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CAS 492-62-6
(2S,3R,4S,5S,6R)-6-(hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol
登记编号：DAPA-012、CANA-016
应用背景（按来源药适应症）
二型糖尿病达格列净丙二醇/盐酸二甲双胍终末期肾脏病卡格列净/盐酸二甲双胍心脏和血管疾病卡格列净/盐酸二甲双胍腹主动脉瘤卡格列净/盐酸二甲双胍二型糖尿病卡格列净/盐酸二甲双胍慢性肾功能不全达格列净丙二醇一水化物心脏衰竭达格列净丙二醇一水化物肾脏疾病达格列净丙二醇一水化物一型糖尿病达格列净丙二醇一水化物二型糖尿病达格列净丙二醇一水化物多囊卵巢综合征达格列净丙二醇一水化物二型糖尿病卡格列净糖尿病肾病卡格列净冠状动脉病变卡格列净糖尿病卡格列净心脏衰竭卡格列净终末期肾脏病卡格列净
来源药（使用该中间体的合成路线）
| 品种 | 梯队 | 到期年 |
|---|---|---|
| 达格列净丙二醇/盐酸二甲双胍Dapagliflozin Propanediol/Metformin Hydrochloride | Tier A · 立即攻坚 | 2030 |
| 卡格列净/盐酸二甲双胍Canagliflozin/Metformin Hydrochloride | Tier B · 提前布局 | 2029 |
| 达格列净丙二醇一水化物Dapagliflozin Propanediol Monohydrate | Tier B · 提前布局 | - |
| 卡格列净Canagliflozin Hemihydrate | Tier C · 观察 / 贸易 | - |
合成路线中的位置（上下游链）
按路线登记顺序排列，左→右为合成方向；高亮为当前 CAS，其余可点击跳转对应档案。
(5-bromo-2-chlorophenyl)(4-ethoxyphenyl)methanone→(2S,3R,4S,5S,6R)-6-(hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol→pivaloyl chloride→(2R,3R,4S,5R,6R)-6-((pivaloyloxy)methyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetrakis(2,2-dimethylpropanoate)→(2R,3R,4S,5R,6R)-2-bromo-6-((pivaloyloxy)methyl)tetrahydro-2H-pyran-3,4,5-triyl tris(2,2-dimethylpropanoate)→(2S,3S,4R,5R,6R)-2-(4-chloro-3-(4-ethoxybenzyl)phenyl)-6-((pivaloyloxy)methyl)tetrahydro-2H-pyran-3,4,5-triyl tris(2,2-dimethylpropanoate)
2-(4-fluorophenyl)-5-(5-iodo-2-methylbenzyl)thiophene→(2S,3R,4S,5S,6R)-6-(hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol→(2R,3R,4S,5R,6R)-6-((pivaloyloxy)methyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetrakis(2,2-dimethylpropanoate)→(2R,3R,4S,5R,6R)-2-bromo-6-((pivaloyloxy)methyl)tetrahydro-2H-pyran-3,4,5-triyl tris(2,2-dimethylpropanoate)→(2S,3S,4R,5R,6R)-2-(3-((5-(4-fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl)-6-((pivaloyloxy)methyl)tetrahydro-2H-pyran-3,4,5-triyl tris(2,2-dimethylpropanoate)
(5-bromo-2-chlorophenyl)(4-ethoxyphenyl)methanone→(2S,3R,4S,5S,6R)-6-(hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol→pivaloyl chloride→(2R,3R,4S,5R,6R)-6-((pivaloyloxy)methyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetrakis(2,2-dimethylpropanoate)→(2R,3R,4S,5R,6R)-2-bromo-6-((pivaloyloxy)methyl)tetrahydro-2H-pyran-3,4,5-triyl tris(2,2-dimethylpropanoate)→(2S,3S,4R,5R,6R)-2-(4-chloro-3-(4-ethoxybenzyl)phenyl)-6-((pivaloyloxy)methyl)tetrahydro-2H-pyran-3,4,5-triyl tris(2,2-dimethylpropanoate)
2-(4-fluorophenyl)-5-(5-iodo-2-methylbenzyl)thiophene→(2S,3R,4S,5S,6R)-6-(hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol→(2R,3R,4S,5R,6R)-6-((pivaloyloxy)methyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetrakis(2,2-dimethylpropanoate)→(2R,3R,4S,5R,6R)-2-bromo-6-((pivaloyloxy)methyl)tetrahydro-2H-pyran-3,4,5-triyl tris(2,2-dimethylpropanoate)→(2S,3S,4R,5R,6R)-2-(3-((5-(4-fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl)-6-((pivaloyloxy)methyl)tetrahydro-2H-pyran-3,4,5-triyl tris(2,2-dimethylpropanoate)
本站可供应的对应中间体
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