CAS 6148-64-7

potassium 3-ethoxy-3-oxopropanoate

登记编号：SITAF-041、PAZU-026、MONT-046、BNC-210-006

应用背景（按来源药适应症）

膀胱炎西他沙星鼻窦炎西他沙星扁桃体炎西他沙星肺炎西他沙星宫颈炎西他沙星冠周炎西他沙星肺炎链球菌感染甲磺酸帕珠沙星脓毒病甲磺酸帕珠沙星传染性疾病甲磺酸帕珠沙星膀胱炎甲磺酸帕珠沙星胆管炎甲磺酸帕珠沙星胆囊炎甲磺酸帕珠沙星过敏性鼻炎孟鲁司特钠哮喘孟鲁司特钠超敏反应孟鲁司特钠季节性过敏性鼻炎孟鲁司特钠常年性变应性鼻炎孟鲁司特钠运动诱发哮喘孟鲁司特钠创伤后应激障碍Soclenicant社交恐惧症Soclenicant躁动Soclenicant

来源药（使用该中间体的合成路线）

品种	梯队	到期年
西他沙星Sitafloxacin Hydrate	Tier C · 观察 / 贸易	-
甲磺酸帕珠沙星Pazufloxacin Mesylate	Tier C · 观察 / 贸易	-
孟鲁司特钠Montelukast	Tier B · 提前布局	-
Soclenicant	Tier C · 观察 / 贸易	-

合成路线中的位置（上下游链）

按路线登记顺序排列，左→右为合成方向；高亮为当前 CAS，其余可点击跳转对应档案。

西他沙星优化路线步数：8总收率：383.3 mg

SITAF-007→1,2-dibromoethane→benzylglycine→N-benzyl-N-(tert-butoxycarbonyl)glycine→potassium 3-ethoxy-3-oxopropanoate→ethyl 4-(benzyl(tert-butoxycarbonyl)amino)-3-oxobutanoate→ethyl 1-(N-benzyl-N-(tert-butoxycarbonyl)glycyl)cyclopropane-1-carboxylate→5-benzyl-5-azaspiro[2.4]heptane-4,7-dione→(S)-5-benzyl-7-hydroxy-5-azaspiro[2.4]heptan-4-one→(S)-5-benzyl-5-azaspiro[2.4]heptan-7-amine→tert-butyl (S)-(5-benzyl-5-azaspiro[2.4]heptan-7-yl)carbamate

甲磺酸帕珠沙星优化路线步数：11总收率：39.7 g

(S)-2-aminopropan-1-ol→2,3,4,5-tetrafluorobenzoic acid→tert-butyl 2-cyanoacetate→ethyl 4-(2-(tert-butoxy)-1-cyano-2-oxoethyl)-2,3,5-trifluorobenzoate→ethyl 4-(cyanomethyl)-2,3,5-trifluorobenzoate→4-(1-cyanocyclopropyl)-2,3,5-trifluorobenzoic acid→4-(1-carbamoylcyclopropyl)-2,3,5-trifluorobenzoic acid→4-(1-aminocyclopropyl)-2,3,5-trifluorobenzoic acid→4-(1-acetamidocyclopropyl)-2,3,5-trifluorobenzoic acid→potassium 3-ethoxy-3-oxopropanoate→ethyl 3-(4-(1-acetamidocyclopropyl)-2,3,5-trifluorophenyl)-3-oxopropanoate→ethyl (S)-2-(4-(1-acetamidocyclopropyl)-2,3,5-trifluorobenzoyl)-3-((1-hydroxypropan-2-yl)amino)acrylate→ethyl (S)-10-(1-acetamidocyclopropyl)-9-fluoro-3-methyl-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylate→(S)-10-(1-acetamidocyclopropyl)-9-fluoro-3-methyl-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid

孟鲁司特钠优化路线步数：7总收率：/

3-Methylbenzoic acidm-Toluic acid→3-Methylbenzoic acid methyl ester→methyl 3-(bromomethyl)benzoate→3-[(E)-2-(7-Chloroquinolin-2-yl)ethenyl]benzoic acid methyl ester→7-Chloro-2-methylquinoline 7-Chloroquinaldine→3-[(E)-2-(7-Chloroquinolin-2-yl)ethenyl]benzoic acid methyl ester→3-[(E)-2-(7-Chloroquinolin-2-yl)ethenyl]benzoic acid→3-[(E)-2-(7-Chloroquinolin-2-yl)ethenyl]benzoyl chloride→potassium 3-ethoxy-3-oxopropanoate

Soclenicant原研路线步数：10总收率：/

2-hydroxynicotinic acid→2-hydroxy-5-nitronicotinic acid→2-chloro-5-nitronicotinic acid→2-methoxy-5-nitronicotinic acid→2-methoxy-5-nitronicotinoyl chloride→potassium 3-ethoxy-3-oxopropanoate→ethyl 3-(2-methoxy-5-nitropyridin-3-yl)-3-oxopropanoate→(Z)-ethyl 3-ethoxy-2-(2-methoxy-5-nitronicotinoyl)acrylate→ethyl 1-ethyl-6-nitro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate→ethyl 6-amino-1-ethyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate→1H-inden-2(3H)-one→ethyl 6-((2,3-dihydro-1H-inden-2-yl)amino)-1-ethyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate→1,8-Naphthyridin-4(1H)-one, 6-[(2,3-dihydro-1H-inden-2-yl)amino]-1-ethyl-3-(4-morpholinylcarbonyl)-

本站可供应的对应中间体

同 CAS 多家在售供应横向对比；价格区间为供应方挂牌口径，实价以询价确认为准。

供应商	产品	价格区间	最小起订	货期	资质	操作
Unibest Nantong cGMP Site	Carbamic acid, (7S)-5-azaspiro[2.4]hept-7-yl-, 1,1-dimethylethyl ester (9CI) Pharmaceutical Intermediates	询价	询价	询价	—

本页为中间体 CAS 注册档案：同 CAS 的多条路线登记已合并；后续供应商报价与买方需求以该 CAS 为主键撮合。