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CAS 603-35-0
triphenylphosphanePhosphorustriphenyl
登记编号：LACO-030、Voclosporin-011
应用背景（按来源药适应症）
强直阵挛性癫痫拉考沙胺癫痫拉考沙胺癫痫部分性发作拉考沙胺癫痫发作拉考沙胺狼疮肾炎伏环孢素肾脏移植排斥伏环孢素新型冠状病毒感染伏环孢素系统性红斑狼疮伏环孢素局灶性节段性肾小球硬化症伏环孢素干眼综合征伏环孢素
来源药（使用该中间体的合成路线）
合成路线中的位置（上下游链）
按路线登记顺序排列，左→右为合成方向；高亮为当前 CAS，其余可点击跳转对应档案。
phenylmethanamine→N-acetyl-O-methyl-D-serine→methyl D-serinate→diethoxytriphenyl-l5-phosphane→ethyl (R)-aziridine-2-carboxylate→methyl (R)-aziridine-2-carboxylate→ethyl (R)-1-acetylaziridine-2-carboxylate→methyl (R)-1-acetylaziridine-2-carboxylate→ethyl N-acetyl-O-methyl-D-serinate→methyl N-acetyl-O-methyl-D-serinate→4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholin-4-ium chloride→triphenylphosphane→sodium ethanolate
Phosphorustriphenyl→(1R,2R,4E)-1-[(2S,5S,11S,14S,17S,20S,23R,26S,29S,32S)-5-Ethyl-1,7,10,16,20,23,25,28,31-nonamethyl-11,17,26,29-tetrakis(2-methylpropyl)-3,6,9,12,15,18,21,24,27,30,33-undecaoxo-14,32-di(propan-2-yl)-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontan-2-yl]-2-methylhex-4-en-1-ylacetate→(1R,2R,4E)-6-bromo-1-[(2S,5S,11S,14S,17S,20S,23R,26S,29S,32S)-5-ethyl-1,7,10,16,20,23,25,28,31-nonamethyl-11,17,26,29-tetrakis(2-methylpropyl)-3,6,9,12,15,18,21,24,27,30,33-undecaoxo-14,32-bis(propan-2-yl)-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontan-2-yl]-2-methylhex-4-en-1-ylacetate→[(2E,5R,6R)-6-(acetyloxy)-6-[(2S,5S,11S,14S,17S,20S,23R,26S,29S,32S)-5-ethyl-1,7,10,16,20,23,25,28,31-nonamethyl-11,17,26,29-tetrakis(2-methylpropyl)-3,6,9,12,15,18,21,24,27,30,33-undecaoxo-14,32-bis(propan-2-yl)-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontan-2-yl]-5-methylhex-2-en-1-yl]triphenylphosphoniumbromide
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