← 返回专利悬崖列表
CAS 35320-23-1
(S)-2-aminopropan-1-ol
登记编号：SAFI-026、PAZU-013
应用背景（按来源药适应症）
帕金森病甲磺酸沙非胺疼痛甲磺酸沙非胺药物性运动障碍甲磺酸沙非胺肝功能衰退甲磺酸沙非胺多系统萎缩甲磺酸沙非胺肾功能不全甲磺酸沙非胺肺炎链球菌感染甲磺酸帕珠沙星脓毒病甲磺酸帕珠沙星传染性疾病甲磺酸帕珠沙星膀胱炎甲磺酸帕珠沙星胆管炎甲磺酸帕珠沙星胆囊炎甲磺酸帕珠沙星
来源药（使用该中间体的合成路线）
合成路线中的位置（上下游链）
按路线登记顺序排列，左→右为合成方向；高亮为当前 CAS，其余可点击跳转对应档案。
1-fluoro-3-(iodomethyl)benzene→4-(hydroxymethyl)phenol→(4-((3-fluorobenzyl)oxy)phenyl)methanol→1-fluoro-3-((4-(iodomethyl)phenoxy)methyl)benzene→SAFI-018→SAFI-019→SAFI-020→SAFI-021→2-((benzyloxy)methyl)oxirane→(R)-2-((benzyloxy)methyl)oxirane→(R)-1-(benzyloxy)propan-2-ol→(S)-((2-azidopropoxy)methyl)benzene→(S)-2-aminopropan-1-ol
ethyl 2,3,4,5-tetrafluorobenzoate→di-tert-butyl malonate→2-(4-(ethoxycarbonyl)-2,3,6-trifluorophenyl)acetic acid→ethyl 4-(2-(benzhydryloxy)-2-oxoethyl)-2,3,5-trifluorobenzoate→ethyl 4-(1-(benzhydryloxy)-3-hydroxy-1-oxopropan-2-yl)-2,3,5-trifluorobenzoate→ethyl 4-(3-(benzhydryloxy)-3-oxoprop-1-en-2-yl)-2,3,5-trifluorobenzoate→ethyl 4-(1-((benzhydryloxy)carbonyl)cyclopropyl)-2,3,5-trifluorobenzoate→1-(4-(ethoxycarbonyl)-2,3,6-trifluorophenyl)cyclopropane-1-carboxylic acid→ethyl 4-(1-(((benzyloxy)carbonyl)amino)cyclopropyl)-2,3,5-trifluorobenzoate→4-(1-(((benzyloxy)carbonyl)amino)cyclopropyl)-2,3,5-trifluorobenzoic acid→3-ethoxy-3-oxopropanoic acid→CAS→(S)-2-aminopropan-1-ol→ethyl (S,Z)-2-(4-(1-(((benzyloxy)carbonyl)amino)cyclopropyl)-2,3,5-trifluorobenzoyl)-3-((1-hydroxypropan-2-yl)amino)acrylate→ethyl (S)-10-(1-(((benzyloxy)carbonyl)amino)cyclopropyl)-9-fluoro-3-methyl-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylate→(S)-10-(1-(((benzyloxy)carbonyl)amino)cyclopropyl)-9-fluoro-3-methyl-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid→(S)-10-(1-aminocyclopropyl)-9-fluoro-3-methyl-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid hydrochloride
(S)-2-aminopropan-1-ol→2,3,4,5-tetrafluorobenzoic acid→tert-butyl 2-cyanoacetate→ethyl 4-(2-(tert-butoxy)-1-cyano-2-oxoethyl)-2,3,5-trifluorobenzoate→ethyl 4-(cyanomethyl)-2,3,5-trifluorobenzoate→4-(1-cyanocyclopropyl)-2,3,5-trifluorobenzoic acid→4-(1-carbamoylcyclopropyl)-2,3,5-trifluorobenzoic acid→4-(1-aminocyclopropyl)-2,3,5-trifluorobenzoic acid→4-(1-acetamidocyclopropyl)-2,3,5-trifluorobenzoic acid→potassium 3-ethoxy-3-oxopropanoate→ethyl 3-(4-(1-acetamidocyclopropyl)-2,3,5-trifluorophenyl)-3-oxopropanoate→ethyl (S)-2-(4-(1-acetamidocyclopropyl)-2,3,5-trifluorobenzoyl)-3-((1-hydroxypropan-2-yl)amino)acrylate→ethyl (S)-10-(1-acetamidocyclopropyl)-9-fluoro-3-methyl-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylate→(S)-10-(1-acetamidocyclopropyl)-9-fluoro-3-methyl-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid
本站可供应的对应中间体
目录暂未收录该靶点的在售中间体 —— 可直接发起询价，需求会进入撮合池。
本页为中间体 CAS 注册档案：同 CAS 的多条路线登记已合并；后续供应商报价与买方需求以该 CAS 为主键撮合。