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拉米夫定/富马酸替诺福韦二吡呋酯
Tier C · 观察 / 贸易Lamivudine/Tenofovir Disoproxil Fumarate
Mylan Nv
原研
2018
首批上市
-
到期年（公开口径）
无销量数据
峰值销售
化学药
类型
靶点：RT、HBV pol
商品名：Temixys、Cimduo
适应症（已批准）：HIV感染、慢性乙型肝炎
各地区研发/上市状态
美国
批准上市
2018-02-28
欧盟
-
中国
批准上市
2019-01-15
日本
-
生产该 API 的工厂13
口径：平台供应网络（富通询价明细 + 产品主档）中登记生产该品种的工厂（在产口径），按报价活跃度排序；快照不含成本与客户信息。
已收录 13 家在产工厂名单，登录后可见（工厂信息不对未登录访客展示）。
登录查看工厂名单 →合成路线与中间体13 routes
原研路线 × 1优化路线（非专利）× 12工艺路线 × 0
路线按「原研路线 → 优化路线 / 工艺路线（非专利）」排序。每条路线附本站自绘的路线流程图（中间体 → 原料药）与中间体表（编号 / CAS / 英文名），可直接用于供应商开发与询价。流程图由本站依据已授权的结构化数据自行渲染，未使用任何第三方路线图。
原研Route 1步骤 6 · 总收率 165 mg
LAMI-0013376-59-8LAMI-00264904-47-8LAMI-00353608-94-9LAMI-004138760-43-7LAMI-00571-30-7LAMI-006143957-12-4LAMI-00798-91-9LAMI-0082032-35-1LAMI-009163348-46-7API · 拉米夫定/富马酸替诺福韦二吡呋酯
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| LAMI-001 | 3376-59-8 | 2,3-dihydroxypropyl benzoate |
| LAMI-002 | 64904-47-8 | 2-oxoethyl benzoate |
| LAMI-003 | 53608-94-9 | 2,2-diethoxyethanethiol |
| LAMI-004 | 138760-43-7 | (5-ethoxy-1,3-oxathiolan-2-yl)methyl benzoate |
| LAMI-005 | 71-30-7在售 | 4-aminopyrimidin-2(1H)-one |
| LAMI-006 | 143957-12-4 | ((2R,5S)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-1,3-oxathiolan-2-yl)methyl benzoate |
| LAMI-007 | 98-91-9 | benzothioic O-acid |
| LAMI-008 | 2032-35-1 | 2-bromo-1,1-diethoxyethane |
| LAMI-009 | 163348-46-7 | S-(2,2-diethoxyethyl) benzothioate |
优化Route 2步骤 4 · 总收率 /
LAMI-00264904-47-8LAMI-006143957-12-4LAMI-01030163-03-2LAMI-011143957-11-3LAMI-012143957-14-6API · 拉米夫定/富马酸替诺福韦二吡呋酯
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| LAMI-002 | 64904-47-8 | 2-oxoethyl benzoate |
| LAMI-006 | 143957-12-4 | ((2R,5S)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-1,3-oxathiolan-2-yl)methyl benzoate |
| LAMI-010 | 30163-03-2 | (S)-2-hydroxy-3-mercaptopropanoic acid |
| LAMI-011 | 143957-11-3 | (2R,5S)-2-((benzoyloxy)methyl)-1,3-oxathiolane-5-carboxylic acid |
| LAMI-012 | 143957-14-6 | ((2R)-5-acetoxy-1,3-oxathiolan-2-yl)methyl benzoate |
优化Route 3步骤 5 · 总收率 /
LAMI-00571-30-7LAMI-01389-78-1LAMI-0141152495-30-1LAMI-01526315-61-7LAMI-01640018-26-6LAMI-017—LAMI-018147126-65-6LAMI-019147027-10-9API · 拉米夫定/富马酸替诺福韦二吡呋酯
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| LAMI-005 | 71-30-7在售 | 4-aminopyrimidin-2(1H)-one |
| LAMI-013 | 89-78-1在售 | (1R,2S,5R)-2-isopropyl-5-methylcyclohexan-1-ol |
| LAMI-014 | 1152495-30-1 | 2-oxoacetic acid hydrate |
| LAMI-015 | 26315-61-7 | (1R,2S,5R)-2-isopropyl-5-methylcyclohexyl 2-oxoacetate |
| LAMI-016 | 40018-26-6 | 1,4-dithiane-2,5-diol |
| LAMI-017 | - | (2R,5S)-(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl 5-hydroxy-1,3-oxathiolane-2-carboxylate |
| LAMI-018 | 147126-65-6 | (2R,5S)-(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl 5-acetoxy-1,3-oxathiolane-2-carboxylate |
| LAMI-019 | 147027-10-9 | (2R,5S)-(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl 5-(4-amino-2-oxopyrimidin-1(2H)-yl)-1,3-oxathiolane-2-carboxylate |
优化Route 4步骤 5 · 总收率 /
LAMI-01389-78-1LAMI-018147126-65-6LAMI-02068-11-1LAMI-021298-12-4LAMI-022138760-34-6LAMI-023—LAMI-024200396-19-6LAMI-018-a147126-65-6API · 拉米夫定/富马酸替诺福韦二吡呋酯
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| LAMI-013 | 89-78-1在售 | (1R,2S,5R)-2-isopropyl-5-methylcyclohexan-1-ol |
| LAMI-018 | 147126-65-6 | (2R,5S)-(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl 5-acetoxy-1,3-oxathiolane-2-carboxylate |
| LAMI-020 | 68-11-1 | 2-mercaptoacetic acid |
| LAMI-021 | 298-12-4在售 | 2-oxoacetic acid |
| LAMI-022 | 138760-34-6 | 5-oxo-1,3-oxathiolane-2-carboxylic acid |
| LAMI-023 | - | (1R,2S,5R)-2-isopropyl-5-methylcyclohexyl 5-oxo-1,3-oxathiolane-2-carboxylate |
| LAMI-024 | 200396-19-6 | (1R,2S,5R)-2-isopropyl-5-methylcyclohexyl 5-hydroxy-1,3-oxathiolane-2-carboxylate |
| LAMI-018-a | 147126-65-6 | (2S,5R)-(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl 5-acetoxy-1,3-oxathiolane-2-carboxylate |
优化Route 5步骤 3 · 总收率 /
LAMI-00264904-47-8LAMI-012143957-14-6LAMI-01640018-26-6LAMI-02518027-23-1LAMI-0261091585-30-6API · 拉米夫定/富马酸替诺福韦二吡呋酯
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| LAMI-002 | 64904-47-8 | 2-oxoethyl benzoate |
| LAMI-012 | 143957-14-6 | ((2R)-5-acetoxy-1,3-oxathiolan-2-yl)methyl benzoate |
| LAMI-016 | 40018-26-6 | 1,4-dithiane-2,5-diol |
| LAMI-025 | 18027-23-1 | N-(trimethylsilyl)-N-(2-((trimethylsilyl)oxy)pyrimidin-4-yl)acetamide |
| LAMI-026 | 1091585-30-6 | ((2R,5S)-5-(4-acetamido-2-oxopyrimidin-1(2H)-yl)-1,3-oxathiolan-2-yl)methyl benzoate |
优化Route 1步骤 11 · 总收率 23.3g(Tenofovir disoproxil phosphate (API))
Tenofovir disoproxil phosphate-00178-95-5Tenofovir disoproxil phosphate-00219141-39-0Tenofovir disoproxil phosphate-00331618-90-3Tenofovir disoproxil phosphate-0043167-63-3Tenofovir disoproxil phosphate-005762-04-9Tenofovir disoproxil phosphate-0063084-40-0Tenofovir disoproxil phosphate-0071316848-77-7Tenofovir disoproxil phosphate-00873-24-5Tenofovir disoproxil phosphate-009180587-75-1Tenofovir disoproxil phosphate-010206184-49-8,147127-19-3,147127-20-6Tenofovir disoproxil phosphate-01135180-01-9Tenofovir disoproxil phosphate-012201341-05-1Tenofovir disoproxil phosphate-01315448-47-2Tenofovir disoproxil phosphate-01414047-28-0Tenofovir disoproxil phosphate-01516606-55-6Tenofovir disoproxil phosphate-01660456-23-7,556-52-5Tenofovir disoproxil phosphate-0174254-14-2API · 拉米夫定/富马酸替诺福韦二吡呋酯
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Tenofovir disoproxil phosphate-001 | 78-95-5 | Chloroacetyl chloride |
| Tenofovir disoproxil phosphate-002 | 19141-39-0 | 1-Chloro-2(R)-propanol |
| Tenofovir disoproxil phosphate-003 | 31618-90-3 | Diethyl (tosyloxy)methylphosphonate |
| Tenofovir disoproxil phosphate-004 | 3167-63-3 | Diethyl (chloromethyl)phosphonate |
| Tenofovir disoproxil phosphate-005 | 762-04-9 | Diethyl phosphonate |
| Tenofovir disoproxil phosphate-006 | 3084-40-0 | Diethyl phosphonomethanol |
| Tenofovir disoproxil phosphate-007 | 1316848-77-7 | Diethyl (2-chloro-1(R)-methylethoxy)methylphosphonate |
| Tenofovir disoproxil phosphate-008 | 73-24-5 | 6-Aminopurine |
| Tenofovir disoproxil phosphate-009 | 180587-75-1 | (R)-9-[2-(Diethylphosphonomethoxy)propyl] adenine |
| Tenofovir disoproxil phosphate-010 | 206184-49-8,147127-19-3,147127-20-6 | (R)-9-(2-Phosphonomethoxypropyl)adenine |
| Tenofovir disoproxil phosphate-011 | 35180-01-9 | Chloromethyl isopropyl carbonate |
| Tenofovir disoproxil phosphate-012 | 201341-05-1 | Bis[[(isopropoxycarbonyl)oxy]methyl] ([[(2R)-1-(6-amino-9H-purin-9-yl)propan-2-yl]oxy]methyl)phosphonate |
| Tenofovir disoproxil phosphate-013 | 15448-47-2 | 2(R)-Methyloxirane |
| Tenofovir disoproxil phosphate-014 | 14047-28-0 | (R)-(+)-9-(2-Hydroxypropyl)adenine |
| Tenofovir disoproxil phosphate-015 | 16606-55-6 | (R)-Propylene carbonate |
| Tenofovir disoproxil phosphate-016 | 60456-23-7,556-52-5 | (S)-Glycidol |
| Tenofovir disoproxil phosphate-017 | 4254-14-2 | (R)-1,2-Propanediol |
优化Route 2步骤 4 · 总收率 1.7g(Tenofovir disoproxil phosphate-014)
Tenofovir disoproxil phosphate-01414047-28-0Tenofovir disoproxil phosphate-01516606-55-6Tenofovir disoproxil phosphate-0184316-94-3Tenofovir disoproxil phosphate-0191492978-64-9Tenofovir disoproxil phosphate-0204316-93-2Tenofovir disoproxil phosphate-0212799-16-8Tenofovir disoproxil phosphate-022180587-74-0API · 拉米夫定/富马酸替诺福韦二吡呋酯
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Tenofovir disoproxil phosphate-014 | 14047-28-0 | (R)-(+)-9-(2-Hydroxypropyl)adenine |
| Tenofovir disoproxil phosphate-015 | 16606-55-6 | (R)-Propylene carbonate |
| Tenofovir disoproxil phosphate-018 | 4316-94-3 | 6-Chloro-5-nitropyrimidin-4-amine |
| Tenofovir disoproxil phosphate-019 | 1492978-64-9 | (2R)-1-[(6-Chloro-5-nitropyrimidin-4-yl)amino]propan-2-ol |
| Tenofovir disoproxil phosphate-020 | 4316-93-2 | 4,6-Dichloro-5-nitropyrimidine |
| Tenofovir disoproxil phosphate-021 | 2799-16-8 | (2R)-1-Aminopropan-2-ol |
| Tenofovir disoproxil phosphate-022 | 180587-74-0 | (2R)-1-(6-Chloro-9H-purin-9-yl)propan-2-ol |
优化Route 3步骤 8 · 总收率 21.8g(Tenofovir disoproxil phosphate-009)
Tenofovir disoproxil phosphate-005762-04-9Tenofovir disoproxil phosphate-009180587-75-1Tenofovir disoproxil phosphate-01414047-28-0Tenofovir disoproxil phosphate-022180587-74-0Tenofovir disoproxil phosphate-02387-42-3Tenofovir disoproxil phosphate-024598-31-2Tenofovir disoproxil phosphate-025100682-42-6Tenofovir disoproxil phosphate-026106938-62-9Tenofovir disoproxil phosphate-0271493808-01-7Tenofovir disoproxil phosphate-028105970-02-3API · 拉米夫定/富马酸替诺福韦二吡呋酯
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Tenofovir disoproxil phosphate-005 | 762-04-9 | Diethyl phosphonate |
| Tenofovir disoproxil phosphate-009 | 180587-75-1 | (R)-9-[2-(Diethylphosphonomethoxy)propyl] adenine |
| Tenofovir disoproxil phosphate-014 | 14047-28-0 | (R)-(+)-9-(2-Hydroxypropyl)adenine |
| Tenofovir disoproxil phosphate-022 | 180587-74-0 | (2R)-1-(6-Chloro-9H-purin-9-yl)propan-2-ol |
| Tenofovir disoproxil phosphate-023 | 87-42-3 | 6-Chloro-9H-purine |
| Tenofovir disoproxil phosphate-024 | 598-31-2 | 1-Bromopropan-2-one |
| Tenofovir disoproxil phosphate-025 | 100682-42-6 | 1-(6-Chloro-9H-purin-9-yl)acetone |
| Tenofovir disoproxil phosphate-026 | 106938-62-9 | Diethoxyphosphoryl)methyl triflate |
| Tenofovir disoproxil phosphate-027 | 1493808-01-7 | Diethyl [2-(6-chloropurin-9-yl)-1(R)-methylethyloxy]methylphosphonate |
| Tenofovir disoproxil phosphate-028 | 105970-02-3 | 1-(6-Amino-9H-purin-9-yl)acetone |
优化Route 4步骤 3 · 总收率 21.8g(Tenofovir disoproxil phosphate-009)
Tenofovir disoproxil phosphate-005762-04-9Tenofovir disoproxil phosphate-0063084-40-0Tenofovir disoproxil phosphate-009180587-75-1Tenofovir disoproxil phosphate-01414047-28-0Tenofovir disoproxil phosphate-029114108-84-8Tenofovir disoproxil phosphate-030145978-18-3Tenofovir disoproxil phosphate-031145978-32-1API · 拉米夫定/富马酸替诺福韦二吡呋酯
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Tenofovir disoproxil phosphate-005 | 762-04-9 | Diethyl phosphonate |
| Tenofovir disoproxil phosphate-006 | 3084-40-0 | Diethyl phosphonomethanol |
| Tenofovir disoproxil phosphate-009 | 180587-75-1 | (R)-9-[2-(Diethylphosphonomethoxy)propyl] adenine |
| Tenofovir disoproxil phosphate-014 | 14047-28-0 | (R)-(+)-9-(2-Hydroxypropyl)adenine |
| Tenofovir disoproxil phosphate-029 | 114108-84-8 | (Diethoxyphosphoryl)methyl methanesulfonate |
| Tenofovir disoproxil phosphate-030 | 145978-18-3 | (Diethoxyphosphoryl)methyl 4-fluorobenzene-1-sulfonate |
| Tenofovir disoproxil phosphate-031 | 145978-32-1 | (Diethoxyphosphoryl)methyl 4-(trifluoromethyl)benzene-1-sulfonate |
优化Route 5步骤 8 · 总收率 1.97g(Tenofovir disoproxil phosphate-013)
Tenofovir disoproxil phosphate-01315448-47-2Tenofovir disoproxil phosphate-0174254-14-2Tenofovir disoproxil phosphate-03279-33-4Tenofovir disoproxil phosphate-03327871-49-4Tenofovir disoproxil phosphate-03463696-98-0Tenofovir disoproxil phosphate-03524590-49-6Tenofovir disoproxil phosphate-03610326-41-7Tenofovir disoproxil phosphate-03717392-83-5Tenofovir disoproxil phosphate-038103775-61-7API · 拉米夫定/富马酸替诺福韦二吡呋酯
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Tenofovir disoproxil phosphate-013 | 15448-47-2 | 2(R)-Methyloxirane |
| Tenofovir disoproxil phosphate-017 | 4254-14-2 | (R)-1,2-Propanediol |
| Tenofovir disoproxil phosphate-032 | 79-33-4 | 2(S)-Hydroxypropionic acid |
| Tenofovir disoproxil phosphate-033 | 27871-49-4 | Methyl (2S)-2-hydroxypropanoate |
| Tenofovir disoproxil phosphate-034 | 63696-98-0 | Methyl (2S)-2-[(methanesulfonyl)oxy]propanoate |
| Tenofovir disoproxil phosphate-035 | 24590-49-6 | (2S)-1-Hydroxypropan-2-yl methanesulfonate |
| Tenofovir disoproxil phosphate-036 | 10326-41-7 | (2R)-2-Hydroxypropanoic acid |
| Tenofovir disoproxil phosphate-037 | 17392-83-5在售 | D-Lactic acid methyl ester |
| Tenofovir disoproxil phosphate-038 | 103775-61-7 | (2R)-2-Hydroxypropyl 4-methylbenzene-1-sulfonate |
优化Route 6步骤 4 · 总收率 /
Tenofovir disoproxil phosphate-0174254-14-2Tenofovir disoproxil phosphate-0391648543-28-5Tenofovir disoproxil phosphate-040685-83-6Tenofovir disoproxil phosphate-0411647147-88-3Tenofovir disoproxil phosphate-00873-24-5Tenofovir disoproxil phosphate-0421664338-79-7API · 拉米夫定/富马酸替诺福韦二吡呋酯
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Tenofovir disoproxil phosphate-017 | 4254-14-2 | Propane-1,2(R)-diol |
| Tenofovir disoproxil phosphate-039 | 1648543-28-5 | (4R)-4-Methyl-1,3-dioxolane |
| Tenofovir disoproxil phosphate-040 | 685-83-6 | N,N,N',N'-Tetraethylphosphorodiamidous chloride |
| Tenofovir disoproxil phosphate-041 | 1647147-88-3 | P-([[(2R)-1-Chloropropan-2-yl]oxy]methyl)-N,N,N',N'-tetraethylphosphonic diamide |
| Tenofovir disoproxil phosphate-008 | 73-24-5 | 6-Aminopurine |
| Tenofovir disoproxil phosphate-042 | 1664338-79-7 | P-([[(2R)-1-(6-Amino-9H-purin-9-yl)propan-2-yl]oxy]methyl)-N,N,N',N'-tetraethylphosphonic diamide |
优化Route 7步骤 3 · 总收率 /
Tenofovir disoproxil phosphate-01414047-28-0Tenofovir disoproxil phosphate-00331618-90-3Tenofovir disoproxil phosphate-009180587-75-1Tenofovir disoproxil phosphate-04357-13-6Tenofovir disoproxil phosphate-04462-56-6Tenofovir disoproxil phosphate-045113-00-8Tenofovir disoproxil phosphate-046—Tenofovir disoproxil phosphate-0472035468-75-6Tenofovir disoproxil phosphate-048—API · 拉米夫定/富马酸替诺福韦二吡呋酯
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Tenofovir disoproxil phosphate-014 | 14047-28-0 | (R)-1-(6-Amino-9H-purin-9-yl)propan-2-ol |
| Tenofovir disoproxil phosphate-003 | 31618-90-3 | (Diethoxyphosphoryl)methyl 4-methylbenzene-1-sulfonate |
| Tenofovir disoproxil phosphate-009 | 180587-75-1 | (R)-9-[2-(Diethylphosphonomethoxy)propyl] adenine |
| Tenofovir disoproxil phosphate-043 | 57-13-6 | Carbamide |
| Tenofovir disoproxil phosphate-044 | 62-56-6在售 | Thiocarbamide |
| Tenofovir disoproxil phosphate-045 | 113-00-8 | Guanidine |
| Tenofovir disoproxil phosphate-046 | - | Ethoxy(imino)methanaminium ethyl ([[(2R)-1-(6-amino-9H-purin-9-yl)propan-2-yl]oxy]methyl)phosphonate |
| Tenofovir disoproxil phosphate-047 | 2035468-75-6 | (Ethylsulfanyl)(imino)methanaminium ethyl ([[(2R)-1-(6-amino-9H-purin-9-yl)propan-2-yl]oxy]methyl)phosphonate |
| Tenofovir disoproxil phosphate-048 | - | (Ethylamino)(imino)methanaminium ethyl ([[(2R)-1-(6-amino-9H-purin-9-yl)propan-2-yl]oxy]methyl)phosphonate |
优化Route 8步骤 1 · 总收率 112.26g(Tenofovir disoproxil phosphate-051)
Tenofovir disoproxil phosphate-049206184-49-8,147127-20-6,147127-19-3Tenofovir disoproxil phosphate-050101-02-0Tenofovir disoproxil phosphate-051379270-35-6Tenofovir disoproxil phosphate-05266003-76-7Tenofovir disoproxil phosphate-053201358-23-8Tenofovir disoproxil phosphate-054313-39-3Tenofovir disoproxil phosphate-05558109-40-3Tenofovir disoproxil phosphate-05662613-15-4Tenofovir disoproxil phosphate-057722-56-5Tenofovir disoproxil phosphate-058322-23-6Tenofovir disoproxil phosphate-059—API · 拉米夫定/富马酸替诺福韦二吡呋酯
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Tenofovir disoproxil phosphate-049 | 206184-49-8,147127-20-6,147127-19-3 | ([[(2R)-1-(6-Amino-9H-purin-9-yl)propan-2-yl]oxy]methyl)phosphonic acid |
| Tenofovir disoproxil phosphate-050 | 101-02-0 | Phenyl phosphite |
| Tenofovir disoproxil phosphate-051 | 379270-35-6 | Phenyl hydrogen ([[(2R)-1-(6-amino-9H-purin-9-yl)propan-2-yl]oxy]methyl)phosphonate |
| Tenofovir disoproxil phosphate-052 | 66003-76-7 | Diphenyliodanium trifluoromethanesulfonate |
| Tenofovir disoproxil phosphate-053 | 201358-23-8 | Diphenyliodanium methanesulfonate |
| Tenofovir disoproxil phosphate-054 | 313-39-3 | Diphenyliodanium tetrafluoridoborate(1-) |
| Tenofovir disoproxil phosphate-055 | 58109-40-3 | Diphenyliodonium hexafluorophosphate |
| Tenofovir disoproxil phosphate-056 | 62613-15-4 | Diphenyliodanium hexafluoridoarsenate(1-) |
| Tenofovir disoproxil phosphate-057 | 722-56-5 | Diphenyliodanium nitrate |
| Tenofovir disoproxil phosphate-058 | 322-23-6 | Diphenyliodanium fluoride |
| Tenofovir disoproxil phosphate-059 | - | Diphenyliodanium bromide |
常见问题（FAQ）
拉米夫定/富马酸替诺福韦二吡呋酯的适应症有哪些？
已批准的适应症包括：HIV感染、慢性乙型肝炎。
拉米夫定/富马酸替诺福韦二吡呋酯的专利什么时候到期？
拉米夫定/富马酸替诺福韦二吡呋酯的专利到期年暂无公开口径，本页会在数据管道核实后更新。
拉米夫定/富马酸替诺福韦二吡呋酯有几条合成路线？
本站收录 13 条合成路线，最短路线 1 步、总收率 112.26g(Tenofovir disoproxil phosphate-051)。每条路线的中间体均带登记编号与 CAS 号。
拉米夫定/富马酸替诺福韦二吡呋酯的关键中间体在哪里可以采购？
拉米夫定/富马酸替诺福韦二吡呋酯的多条路线中间体已挂接 CAS 档案，其中 5 个 CAS 已有优贝德（Unibest）供应网络在售报价，可在本页路线表中直接查看并询价。
如何获取拉米夫定/富马酸替诺福韦二吡呋酯中间体的报价？
在本页选择目标中间体的 CAS 进入档案页，或在询价页直接提交需求；CAS 会自动带入供需撮合流程，由供应网络反馈报价。
数据来源：多源数据交叉核实（仅结构化字段） · 2026-10-22