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CAS 298-12-4
2-oxoacetic acid
登记编号：BRIV-002、LAMI-021、EMTR-029、TELAP-041、VILD-020、Vornorexant-002
应用背景（按来源药适应症）
癫痫部分性发作布瓦西坦癫痫布瓦西坦癫痫发作布瓦西坦HIV感染多替拉韦/拉米夫定/艾酚福韦HIV感染拉米夫定/富马酸替诺福韦二吡呋酯慢性乙型肝炎拉米夫定/富马酸替诺福韦二吡呋酯HIV感染比克恩丙诺乙型肝炎比克恩丙诺HIV感染依非韦伦/拉米夫定/富马酸替诺福韦二吡呋酯HIV感染恩曲他滨/富马酸磷丙替诺福韦获得性免疫缺损综合征恩曲他滨/富马酸磷丙替诺福韦进行性多病灶脑白质病恩曲他滨/富马酸磷丙替诺福韦HIV感染恩曲他滨/盐酸利匹韦林/富马酸替诺福韦二吡呋酯丙型肝炎特拉匹韦慢性丙型肝炎特拉匹韦HIV感染特拉匹韦肝功能衰退特拉匹韦阿片类依赖特拉匹韦肾脏疾病特拉匹韦二型糖尿病维格列汀精神分裂症维格列汀血脂障碍维格列汀胰岛素抵抗维格列汀一型糖尿病维格列汀糖尿病维格列汀乙型肝炎拉米夫定慢性乙型肝炎拉米夫定HIV感染拉米夫定Rett综合征拉米夫定阿尔茨海默病拉米夫定视网膜脱离拉米夫定HIV感染恩曲他滨阿尔茨海默病恩曲他滨痴呆恩曲他滨轻度认知障碍恩曲他滨入睡和睡眠障碍Vornorexant肝功能衰退Vornorexant睡眠呼吸暂停Vornorexant
来源药（使用该中间体的合成路线）
| 品种 | 梯队 | 到期年 |
|---|---|---|
| 布瓦西坦Brivaracetam | Tier C · 观察 / 贸易 | 2028 |
| 多替拉韦/拉米夫定/艾酚福韦Dolutegravir/Lamivudine/Tenofovir Alafenamide | Tier C · 观察 / 贸易 | - |
| 拉米夫定/富马酸替诺福韦二吡呋酯Lamivudine/Tenofovir Disoproxil Fumarate | Tier C · 观察 / 贸易 | - |
| 比克恩丙诺Bictegravir/Emtricitabine/Tenofovir Alafenamide Fumarate | Tier B · 提前布局 | - |
| 依非韦伦/拉米夫定/富马酸替诺福韦二吡呋酯Efavirenz/Lamivudine/Tenofovir Disoproxil Fumarate | Tier C · 观察 / 贸易 | - |
| 恩曲他滨/富马酸磷丙替诺福韦Emtricitabine/Tenofovir Alafenamide Fumarate | Tier B · 提前布局 | - |
| 恩曲他滨/盐酸利匹韦林/富马酸替诺福韦二吡呋酯Emtricitabine/Rilpivirine Hydrochloride/Tenofovir Disoproxil Fumarate | Tier B · 提前布局 | - |
| 特拉匹韦Telaprevir | Tier B · 提前布局 | - |
| 维格列汀Vildagliptin | Tier B · 提前布局 | - |
| 拉米夫定Lamivudine | Tier C · 观察 / 贸易 | - |
| 恩曲他滨Emtricitabine | Tier C · 观察 / 贸易 | - |
| Vornorexant | Tier C · 观察 / 贸易 | - |
合成路线中的位置（上下游链）
按路线登记顺序排列，左→右为合成方向；高亮为当前 CAS，其余可点击跳转对应档案。
(1R,2S,5R)-2-isopropyl-5-methylcyclohexan-1-ol→(2R,5S)-(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl 5-acetoxy-1,3-oxathiolane-2-carboxylate→2-mercaptoacetic acid→2-oxoacetic acid→5-oxo-1,3-oxathiolane-2-carboxylic acid→(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl 5-oxo-1,3-oxathiolane-2-carboxylate→(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl 5-hydroxy-1,3-oxathiolane-2-carboxylate→(2S,5R)-(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl 5-acetoxy-1,3-oxathiolane-2-carboxylate
(1R,2S,5R)-2-isopropyl-5-methylcyclohexan-1-ol→(2R,5S)-(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl 5-acetoxy-1,3-oxathiolane-2-carboxylate→2-mercaptoacetic acid→2-oxoacetic acid→5-oxo-1,3-oxathiolane-2-carboxylic acid→(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl 5-oxo-1,3-oxathiolane-2-carboxylate→(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl 5-hydroxy-1,3-oxathiolane-2-carboxylate→(2S,5R)-(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl 5-acetoxy-1,3-oxathiolane-2-carboxylate
1,4-dithiane-2,5-diol→2-oxoacetic acid→5-hydroxy-1,3-oxathiolane-2-carboxylic acid→(2R,5R)-5-acetoxy-1,3-oxathiolane-2-carboxylic acid→(1R,2S,5R)-2-isopropyl-5-methylcyclohexan-1-ol→(2R,5R)-(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl 5-acetoxy-1,3-oxathiolane-2-carboxylate→4-amino-5-fluoropyrimidin-2(1H)-one→(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl (2R,5S)-5-(4-amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)-1,3-oxathiolane-2-carboxylate
5-fluoro-N-(trimethylsilyl)-2-((trimethylsilyl)oxy)pyrimidin-4-amine→1,4-dithiane-2,5-diol→2-oxoacetic acid→(1R,2S,5R)-2-isopropyl-5-methylcyclohexan-1-ol→(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl 2-oxoacetate→(2R,5S)-(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl 5-hydroxy-1,3-oxathiolane-2-carboxylate→(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl (2R,5R)-5-chloro-1,3-oxathiolane-2-carboxylate→(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl (2R,5S)-5-(4-amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)-1,3-oxathiolane-2-carboxylate oxalate→4-amino-5-fluoro-1-((2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl)pyrimidin-2(1H)-one hydrochloride
本站可供应的对应中间体
同 CAS 多家在售供应横向对比；价格区间为供应方挂牌口径，实价以询价确认为准。
| 供应商 | 产品 | 价格区间 | 最小起订 | 货期 | 资质 | 操作 |
|---|---|---|---|---|---|---|
| Unibest Taizhou GMP-like Site | Brivaracetam Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Qualified Partner — East China API Works | (+)-(R)-4-propyl-4,5-dihydrofuran-2(3H)-one Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
本页为中间体 CAS 注册档案：同 CAS 的多条路线登记已合并；后续供应商报价与买方需求以该 CAS 为主键撮合。