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CAS 78191-00-1
N-methoxy-N-methylacetamideN-Acetyl-N,O-dimethylhydroxylamine
登记编号：ALPE-013、(XXXVIII)700647-1-e、VILA-011
应用背景（按来源药适应症）
生长障碍阿吡利塞遗传病阿吡利塞PIK3CA相关生长过度谱系阿吡利塞乳腺癌阿吡利塞蠕形螨性睑缘炎洛替拉纳螨虫感染洛替拉纳莱姆病洛替拉纳酒渣鼻洛替拉纳睑板腺功能障碍洛替拉纳哮喘三苯乙酸维兰特罗慢性阻塞性肺疾病三苯乙酸维兰特罗
来源药（使用该中间体的合成路线）
合成路线中的位置（上下游链）
按路线登记顺序排列，左→右为合成方向；高亮为当前 CAS，其余可点击跳转对应档案。
4-methyl-5-(2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl)thiazol-2-amine→(S)-pyrrolidine-2-carboxamide→4-methyl-2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridine→N-methoxy-N-methylacetamide→1-(2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl)propan-2-one→1-bromopyrrolidine-2,5-dione→4-methyl-5-(2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl)thiazol-2-amine hydrobromide→phenyl (4-methyl-5-(2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl)thiazol-2-yl)carbamate
Methyl 5-acetyl-3-methylthiophene-2-carboxylate→5-Acetyl-3-methylthiophene-2-carboxylic acid→2-Carboxy-3-methylthiophene→N-Acetyl-N,O-dimethylhydroxylamine
N-methoxy-N-methylacetamide→1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethan-1-one→2-bromo-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethan-1-one→VILA-014→tert-butyl (2-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)-2-oxoethyl)carbamate→tert-butyl (R)-(2-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)-2-hydroxyethyl)carbamate→2-(bromomethyl)-1,3-dichlorobenzene→2-((2,6-dichlorobenzyl)oxy)ethan-1-ol→1,6-dibromohexane→2-((2-((6-bromohexyl)oxy)ethoxy)methyl)-1,3-dichlorobenzene→(R)-5-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)oxazolidin-2-one→(R)-3-(6-(2-((2,6-dichlorobenzyl)oxy)ethoxy)hexyl)-5-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)oxazolidin-2-one→(R)-2-((6-(2-((2,6-dichlorobenzyl)oxy)ethoxy)hexyl)amino)-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethan-1-ol→2,2,2-triphenylacetic acid→4-bromo-2-(hydroxymethyl)phenol→6-bromo-2,2-dimethyl-4H-benzo[d][1,3]dioxine
本站可供应的对应中间体
同 CAS 多家在售供应横向对比；价格区间为供应方挂牌口径，实价以询价确认为准。
| 供应商 | 产品 | 价格区间 | 最小起订 | 货期 | 资质 | 操作 |
|---|---|---|---|---|---|---|
| Unibest Nantong cGMP Site | 2-bromo-3-methyl-5-acetylthiophene Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Unibest Taizhou GMP-like Site | methyl 5-acetyl-3-methylthiophene-2-carboxylate Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Qualified Partner — East China API Works | 5-acetyl-3-methyl-2-Thiophenecarboxylic acid Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
本页为中间体 CAS 注册档案：同 CAS 的多条路线登记已合并；后续供应商报价与买方需求以该 CAS 为主键撮合。