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CAS 90213-66-4
2,4-dichloro-7H-pyrrolo[2,3-d]pyrimidine
登记编号：TOFA-014、PF-06651600-007、AVITI-001
应用背景（按来源药适应症）
强直性脊柱炎枸橼酸托法替布幼年型类风湿性关节炎枸橼酸托法替布溃疡性结肠炎枸橼酸托法替布银屑病关节炎枸橼酸托法替布类风湿关节炎枸橼酸托法替布斑秃甲磺酸利特希替尼白癜风甲磺酸利特希替尼慢性荨麻疹甲磺酸利特希替尼化脓性汗腺炎甲磺酸利特希替尼瘢痕疙瘩甲磺酸利特希替尼乳糜泻甲磺酸利特希替尼非小细胞肺癌马来酸艾维替尼非霍奇金淋巴瘤马来酸艾维替尼淋巴瘤马来酸艾维替尼慢性淋巴细胞白血病马来酸艾维替尼弥漫性大B-细胞淋巴瘤马来酸艾维替尼套细胞淋巴瘤马来酸艾维替尼
来源药（使用该中间体的合成路线）
合成路线中的位置（上下游链）
按路线登记顺序排列，左→右为合成方向；高亮为当前 CAS，其余可点击跳转对应档案。
(3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine hemi((2R,3R)-2,3-bis((4-methylbenzoyl)oxy)succinate)→2,4-dichloro-7H-pyrrolo[2,3-d]pyrimidine→N-((3R,4R)-1-benzyl-4-methylpiperidin-3-yl)-2-chloro-N-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine→1-benzyl-N,4-dimethylpiperidin-3-amine→N-methyl-N-(4-methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine→ethyl 2-cyanoacetate→methyl (4-methylpyridin-3-yl)carbamate→1-benzyl-3-((methoxycarbonyl)amino)-4-methylpyridin-1-ium chloride→methyl (1-benzyl-4-methyl-1,2,5,6-tetrahydropyridin-3-yl)carbamate
1-((2S,5R)-5-((7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-2-methylpiperidin-1-yl)prop-2-en-1-one→6-methylpyridin-3-amine→tert-butyl (6-methylpyridin-3-yl)carbamate→tert-butyl (6-methylpiperidin-3-yl)carbamate→benzyl 5-((tert-butoxycarbonyl)amino)-2-methylpiperidine-1-carboxylate→(2S,5R)-benzyl 5-((tert-butoxycarbonyl)amino)-2-methylpiperidine-1-carboxylate→(2S,5R)-benzyl 5-amino-2-methylpiperidine-1-carboxylate→2,4-dichloro-7H-pyrrolo[2,3-d]pyrimidine→(2S,5R)-benzyl 5-((2-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-2-methylpiperidine-1-carboxylate→N-((3R,6S)-6-methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine hydrochloride→1-((2S,5R)-5-((7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-2-methylpiperidin-1-yl)prop-2-en-1-one
2,4-dichloro-7H-pyrrolo[2,3-d]pyrimidine→2,4-dichloro-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidine→3-nitrophenol→2-chloro-4-(3-nitrophenoxy)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidine→3-fluoro-4-(4-methylpiperazin-1-yl)aniline→N-(3-fluoro-4-(4-methylpiperazin-1-yl)phenyl)-4-(3-nitrophenoxy)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine→4-(3-aminophenoxy)-N-(3-fluoro-4-(4-methylpiperazin-1-yl)phenyl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine→acryloyl chloride→N-(3-((2-((3-fluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy)phenyl)acrylamide→N-(3-((2-((3-fluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-7-(hydroxymethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy)phenyl)acrylamide
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同 CAS 多家在售供应横向对比；价格区间为供应方挂牌口径，实价以询价确认为准。
| 供应商 | 产品 | 价格区间 | 最小起订 | 货期 | 资质 | 操作 |
|---|---|---|---|---|---|---|
| Unibest Nantong cGMP Site | 2,4-dichloro-7H-pyrrolo[2,3-d]pyrimidine Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
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