2-oxoethyl)(6-(4-phenylbutoxy)hexyl)carbamate→6-bromo-2,2-dimethyl-4H-benzo[d][1,3]dioxine→benzyl (2-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)-2-hydroxyethyl)(6-(4-phenylbutoxy)hexyl)carbamate→1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)-2-((6-(4-phenylbutoxy)hexyl)amino)ethanol→4-bromo-2-(hydroxymethyl)phenol
1,6-dibromohexane→4-phenylbutan-1-ol→(4-((6-bromohexyl)oxy)butyl)benzene→2,2-dimethoxyethanamine→N-(2,2-dimethoxyethyl)-6-(4-phenylbutoxy)hexan-1-amine→benzyl (2,2-dimethoxyethyl)(6-(4-phenylbutoxy)hexyl)carbamate→benzyl (2-oxoethyl)(6-(4-phenylbutoxy)hexyl)carbamate→6-bromo-2,2-dimethyl-4H-benzo[d][1,3]dioxine→benzyl (2-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)-2-hydroxyethyl)(6-(4-phenylbutoxy)hexyl)carbamate→1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)-2-((6-(4-phenylbutoxy)hexyl)amino)ethanol→4-bromo-2-(hydroxymethyl)phenol
N-methoxy-N-methylacetamide→1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethan-1-one→2-bromo-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethan-1-one→VILA-014→tert-butyl (2-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)-2-oxoethyl)carbamate→tert-butyl (R)-(2-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)-2-hydroxyethyl)carbamate→2-(bromomethyl)-1,3-dichlorobenzene→2-((2,6-dichlorobenzyl)oxy)ethan-1-ol→1,6-dibromohexane→2-((2-((6-bromohexyl)oxy)ethoxy)methyl)-1,3-dichlorobenzene→(R)-5-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)oxazolidin-2-one→(R)-3-(6-(2-((2,6-dichlorobenzyl)oxy)ethoxy)hexyl)-5-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)oxazolidin-2-one→(R)-2-((6-(2-((2,6-dichlorobenzyl)oxy)ethoxy)hexyl)amino)-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethan-1-ol→2,2,2-triphenylacetic acid→4-bromo-2-(hydroxymethyl)phenol→6-bromo-2,2-dimethyl-4H-benzo[d][1,3]dioxine
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