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CAS 461432-22-4
(5-bromo-2-chlorophenyl)(4-ethoxyphenyl)methanone
登记编号：DAPA-003
应用背景（按来源药适应症）
二型糖尿病达格列净丙二醇/盐酸二甲双胍慢性肾功能不全达格列净丙二醇一水化物心脏衰竭达格列净丙二醇一水化物肾脏疾病达格列净丙二醇一水化物一型糖尿病达格列净丙二醇一水化物二型糖尿病达格列净丙二醇一水化物多囊卵巢综合征达格列净丙二醇一水化物
来源药（使用该中间体的合成路线）
| 品种 | 梯队 | 到期年 |
|---|---|---|
| 达格列净丙二醇/盐酸二甲双胍Dapagliflozin Propanediol/Metformin Hydrochloride | Tier A · 立即攻坚 | 2030 |
| 达格列净丙二醇一水化物Dapagliflozin Propanediol Monohydrate | Tier B · 提前布局 | - |
合成路线中的位置（上下游链）
按路线登记顺序排列，左→右为合成方向；高亮为当前 CAS，其余可点击跳转对应档案。
(3R,4S,5S,6R)-2-(4-chloro-3-(4-ethoxybenzyl)phenyl)-6-(hydroxymethyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triol→(2R,3R,4R,5S,6S)-2-(acetoxymethyl)-6-(4-chloro-3-(4-ethoxybenzyl)phenyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate→5-bromo-2-chlorobenzoic acid→ethoxybenzene→(5-bromo-2-chlorophenyl)(4-ethoxyphenyl)methanone→4-bromo-1-chloro-2-(4-ethoxybenzyl)benzene→(3R,4S,5R,6R)-3,4,5-tris((trimethylsilyl)oxy)-6-(((trimethylsilyl)oxy)methyl)tetrahydro-2H-pyran-2-one
5-bromo-2-chlorobenzoic acid→ethoxybenzene→(5-bromo-2-chlorophenyl)(4-ethoxyphenyl)methanone→4-bromo-1-chloro-2-(4-ethoxybenzyl)benzene→(3R,4S,5R,6R)-3,4,5-tris((trimethylsilyl)oxy)-6-(((trimethylsilyl)oxy)methyl)tetrahydro-2H-pyran-2-one→(3R,4S,5S,6R)-2-(4-chloro-3-(4-ethoxybenzyl)phenyl)-6-(hydroxymethyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triol→L-proline compound with (2S,3R,4R,5S,6R)-2-(4-chloro-3-(4-ethoxybenzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol (2:1)
(5-bromo-2-chlorophenyl)(4-ethoxyphenyl)methanone→(1R,2S,3S,4R,5R)-6,8-dioxabicyclo[3.2.1]octane-2,3,4-triol→(1R,2S,3S,4R,5R)-2,4-bis((tert-butyldiphenylsilyl)oxy)-6,8-dioxabicyclo[3.2.1]octan-3-ol→(2S,3R,4S,5S,6R)-3,5-bis((tert-butyldiphenylsilyl)oxy)-2-(4-chloro-3-(4-ethoxybenzyl)phenyl)-6-methyltetrahydro-2H-pyran-4-ol
(5-bromo-2-chlorophenyl)(4-ethoxyphenyl)methanone→(2S,3R,4S,5S,6R)-6-(hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol→pivaloyl chloride→(2R,3R,4S,5R,6R)-6-((pivaloyloxy)methyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetrakis(2,2-dimethylpropanoate)→(2R,3R,4S,5R,6R)-2-bromo-6-((pivaloyloxy)methyl)tetrahydro-2H-pyran-3,4,5-triyl tris(2,2-dimethylpropanoate)→(2S,3S,4R,5R,6R)-2-(4-chloro-3-(4-ethoxybenzyl)phenyl)-6-((pivaloyloxy)methyl)tetrahydro-2H-pyran-3,4,5-triyl tris(2,2-dimethylpropanoate)
(3R,4S,5S,6R)-2-(4-chloro-3-(4-ethoxybenzyl)phenyl)-6-(hydroxymethyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triol→(2R,3R,4R,5S,6S)-2-(acetoxymethyl)-6-(4-chloro-3-(4-ethoxybenzyl)phenyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate→5-bromo-2-chlorobenzoic acid→ethoxybenzene→(5-bromo-2-chlorophenyl)(4-ethoxyphenyl)methanone→4-bromo-1-chloro-2-(4-ethoxybenzyl)benzene→(3R,4S,5R,6R)-3,4,5-tris((trimethylsilyl)oxy)-6-(((trimethylsilyl)oxy)methyl)tetrahydro-2H-pyran-2-one
本站可供应的对应中间体
同 CAS 多家在售供应横向对比；价格区间为供应方挂牌口径，实价以询价确认为准。
| 供应商 | 产品 | 价格区间 | 最小起订 | 货期 | 资质 | 操作 |
|---|---|---|---|---|---|---|
| Unibest Taizhou GMP-like Site | (5-Bromo-2-chlorophenyl)(4-ethoxyphenyl)methanone Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
本页为中间体 CAS 注册档案：同 CAS 的多条路线登记已合并；后续供应商报价与买方需求以该 CAS 为主键撮合。